Perimenopause refers to the period during which a woman’s body makes its natural transition towards permanent infertility (Rabinstein & Klimo, 32). Hormones are messengers in the body that move through the bloodstream to start and speed up or slow down your physical and chemical functions and processes across all the body systems. Ovaries are the basis of estrogen and progesterone; the two essential hormones manage the reproductive system, with the menstrual cycle and fertility in women (Shulman & Jeffrey, 279). Eggs are in follicles, which are established in the ovaries. During menopause, a quantity of ovarian follicles declines and the ovaries happen to be less responsive to the two extra hormones involved in reproduction—Luteinizing Hormone plus Follicle-Stimulating Hormone (Rabinstein & Klimo, 32). As ovaries age and discharge less hormones, FSH and LH can no longer do their usual functions t
...o manage estrogen, progesterone plus testosterone.
Women who are menopausal have naturally abridged levels of the estrogen hormone in their body. More conditions that can cause a decrease in the estrogen levels are unsuccessful pregnancies, anorexia nervosa, excessive exercise, hypogonadism and hypopituitarism according to WebMD (Shulman & Jeffrey, 275). As soon as the estrogen levels fall, the body is not capable of absorbing and using the calcium needed to make bone mass and density. This is mainly contributing factor in the occurrence of osteoporosis according to Healing with Nutrition (Dvornyk & Volodymyr, 57). These doctors often advise post-menopausal women to get estrogen replacement therapy. ERT can diminish the danger of osteoporosis if commenced in three to five years after the beginning of menopause, according to Healing with Nutrition.com. ERT carries the risk of causing some cancers, hear
disease, and gall bladder illness (Brincat et.al, 56).
Smoking lowers a woman’s estrogen levels and aids in calcium assimilation. If the body cannot absorb as much calcium, it can lead to osteoporosis and fragile bones. Smoking blocks the hormones that manage menstruation, hence lowering estrogen levels. Smoking reduces the quantity of calcium that bones absorb and interferes with how the body uses vitamin D. In general; smoking is very harmful to one's health and significantly affects their estrogen and calcium levels (Dvornyk & Volodymyr, 54).
HRT stand for Hormone Replacement Therapy (Rabinstein & Klimo, 45). It is a treatment for inserting Hormones keen on the body when the body can no longer create them. It is planned for women whose estrogen and progesterone levels are low owing to menopause. HRT mechanically boosts the hormone levels which are essential for women with low hormone levels.
Some pros of HRT include it is considered the most excellent treatment option for low estrogen and progesterone levels, it's very useful in plummeting the risk of osteoporosis, relieves sign of menopause, lowers risk of colon tumor and reduces the risk of macular disintegration. There are several cons of HRT that comprise of increased risk of blood clots, strokes, endometrial cancer, blood pressure plus breast cancer (Brincat et.al, 66). The option to make use of HRT ought to be careful thought before proceeding after knowing all of the possible risks.
Four other options (drugs) available to men and women to help prevent and treat osteoporosis:
- Bisphosphonates
Bisphosphonates are used to prevent and treat postmenopausal osteoporosis through slowing bone loss while increasing bones mass. Bisphosphonates help diminish the risk of spine, non-spine, and hip fractures (Rabinstein &
Klimo, 36).
- Denosumab
Denosumab is approved to prevent and treat osteoporosis in postmenopausal women enhancing risk for fractures. It is used when patients cannot tolerate other osteoporosis medicines or if other medications are not working well. It is used to treat bone loss in women who are receiving treatment for breast cancer (Brincat et.al, 75). It is as well used to prevent bone ills in patients with bone metastases cancer that has spread to the bones from particular types of tumors.
- Raloxifene
Raloxifene is approved to prevent and treat osteoporosis in postmenopausal women. It is a class of drugs called selective estrogen receptor modulators, which are estrogen-like medications. Raloxifene increases fillet density and reduces the risk of bristle fractures, though it has not been showing to decrease the risk of non-spinal fracture (Brincat et.al, 75).
- Teriparatide
Teriparatide is an injectable form of the human parathyroid hormone. It is approved for postmenopausal women plus men with osteoporosis who have been elevated risk for having a fracture (Brincat et.al, 78). Teriparatide stimulates different bone formation in both the spine and the hip. It is as well as reducing the risk of vertebral and nonvertebral fracture in postmenopausal women
Work cited
- Dvornyk, Volodymyr. Current Topics in Menopause. Sharjah, United Arab Emirates: Bentham Science Publishers, 2013. Print
- Brincat,Mark R., Raymond P.Galea, and Eleanor Borg. “Evaluation of FRAX Score use in maltese osteoporosis management guidelines.“Malta Medical Journal 27.4(2015): 8-12
- Academic Serch Remier.Web.30 Oct.2016 Shulman, Lee, and Jeffrey S. Dungan. Year Book of Obstetrics, Gynecology and Women's
- Health. London: Elsevier Health Sciences, 2012. Print
- Rabinstein, Alejandro, and Jr M. P. Klimo. Year Book of Neurology and Neurosurgery. London:
- Elsevier Health Sciences, 2012. Internet. Print
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