Antibacterial drugs – Flashcards
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| Penicillin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis |
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| methicillin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -penicillinase-resistant |
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| naficillin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -penicillinase-resistant |
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| ampicililn |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -broad spectrum |
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| amoxicillin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -broad spectrum |
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| cephalosporin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -resistant to beta-lactamases -"cef" |
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| cephamycin |
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| PBP-crosslinking of petidoglycan -inhibit cell wall synthesis -resistant to beta-lactamases -"cef" |
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| bacitracin |
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| -peptidoglycan precursor -inhibit cell wall synthesis |
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| polymyxin |
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| -outer membrane of gram (-)-LPS |
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| Vancomycin |
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| D-ala-D-ala peptidoglycan subsitute -disrupts peptidoglycan by preventing the incorportation of NAG and NAM -IV |
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| Daptomycin |
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| -inhibits cell membrane-only gram (+) |
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| Isoniazid |
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| inhibits synthesis of mycolic acid->main player in TB |
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| ethionamide |
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| -inhibits synthesis of mycolic acid-TB |
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| ethambutol |
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| -inhibits arabinogalactan synthesis in cell wall-TB |
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| quinolone |
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| -bacterial topoisomerase II and IV -both gram (+) and gram (-) -inhibits DNA replication |
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| floroquinolone |
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| -bacterial topoisomerase II and IV -both gram (+) and gram (-) -inhibits DNA replication |
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| metronidazole |
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| -inhibits DNA synthesis -anaerobic bacteria |
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| clofazimine |
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| -guanine base analog->blocks DNA -TB and Leprosy |
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| rifampin |
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| DNA-dependent RNA polymerase -TB -orange secretions |
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| sulfonaminde |
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| inhibit folic acid synthesis-dihydropteroate synthetase |
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| trimethoprim |
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| inhibit folic acid synthesis-DHF reductase |
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| dapsone |
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| inhibit folic acid synthesis--competitive inhibitor of dihydropteroate synthase -used with rifampin and clofazimine to treat leprosy |
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| aminoglycoside |
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| 30S ribosome -gram (-) |
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| streptomycin |
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| 30S ribosome -gram (-) |
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| tetracycline |
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| 30S ribosome -broad spectrum |
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| doxycycline |
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| 30S ribosome -broad spectrum |
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| linezolid |
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| 50S ribosome -oxazolidinone |
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| chloramphenical |
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| 50S ribosome -interupts with done marrow protient synthesis->aplastic anemia |
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| macrolide |
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| 50S ribosome |
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| erythromycin |
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| 50S ribosome macrolide |
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| azithromycin |
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| 50S ribosome macrolide |
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| ketolide |
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| 50S ribosome telithromycin-derivative of erthromycin |
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| telithromycin |
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| 50S ribosome -ketolide |
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| clindamycin |
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| 50S ribosome |
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| streptogramin |
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| 50S ribosome -quinupristin-dalfopristan given back to back |
