If a patient inherits or develops a mutation in a tumor suppressor gene, the complementary allele must be deleted/mutated before cancer develops. This is not true of oncogenes. What is the genetic term?

Loss of heterozygosity More test answers on https://studyhippo.com/step-1-first-aid-genetics/

what is the main gene involved in bladder cancer? is it a tumor suppressor gene or oncogene?

RAS-oncogene RAS becomes an oncogene when it is locked into an active state and does not allow hydrolysis of GTP after tyrosine kinase receptor activation by growth factors. More test answers on https://studyhippo.com/cancer-set/

If a tumor suppressor gene becomes mutated, which of the following is not true?

A “gain-of function” mutation has occurred. More test answers on https://studyhippo.com/19/

Is the VHL gene an oncogene or tumor suppressor gene? How does it work?

VHL is a tumor suppressor gene (VEHLL THEN = suppressive). It degrades the protein HIF-1alpha which induces VEGF, CA-IX -> formation of vasculature -> progression of tumor More test answers on https://studyhippo.com/tumors-of-the-kidney-and-urinary-tract/

What occur when proto onco or tumor suppressor gene are mutated and why that occur

1. Uncontrollable growth, cell prolifilation, transformation 2. excape Apoptosis 3. This occur because they are not responding to ligand that tell it when to turn on and off or sometime death signal More test answers on https://studyhippo.com/cancer-biology/

Mutations in the proto-oncogene ras and the tumor suppressor gene p53 a.) increase protein synthesis by the cell. b.) can improve the chance of avoiding cancer as one ages. c.) disrupt normal regulation of the cell cycle. d.) can enhance further mutations, which can develop into cancer.

c.) disrupt normal regulation of the cell cycle. More test answers on https://studyhippo.com/mastering-biology-11-15-11-18/

Which mutated tumor suppressor gene is most likely to contribute to many types of cancer, including bladder, breast, colorectal and lung? a. p53 b. APC c. BRCA1 D. BRCA2

a. p53 More test answers on https://studyhippo.com/lewis-chapter-15-cancer/

Which mutated tumor suppressor gene is most likely to contribute to many types of cancer, including bladder, breast, colorectal, and lung? a. p53 b. APC c. BRCA1 d. BRCA2

a. Mutations in the p53 tumor suppressor gene have been found in many cancers, including bladder, breast, colorectal, esophageal, liver, lung, and ovarian cancers. APC gene mutations increase a person’s risk for familiar adenomatous polyposis, which is a precursor for colorectal cancer. BRCA1 and BRCA2 mutations increase the risk for breast and ovarian cancer. More test answers on https://studyhippo.com/ch-16-cancer-study-guide-qs/

Define each of the following genes and their distinctions, then explain how each type of gene can participate in the pathogenesis of cancer: tumor suppressor gene; oncogene; and, DNA repair genes.

Tumor suppressor gene-normally suppressor tumors, pRB, P53, recessive trait, loss of function mutation Oncogene-as mutated this can change characteristics of growth factors and receptors. dominant gene. Helps with proliferation DNA repair gene-multi step, genes normally encode enzymes that can proof read, when we lose their effectiveness increased changes of cancer More test answers on https://studyhippo.com/2-cancer-case-studies-patho-404/

What does a tumor suppressor gene do?

(stop) cell division More test answers on https://studyhippo.com/cell-cycle-cancer-stem-cell-review/

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Tumor Suppressor Gene Flashcards, test questions and answers

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What is Tumor Suppressor Gene?

A tumor suppressor gene (also known as an anti-oncogene) is a gene that works to inhibit the development and growth of tumors. These genes are important for controlling cell growth and division, as they act to ensure that cells do not divide too rapidly or become cancerous. Mutations in these genes can lead to an increased risk of developing cancer. The most well-known tumor suppressor gene is the p53 gene, which plays a major role in preventing tumor formation. It does this by inducing cell cycle arrest, triggering apoptosis (programmed cell death), or stimulating DNA repair mechanisms when there is damage to the genetic material. Mutations in this gene are found in many types of cancers including breast, colorectal, lung, ovarian and pancreatic cancers. Other important tumor suppressor genes include APC, RB1 and BRCA1/2. The APC gene helps regulate the activity of beta-catenin which plays an important role in cell proliferation and survival; mutations in this gene are associated with colorectal cancer. The RB1 gene helps control the progression through the cell cycle; it also plays a role in maintaining genomic stability; mutations are associated with retinoblastoma (a type of eye cancer). And finally BRCA1/2 helps repair damaged DNA; mutations can increase the risk for breast and ovarian cancer significantly among other types of cancers like prostate cancer. In summary, tumor suppressor genes help maintain cellular homeostasis by regulating cell growth and division while also helping to prevent mutation accumulation that may lead to malignant transformation and thus promote carcinogenesis. Mutation or loss of function within these genes can result in uncontrolled cellular proliferation leading to tumors or even cancer.