Virology – Microbiology Answers – Flashcards
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| Polio 1, 2, 3 Human Rhinovirus Hepatitis A/E |
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| ssRNA (+) non-segmented no envelope |
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| Rubella Hepatitis C |
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| ssRNA (+) enveloped 1 sub-genomic mRNA |
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| Coronaviruses SARS |
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| ssRNA (+) non-segmented enveloped |
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| Mumps Measles Rabies Ebola (Zaire & Sudan) |
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| ssRNA (-) non-segmented enveloped |
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| Influenza A, B, C |
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| ssRNA (-) segmented enveloped |
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| Reovirus 1, 2, 3 Rotavirus A, B Colorado Tick Fever |
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| dsRNA (+) segmented no envelope |
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| HTLV HIV 1, 2 |
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| ssRNA (+) retroid DNA step in replication |
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| Hepatitis B (HBV) |
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| ds/ssDNA enveloped retroid DNA step in replication |
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| Parvoviridae (RA-1) |
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| ssDNA no envelope |
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| Polyoma Papilloma |
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| dsDNA no envelope |
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| Herpesviridae (HSV, HHV, Herpes B) Poxviridae (smallpox) |
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| dsDNA enveloped |
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| Baltimore Classifications (1 - 7) |
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| 1) dsDNA 2) ssDNA 3) dsRNA 4) ssRNA (+) 5) ssRNA (-) 6) ssRNA (+) w/DNA intermediate 7) gapped circular dsDNA |
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| Class I - dsDNA |
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| Pox Papilloma |
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| Class II - ssDNA |
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| Parvo |
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| Class III - dsRNA |
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| Reo/Rota |
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| Class IV - ssRNA (+) |
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| Polio |
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| Class V - ssRNA (-) |
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| Rabies Influenza |
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| Class VI - ssRNA (+) w/DNA intermediate |
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| HIV |
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| Class VII - gapped circular dsDNA |
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| HBV |
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| What 2 viruses have segmented genomes? |
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| Influenza Reo/Rota |
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| What 3 viruses have circular genomes? |
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| SV40 (polyoma) Papilloma HPB (not covalently closed) |
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| Genome - RABIES |
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| ssRNA (-) linear NO direct/inverted repeats NOT covalently linked to proteins |
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| Virion - RABIES |
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| enveloped rod shaped/filamentous genome coated w/VIRAL protein viral RNA polymerase |
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| Attachement/Entry - RABIES |
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| genome in cytoplasm entry by fusion |
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| mRNA synthesis - RABIES |
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| cytoplasm viral RNA-dep RNA-pol NO genome conversion |
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| Capping - RABIES |
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| viral polymerase and host enzyme poly(A) tail via polymerase slippage |
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| Rep. intermediates NOT mRNAs. |
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| Rabies Influenza |
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| What VSV/Rabies virus uses protease for maturation? |
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| EBOLA uses Furin, a CELL protease. |
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| Genome - INFLUNZA |
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| ssRNA(-) linear segmented NO direct terminal repeats NOT covalently linked to protein |
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| Virion - INFLUNZA |
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| enveloped genome coated with viral protein viral RNA polymerase |
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| Attachment/Entry - INFLUENZA |
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| binds carbohydrate uncoated via fusion (late endosomes) genome migration to nucleus |
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| mRNA synthesis - INFLUENZA |
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| Nuclear process HOST RNApolII |
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| capping - INFLUENZA |
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| VIRAL endonuclease cleaves host enzyme after capping. Host mRNAs provide caps. Cleaved oligonucleotide used as primer. |
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| maturation - INFLUENZA |
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| HOST protease used to cleave after assembly at plasma membrane. |
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| Genome - POLIO |
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| ssRNA (+) linear non-segmented covalently linked to protein |
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| Virion - POLIO |
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| naked virus - icosahedral shape uses host polymerase |
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| attachment/entry - POLIO |
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| binds cell surface protein genome remains in cytoplasm |
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| Which is the only virus to make a single mRNA? |
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| Polio (picornavirus) |
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| What virus encodes poly(A) tail in genome? |
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| Polio (picornavirus) |
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| Which 3 viruses initiate genome replication via protein priming? |
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| Polio (picornavirus) Adenovirus HBV |
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| Which 3 viruses produce equal amounts of viral capsids and polymerase? |
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| Polio (picornavirus) Togavirus Retrovirus |
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| What 2 viruses assemble capsids in the cytoplasm(using a viral protease) |
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| Polio (picornavirus) Togavirus |
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| Genome - TOGAVIRUS |
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| ssRNA (+) linear |
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| Virion - TOGAVIRUS |
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| enveloped icosahedral |
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| TOGAVIRUS after attachment... |
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| mRNA synthesized in cytoplasm via VIRAL polymerase. Encodes protease that makes individual proteins. Produces 2 mRNAs. |
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| Which 2 viruses code for a DNA polymerase in the virion? |
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| Retrovirus Hepatitis B |
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| Genome - CORONA/SARS |
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| ssRNA (+) linear |
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| Virion - CORONA/SARS |
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| enveloped spherical |
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| Uncoating - CORONA/SARS |
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| uncoated via fusion genome remains in cytoplasm |
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| Capping - CORONA/SARS |
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| Capping/mRNA synthesis via viral polymerase in cytoplasm. Viral protease makes polyproteins. |
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| Genome - RETROVIRUS |
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| diploid ssRNA (+) linear direct terminal repeats |
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| Virion - RETROVIRUS |
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| enveloped icosahedral genome coated w/viral protein DNA polymerase |
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| Which virus converts the genome in the cytoplasm? |
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| Retroviruses |
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| Attachment/entry - RETROVIRUS |
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| Binds cell surface protein. Fusion to plasma membrane. Genome migrates to nucleus. |
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| Which 2 viruses encode a reverse transcriptase? |
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| Retrovirus Hepatitis B |
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| Genome - HBV |
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| partial dsDNA covalently linked to protein circular genome 3 direct repeats - 2 near 3' end |
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| Virion - HBV |
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| enveloped icosahedral DNA polymerase encoded |
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| T/F - HBV genome migrates to the nucleus. |
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| TRUE |
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| Which 2 viruses encode a DNA-dep DNA pol, RNA-dep DNA pol, and a reverse transcriptase? |
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| Retroviruses HBV |
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| SV40 |
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| Polyoma |
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| Genome - SV40 |
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| dsDNA circular |
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| Virion - SV40 |
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| icosahedral not enveloped genome coated w/CELL protein |
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| T/F - SV40 genome migrates to the nucleus after entry. |
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| TRUE |
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| SV40 after uncoating.. |
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| mRNA synthesis in nucleus by polII capsids assemble in nucleus bidirectional DNA synthesis |
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| Which 3 viruses produce mRNAs from both DNA strands? |
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| SV40 Adeno Herpes |
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| Which 2 viruses replicate their genome via strand displacement? |
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| Adeno POX |
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| Genome - Papilloma |
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| dsDNA circular |
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| Virion - Papilloma |
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| icosahedral genome coated w/CELL protein genome migrates to nucleus |
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| What 3 viruses use host polymerases? |
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| SV40 Papilloma Parvo |
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| Genome - ADENO |
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| dsDNA linear unsegmented covalently linked to protein inverted terminal repeats |
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| Virion - ADENO |
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| icosahedral genome migrates to nucleus |
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| Genome - REO/ROTA |
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| dsDNA linear |
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| Virion - REO/ROTA |
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| icosahedral RNA polymerase in virion genome remains in cytoplasm |
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| T/F - mRNA synthesis and capping is done by a viral polymerase in REO/ROTA. |
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| TRUE |
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| This virus assembles in the endoplasmic reticulum. |
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| Herpes |
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| What is the only virus to produce one mRNA? |
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| Polio (picornavirus) |
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| Genome - HERPES & POX |
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| dsDNA linear |
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| This virus uses fusion to uncoat, then sends the genome to the nucleus. |
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| Herpes |
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| This is the only virus to produce 2 mRNAs. |
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| Togavirus |
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| This is the only virus to inhibit host translation. |
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| Polio (picornavirus) |
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| Only virus to use cell RNA to initiate genome replication. |
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| Retrovirus |
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| Encodes poly(A) tail in genome. |
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| Polio (picornavirus) |
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| Genome conversion in nucleus only occurs in which 2 viruses? |
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| Hepatitis B Parvo |
