Type Iii Secretion System Flashcards, test questions and answers
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What is Type Iii Secretion System?
The Type III Secretion System (T3SS) is a molecular syringe that certain bacteria use to inject toxins into host cells. It is a process of translocation and consists of several proteins which are secreted by the bacteria and injected into the host cell’s cytoplasm. The T3SS enables pathogenic bacteria to penetrate and invade host cells, while also evading immune defenses. It is responsible for a variety of human diseases, including gastrointestinal infections, sepsis, meningitis, and cholera.The T3SS allows bacterial pathogens to inject effector proteins into the cell membrane of their target eukaryotic cell. This injection allows the bacteria to manipulate cellular processes in order to survive within the host cell and replicate itself inside it. The effector proteins secreted by the T3SS are able to act as toxins that inhibit or even destroy important cellular components such as DNA replication machinery or protein synthesis machinery, thus allowing bacterial replication inside the eukaryotic cell without being attacked by its immune system. Additionally, some effector proteins can act as virulence factors that promote infection by binding receptors on target cells or promoting phagocytosis of invading bacteria into cells. In recent years, researchers have been working towards understanding how this system works in detail in order to develop new treatments for diseases caused by bacterial pathogens using this secretion system. Understanding how this type of secretion works will help us develop better therapeutics against pathogenic infections in humans as well as animals and plants alike due to its widespread use among various species of microorganisms causing disease worldwide.