Diseases of the Skin and Eyes – Flashcards

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What does acne include?
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All follicle associated lesions.
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What is the causative agent of acne?
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Propionibacterium acnes
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How does P. Acnes manifest?
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Digests the oil surplus resulting in local inflammation that can eventually burst the follicle.
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Is acne considered a communicable infection?
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No
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What is a comedo?
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Skin initially swells over pore leading out of the hair follicle. If the pore is closed its a whitehead. If its open but blocked with dark plug of sebum its a black head.
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What is a pustule/papule?
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When lesion erupts on the surface
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What is a cyst?
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Pustules that come to involve deeper layer of skin
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What is the causative agent of folliculitis, hidradentitis, furuncles, and carbuncles?
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S. Aureus
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What is S. Aureus virulence factors?
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1.)Capsule
2.)Enzymes (coagulase)
3.)Toxins
4.)mecA gene
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What does the enzyme Coagulase do for S. Aureus?
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impedes progress of leukocytes into infected areas but producing clots.
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What toxins does S. Aureus produce?
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Hemolysin- kills RBC
Enterotoxin - causes symptoms in GI tract
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What is the mecA gene?
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Provides resistance to methicilin, penicilin, and other penicillin like drugs.
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What is folliculitis?
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Inflammation of the hair follicle.
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What is hiradradentitis?
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Inflammation of a gland
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What is a furuncle?
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A boil. Infection extends from the follicle/gland into surrounding tissues.
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What is a carbuncle?
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Larger, deeper lesion resulting from aggregating and interconnections of multiple furuncles.
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What causes impetigo?
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Strep Pyrogenes or Staph Aureus
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What is impetigo?
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Superficial bacterial infection
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What is S. Pyrogenes virulence factor?
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Streptolysin - destroys RBC
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Is impetigo highly contagious?
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Yes
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How is impetigo transmitted?
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Direct contact but someimtes fomites
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Who does impetigo infect and what does it look like?
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Children. Flaky scabs, honey colored crusts, peeling skin. Around mouth, face and extremities.
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What is Staphylococcal Impetigo?
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Superficial skin infection characterized by weeping pus production (pyoderma)
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What are the symptoms of Strep impetigo?
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Burning, itching lesions that break and weep highly contagious yellow crust
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What is a Pseudomonas aeurginosa infection a common cause of?
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Infection in burn patients and bacterial nosocomial pneumonia.
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Is P. Aeurginosa opportunistic or true?
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Opportunistic.
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What can P. Aeurginosa cause?
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Endocarditis, meningitis, skin rashes, UTI's, external ear infections, corneal ulcers via contacts
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What is a characteristic of P. Aeurginosa infection?
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Grape-like odor and bluish-colored pus
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What is the cause of Gas Gangrene?
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Clostridium Perfringens
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How is Gas Gangrene contracted?
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Bacteria/spores enter damaged tissues and release endotoxins that cause necrosis of the surrounding tissues.
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What results from the release of endotoxins?
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Hydrogen and CO2 are produced via fermentation of amino acid and glycogen in the dead tissues.
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How is Gas Gangrene treated?
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Removal of dead/infected tissue or amputation
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Is there a toxoid or vaccine for Gas Gangrene?
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No
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What is used to slow bacterial growth in Gas Gangrene infections?
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Hyperbaric oxygen treatment
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What is the causative agent in Necrotizing Fasciitis?
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Strep Pyrogenes or Staph Aureus
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How is Necrotizing Fasciitis transmitted?
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Contaminate skin wounds
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How does Necrotizing Fasciitis attack?
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Release toxins resulting in destruction of fat and muscle that can spread via blood steam and result in organ failure or death.
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What is the causative agent of Chickenpox?
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Varicella-Zoster Virus.
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Is Chickenpox a DNA or RNA virus?
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DNA
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What are the symptoms of the chicken pox virus?
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Rash with macules (small red spots), papules (little bumps), vesicles (small blisters), and pustules (pus-filled blisters)
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The pustules of a chickenpox infection eventually crust over and fall off. The rash radiates in sparse crops to the extremities. T or F?
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T
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When can shingles occur?
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Months or years after the primary chickenpox infection and is caused by the latent virus harbored in sensory neurons.
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What leads to pain and tenderness that can last for months with shingles?
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Inflammation of portions of neurons
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Why are children are prone to secondary infections? What is the causative agent of these?
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Because the chickenpox lesions are itchy. S. Pyrogenes and S. aureus
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What is measles caused by?
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Rubeola virus
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How are the measles transmitted?
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Direct contact with respiratory secretions. One of the most contagious diseases.
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What is the main characteristic of measles?
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Small oral lesions called Koplik's Spots that ultimately causes a skin rash starting at the head and progressing to the trunk and extremities and disappearing in that order.
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What is a secondary infection of measles?
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Ear infections and pneumonia
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Is measles self-limiting? How long can it last? What are complications of it?
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Yes. 20-22 days from time of infection. Lung or brain damage.
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What causes Rubella?
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Rubella virus.
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What are the 2 forms?
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Postnatal - acquired after birth

Congenital - virus is obtained in utero
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What are the characteristic symptoms of Postnatal Rubella?
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Spreading pink rash or joint pain
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About _____ of postnatal rubella infections are asymptomatic.
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half
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Postnatal Rubella clears up in __-___ days leaving ________ immunity.
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2-3. Lifelong
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If the Rubella virus is exposed to the fetus in the first trimester, what is the effect?
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Always results in miscarraige or multiple permanent defects of the eyes, ears, brain and heart.
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Infants that survive exposure to the rubella virus in utero do what?
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Excrete the disease for months.
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What is the causative agent of fifths disease?
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parvovirus
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What is the characteristic symptom of fifths disease?
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Begins as a reddish rash on the face (slap-cheek) then spreads over the body primarily on the arms, legs and trunk.
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How long can Fifths Disease last? Can it come back?
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days to weeks and can recur at times of stress.
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What is the causative agent of Roseola?
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HHV-6
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What are the symptoms of Roseola?
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Results in a high fever which can be followed by rash but most cases proceed without the rash. Fever disappears on 4th day but rash can appear after.
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What virus is thought to have been exposed to every adult?
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HHV-6
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What are papillomas caused by?
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Warts. Caused by Human Papillomavirus.
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What is a papilloma?
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Benign squamous cell, epithelial growths that may be covered by skin (wart) or mucus membrane (papilloma)
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What are the 3 types of warts?
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1.) Common Warts - affects fingers and occasionally other parts.
2.)Plantar warts - deep painful warts on the soles of feet
3.)Genital warts - Most common STD in US. Range from tiny to cauliflower like growths. Primarily affects the external genetalia but can infect the cervix, urethra and anus.
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Some strains of non-wart causing HPV has been linked to what?
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Cervical and oropharyngeal cancer.
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There are currently over _____ known strains of HPV with about _____ affecting the genitalia.
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100/30
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How are all 3 warts treated?
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Freezing them with liquid nitrogen or electrocautery.
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What cream is used to treat external genital warts?
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Aldara
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What is the recurrence rate of between __-__%?
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10-40%
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What does Gardisil build immunity against?
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HPV strains 6,11,16,18. Reccomended for girls and boys 9-24
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What is the causative agent of M. Whitlow?
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HSV-1 or HSV-2
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How is M. Whitlow contracted?
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Virus enters through small breaks in unprotected skin causing the same types of lesions seen with cold sores or genital herpe infections
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What is M. Whitlow?
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Deep and extremely painful localized infecton of the fingers
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What was M. Whitlow common in many years ago?
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Nurses and hygienists because gloves were not common
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Who is M. Whitlow common in now?
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People with HSV infections in other parts of their bodies.
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What is the causative agent of Cutaneous Anthrax?
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Bacillus Anthracis
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What is Cutaneous Anthrax?
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Papule that becomes increasingly necrotic then ruptures to form a black eschar (scab).
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How is cutaneous anthrax contracted?
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Endospores enter the skin through small cuts or abrasions leading to a localized infection resulting in the formation of a papule.
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What is the causative agent of Cutaneous Mycoses?
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Dermatophytes such as Trichophyton, Microsporum, Epidermophyton.
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What causes an immune response or redness and inflammation in Cutaneous Mycoses?
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Products of the fungal metabolism.
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What is the Cutaneous Mycoses infection limted to?
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Nonliving epidermal tissues and their derivatives
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What is tine capitis?
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scalp ringworm
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What is tinea barbae?
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beard ringworm
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What is tinea axillaries?
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Armpit ringworm
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What is Tinea corpus?
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Body ringworm
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What is Tinea cruris?
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groin ringworm (jock itch)
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What is tinea pedis?
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Feet ringworm. Athlete's foot
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What is tinea manuum?
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Hand ringworm
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What is tinea ungiunum?
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Nail ringworm
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What is bacterial conjuctivitis caused by?
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Haemophilus aegyptius, " influenzae, Strep pneumo, Strep pyrogenes, Neisseria gonorrhoeae, and S. aureus
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What is viral conjuctivits caused by?
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Adenovirus
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What are the symptoms of conjuctivitis?
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Senstivity to light, swelling eye lids, increased tears, redness, and lg amounts of pis
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What does milky discharge indicate?
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Bacterial conjuctivitis infection
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What does clear exudate indicate?
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Viral conjuctivitis infection
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Is Keratitis more or less serious than conjunctivitis?
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More
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What is Keratitis?
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invasion of deeper eye tissues occurs, leads to complete coroneal destruction
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What is the most common causative agent of Keratitis?
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Herpes simplex viruses
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What does Keratitis result from?
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misdirected reactivation of a cold sore causing HSV. Can be direct contact of the virus within the eye area.
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What are preliminary symptoms of Keratitis?
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Feeling gritty in eye, conjunctivitis, sharp pain, sensitivity to light.
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What is the leading cause of infectious blindness in the US?
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Keratitis
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