Pathoma GI (Colorectal Carcinoma) – Flashcards
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two pathways that can lead to colon cancer
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adenoma-carcinoma sequence and microsatellite instability
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inherited mutation in the DNA mismatch repair enzymes that leads to the development of colon cancer through the microsatellite instability pathway
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hereditary nonpolyposis colorectal carcinoma
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three types of carcinoma that patients with the HNPCC mutation are more likely to develop
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colorectal, ovarian, and endometrial
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age at which screening for colon cancer with colonoscopy and fecal occult blood begins
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50
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specific type of lesion that is characteristic for left-sided carcinoma that develops from the adenoma-carcinoma sequence
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napkin-ring lesion
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side of the colon that carcinoma from the adenoma-carcinoma sequence is most likely to develop from
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left side
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side of the colon that carcinoma from the microsatellite instability pathway is most likely to develop from
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right side
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two symptoms associated with right-sided colon carcinoma
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iron deficiency anemia and vague pain
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three symptoms associated with left-sided colon carcinoma
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decreased stool caliber, left lower quadrant pain, and blood-streak stool
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infectious agent that causes endocarditis and increases the risk of colon cancer
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Streptococcus bovis
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most common metastatic site for colon cancer
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liver
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serum marker for colon cancer that is useful in treatment response monitoring and detecting recurrence
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CEA
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true or false: CEA is useful when screening for colon cancer
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false
