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Patrick Thompson
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Emily Kemp
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Matilda Campbell
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Marlon Riddle
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Tilly Wilkinson
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Jamie Hutchinson
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Type Iii Secretion System
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Killian Parsons
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Joel Boykin
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Ken Ericksen
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what is a type III secretion system?
a method bacteria use to gain entrance to host cells, by which they initially use pili to make contact with the host cell membrane and then form a pore by which proteins can be injected into the host cell/nutrients can be extracted from the host cell.
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what kinds of things can be transferred into the host cell by a pathogen via the type III secretion system?
transcription factors, to allow the host cell control via the invading pathogen
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fever and scant bloody diarrhea with mucus and pus, although in the early stages of disease voluminous watery diarrhea is seen in many patientsdoes not invade beyond the mucosa to reach the lamina propria and the mesenteric lymph nodes and does not lead to bacteremia.antibiotics shortens the duration of symptoms and sheddingreplacement of fluid and electrolytes. Only rarely does a chronic carrier state occur. Invasiveness is the primary virulence factor,has enterotoxic, cytotoxic, and neurotoxic activities, and is nearly identical to the verotoxin produced by EHEC strains of E. coliformation of actin “comets”, similar to the mechanism used by ListeriaType III secretion system and uses the “trigger”-type mechanism to invade target cells.contains a large (220 kb) virulence plasmid which carries the genes for these virulence factors.
S. sonnei accounts for between 60 and 80 percent of the cases remaining cases are mostly caused by S. flexneri.
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