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• CD1

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These types of receptors are MHC class 1 like; CD1d; Deals with gamma:delta T cells

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• CD2

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Deals with T cell development and commits to double negative

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• CD3

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Part of T cell signaling

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• CD4

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CD4 helper T cells helping with adhesion and communicating with MHC 2

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• CD5

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Seen on B-1 B cells, Is also dealing with T-cell development in the thymus

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• CD8

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CD8 CTL T-cell, helps with adhesion and communicates with MHC 1

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• CD10

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This is the common lymphoid precursor

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• CD11b

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On macrophages and helps them detect stuff, complement receptor 3 and 4?

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• CD14

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This is on macrophages and is in a complex with MD2 and TLR4 to detect bacteria LPS

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• CD16

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This is another name for the FcyRIII which is on NK cells and detects IgG to destroy the infected cell

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• CD18

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This is on macrophages and helps them detect stuff, complement receptor 3 and 4; The Beta 2 chain of this receptor is also contained in Leukocyte integrins

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• CD19

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This is the marker for a pro-B cell in development; also apart of B-cell signaling with CD81 and CD21 (CR2)

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• CD20

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This is a marker for B cells, Rituximab the drug targets this; ADCC on NK cells will attack anti-CD20 receptors on B-cell lymphoma cells to destroy them

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• CD21

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This is the same as CR2 and it is an amplification signal which will bind to C3d (Signal 2 in B-cell signaling); B-cell will then activate and isotype switch for the antigen

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• CD23

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This is the same as FceRII which is on B-cells and will create IgG4 to counter IgE

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• CD25

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This is the same as IL-2R(alpha) and it is on Tregs

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• CD27

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This is a marker for Naïve gamma delta T cells.

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• CD28

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This is a receptor on developing T-cells. This is the 2nd signal for them to develop. The ligand is B7-1/B7-2 on APCs

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• CD34

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This is a receptor on epithelial surfaces that attaches to L-selectin (CD62L). This is also a pluripotent hematopoietic stem cell marker. T-cells and neutrophils use this for the rolling action. This is to get to the right place.

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• CD38

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This is just a marker for Germinal Centers. It is present in both Light and Dark zones

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• CD40

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This is on macrophages and B-cells. The interaction with CD40 and CD40L is the 2nd signal needed to activate B-cells and macrophages by CD4 T cells

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• CD40L

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This is on CD4 T Cells. This will react with CD40 on macrophages and B-cells. 2nd signal needed to activate.

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• CD44

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CD44 is a marker in the Germinal Center to distinguish zones. The dark zone DOES NOT have CD44. The light zone DOES have CD44 marker.

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• CD45RO

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Memory T cell marker

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• CD45RA

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Naïve T cell marker. Terminally differentiated gamma delta T cells will only have CD45RA.

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• CD48

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This is one of the body's cell receptors that tells NK cells that the cell is in distress. This will bind to 2B4 on NK cells and cause the NK cell to activate and kill the cell.

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• CD55

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CD55 is the same as DAF. This regulated the amount of C3 Convertase that is created to save C3.

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• CD59

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This is the same as protectin. This will prevent MAC from going on healthy cells and killing them.

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• CD62

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This is the same as selectin L.

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• CD77

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This is also a marker for Germinal Centers. It is present in both dark and light zones.

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• CD80

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This is the same as B7-1 which will interact with CD28 on T-cells to help the T-cell develop.

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• CD81

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This is part of the B-cell signaling with CD19 and CR2 (CD21) which will result in the activation of the B-cell and isotype switch to the antigen.

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• CD86

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This is the same as B7-2 which will interact with CD28 on T-cells to help the T-cell develop.

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• CD94:NKG2A

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This is the universal KIR which recognizes healthy cells. This is on NK cells and prevents them from killing NK cells.

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• CD127

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This is the same as IL-7. This signals the development of a B-cell precursor.

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• CD277

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This is the same as BTN3A1 and is on tissue cells. These receptors will bind to MHBPP created by bacteria. CD277 with MHBPP will present to V gamma 9:V delta 2 T cells. These T-cells are in the blood.

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• TLR 1

answer

TLR 1: TLR 2

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• TLR 2

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TLR 2: TLR 6

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• TLR 4

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Mainly for Bacteria and present on macrophages; forms a complex with CD14 and MD2 to search for LPS.

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• TLR 5

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Mainly detect flagellin of bacteria in the intestines.

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• TLR 3

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Detects dsRNA viruses on NK cells.

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• TLR 7

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Detects ssRNA viruses

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• TLR 8

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Detects ssRNA viruses

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• TLR 9

answer

Detects dsDNA of viruses and bacteria

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• IL-1

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Created by cleaving pro IL-1 by capsases recruited by CARDs. It will be secreted by macrophages. This will cause inflammatory response.

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• IL-2

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This also helps T-cells survive, proliferate, and differentiate. This cytokine is released by DCs to mature/activate naïve T-cells. Activated T cells express high affinity for IL-2 (good IL-2R).

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• IL-4

answer

CD4 T cells secret this cytokine. B-cells have IL-4R in order to class switch to IgE. Th2 response from T-cells. This cytokine also helps differentiate stuff into TH17 cells. IL-4 will induce IgG1 and IgE but inhibit IgM, IgG3, and IgG2a. T (FH) - cells that release this cytokine will cause B-cells to turn into memory B cells.

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• IL-5

answer

Secreted by CD4 T cells (TH2 response) and this will recruit and activate eosinophils.

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• IL-6

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This cytokine is secreted by macrophages and helps with the inflammatory response. This will also go to the liver and help it secrete CRP, MBL, and fribinogen.

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• IL-7

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This is the same as CD 127 and is the marker for B-cell precursor. It is also a growth factor for B-cells.

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• IL-9

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Secreted by TH9 cells

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• IL-10

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This can be seen in B-1 B cells and is thought to help renew it (aka cause cancer). This can also be secreted by Treg cells to inhibit other T helper cells. This can be secreted by TH2 response cells along with TH9. It is thought that this can induce IgA along with turn B-cells into Plasma cells.

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• IL-12

answer

This is secreted by macrophages and attracts NK cells. It will also cause NK to proliferate and secrete IFN gamma to activate the macrophages. This can also be secreted by DCs to activate T cells. This will turn naïve CD4 T cells into TH1 response. This is also secreted by APCs in order to activate NKT cells (NKT cells also need CD1d signal with this). Defect in this receptor will cause mycobacterium avium.

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• IL-13

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This is secreted with the TH2 response and will induce epithelial cell repair and mucous secretion.

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• IL-15

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This is secreted by macrophages only when the macrophages form a link with NK cells. This will further activate NK cells in close proximity.

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• IL-17

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This will be secreted by TH17 T cells. This will attract PMNs (aka neutrophils). This is also secreted by Follicular helper T cells.

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• IL-21

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TH9 cells can secrete this and this will cause some T cells to become T(fh) cells

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• IL-22

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This is secreted by TH17 cells and TH22 cells

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• IL-23

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This inhibits T(fh) cells, it stimulates TH17 cells

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• IL-35

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This is secreted by Treg cells to inhibit.

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• CR1

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This is present on macrophages, FDCs, B-cells, and RBCs. On regular macrophages, it will sense C3b and phagocytosis it using the complement system. On FDCs, it will sense C3b and fish for it and bind to it to show to the B cells. On B cells, it will sense the C3b and cause it to facilitate the production of C3d. C3d will be able to bind to the CD21 (CR2) and amplify the signal of the B cell. On RBCs they will see immune complexes and attach to them. Macrophages can then get rid of the immune complexes bound to the RBC CR1.

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• CR2

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This is the same as CD21. It recognizes C3d which is created by CR1. It is an amplification signal on B-cells that works with CD19 and CD81 in order to isotype switch and what not to the antigen.

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• CR3

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This is on PMNs or neutrophils that recognizes iC3b and phagocytose.

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• CR4

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This is on PMNs or neutrophils that recognize iC3b and phagocytose.

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• CXCL8

answer

This is secreted by macrophages and recruits PMNs. This works by a G-protein.

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• CXCL13

answer

This is secreted by FDC which communicate with immature B- cells

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• FcRn

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This will actively transport IgG across placenta and mucosal surfaces.

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• FcyRI

answer

This is on monocytes, macrophages, PMNs, dendritic cells, and eosinophils. It will react with 2 IgG cross reacting molecules and stimulate phagocytosis.

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• FcyRIIB

answer

This is on macrophages and IgG4 binds to it to inhibit cytokine release and phagocytosis

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• FcyRIIA

answer

This is on macrophages and IgG1 binds to it to activate the release of cytokines.

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• FcyRIIBI

answer

This is on naïve B cells and this is especially for 2ndary responses to an antigen. It will make sure to shut of IgM production and focus more on high-affinity IgG production from proliferating memory cells. It will bind to excess IgG.

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• FcyRIII

answer

It is on NK cells and mediates antibody dependent cell mediated cytotoxicity. It is just an alternative activation for NK cells. Anti-CD20 for B cell lymphomas. This is also on mast cells dealing with Type III HS Arthus reaction???

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• FceRI

answer

This is the one on mast cells, basophil, and eosinophils. These will bind to IgE and cause degranulations.

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• FceRII

answer

This one is on B-cells. Has 2 forms: a monomer and trimer form. Monomer form is low affinity while trimer form is high affinity. When only the trimer form is attached to IgE then B-cell will create more IgE. If the monomer form is filled, this means there is a shit ton of IgE and will signal the B-cell to stop making IgE.

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• FcaRI

answer

This is expressed on PMNs and macrophages to detect IgA on antigens. It will cause them to phagocytose.

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• CCL3

answer

This is secreted by mast cell granules and attracts monocytes, macrophages, and neutrophils.

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• CCL11

answer

Stimulates eosinophils and called Eotaxin

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• CCL19

answer

This is secreted by DCs in T cell area and attracts immature B-cells into lymph nodes.

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• CCL21

answer

Stromal cells in T cell area secrete this along with DCs in T cell area secrete this. It will attract immature B-cells into lymph nodes.

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• CCR7

answer

This is a receptor on immature B cells that will recognize CCL19 and CCL21 to attract them into lymph nodes.

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• IFN alpha

answer

This is secreted during an antiviral state from the infected cell. It activates NK cells.

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• IFN beta

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This is secreted during an antiviral state from the infected cell. It can warn neighboring cells. It activates NK cells. After the receptor is activated by IFN beta, IRF7 is activated.

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• IFN gamma

answer

This is secreted by CTL, NK cells, T-helper cells (TH1). This activates macrophages into attack mode.

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• IGF-beta

answer

This induces IgG2b and IgA and inhibits IgM and IgG3

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• ICAM-1

answer

This is on endothelial cells and also can be expressed in DCs to activate T-cells. ICAM-1 can also be expressed on B-cells. T-cells interact with ICAM-1 with its LFA-1. Neutrophils can also interact with ICAM-1 with its LFA-1.

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• glyCAM-1

answer

Naïve T-cells will attach to this and CD34 to allow for rolling interaction.

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• Selectin P

answer

This is on endothelial cells

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• Selectin E

answer

This is on endothelial cells

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• Selectin L

answer

This is on neutrophils and T-cells. It attaches to CD34 to allow for rolling interaction.

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• LFA-1

answer

This attaches to ICAM-1 in both neutrophils and T-cells.

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• Sialyl-Lewis(x)

answer

This is on neutrophils

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• MHC class 1

answer

This has the 3 alpha parts and 1 Beta microglobin. Its cleft is connected allowing for 8-11 amino acid peptide. CD8 will bind to alpha 3 portion. Peptide will bind in alpha region. • HLA-A, HLA-B, HLA-C

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• MHC class 2

answer

This has 2 alpha parts and 2 beta parts. The cleft is created by alpha 1 and beta 1. The peptide will bind mostly to the beta chain. The CD4 will bind to beta 2 chain. • HLA-DR, HLA-DQ, HLA-DP

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• V delta 2

answer

in the blood

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• V delta 1

answer

in the tissue

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• V gamma 4

answer

V delta 5: deals with CMV infected cells and tumor cells (sees EPCR)

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• V gamma 9

answer

V delta 2: deals with the CD277 receptor and the MHBPP from bacteria

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• V gamma

answer

V delta: In the tissue and sees CD1d (MHC class 1 like molecule) that presents lipids.

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• NKT cells

answer

express NKG2D and other a:B TCR receptors; need CD1d signal and IL-12 from APC signal; activates TH1, TH2, or TH17 depending on antigen

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• MAIT cells

answer

Unique CD8 cells that see pterin in bacteria and yeast. Riboflavin (vitamin B2) and presented by MR1

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• CD94:NKG2A

answer

This is an inhibitor to know what self is! This is universal KIR.

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• CD94:NKG2C

answer

This will deal with CMV and how they identify cells that have it. It will control an outbreak. It recognizes HLA-E.

question

• NKG2D

answer

This is the receptor on NK cells that see MIC and know that a cell is stressed out.

question

• iKIRs

answer

Inhibitory signals on NK. Have 2 types. A and B. Type A is stronger education than Type B. Type A = pre eclampsia. Type B = over nourishment and obstructed birth.

question

• CD48

answer

This is shown on the stressed out cell and is recognized by 2B4 on NK cells.

question

• MIC

answer

This is on stressed out cells and is recognized by NKG2D.

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• 2B4

answer

On NK cells that recognize CD48.

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• KIR2DL4

answer

Receptor on uterine NK cell that recognizes soluble HLA-G from extravillous trophoblast.

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• LILRB1

answer

Receptor on uterine NK cell that recognizes HLA-G on extravillous trophoblast cell

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Complements

answer

• C1-C9 • CD55 (DAF) • MCP

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Classical Pathway

answer

• CRP • C1 • C4b • C2a

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Lectin Pathway

answer

• MLB • MASP1 • MASP2 • C4b • C2a

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Alternative Pathway

answer

• iC3Bb • C3bBb • Factor B • Factor D • Properdin

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MAC

answer

• C3b2Bb • C5b • C5b67 • C8 • C9 • Factor J • Protein S • Clusterin • CD59

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Viral Receptors inside cells

answer

• RLR • MAVS • IRF3 • IRF7

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Growth Factors

answer

• SCF • IL-7 • IL-2 • Kit

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X-linked diseases

answer

• Immune Dysregulation, Polyendocrinopathy, Enteropathy, and X-Linked Syndrome • CH40L/CH40 deficiency • X-linked Agammaglobulinemia: Missing BtK • Common gamma chain: Loss of IL receptors • Wiskott-Aldrich syndrome • X-linked lymphoproliferative syndrome

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