Effect Of Selenium And Vitamin E On Prostate Cancer Essay Example

negative effects were monitored. Various assessments were carried out annually including weight, blood pressure, and smoking status. The undesirable events were prespecified and known to have been caused by selenium or vitamin E were ranked following toxicity criteria. Since the standards were anticipated to change, 7.8 % of the participants were provided with multivitamin without vitamin E or selenium and serum levels were assessed.

Results

The committee of data and safety monitoring discontinued the study supplements after seven years of trial. It was revealed that it accrued no benefit from the agent of study as it demonstrated lack of any degree of benefit even with continued follow-up. Until 23rd October 2008, the median of those followed up was 5.46. The risk of prostate cancer for vitamin E was 1.13, 99 percent confidence levels. Selenium showed 1.04 while combination showed 1.05. No significant discrepancies were revealed as all p-values were greater than 0.5 in any endpoints of prespecified cancer. In the arm of vitamin E, the study showed a lack of increased risks associated with prostate cancer. There was no significant rise in diabetes mellitus of type two in the arm of selenium. In the combination arm, no observation was made.

Conclusion

The study revealed that Vitamin E or selenium either in combination or alone did not prevent prostate cancer in relatively healthy men. Even if prostate cancer has reduced recently, it remains risky to men as it is among the primary causes of deaths related to cancer whose risk is not prevented by selenium or vitamin E.

Bibliography

1. Lippman, Scott M., et al. "Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and
   

Vitamin E Cancer Prevention Trial (SELECT)." Jama 301.1 (2009): 39-51