Critical Review of the Literature of the role that Dietary Factors Play in Preventing Type 2 Diabetes
Critical Review of the Literature of the function that Dietary Factors Play in Preventing Type 2 Diabetes’
Type 2 Diabetes ( T2D ) is a quickly turning international public wellness issue. It has been reported that 285 million 20–79 twelvemonth olds had the disease in 2010 worldwide and this is estimated to turn to 439 million by 2030. ( 19 ) T2D has been associated with a assortment of other wellness jobs such as cardiovascular disease. sightlessness and shortened life anticipation. ( 4. 40 ) The prevalence of the disease is associated with fleshiness and corpulence every bit good as a ‘Western’ dietetic form and deficiency of exercising. ( 17 ) It has been reported that about 80 % of people who develop T2D are corpulent or fleshy prior to diagnosing. ( 8 ) Diabetes is a preventable disease. ( 19 ) with weight loss being identified as one of the most powerful intercessions. ( 4 ) Diet and physical activity ( PA ) are effectual intercessions in achieving this ( 25 ) and have besides been linked with decrease in hazard independently.
( 40 ) The primary focal point of this paper will look at diet and reexamine the grounds on whether diet entirely can assist to forestall T2D. As a secondary subject it will besides look at the grounds that diet can assist to forestall the development of and assist to command symptoms after T2D has been diagnosed. 8 documents will reexamine. ( 26-33 ) with a intent of placing some practical. grounds based dietetic guidelines. Dietary guidelines are easier to follow when they indicate specific nutrients and forms instead than foods and belongingss of nutrients and greater conformity can be achieved. ( 29. 31 ) For this ground the surveies reviewed focal point on specific nutrients and diet manners instead than macronutrients and or micronutrients which do non interpret into dietetic guidelines as easy.
A literature reappraisal utilizing the undermentioned databases was carried out ; Pubmed. Web of Science. Embase. CINAHL. British Nursing Index and Medline. The undermentioned keywords were used in assorted combinations ;
Diet. bar. nutrient. T2D. intercessions. dietetic. fruit. veggies. nutrition. Other resources such as ‘Google scholar’ and NHS Choices ‘behind the headlines’ were besides utilised. Because T2D is an international issue. documents from around the universe were considered. The standard for inclusion was less than 10 old ages old. the intercession had to be a specific nutrient group or diet manner. mensurating new incidents of T2D. or alterations is symptoms associated with T2D and grownups as the sample group.
Diet as a tool to forestall T2D
6 Studies looked at whether diet can forestall T2D. Please refer to Postpone 1 for inside informations of all the surveies. Villegas et Al ( 26 ) and Bazzano et Al ( 27 ) looked at fruit. vegetable and fruit juices ingestion and fruit and vegetable ingestion severally. Both of the surveies used adult females merely in their sample groups. restricting the generalizability of the findings to the wider population. ( 5 ) Dietary appraisal was achieved through Food Frequency Questionnaires ( FFQ ) in both surveies. Villegas et Al ( 26 ) provided grounds of their FFQ holding been validated. ( 21 ) nevertheless reported utilizing it merely 3 times within a 4. 6 twelvemonth timeframe. oppugning the truth of their collected informations. Bazzano et Al ( 27 ) informations aggregation was retrospective in that the FFQ was designed in 1984 and followed up at 4 twelvemonth intervals. The concern with such a dated questionnaire is that it has non accounted for different tendencies that have occurred over clip. impacting the truth of the consequences.
Villegas et Al ( 26 ) confirmed incidence of T2D through topics run intoing the standard set out by the American Diabetic Association. ( 2 ) Bazzano et Al ( 27 ) used standards set out by National Diabetes Data Group for all participants up to and including 1997. ( 16 ) The Criteria for participants after 1998 was set out by the American Diabetic Association. The ground for this was due to new standards being published at this clip. ( 2 ) The chief difference being the plasma glucose reading altering from 7. 8mmol/l or more to 7. 0mmol/l or more. ( 9 ) The Criteria Set out by the World Health Organisation in 1985. ( 24 ) could hold been used to corroborate incidence of T2D in the Bazzano et Al ( 27 ) survey. It was published 1 twelvemonth after baseline information was taken and would hold resulted in a higher per centum of participants being diagnosed with the same standard. increasing consistence
and dependability in the consequences.
Villegas et Al ( 26 ) reported that a higher ingestion of veggies was associated with a decreased hazard of T2D. Participants who had a higher vegetable consumption were besides less likely to smoke and hold higher degrees of PA. both factors that can cut down the hazard of T2D oppugning the causality of the decrease in hazard. ( 4 ) Participants with a higher fruit consumption were besides less likely to smoke and hold higher degrees of PA. There was no association made between fruit consumption and hazard of T2D therefore it is possible to see that confounders like PA and smoke may non hold effected the degree of hazard to T2D in this survey.
Bazzano et Al ( 27 ) reported an opposite association between whole fruit and green leafy vegetable consumption. Womans who had a higher consumption of fruit and veggies were older. less likely to smoke and more likely to hold higher degrees of PA. Fruit Juice was positively associated with incidence of T2D which could be due to high sugar content. . ( 22 ) Besides participants who had the highest fruit juice consumption had the lowest degrees of PA which is associated with increased hazard of T2D. ( 20 ) Salas-Salvado et Al ( 28 ) and Martinez-Gonzalez et Al ( 29 ) both studied the hazard of T2D and attachment to the Mediterranean diet ( MedDiet ) . A MedDiet is characterised by high ingestion of fruit. veggies. whole grains. olive oil. nuts. pulsations. fish and decreased ingestion of ruddy and processed meats. high fat dairy refined additions and nutrients high in sugar and amylum. ( 11 ) Salas-Salvado et Al ( 28 ) compared attachment to a MedDiet supplemented with either olive oil or nuts with a low fat diet ( command group ) .
The supplemented points in the MedDiets were given to participants. Participants in the control group were given non dietetic gifts to promote attachment. There are concerns about the moralss of utilizing inducements and gifts in research. ( 6 ) Within this survey the usage of gifts appears innocuous. the concern lies with how attachment to the diet is faithfully measured. When participants are given critical ingredients. this will act upon their dietetic consumption. doing it hard generalise the consequences. ( 13 ) The sample population in this survey were older and had at least 3 hazard factors associating to cardiovascular disease once more doing it more hard to generalize consequences. Participants were given 7 ends. including ; increasing vegetable and fruit ingestion. cut downing ruddy and processed meat and increasing the ingestion of either olive oils or nuts.
The control group were asked to cut down all types of fat. Consequences showed that participants in the MedDiet groups had a greater decreased hazard of T2D. Hazard was reduced by 51 % in the olive oil group and 52 % in the nut group. These findings are backed up by other surveies. ( 38-39 ) Diabetes incidence was lower in those who attained ? 4 of the 7 ends. PA degrees and alterations in weight did non differ through all 3 groups. although the participants in the both the MedDiet groups were associated with higher degrees of PA. This survey was carried out on Spanish participants. who traditionally follow a MedDiet. The control group may hold had a strong attachment to a MedDiet of course. which could impact on the dependability of the consequences.
Martinez-Gonzalez et Al ( 29 ) used participants who were nurses and university alumnuss. Prevalence in T2D is associated with lower socioeconomic position. ( 1 ) so by utilizing the participants from a higher socioeconomic group may bias the findings. ( 13 ) Participants were non excluded if they had Diabetess at baseline. Data was collected via FFQ which consisted of 136 points with 9 responses runing from ne’er to more than 6 times a twenty-four hours. Points were allocated to find a mark bespeaking degree of attachment. Questions covered countries such as cooking methods. addendums and fats and oils. This FFQ goes into a batch of item to obtain the most information it can about participants diets. increasing the cogency of the informations.
However dependability is compromised as participants are asked to remember nutrient consumption from the old twelvemonth diminishing the truth of informations collected. ( 5 ) The consequences indicated a important decrease in hazard of developing T2D in those who with strong attachment to the MedDiet after accommodation for age and sex. Participants with a mark of ? 6 had an 83 % decrease. Although participants in this group had the highest degrees of physical activity. which is a known factor in diminishing the hazard of T2D. they besides had a higher baseline prevalence for increased hazard factors for Diabetess such as age higher BMI and higher blood force per unit area. This adds weight to the findings the MedDiet can cut down the hazard of developing T2D.
Fung et Al ( 30 ) and VanDam et Al ( 31 ) looked at more generalized dietetic forms. VanDam et Al ( 31 ) used a 131 point FFQ stipulating specific nutrients. part sizes and frequence of consumption. Over a infinite of 12 old ages informations on nutrient consumption was collected 3 times. In order to do these consequences more dependable informations aggregation should hold occurred more often. The participants were all male wellness professionals doing the sample group rather specific cut downing the ability to generalize the findings to the wider population. ( 13 ) Foods were classified into groups based on nutritionary profiles. Factor analysis was so applied in order to place nutrient forms. Two dietetic forms were identified ‘Prudent’ and ‘Western’ . Prudent was characterised by high ingestion of veggies. fish and whole grains and Western by high ingestion of ruddy and processed meat. high-fat dairy and eggs.
Work force with higher Western forms were younger. more likely to smoke and did less PA. Men with higher Prudent diet forms were older less likely to smoke and engaged in more PA. The Prudent diet was associated with a modest decrease in hazard in developing T2D with wholegrain nutrients holding the highest reverse association. Fruit and veggies were non well associated with decreased hazard. The Western diet was associated with well higher hazard of developing T2D. Processed meat. other processed nutrients and refined grains bespeaking the most important association. This could bespeak that cutting out specific nutrients could me more good in cut downing the hazard of T2D than increasing consumption of other nutrients.
Fung et Al ( 30 ) used participants from the Nurses Health Study which was established in 1976. This is the same survey from which Bazzano et Al ( 27 ) took their participants. The same FFQ was used in this survey with baseline besides being the 1984 FFQ as this was the expanded 116 point version. The information obtained was so used and classified in the same manner as the VanDam et Al ( 31 ) survey bring forthing the same Prudent and Western dietetic forms. The consequences from this survey focus chiefly on the Western diet form. Similarly to the work forces in the VanDam et Al ( 31 ) survey. adult females who scored high in the Western diet form were more likely to smoke. The consequences besides mirrored that of the VanDam et Al ( 31 ) survey in that it reported an increased hazard of developing T2D and a Western diet form. This survey investigated the features of the Western dietetic form further and found positive associations between ruddy and processed meats and the development of T2D.
This could besides add weight to the old remark that cutting out specific nutrients. such as ruddy and processed meats could be more good than adding other nutrient groups in forestalling T2D. A reproduction survey utilizing the same FFQ and Prudent and Western diet form and utilizing a sample group that consisted of both work forces and adult females could add strength to the discoveries of both of these surveies. ( 5 )
Diet as a tool in forestalling the development of and giving greater control over the symptoms of T2D
Elhayany et Al ( 32 ) compared a low saccharide Mediterranean diet ( LCM ) a traditional Mediterranean diet ( TM ) and the 2003 American Diabetic Association diet ( ADA ) on wellness parametric quantities. Glycemic control for people with T2D diagnosing was one of the result steps. Participants were indiscriminately assigned to 1 of the 3 groups. given recommendations for day-to-day consumption on nutritionary elements such as Calories and protein and advised to prosecute in 30-45 proceedingss of PA a hebdomad. The LCM and TM diets included merely low glycemic index saccharides. with LCM holding a lower % . The TM and ADA diets had the same % of saccharides but the ADA besides included assorted glycemic index saccharides.
FFQ were used inquiring the participants to remember the last 24hour nutrient consumption. It is felt this information will be more accurate than those surveies inquiring participants to remember nutrient consumption from the old twelvemonth. doing consequences more dependable. Data was collected 3 times over a 12 month period. Consequences showed all groups had reduced weight and BMI with no important difference. All 3 dietetic intercessions reduced factors that addition glycemic control such as HbA1c and triglyceride degrees. The LCM diet was the most effectual in increasing glycemic control.
Esposito et Al ( 33 ) compared a LCM and a low fat Calorie restricted diet ( LFD ) on glycemic control and the hold on necessitating to get down antihyperglycemic medicine in people freshly diagnosed with T2D. The LCM diet was rich in fruit veggies and whole grains and low in ruddy meat. There was besides a demand that no more than 50 % of Calories was from saccharides. Complex carbohydrates instead than low GI saccharides were stipulated. Some complex saccharides can hold high GI degrees. which are associated with increased hazard of Diabetes. ( 10 ) The LFD was based on American Heart Association guidelines. ( 12 ) Participants were randomized into 1 of 2 groups asked to maintain nutrient journals and given guidelines on increasing physical activity.
Data was collected through reappraisals of the journal. Food journals could supply more dependable information than FFQ if they are filled out daily. There is still a hazard that they could be filled out inaccurately. and that participants may modifies their consumption as a consequence of maintaining a journal. The survey reported that both groups lost weight. but decrease was greater in the LCM. Overall there was a important difference in the demand to get down antihyperglycemic medicine between the LCM and the LFD ; 44 % and 70 % severally. Potentially this consequence could hold shown more significance if low GI saccharides were stipulated alternatively of complex saccharides.
The findings coming out of this reappraisal indicate that certain dietetic intercessions possibly helpful in cut downing the hazard of developing T2D and may besides assist with glycemic control after diagnosing. ( 26-33 ) Some nutrient groups and dietetic forms supply more consistent grounds than others. The consequences sing fruit consumption and hazard of T2D are inconsistent within this reappraisal with Villegas et Al ( 26 ) describing no association between fruit and hazard decrease. where as Bazzano et Al ( 27 ) did. High ingestion of fruit and veggies are a major constituent in the Mediterranean diet and the Prudent dietetic form. both of which were associated with an reverse association. Vegetables are more systematically associated with a reduced hazard. in this reappraisal and a recent meta-analysis. ( 3 ) peculiarly green leafy veggies. ( 27 ) More research analyzing the effects of fruit and veggies individually is needed. This incompatibility is reflected in other surveies and systematic reappraisals. ( 7 ) High consumption of fruit and veggies has frequently been associated with higher Dad degrees within this reappraisal. ( 26-29. 31 ) which is a hazard cut downing factor in itself.
Part of the job could be that many surveies that look at dietetic intercessions are prospective cohort surveies and although they can supply an association they can non turn out whether the cause is due to the dietetic point or another factor such as PA or weight loss. More experimental designed research is needed so that a direct cause between diet and the decrease of T2D can be established. ( 13 ) While it is ill-defined the exact function that fruit and veggies play in cut downing the hazard of T2D there is an copiousness of grounds that a diet rich in fruit and veggies is good in overall wellness ( 34-35 ) and weight decrease. ( 23 ) so including them as portion of a healthy diet may indirectly assist to cut down the hazard of T2D.
Red and processed meat has been more consistent in its positive association to developing T2D. Fung et Al ( 28 ) and VanDam et Al ( 29 ) found strong associations between ingestion and increased hazard of T2D. One of the features of The Mediterranean diet is the absence or decrease of ruddy and processed meats. and this diet has been associated with decreased hazard. These findings were backed up in a recent meta-analysis paper ( 18 ) analyzing 3 cohorts who’s decision suggests that ruddy meat ingestion. peculiarly processed ruddy meat is linked to higher hazard of developing T2D.
Meta-analysis green goodss level 1 grounds. supplying increased assurance in the decisions and good foundation for supplying grounds based information such as dietetic guidelines. ( 13 ) Diets high in ruddy and processed meats are linked to high cholesterin ( 14 ) which is one of the prima causes of decease in people with T2D ( 15 ) and other serious wellness conditions such as malignant neoplastic disease and cardiovascular disease. ( 36 ) So while increasing fruit and vegetable consumption may hold a more good and holistic consequence on wellness. the same could be said for cut downing the consumption of ruddy and processed.
Salas-Salvado et Al ( 28 ) produced higher degree grounds being a randomised control test giving more weight to their findings ; ( 5 ) following a MedDiet can cut down the hazard of T2D. One of the surveies that looked at the consequence of diet after diagnosing. ( 32 ) was besides a randomised control test supplying the same degree of grounds and weight to their findings that LCM can detain the demand for hyperglycaemic medicine hence holding a positive good consequence on T2D. Although these two surveies looked at the consequence of diet after diagnosing it could be sensible to propose that following the dietetic forms associated with these findings. prior to diagnosing could assist forestall T2D as they are similar dietetic forms to two of the other surveies. ( 28-29 )
While the findings from this reappraisal indicate that doing alterations to 1s diet may assist to cut down the hazard of Diabetes happening. it besides suggests that implementing the same sort of dietetic alterations may assist with glucose control after Diabetes has been diagnosed. forestalling the farther development of the disease and the demand for antihyperglycemic medicine. ( 32-33 ) One survey has implied that dietetic alterations in the signifier of energy limitation can really change by reversal beta cell failure and insulin opposition. symptoms found in T2D.
( 37 ) It is a really little survey and the dietetic intercession is terrible energy limitation doing it hard to generalize to the wider population. but it is a controlled survey and could supply interesting findings that farther research could be built upon. that dietetic intercessions may be able to change by reversal the symptoms of T2D. Collating this information together it seems sensible to propose that doing positive alterations to dietetic wonts could hold benefits pre and post T2D diagnosing.
The findings from the 8 surveies in this reappraisal can non all be discussed in item due to word restriction. However repeating subjects seem to be happening. supplying information on which to establish a set of guidelines. Traveling by these findings the undermentioned guidelines are recommended:
Reduce consumption of ruddy meat and processed meat ( all colorss )
Substitute these with white meats and angle
Reduce consumption of other processed nutrients
Reduce consumption of refined grains
Reduce consumption of high sugar nutrients and drinks including fruit juices Carbohydrate consumption should be based on points with a low GI mark Increase consumption of olive oil
Increase nut intake
Increase consumption of pulsations
Increase wholegrain consumption
Increase vegetable consumption particularly green leafy veggies
Increase fruit consumption
A Mediterranean manner diet is characterised by much of this advise and is hence a recommended diet manner to follow.
The prevalence of T2D is turning around the universe. It has been associated with many other wellness jobs and reduces quality of life and life anticipation. It is a preventable disease and diet is one of the ways in which this disease can be combated. Dietary guidelines have been recommended from the findings of this reappraisal. based on following a Mediterranean diet. cut downing consumption of ruddy and processed meats and other processed nutrients and increasing consumption of nutrients such as fruit and veggies. wholegrains and olive oils and nuts. While it has been acknowledged that more research needs to be carried out to farther analyze the cause and consequence between diet and T2D. it is sensible to propose that one may happen these dietetic alterations beneficial in assisting to cut down the hazard of T2D and other countries of wellness. perchance assisting to indirectly cut down hazard of T2D. It is besides sensible to propose that a alteration in diet may convey good alterations one time diagnosing has been given.
1. Agardh E. Allenbeck P. Hallqvist J. Moadi T and Sidorchuk A. Type 2 Diabetes and Socioeconomic Position: A Systematic Review and Meta-analysis. International Journal of Epidemiology. 2011: 40 ( 3 ) 804-818
2. American Diabetic Association Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2000: 23 ( 1s )
3. Carter P. Gray LJ. Troughton J. Khunti K. and Davies M. Fruit and vegetable consumption and incidence of Type 2 Diabetes mellitus: A Systematic Review and Meta-analysis. British Medical Journal. 2010: 341: c4229
4. Davis MJ. Tringham JR. Troughton J. Kunit KK. Prevention of T2D mellitus. A reappraisal of the Evidence and its Application in a UK Setting. Diabetic Medicine. 2004: 21: 403-414
5. Gerrish K and Lacey A. The Research Process in Nursing. 2006 fifth Edition. Oxford: Blackwell Publishing.
6. Grant RW and Sugarman J. Ethical motives in Human Subjects Research: Do Incentives Matter? Journal of Medicine and Philosophy. 2004: 29 ( 6 ) 717-738
7. Hamer M. Chida Y. Intake of Fruit and Vegetables and Antioxidants and Risk of Type 2 Diabetes. A Systematic Review and Meta-analysis. Journal of Hypertension. 2007: 25:2361-2369
8. Hensrud DD. Dietary Treatment and Long-term Weight Loss and Maintenance in T2D. Obesity Research. 2001:9 ( 4 addendum ) :348S-353S
9. Hickner RC. Brunson MA. McCammon M. Mahar MT. Garry JP. Houmard JA. Diabetic Groups as Defined by ADA and NDDG Criteria have a Similar Aerobic Capacity. Blood Pressure and Body Composition. American Diabetes Association and National Diabetes Data Group. Diabetologica. 2001: Jan 44 ( 1 ) 26-32
10. Hodge AM. O’Dea K. English DR. and Giles GG. Glycemic Index and Dietary Fibre and the Hazard of Type 2 Diabetes. Diabetes Care. 2004: 27 ( 11 ) 2701-2706
11. Kastorini MC. Milionis HJ. Esposito K. Giugliano D. Goudevenos JA. Panagiotakos. The Effect of Mediterranean Diet on Metabolic Syndrome and its Components. Journal of the American College of Cardiology 2011: 57 ( 11 ) 1299-1313
12. Krauss RM. Eckle RH. Howard B. Appel LJ. Daniels SR. and Deckelbaum RJ.
AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals from the Nutrition Committee of the American Heart Association. Circulation. 2002: 102:2284-99
13. LoBiondo-Wood G. and Haber J. Nursing Research. Methods and Critical Appraisal for Evidence Based Practice. 2006: 6th Edition. Mosby: Show me state
14. Micha R. Wallace SK. and Mozaffarian MD. Epidemiology and Prevention. Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease. Stroke and Diabetes Mellitus. A systematic Review and Meta-Analysis. American Heart Association. 2010: 121 2271-2283
15. Heart Disease and Stroke: The Nations taking Killers. At a Glance National Centre for Chronic Disease Prevention and Health Promotion. Division for Heart Disease and Stroke bar. 2011: CS217229-AI
16. National Diabetes Data Group Classifications and Diagnosis of Diabetes Mellitus and Other Classs of Glucose Intolerance. Diabetes. 1979: 28 1039-1057
17. Neild L. Summerbell CD. Hooper L. Whittaker V. Moore H. Dietary Advice for the Prevention of T2D Mellitus in Adults ( Review ) The Cochrane Collaboration. 2008: Wiley
18. Pan A. Sun Q. Bernstein AM. Schulze MB. Manson JE. Willett WC and Hu FB. Red Meat Consumption and Risk of Type 2 Diabetess: 3 Cohorts of US Adults and an Updated Meta-analysis. American Journal of Clinical Nutrition. 2011: 94 ( 4 ) 1088-1096
19. Shaw JE. Sicree RA. Zimmet PZ. Global Estimates of the Prevalence of Diabetes for 2010 and 2030. Diabetes Research in Clinical Practice. 2010:87:4-14
20. Sigal RJ. Kenny GP. Wasserman DH. Castaneda-Sceppa C and White RD. Physical Activity/Exercise and Type 2 Diabetes. A Consensus Statement from
the American Diabetes Association. Diabetes Care. 2006: 29 ( 6 ) 1433-1438
21. Shu XO. Yang G. Jin F. Liu D. Kushi L. Wen W. Gao YT. Zheng W. Validity and Reproducibility of the Food Frequency Questionnaire Used in the Shanghai Women’s Health Study. European Journal of Clinical Nutrition. 2004:58:17–23
22. Shulze MB. Manson JE. Ludwig DS. Colditz GA. Stampfer MD. Willet WC. and Hu FB. Sugar-Sweetened Beverages. Weight Gain. and Incidence of Type 2 Diabetes in Young and Middle-aged Women. The Journal of the American Medical Association. 2004: 292 ( 8 ) :927-934
23. Tohill B. Seymour J. Serdula M. Kettle-Khan L. and Rolls BJ. What Epidemiologic Studies Tell Us about the Relationship between Fruit and Vegetable Consumption and Body Weight. Nutrition Reviews. 2004: 365 -374
24. WHO Study Group on Diabetes Mellitus. Diabetes Mellitus: Report of a WHO Study Group. Geneva: World Health Administration: 1985
25. NICE Public Health Guidance. Preventing Type 2 Diabetess: Population and Community Interventions. National Institute for Health and Clinical Excellence. 2011: Issue 35
26. Villagers R. Shu OX. Gao YT. Yang G. Elasy T. Li H and Zheng W. Vegetable but Not Fruit Consumption Reduces the Hazard of Type 2 Diabetes in Chinese Women. The Journal of Nutrition. 2008: 138 574-580
27. Bazzano LA. Kamudi JJ. Hu FB. and Li TY. Intake of Fruit. Vegetables and Fruit Juices and Risk of Diabetes in Women. Diabetes Care. 2008: 31 ( 7 ) 1311-1317
28. Salas-Salvado J. Bullo M. Babio N. Martinez-Gonzalez MA. Jurado NI. Basora J. Estruch R. Covas MI. Corella D. Aros F. Gutierrez VR. and Ros E. Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet. Diabetes Care. 2011. 34:14-19
29. Martinez-Gonzalez MA. Fuente-Arrillaga CDL. Nunez-Cordoba JM. Basterra-Gotari FJ. Beunza JJ. Vazquez Z. Benito S. Tortosa A and Bes-Rasrollo M. Adherence to Mediterranean Diet and Risk of Developing Diabetess: Prospective Cohort Study. British Medical Journal. 2008: 336:1351
30. Fung TT. Schulze M. Manson JE. Willet WC. and Hu FB. Dietary Patterns. Meat Intake and the Hazard of Type 2 Diabetes in Women. Archivess of International Medicine. 2004:164:2235-2240
31. VanDam RM. Rimm EB. Willet WC. Stampfer MJ and Hu FB. Dietary Patterns and Risk for Type 2 Diabetes Mellitus in US Men. Annalss of Internal Medicine. 2002:136: 201-209
32. Elhayany A. Lustman A. Abel R. Attal-Singer J and Vinker S. A Low Carborhydrate Mediterranean Diet Improves Cardiovascular Risk Factors and Diabetes Control Among Overweight Patients with Type 2 Diabetes Mellitus: A 1-year Prospective randomized intercession Study. Diabetes. Obesity and Metabolism. 2010: 12:204-209
33. Esposito K. Maiorino IM. Ciotola M. Palo CD. Scognamiglio P. Gicchino M. Petrizzo M. Saccomanno F. Beneduce F. Ceriello A and Guigliano D. Effects of a Mediterranean-Style Diet on the Need for Antihyperglycemic Drug Therapy in Patients with Newly Diagnosed Type 2 Diabetes. Annalss of Internal Medicine. 2009: 151: 306-314
34. Van Duyn MAS and Pivonka E. Over position of the wellness benefits of fruit and vegetable ingestion for the Dietetics Professional. Journal of the American Dietetic Association. 2000: 100 ( 12 ) 1511-1521
35. Anderdson JW. Baird P. Davis RH. Ferreri S. Knudtson M. Koraym A. Waters V. and Williams CL. Health Benefits of Dietary Fibre. Nutrition Reviews. 2009: 67 ( 4 ) 188-205
36. Sinha R. Cross AJ. Graubaed BI. Leitzmann MF. and Schatzin A. Meat Intake and Mortality. A Prospective Study of Over Half a Million People.
Archivess of Internal Medicine. 2009 169 ( 6 ) 562-571
37. Lim EL. Hollingsworth KG. Aribisala BS. Chen MJ. Mathers JC and Taylor R. Reversal of type 2 Diabetess: Standardization of Beta Cell Function in Association with Decreased Pancreas and Liver Triacylglycerol. Diabetologica. 2011: 54:2506-2514
38. Jiang R. Manson JE. Stampfer MJ. Liu S. Willet WC. Hu FB. Nut and Peanut Butter Consumption and Risk of Type 2 Diabetes in Women. Journal of the American Medical Association. 2002: 28 ( 20 ) 2554-2560
39. Riserus U. Willet WC. and Hu FB. Dietary Fats and Prevention of Type 2 Diabetes. Advancement in Lipid Research. 2009: 48 ( 1 ) 44-51
40. Tuomilehto J. Lindstrom J. Eriksson JG. Valle TT. Hamalainen H. Ilanne-parikka P. Keinanen-Kiukaanniemi S. Laakso M. Louheranta A. Rastas M. Salminen V and Uusitupa M. Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Intolerance. The New England Journal of Medicine. 2001: 344 ( 18 ) 1343-1350