Tumor Markers Flashcard
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| Free PSA |
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| < 4 ng/mL is healthy. Varies. >25% free PSA. Prostate cancer correlation. |
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| AFP |
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| hepatoma, some ovarian and testes. |
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| CEA clinical utility |
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| Secreted by various including breast, lung, colorectal, and stomach cancers. Mainly used to monitor recurrence of cancer but it is a useful marker for colorectal cancer. NOt a screening tool |
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| Thryoglobulin (tumor marker) |
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| check for recurrence after surgery. It is elevated in grave's disease, and thryoditis. Anti thyroglobulins are also screened. |
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| Neuron specific enolase |
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| glycotic enzyme. Formed in neuroendocrine system, and it is elevated in neuroblastoma and small lung cancer. |
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| calcitonin |
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| polypeptide hormone, made by C cells in thryoid to regulate calcium. Elevated in thyroid medullary carcinoma. Helps diagnosis, monitor treatment, and reccurence. |
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| H factor. Nuclear matrix protein |
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| Bladder tumor marker |
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| Her-2/neu gene |
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| oncogene product (genetic marker). Breast cancers mainly followed by GI and ovarian. |
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| HCG |
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| Unique Beta subunit. Elevated in germ cell cancers, trophoblastic, and others. |
