Diseases of the Skin and Eyes – Flashcards
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What does acne include? |
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All follicle associated lesions. |
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What is the causative agent of acne? |
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Propionibacterium acnes |
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How does P. Acnes manifest? |
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Digests the oil surplus resulting in local inflammation that can eventually burst the follicle. |
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Is acne considered a communicable infection? |
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No |
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What is a comedo? |
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Skin initially swells over pore leading out of the hair follicle. If the pore is closed its a whitehead. If its open but blocked with dark plug of sebum its a black head. |
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What is a pustule/papule? |
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When lesion erupts on the surface |
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What is a cyst? |
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Pustules that come to involve deeper layer of skin |
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What is the causative agent of folliculitis, hidradentitis, furuncles, and carbuncles? |
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S. Aureus |
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What is S. Aureus virulence factors? |
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1.)Capsule 2.)Enzymes (coagulase) 3.)Toxins 4.)mecA gene |
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What does the enzyme Coagulase do for S. Aureus? |
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impedes progress of leukocytes into infected areas but producing clots. |
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What toxins does S. Aureus produce? |
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Hemolysin- kills RBC Enterotoxin - causes symptoms in GI tract |
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What is the mecA gene? |
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Provides resistance to methicilin, penicilin, and other penicillin like drugs. |
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What is folliculitis? |
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Inflammation of the hair follicle. |
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What is hiradradentitis? |
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Inflammation of a gland |
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What is a furuncle? |
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A boil. Infection extends from the follicle/gland into surrounding tissues. |
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What is a carbuncle? |
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Larger, deeper lesion resulting from aggregating and interconnections of multiple furuncles. |
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What causes impetigo? |
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Strep Pyrogenes or Staph Aureus |
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What is impetigo? |
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Superficial bacterial infection |
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What is S. Pyrogenes virulence factor? |
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Streptolysin - destroys RBC |
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Is impetigo highly contagious? |
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Yes |
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How is impetigo transmitted? |
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Direct contact but someimtes fomites |
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Who does impetigo infect and what does it look like? |
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Children. Flaky scabs, honey colored crusts, peeling skin. Around mouth, face and extremities. |
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What is Staphylococcal Impetigo? |
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Superficial skin infection characterized by weeping pus production (pyoderma) |
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What are the symptoms of Strep impetigo? |
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Burning, itching lesions that break and weep highly contagious yellow crust |
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What is a Pseudomonas aeurginosa infection a common cause of? |
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Infection in burn patients and bacterial nosocomial pneumonia. |
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Is P. Aeurginosa opportunistic or true? |
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Opportunistic. |
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What can P. Aeurginosa cause? |
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Endocarditis, meningitis, skin rashes, UTI's, external ear infections, corneal ulcers via contacts |
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What is a characteristic of P. Aeurginosa infection? |
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Grape-like odor and bluish-colored pus |
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What is the cause of Gas Gangrene? |
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Clostridium Perfringens |
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How is Gas Gangrene contracted? |
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Bacteria/spores enter damaged tissues and release endotoxins that cause necrosis of the surrounding tissues. |
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What results from the release of endotoxins? |
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Hydrogen and CO2 are produced via fermentation of amino acid and glycogen in the dead tissues. |
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How is Gas Gangrene treated? |
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Removal of dead/infected tissue or amputation |
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Is there a toxoid or vaccine for Gas Gangrene? |
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No |
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What is used to slow bacterial growth in Gas Gangrene infections? |
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Hyperbaric oxygen treatment |
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What is the causative agent in Necrotizing Fasciitis? |
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Strep Pyrogenes or Staph Aureus |
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How is Necrotizing Fasciitis transmitted? |
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Contaminate skin wounds |
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How does Necrotizing Fasciitis attack? |
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Release toxins resulting in destruction of fat and muscle that can spread via blood steam and result in organ failure or death. |
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What is the causative agent of Chickenpox? |
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Varicella-Zoster Virus. |
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Is Chickenpox a DNA or RNA virus? |
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DNA |
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What are the symptoms of the chicken pox virus? |
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Rash with macules (small red spots), papules (little bumps), vesicles (small blisters), and pustules (pus-filled blisters) |
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The pustules of a chickenpox infection eventually crust over and fall off. The rash radiates in sparse crops to the extremities. T or F? |
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T |
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When can shingles occur? |
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Months or years after the primary chickenpox infection and is caused by the latent virus harbored in sensory neurons. |
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What leads to pain and tenderness that can last for months with shingles? |
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Inflammation of portions of neurons |
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Why are children are prone to secondary infections? What is the causative agent of these? |
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Because the chickenpox lesions are itchy. S. Pyrogenes and S. aureus |
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What is measles caused by? |
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Rubeola virus |
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How are the measles transmitted? |
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Direct contact with respiratory secretions. One of the most contagious diseases. |
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What is the main characteristic of measles? |
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Small oral lesions called Koplik's Spots that ultimately causes a skin rash starting at the head and progressing to the trunk and extremities and disappearing in that order. |
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What is a secondary infection of measles? |
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Ear infections and pneumonia |
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Is measles self-limiting? How long can it last? What are complications of it? |
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Yes. 20-22 days from time of infection. Lung or brain damage. |
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What causes Rubella? |
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Rubella virus. |
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What are the 2 forms? |
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Postnatal - acquired after birth Congenital - virus is obtained in utero |
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What are the characteristic symptoms of Postnatal Rubella? |
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Spreading pink rash or joint pain |
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About _____ of postnatal rubella infections are asymptomatic. |
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half |
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Postnatal Rubella clears up in __-___ days leaving ________ immunity. |
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2-3. Lifelong |
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If the Rubella virus is exposed to the fetus in the first trimester, what is the effect? |
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Always results in miscarraige or multiple permanent defects of the eyes, ears, brain and heart. |
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Infants that survive exposure to the rubella virus in utero do what? |
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Excrete the disease for months. |
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What is the causative agent of fifths disease? |
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parvovirus |
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What is the characteristic symptom of fifths disease? |
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Begins as a reddish rash on the face (slap-cheek) then spreads over the body primarily on the arms, legs and trunk. |
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How long can Fifths Disease last? Can it come back? |
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days to weeks and can recur at times of stress. |
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What is the causative agent of Roseola? |
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HHV-6 |
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What are the symptoms of Roseola? |
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Results in a high fever which can be followed by rash but most cases proceed without the rash. Fever disappears on 4th day but rash can appear after. |
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What virus is thought to have been exposed to every adult? |
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HHV-6 |
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What are papillomas caused by? |
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Warts. Caused by Human Papillomavirus. |
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What is a papilloma? |
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Benign squamous cell, epithelial growths that may be covered by skin (wart) or mucus membrane (papilloma) |
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What are the 3 types of warts? |
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1.) Common Warts - affects fingers and occasionally other parts. 2.)Plantar warts - deep painful warts on the soles of feet 3.)Genital warts - Most common STD in US. Range from tiny to cauliflower like growths. Primarily affects the external genetalia but can infect the cervix, urethra and anus. |
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Some strains of non-wart causing HPV has been linked to what? |
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Cervical and oropharyngeal cancer. |
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There are currently over _____ known strains of HPV with about _____ affecting the genitalia. |
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100/30 |
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How are all 3 warts treated? |
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Freezing them with liquid nitrogen or electrocautery. |
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What cream is used to treat external genital warts? |
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Aldara |
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What is the recurrence rate of between __-__%? |
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10-40% |
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What does Gardisil build immunity against? |
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HPV strains 6,11,16,18. Reccomended for girls and boys 9-24 |
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What is the causative agent of M. Whitlow? |
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HSV-1 or HSV-2 |
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How is M. Whitlow contracted? |
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Virus enters through small breaks in unprotected skin causing the same types of lesions seen with cold sores or genital herpe infections |
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What is M. Whitlow? |
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Deep and extremely painful localized infecton of the fingers |
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What was M. Whitlow common in many years ago? |
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Nurses and hygienists because gloves were not common |
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Who is M. Whitlow common in now? |
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People with HSV infections in other parts of their bodies. |
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What is the causative agent of Cutaneous Anthrax? |
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Bacillus Anthracis |
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What is Cutaneous Anthrax? |
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Papule that becomes increasingly necrotic then ruptures to form a black eschar (scab). |
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How is cutaneous anthrax contracted? |
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Endospores enter the skin through small cuts or abrasions leading to a localized infection resulting in the formation of a papule. |
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What is the causative agent of Cutaneous Mycoses? |
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Dermatophytes such as Trichophyton, Microsporum, Epidermophyton. |
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What causes an immune response or redness and inflammation in Cutaneous Mycoses? |
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Products of the fungal metabolism. |
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What is the Cutaneous Mycoses infection limted to? |
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Nonliving epidermal tissues and their derivatives |
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What is tine capitis? |
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scalp ringworm |
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What is tinea barbae? |
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beard ringworm |
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What is tinea axillaries? |
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Armpit ringworm |
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What is Tinea corpus? |
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Body ringworm |
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What is Tinea cruris? |
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groin ringworm (jock itch) |
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What is tinea pedis? |
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Feet ringworm. Athlete's foot |
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What is tinea manuum? |
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Hand ringworm |
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What is tinea ungiunum? |
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Nail ringworm |
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What is bacterial conjuctivitis caused by? |
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Haemophilus aegyptius, " influenzae, Strep pneumo, Strep pyrogenes, Neisseria gonorrhoeae, and S. aureus |
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What is viral conjuctivits caused by? |
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Adenovirus |
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What are the symptoms of conjuctivitis? |
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Senstivity to light, swelling eye lids, increased tears, redness, and lg amounts of pis |
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What does milky discharge indicate? |
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Bacterial conjuctivitis infection |
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What does clear exudate indicate? |
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Viral conjuctivitis infection |
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Is Keratitis more or less serious than conjunctivitis? |
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More |
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What is Keratitis? |
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invasion of deeper eye tissues occurs, leads to complete coroneal destruction |
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What is the most common causative agent of Keratitis? |
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Herpes simplex viruses |
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What does Keratitis result from? |
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misdirected reactivation of a cold sore causing HSV. Can be direct contact of the virus within the eye area. |
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What are preliminary symptoms of Keratitis? |
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Feeling gritty in eye, conjunctivitis, sharp pain, sensitivity to light. |
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What is the leading cause of infectious blindness in the US? |
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Keratitis |