Diseases of the Skin and Eyes – Flashcards
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| What does acne include? |
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| All follicle associated lesions. |
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| What is the causative agent of acne? |
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| Propionibacterium acnes |
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| How does P. Acnes manifest? |
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| Digests the oil surplus resulting in local inflammation that can eventually burst the follicle. |
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| Is acne considered a communicable infection? |
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| No |
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| What is a comedo? |
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| Skin initially swells over pore leading out of the hair follicle. If the pore is closed its a whitehead. If its open but blocked with dark plug of sebum its a black head. |
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| What is a pustule/papule? |
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| When lesion erupts on the surface |
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| What is a cyst? |
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| Pustules that come to involve deeper layer of skin |
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| What is the causative agent of folliculitis, hidradentitis, furuncles, and carbuncles? |
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| S. Aureus |
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| What is S. Aureus virulence factors? |
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| 1.)Capsule 2.)Enzymes (coagulase) 3.)Toxins 4.)mecA gene |
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| What does the enzyme Coagulase do for S. Aureus? |
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| impedes progress of leukocytes into infected areas but producing clots. |
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| What toxins does S. Aureus produce? |
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| Hemolysin- kills RBC Enterotoxin - causes symptoms in GI tract |
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| What is the mecA gene? |
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| Provides resistance to methicilin, penicilin, and other penicillin like drugs. |
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| What is folliculitis? |
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| Inflammation of the hair follicle. |
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| What is hiradradentitis? |
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| Inflammation of a gland |
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| What is a furuncle? |
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| A boil. Infection extends from the follicle/gland into surrounding tissues. |
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| What is a carbuncle? |
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| Larger, deeper lesion resulting from aggregating and interconnections of multiple furuncles. |
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| What causes impetigo? |
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| Strep Pyrogenes or Staph Aureus |
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| What is impetigo? |
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| Superficial bacterial infection |
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| What is S. Pyrogenes virulence factor? |
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| Streptolysin - destroys RBC |
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| Is impetigo highly contagious? |
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| Yes |
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| How is impetigo transmitted? |
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| Direct contact but someimtes fomites |
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| Who does impetigo infect and what does it look like? |
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| Children. Flaky scabs, honey colored crusts, peeling skin. Around mouth, face and extremities. |
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| What is Staphylococcal Impetigo? |
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| Superficial skin infection characterized by weeping pus production (pyoderma) |
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| What are the symptoms of Strep impetigo? |
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| Burning, itching lesions that break and weep highly contagious yellow crust |
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| What is a Pseudomonas aeurginosa infection a common cause of? |
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| Infection in burn patients and bacterial nosocomial pneumonia. |
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| Is P. Aeurginosa opportunistic or true? |
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| Opportunistic. |
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| What can P. Aeurginosa cause? |
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| Endocarditis, meningitis, skin rashes, UTI's, external ear infections, corneal ulcers via contacts |
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| What is a characteristic of P. Aeurginosa infection? |
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| Grape-like odor and bluish-colored pus |
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| What is the cause of Gas Gangrene? |
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| Clostridium Perfringens |
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| How is Gas Gangrene contracted? |
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| Bacteria/spores enter damaged tissues and release endotoxins that cause necrosis of the surrounding tissues. |
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| What results from the release of endotoxins? |
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| Hydrogen and CO2 are produced via fermentation of amino acid and glycogen in the dead tissues. |
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| How is Gas Gangrene treated? |
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| Removal of dead/infected tissue or amputation |
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| Is there a toxoid or vaccine for Gas Gangrene? |
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| No |
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| What is used to slow bacterial growth in Gas Gangrene infections? |
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| Hyperbaric oxygen treatment |
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| What is the causative agent in Necrotizing Fasciitis? |
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| Strep Pyrogenes or Staph Aureus |
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| How is Necrotizing Fasciitis transmitted? |
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| Contaminate skin wounds |
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| How does Necrotizing Fasciitis attack? |
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| Release toxins resulting in destruction of fat and muscle that can spread via blood steam and result in organ failure or death. |
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| What is the causative agent of Chickenpox? |
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| Varicella-Zoster Virus. |
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| Is Chickenpox a DNA or RNA virus? |
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| DNA |
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| What are the symptoms of the chicken pox virus? |
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| Rash with macules (small red spots), papules (little bumps), vesicles (small blisters), and pustules (pus-filled blisters) |
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| The pustules of a chickenpox infection eventually crust over and fall off. The rash radiates in sparse crops to the extremities. T or F? |
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| T |
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| When can shingles occur? |
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| Months or years after the primary chickenpox infection and is caused by the latent virus harbored in sensory neurons. |
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| What leads to pain and tenderness that can last for months with shingles? |
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| Inflammation of portions of neurons |
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| Why are children are prone to secondary infections? What is the causative agent of these? |
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| Because the chickenpox lesions are itchy. S. Pyrogenes and S. aureus |
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| What is measles caused by? |
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| Rubeola virus |
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| How are the measles transmitted? |
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| Direct contact with respiratory secretions. One of the most contagious diseases. |
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| What is the main characteristic of measles? |
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| Small oral lesions called Koplik's Spots that ultimately causes a skin rash starting at the head and progressing to the trunk and extremities and disappearing in that order. |
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| What is a secondary infection of measles? |
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| Ear infections and pneumonia |
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| Is measles self-limiting? How long can it last? What are complications of it? |
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| Yes. 20-22 days from time of infection. Lung or brain damage. |
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| What causes Rubella? |
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| Rubella virus. |
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| What are the 2 forms? |
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| Postnatal - acquired after birth Congenital - virus is obtained in utero |
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| What are the characteristic symptoms of Postnatal Rubella? |
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| Spreading pink rash or joint pain |
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| About _____ of postnatal rubella infections are asymptomatic. |
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| half |
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| Postnatal Rubella clears up in __-___ days leaving ________ immunity. |
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| 2-3. Lifelong |
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| If the Rubella virus is exposed to the fetus in the first trimester, what is the effect? |
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| Always results in miscarraige or multiple permanent defects of the eyes, ears, brain and heart. |
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| Infants that survive exposure to the rubella virus in utero do what? |
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| Excrete the disease for months. |
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| What is the causative agent of fifths disease? |
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| parvovirus |
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| What is the characteristic symptom of fifths disease? |
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| Begins as a reddish rash on the face (slap-cheek) then spreads over the body primarily on the arms, legs and trunk. |
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| How long can Fifths Disease last? Can it come back? |
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| days to weeks and can recur at times of stress. |
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| What is the causative agent of Roseola? |
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| HHV-6 |
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| What are the symptoms of Roseola? |
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| Results in a high fever which can be followed by rash but most cases proceed without the rash. Fever disappears on 4th day but rash can appear after. |
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| What virus is thought to have been exposed to every adult? |
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| HHV-6 |
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| What are papillomas caused by? |
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| Warts. Caused by Human Papillomavirus. |
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| What is a papilloma? |
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| Benign squamous cell, epithelial growths that may be covered by skin (wart) or mucus membrane (papilloma) |
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| What are the 3 types of warts? |
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| 1.) Common Warts - affects fingers and occasionally other parts. 2.)Plantar warts - deep painful warts on the soles of feet 3.)Genital warts - Most common STD in US. Range from tiny to cauliflower like growths. Primarily affects the external genetalia but can infect the cervix, urethra and anus. |
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| Some strains of non-wart causing HPV has been linked to what? |
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| Cervical and oropharyngeal cancer. |
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| There are currently over _____ known strains of HPV with about _____ affecting the genitalia. |
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| 100/30 |
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| How are all 3 warts treated? |
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| Freezing them with liquid nitrogen or electrocautery. |
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| What cream is used to treat external genital warts? |
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| Aldara |
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| What is the recurrence rate of between __-__%? |
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| 10-40% |
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| What does Gardisil build immunity against? |
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| HPV strains 6,11,16,18. Reccomended for girls and boys 9-24 |
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| What is the causative agent of M. Whitlow? |
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| HSV-1 or HSV-2 |
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| How is M. Whitlow contracted? |
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| Virus enters through small breaks in unprotected skin causing the same types of lesions seen with cold sores or genital herpe infections |
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| What is M. Whitlow? |
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| Deep and extremely painful localized infecton of the fingers |
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| What was M. Whitlow common in many years ago? |
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| Nurses and hygienists because gloves were not common |
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| Who is M. Whitlow common in now? |
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| People with HSV infections in other parts of their bodies. |
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| What is the causative agent of Cutaneous Anthrax? |
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| Bacillus Anthracis |
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| What is Cutaneous Anthrax? |
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| Papule that becomes increasingly necrotic then ruptures to form a black eschar (scab). |
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| How is cutaneous anthrax contracted? |
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| Endospores enter the skin through small cuts or abrasions leading to a localized infection resulting in the formation of a papule. |
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| What is the causative agent of Cutaneous Mycoses? |
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| Dermatophytes such as Trichophyton, Microsporum, Epidermophyton. |
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| What causes an immune response or redness and inflammation in Cutaneous Mycoses? |
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| Products of the fungal metabolism. |
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| What is the Cutaneous Mycoses infection limted to? |
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| Nonliving epidermal tissues and their derivatives |
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| What is tine capitis? |
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| scalp ringworm |
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| What is tinea barbae? |
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| beard ringworm |
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| What is tinea axillaries? |
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| Armpit ringworm |
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| What is Tinea corpus? |
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| Body ringworm |
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| What is Tinea cruris? |
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| groin ringworm (jock itch) |
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| What is tinea pedis? |
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| Feet ringworm. Athlete's foot |
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| What is tinea manuum? |
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| Hand ringworm |
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| What is tinea ungiunum? |
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| Nail ringworm |
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| What is bacterial conjuctivitis caused by? |
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| Haemophilus aegyptius, " influenzae, Strep pneumo, Strep pyrogenes, Neisseria gonorrhoeae, and S. aureus |
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| What is viral conjuctivits caused by? |
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| Adenovirus |
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| What are the symptoms of conjuctivitis? |
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| Senstivity to light, swelling eye lids, increased tears, redness, and lg amounts of pis |
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| What does milky discharge indicate? |
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| Bacterial conjuctivitis infection |
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| What does clear exudate indicate? |
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| Viral conjuctivitis infection |
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| Is Keratitis more or less serious than conjunctivitis? |
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| More |
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| What is Keratitis? |
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| invasion of deeper eye tissues occurs, leads to complete coroneal destruction |
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| What is the most common causative agent of Keratitis? |
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| Herpes simplex viruses |
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| What does Keratitis result from? |
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| misdirected reactivation of a cold sore causing HSV. Can be direct contact of the virus within the eye area. |
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| What are preliminary symptoms of Keratitis? |
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| Feeling gritty in eye, conjunctivitis, sharp pain, sensitivity to light. |
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| What is the leading cause of infectious blindness in the US? |
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| Keratitis |