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amino acid similarities (Model 1)
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each amino acid contains a central carbon atom attached to an amine group, a carboxyl group, and a hydrogen atom.
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amino acid differences (Model 1)
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The difference between the R groups in the two amino acids (-CH2OH and -CH3)
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two
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How many amino acids are involved in the reaction to make a dipeptide?
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peptide bond
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A ________________ is a covalent bond linking two amino acids together in a peptide; located between carbon and nitrogen atoms, and more broadly, between the functional groups of a carboxylic acid and an amine
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primary structure
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The ________________ of a protein is the sequence of the amino acids that make up the protein chain.
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hydrogen bonds
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What types of bonds are holding the secondary structure in place?
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secondary structure
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The _____________ is formed by hydrogen bonds holding 2 different parts of the primary structure together into a folded or coiled molecule.
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hydrophobic interactions, hydrogen bonds, disulfide bridges, ionic bonds
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bonds or interactions in tertiary structure and quaternary structure (plural)
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between R groups
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Where do the interactions in tertiary structure take place?
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alcohols, acids, amines
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R-groups would need to contain ___________ (O-H), ___________ (COOH), ____________ (NH2)- polar groups that would contain either oxygen or hydrogen on the end of a polar bond in order for
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hydrogen bonding to occur between two amino acids in a protein chain (3)
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hydrocarbon chains
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R-groups would need to be nonpolar, containing only _________________ or rings, in order for hydrophobic interactions to occur between two amino acids in a protein chain
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tertiary protein structure
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________________ is formed by further folding of the amino acid chain (beyond secondary structure), and is held together by various types of bonds between groups.
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quaternary protein structure
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_______________ is formed when 2 or more polypeptide chains that make up a protein associate with one another and are held together, by bonds between their R groups.
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hydrogen bonding
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All amino acids can participate in ________________ to stabilize secondary structure.
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cysteine
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Which of the amino acids could form disulfide bonds with another amino acid in the chain to stabilize the tertiary structure of the protein?
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phenylalanine
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Which of the amino acids could participate in the hydrophobic interactions with another amino acid in the chain to stabilize the tertiary structure of the protein?
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hydrogen bonds
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What type of bonds or interactions could asparagine form with another amino acid in the chain in order to form a quaternary structure with another protein chain?
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primary structure
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Bonds or interactions holding structure together: peptide (covalent) bonds
Description: the sequence of amino acids
Number of polypeptide chains: 1
Description: the sequence of amino acids
Number of polypeptide chains: 1
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secondary structure
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Bonds or interactions holding structure
together: hydrogen bonds
Description: hydrogen bonds form between the oxygen of the carboxyl groups and the hydrogen of the amine groups in the carbon backbone causing helix formation or pleating
Number of polypeptide chains: 1
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tertiary structure
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Bonds or interactions holding structure together: hydrogen bonds, ionic bonds, disulfide bridges, and hydrophobic interactions
Description: R-group side chains of different amino acids interact to further fold the protein
Number of polypeptide chains: 1
Description: R-group side chains of different amino acids interact to further fold the protein
Number of polypeptide chains: 1
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quaternary structure
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Bonds or interactions holding structure together: hydrogen bonds, ionic bonds, disulfide bridges, and hydrophobic interactions
Description: Bonds form between individual polypeptide chains
Number of polypeptide chains: 2 or more
Description: Bonds form between individual polypeptide chains
Number of polypeptide chains: 2 or more
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primary structure
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________________ is the only level of structure that is maintained after denaturing, as only peptide bonds are retained
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denaturing
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Heating and changing pH levels are two ways to disrupt the shape of a protein. High T or pH levels that vary from the natural environment of the protein will break hydrogen bonds, ionic bonds, disulfide bridges, and hydrophobic interactions. Covalent bonds will remain undisturbed. This process of destroying the shape of a protein is called _____________.
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enzyme
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The heat or pH change would disrupt the shape of the _____________ and prevent it from working properly
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tertiary and quaternary
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When hair is chemically straightened, this affects the ______________ and ___________ structures of the proteins. (2)
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