out of every 1,000 individuals. Many factors can cause epilepsy, such as genetic and zygotic abnormalities in both early and late-life development/aging, which explains why it affects the young and elderly populations more.

Research is focused on investigating the safety and effectiveness of seizure medications and epilepsy drugs, alongside identifying novel approaches for detecting indicators that can anticipate seizures. Development of computer-based algorithms is underway for seizure forecasting, using in vivo rodent experimentation to gather EEG data for analysis. Notably, when dynamic changes in EEG readings are observed, seizures can be predicted with 90% accuracy up to 30 minutes ahead of time. The ultimate goal is to create an automated paradigm for predicting seizures.

Researchers are gathering significant amounts of data and developing pattern recognition algorithms to create a seizure warning system that relies on the dynamical properties of brain electrical activity. This goal could be achieved using techniques such as Electroencephalogram (EEG), complex nonlinear systems (computer models), multivariate time-series analysis, optimization techniques, neuroimaging, and neurosurgery. To complement these computer predictions, experts are designing an implantable device that uses electronic pulses to prevent seizures before they occur. Dr. Sackellares and his research group along with other laboratories like the Brain Dynamics Laboratory at the McKnight Brain Institute and the Epilepsy Monitoring Laboratory at Shands Hospital are collaborating closely in this project. The bibliography includes Holmes GL, Sackellares JC, McKiernan J, Ragland M, Dreifuss FE's study which assessed childhood pseudoseizures using EEG telemetry and video monitoring.

J Pediat 97:554-558, 1980. Two cases are reported where shoulder enlargement was the initial sign of syringomyelia. The literature on the subject is also reviewed (Sackellares JC, Swift TR). In another case study,

a patient who received penicillin experienced myoclonus and electrocerebral silence (Sackellares JC, Smith DB). This was reported in Arch Neurol 36:857-858, 1979.

Sackellares and Dreifuss published an article in Current Prescribing in 1979 about treating epilepsy in children, while another article in Epilepsia from the same year focused on patients who experienced stupor after taking valproic acid in conjunction with other antiepileptic drugs. Additionally, Sutula, Sackellares, Miller, and Dreifuss explored the use of intensive monitoring for refractory epilepsy.

The neurological publication from 1981 can be found in Neurology, with the page numbers being 31:243-247.