Dose Response Relationship Flashcards, test questions and answers

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What is Dose Response Relationship?

Dose-response relationship is an important concept in pharmacology, toxicology, and medicine. It refers to the relationship between the amount of a drug or environmental agent taken by an individual and the resulting effect on that individual. The amount of a drug or environmental agent taken by an individual is referred to as a dose while the resulting effect can be physical, psychological, or both. This relationship is important because it helps determine how much exposure is safe for each individual and how much may cause harm.The dose-response relationship can vary greatly depending on many factors such as age, weight, sex, genetics, lifestyle factors (such as smoking), and even time of day. Generally speaking however, it can be said that increasing doses will lead to increased effects until there is a point known as the threshold where further increases in dose do not cause any more significant changes in effect. In other words the response does not increase linearly with dose but rather follows an S shaped curve with an optimal level at which there are maximized responses for minimal risk of adverse side effects or toxicity.This relationship has been studied extensively in order to better understand drug action and develop appropriate dosing regimens for medical treatments from antibiotics to chemotherapy drugs. It also plays a critical role in toxicology where understanding how exposure levels affect response helps us protect public health from hazardous chemicals found in our environment such as air pollutants and pesticides.