Chronic disease prevention Test 2 – Flashcards
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Cohort Study
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Studied over a long period of time. Study them until their death. Don't intervene.
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Case-Control Study
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Study where an individual with a disease is compared to an individual without the disease
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Randomized Clinical Trial
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Each participant is randomly assigned to either a control group or a treatment group
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What type of study strongly support cause-and-effect conclusions
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Randomized Clinical Trial
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Normal BP levels (Systolic/ diastolic)
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;120/;80
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Early High BP (Systolic/ diastolic)
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120-139/80-89
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High BP (Systolic/ diastolic)
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140-159/90-99
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Normal Cholesterol
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;200
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Borderline High Cholesterol
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200-239
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High risk Cholesterol
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Greater than or equal to 240
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What is a good predictor of heart disease?
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Cholesterol
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Dangerous BP
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Greater than or equal to 160/ greater than or equal to 100
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There is a 2-3% decrease in heart disease risk for (Heart Disease Rick reduction):
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-Every 1 mm decrease in diastolic BP -Every 1% decrease in total cholesterol
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The more mac and cheese someone was served (effect of portion size on energy intake):
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The more they would eat.
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The more they ate:
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The greater risk of obesity
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Atherosclerosis
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-The buildup of fatty plaque in the inner layer of the after wall -Begins as an inflammatory response to damage to the artery wall
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Physical inactivity: % of US adults (Modifiable risk factors for CVD)
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39%
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Obesity- BMI;30: % of US adults (Modifiable risk factors for CVD)
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31%
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Nurses Health Study What does a person with 5 risk have?
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He will have 5
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What is a low risk profile?
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1/2 drink of alcohol per day BMI ;25 30 min of daily excercise No smoking Healthy diet
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What percentage of the women in the low risk profile study followed all 5 things?
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3%
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What is the cancer staging from least dangerous to most dangerous?
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T - Primary tumor (Least dangerous) N- Lymph node involvement M- Distant Metastasis (Most dangerous)
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What do the Cancer Modifiers I-IV represent?
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I- Early stage IV- Late stage (Most dangerous)
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High Blood Pressure: % of US adults (Modifiable risk factors for CVD)
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26%
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Smoking: % of US adults (Modifiable risk factors for CVD)
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22%
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High Blood Cholesterol: % of US adults (Modifiable risk factors for CVD)
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17%
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Diabetes: % of US adults (Modifiable risk factors for CVD)
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7%
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Carcinoma
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Cancer that begins in the skin or in tissue that line or covers internal organs
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What is the leading cause of death before the age of 75?
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Cancer
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Common Cancer in Women
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Lung and breasts
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What is the leading cause of death after the age of 75?
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CVD
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Which disease could replace the other as the overall disease top killer in the future?
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Cancer may replace CVD
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Sarcoma
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Cancer that begins in bone, cartilage, fat, muscle blood vessels, or other connective or supportive tissue
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Common Cancer in Men
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Skin, Large intestines, lungs, and prostate
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For every _________ , there was a 12% improvement in survival (Exercise capacity and mortality article)
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1- Met increase in treadmill
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For every 1- Met increase in treadmill performance there was a ___ improvement in survival (Exercise capacity and mortality article)
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12%
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What BMI category is considered ideal weight/ low risk?
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19-24
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What BMI category is considered overweight/ moderate risk?
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25-29
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What BMI category is considered obese/high risk?
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Greater than or equal to 30
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Metabolic syndrome "X"
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Insulin resistant Presence of obesity from abnormal fat High blood cholesterol High blood pressure
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What BMI category is considered underweight?
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;19
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Tobacco: (% Cause of Cancer death in the US)
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30%
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True/False There is evidence that increased intake of red meat and processed meat increased risk of colorectal cancer
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True
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What fruit has the highest number of antioxidant?
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Cranberries
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What fruit has the highest number of antiproliferatives?
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Cranberries
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What veggie has the highest number of antioxidants?
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Red Pepper
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What veggie has the highest number of antiproliferatives?
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Spinach
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Should you only eat red peppers, spinach, and cranberries since they are the "Best"?
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No! You should eat a variety of fruits and veggies
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How many calories a day might result in a gain of 15 pounds in 10 years?
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14 calories a day
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What is the percentile of overweight children?
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85-95th percentile
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What is the percentile for obese children?
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MBI;95th percentile
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________ in 3 children are overweight or obese
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1 in 3 (33%)
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Pediatric obesity may shorten life expectancy by how many years?
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2-5 years
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What disease has the highest relative risk than any other disease in an obese person?
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Diabetes
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What is the largest predictor of type 2 diabetes
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Obesity
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What levels of fasting plasma glucose is considered diabetes?
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Greater than or equal to 126 mg/dl
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What levels of fasting plasma glucose is considered pre diabetic (Impaired)?
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100-125 mg/dl
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Pre diabetic is also known as_______
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Impaired
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What levels of fasting plasma glucose is considered normal?
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less than 100 mg/dl
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What percent of the Diabetics in the US are obese at the time of diagnosis?
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85%
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What percentage of type 2 diabetes can be attributed to poor lifestyle?
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90%
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A study design that randomly assigns participants into an experimental group or a control group. As the study is conducted, the only expected difference between the control and experimental groups is the outcome variable being studied.
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RCT (Randomized clinical trial)
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A particular type of study involving a group of people who share defining characteristics (typically who experienced a common event in a selected period) that are followed prospectively while performing cross-sectional analysis at set intervals.
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Cohort
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A study that compares patients who have a disease or outcome of interest with patients who do not have the disease or outcome, and looks back retrospectively to compare how frequently the exposure to a risk factor is present in each group to determine level of risk.
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Case-Control
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For each 1mmHg drop in blood pressure and each 1% drop in total cholesterol there is a _____% to _____% decrease in risk of heart disease?
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2 to 3%
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Obesity Risk Factors
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-Cancer -Hypetension -Hypercholesterolema -Psychological burden -Increased risk of gallstones, osteoarthritis, diabetes, cancer, heart disease -Increased risk of early death
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If all form of CVD were eliminated, life expectancy would be increased by how many years?
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7 years if all forms of CVD were eliminated and 3 years if all cancer was eliminated
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Does cancer or CVD result in more years of life lost?
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o Cancer
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Atherosclerosis contributes to about ___ of CVD
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85%
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If all forms of cancer were eliminated, the increase is just ___ years.
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3 years
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What percent change in risk might be expected when changing from the highest quintile of Western Pattern to the highest quintile of Prudent Pattern? Don't have picture
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95% change in risk
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T or F According to some research, the more food a person is served the more they tend to eat
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True
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A diet characterized by higher intake of vegetables, fruit, legumes, whole grains, fish, and poultry is commonly termed a... (1 pts). a. Western diet b. Prudent diet C. Mediterranean diet
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Prudent Diet
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Research has shown that atherosclerosis can be reversed over a fairly long period of time by modifying what particular lifestyle factor?
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Diet
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f all forms of major CVD were eliminated, total life expectancy would increase nearly ____ years.
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7 years
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The primary cause of CVD is _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
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Atherosclerosis
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Is lifestyle or metformin more effective at lowering diabetes?
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o lifestyle
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· Increased levels of body fatness results in lower risk of breast cancer for pre or post-menopausal women?
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o Premenopausal women
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What is angiogenesis?
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o When a tumor creates its own blood supply
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Cardiovascular disease has been the leading cause of death every year except what year? What was the leading cause of death that year?
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o Influenza and 1918
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Long Term Complications of Diabetes
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· Dental disease · Kidney disease · Diabetic Retinopathy (Blindness) · Heart disease (leading cause of diabetic death is heart disease) · Stroke · High blood pressure
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Nutrition/ Obesity (% Cause of Cancer death in the US)
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30%
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Symptoms of diabetes (Hyperglycemia)
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·Excessive urination (polyuria) ·Excessive thirst (polydipsia) ·Weight loss, sometimes with excessive eating (polyphagia) ·Fatigue, weakness ·Blurred vision ·Slowed healing ·Increased risk of infection
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Why is HCG Diet rising in popularity?
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Inappropriate incentives
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HCG Diet: Effective or not effective?
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Studies show that it is not effective - Loss of weight was due to caloric restriction
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How is obesity epidemic explained?
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By consuming more calories than expended.
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Fat overfeeding vs. Carbohydrate overfeeding: Which one equals more weight gain?
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Fat overfeeding
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Energy Intake
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-Alcohol -Fat -Protein -Carbohydrate
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Energy Expenditure
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-NEAT (non- exercise activity thermogenesis) -BMR -Activity/ Exercise
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Inactivity (% Cause of Cancer death in the US)
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5%
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Family History (% Cause of Cancer death in the US)
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5%
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Fat as % of total calories has decreased, but body fat percentage has _____
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increased
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Someone that originally weighs 300 lbs should have a goal to lose ___ lbs (Clue: what is a good percentage goal for weight loss of starting weight?)
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30 lbs
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Viruses and other biological agents (% Cause of Cancer death in the US)
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5%
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A good goal for weight loss would be ___ of starting weight.
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10%
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In the Nurses Health Study (NHS), population attributable risk for coronary disease went from 64% for women who had 4 low-risk factors to 82% for women who had 5 low-risk factors. What additional risk factor was thought to contribute to the increase in population attributable risk?
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½ drink alcohol/day
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In this study (NHS) what were at least 3 of the 5 components of a low-risk profile?
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BMI < 25, exercise 30 min/day, ½ drink alcohol/day, no smoking, healthy diet
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When studied, which drink was most effective at inhibiting atherosclerosis and improving lipids in hamsters when polyphenol dose was normalized?
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Grape juice
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The French have low coronary heart disease mortality with high fat consumption; this epidemiological anomaly is known as the _______
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French Paradox
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Which disease contributes to more years of life lost? (1 pts) a. CVD b. Cancer c. Diabetes d. Obesity
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b. Cancer
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T or F The lifetime risk for developing cancer is greater for women than men.
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False
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Which is the most common cancer in men?
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Prostate
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Which is the most common cancer in women?
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Breast
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What is it called when a tumor/cancer migrates to a distant site from its origin?
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Metastasis
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What is it called when something (Cancer) creates its own blood supply?
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angiogenesis
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Genetics accounts for about _____% and lifestyle/environment about ______% in terms of population susceptibility to cancer?
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20% and 80%
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What are at least two sites in the body where risk of cancer is increased with alcohol consumption?
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Oral, esophageal, stomach, intestines, liver, breast, colon
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T or F Research has shown probable links between decreased risk of cancer and consumption of supplements derived from vegetables, fruits, pulses, nuts, seeds, herbs, and spices.
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False
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Convincing evidence indicates that red meat and processed meat consumption increases risk of what type of cancer?
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Colorectal
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Name the chemical carcinogen that comes from certain molds or fungus found in or on grains, nuts, or seeds that significantly increases risk of liver cancer
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Aflatoxin
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Studies that have used nutrition and exercise programs to lower health risks such as blood pressure, cholesterol, and diabetes have also exhibited what "healthy lifestyle side effect"?
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Weight Loss
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What is the term that Kelly Brownell of Yale University uses to describe the pervasive problem of over consumption and sedentary lifestyle?
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Toxic Environment
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An RQ of 1.00 indicates that _______ is the predominant energy source and an RQ of 0.70 indicates that ______ is the predominant energy source.
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Carbohydrate Fat
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Fat oxidation goes (up or down or stays the same) during CHO overfeeding and goes (up or down or stays the same) during Fat overfeeding.
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Down Stays the same
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What is the name of the diet that involves injections of a female pregnancy hormone to suppress appetite?
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HcG diet
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T or F Like many other chronic disease conditions diabetes is more common among men than women.
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False
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Non-insulin dependent diabetes mellitus is also called?
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Type 2
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Diabetes and insulin dependent diabetes mellitus is called?
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Type 1
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T or F Fewer persons diagnosed with type 2 diabetes are lean compared to obese at the time of diagnosis. (More people are obese when diagnosed)
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True
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Which is the leading cause of diabetes-related death? a. Cancer b. Heart disease c. Infection
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Heart Disease
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Which category would be considered "impaired fasting glucose" or "pre-diabetes"? a. ? 126 mg/dl b. 100-125 mg/dl c. <100 mg/dl
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b. 100-125 mg/dl
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T or F Jihoon is gay
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True
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Which 3 risk factors add up to more than 2/3 of all risk?
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Tobacco- 30% Nutrition/ Obesity- 30% Inactivity- 5%
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What are the preventative mechanisms for colon cancer?
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Decreased transit time Enhanced immune function Decreased insulin levels Enhanced defense against oxidative stress
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Key Concept: There is enough valid scientific information on the requirements for healthy living to transform the health of most Americans- by doing what two things
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30 min or more of PA on most days & Healthy diet
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If a person reduced their BP by 6mm, how much does their risk decrease?
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12-18%
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Of all cancers ____ has the strongest link with physical inactivity
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Colon Cancer
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What factor of the low risk factor in the Nurse study made the biggest difference?
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Alcohol
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What is important in treating/ preventing CVD because diet is closely related to so many diseases (obesity, hypertension, etc)
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Healthy Diet
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What is a good predictor of overall risk and CVD?
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Exercise activity
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True of False: Exercise is beneficial to everyone. Not Just healthy people.
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True
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What is the most common way to lose weight?
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Eat less calories.
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What is NEAT?
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(non- exercise activity thermogenesis), burning calories through physical activity - Unplanned activities that burn calories
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Which is most lethal cancer? -N-II -T-IV -M-II -M-III
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M-III
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3 in 4 published studies show an average of ____ reduction in colon cancer risk in the most physically active men and women.
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50% (70% max)
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Diabetes impairs what?
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The body's ability to burn fuel or glucose
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Type 1
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Beta cells in pancreas are mostly or entirely destroyed by the body's own immune system. This person needs insulin injections
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Type 2
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Beta cells make insulin, but the persons' tissues are not sensitive enough to the hormone and use it inefficiently.
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True/False: Diagnosis comes after confirmation on a different day.
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True
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What was the strongest predictor of mortality after adjusting for age?
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Exercise capacity measured in METS
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What are good predictors of overall mortality risk and CVD?
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Exercise capacity and activity status.
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What is attributable risk?
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The % of risk that can be avoided if risk factors werent present.
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True/ False: Breast cancer has the highest mortality for women
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False: Lung does
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True/ False: Prostate cancer has the highest mortality for men.
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False: Lung does
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What is the chronic disease that contributes to the highest number of deaths?
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Heart disease
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What is the chronic disease that contributes to the most year of life lost?
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Cancer
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What is the lifetime risk for developing cancer in men?
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1/2
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What is the lifetime risk for developing cancer in women?
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1/3
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True/ False: osteoporosis is a risk factor for obesity?
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False
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Obesity is Explained by....
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-Obesity epidemic is explained by consuming more calories than expended
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Lesson learned from energy balance:
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Technology affects energy expenditure. -cars, dishwater