Randomized Clinical Trials Flashcards, test questions and answers

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What is Randomized Clinical Trials?

Randomized Clinical Trials (RCTs) are a type of clinical study where participants are assigned, by chance, to one of two or more groups. The goal of an RCT is to test the effectiveness of a new treatment or other intervention, such as a drug, device, procedure or lifestyle change. RCTs are widely used in medicine and public health research to determine the safety and efficacy of interventions.The advantages of using RCTs include that they provide the most reliable evidence for assessing the effectiveness of interventions. This is because random assignment ensures that groups being compared have similar characteristics on average and therefore any differences seen between them can be attributed to the intervention being tested. Furthermore, when done correctly, randomization eliminates selection bias which can lead to biased results from observational studies. On the other hand, there are some disadvantages associated with RCTs. They can be expensive due to the resources needed for setting up and conducting trials. Additionally, many trials require participants who meet strict inclusion criteria which can limit generalizability since only certain types of people may be eligible for participation in such trials. Moreover, ethical issues may arise when assigning participants at random since some individuals may receive treatments that could potentially harm them or have no benefit at all if not effective for their condition. In conclusion, randomized clinical trials provide reliable evidence when assessing new interventions but this comes with certain drawbacks such as high costs and ethical considerations in terms of participant selection and assigning treatments at random risk-benefit ratio must be taken into account before carrying out such studies .