Vascular Endothelial Growth Factor In Portal Hypertensive Gastropathy Essay Example

Portal hypertensive gastropathy is increasingly being recognized as a major cause of anemia and bleeding apart from oesophageal varices. We know that, in portal hypertension, there is a relative hypoxia of the gastric antral and fundal mucosa, This mucosal ischemia causes increased risk of mucosal breakdown and thus leads to ulceration and in the setting of portal hypertension, it causes massive bleeding.

VEGF (vascular endothelial growth factor) has been proven to play a role in development gastric ulcers even in patients who are not having portal hypertensive, for example peptic ulcers.The data on increased VEGF in PHG is controversial with some autjors reporting an increase, and others reporting decreased levels. In addition it is know that patients of PHT produce less gastric mucus secretion, which causes poor protection from acid environment of the stomach and leads to bleeding The authors devised a