Pathoma- Female GU (Vulva) – Flashcards
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vulva, vagina, and cervix
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three components of the female GU that comprise the lower GU tract
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squamous cells
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type of epithelial cells that comprise the vulva
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inflammation
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this immune response causes Bartholin's cysts
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Bartholin's cyst
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typically presents as a unilateral, painful cystic lesion at the lower vestibule
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reproductive age
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age during which Batholin's cysts are most common
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6 and 11
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types of HPV that are considered low-risk and result in condyloma
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koilocytes
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cells that exhibit a raisin-esque nucleus in response to HPV infection (high risk or low risk)
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lichen sclerosis
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condition characterized by thinning of the epidermis and fibrosis of the dermis over the vulva. Vulvar skin is considered "parchment-like"
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leukoplakia
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lichen sclerosis, lichen simplex chronicus, and vulvar carcinoma all have this common presentation
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postmenopausal
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age group most at risk of lichen sclerosis
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squamous cell carcinoma
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potential cancer that could result from long-standing lichen sclerosis
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lichen simplex chronicus
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characterized by hyperplasia of the vulvar squamous epithelium. Vulvar skin is considered "leathery"
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false
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true or false: lichen simplex chronicus is associated with increased risk of squamous cell carcinoma
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HPV and lichen sclerosis
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two conditions that can result in rare vulvar carcinoma
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16, 18, 31, and 33
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four high-risk HPV subtypes that are associated with dysplasia and progression to vulvar carcinoma
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age
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demographic feature that differentiates women with vulvar carcinoma from HPV from women with vulvar carcinoma from lichen sclerosis
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extramammary paget's disease
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condition characterized by malignant epithelial cells in the epidermis that represents carcinoma in-situ (no underlying carcinoma) that presents as erythematous, pruritic, and ulcerated vulvar skin
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nipple
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this particular type of Paget's disease is associated with underlying carcinoma, but not in the vulvar region
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PAS +, keratin +, and S-100 -
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three cell markers that would be indicative of extramammary paget's disease
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PAS -, keratin -, and S-100 +
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three cell markers that would be indicative of melanoma of the vulvar
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melanoma
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specific cancer that must be ruled-out when extrammary paget's disease is considered
