Effect Of Selenium And Vitamin E On Prostate Cancer Essay Example
Effect Of Selenium And Vitamin E On Prostate Cancer Essay Example

Effect Of Selenium And Vitamin E On Prostate Cancer Essay Example

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  • Pages: 2 (550 words)
  • Published: April 13, 2022
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The previous research study showed that selenium reduces the risk of prostate cancer by 63% while vitamin E reduces it by 32 percent. Randomized controlled trials (RCTs) were conducted in large-scale that involved a combination of vitamin E, selenium, and beta-carotene and were found to reduce deaths caused by cancer. The research question in the study is whether vitamin E or selenium or a combination of the two has an effect of preventing prostate cancer without or with little toxicity in healthy men.


The design employed placebo-controlled trial using vitamin E and selenium supplements for prevention of prostate cancer. The study was to be conducted for a minimum of 7 years and 12 years maximum. For the participants to be eligible for the research, they had to be over 50 years for African American men. Other participants were required to be over 55 years. It was a requirement for one not to have undergone cancer diagnosis as digital rectal examination was not supposed to show any signs of cancer. To be eligible men, were also required to have normal blood pressure and not have experienced hemorrhagic stroke. Self-reporting was used to identify characteristics of the participants. Randomized criteria were used to assign 35, 533 men to the four arms of the study. The interventions included oral selenium with vitamin E placebo match, a match of vitamin E and selenium placebo or their combination and placebo combined with placebo. Baseline blood and specimens of toenail were collected and a sample of five-year blood. Samples of prostate tissue gathered on the eve of the trial were revie


wed by the pathology. The participants visited the clinic twice annually, where negative effects were monitored. Various assessments were carried out annually including weight, blood pressure, and smoking status. The undesirable events were prespecified and known to have been caused by selenium or vitamin E were ranked following toxicity criteria. Since the standards were anticipated to change, 7.8 % of the participants were provided with multivitamin without vitamin E or selenium and serum levels were assessed.


The committee of data and safety monitoring discontinued the study supplements after seven years of trial. It was revealed that it accrued no benefit from the agent of study as it demonstrated lack of any degree of benefit even with continued follow-up. Until 23rd October 2008, the median of those followed up was 5.46. The risk of prostate cancer for vitamin E was 1.13, 99 percent confidence levels. Selenium showed 1.04 while combination showed 1.05. No significant discrepancies were revealed as all p-values were greater than 0.5 in any endpoints of prespecified cancer. In the arm of vitamin E, the study showed a lack of increased risks associated with prostate cancer. There was no significant rise in diabetes mellitus of type two in the arm of selenium. In the combination arm, no observation was made.


The study revealed that Vitamin E or selenium either in combination or alone did not prevent prostate cancer in relatively healthy men. Even if prostate cancer has reduced recently, it remains risky to men as it is among the primary causes of deaths related to cancer whose risk

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is not prevented by selenium or vitamin E.


  1. Lippman, Scott M., et al. "Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)." Jama 301.1 (2009): 39-51