Mannitol (Osmitrol, Resectisol)

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Mannitol (Osmitrol, Resectisol) Pharmacological Class:
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Osmotic Diuretic
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Mannitol (Osmitrol, Resectisol) Therapeutic Class:
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diuretics Pregnancy Category C drug.
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Mannitol (Osmitrol, Resectisol) Actions/Uses:
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Used in acute renal failure, high intraocular or intracranial pressure, edema, and drug intoxication (to induce diuresis). Mannitol works along the entire nephron and is non-absorbable. It inhibits reabsorption of H2O and lytes. Take away- mannitol is pulling fluids from the interstitial spaces into the vasculature.
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Mannitol (Osmitrol, Resectisol) Interactions:
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hypokalemia increases risk for dig toxicity
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Mannitol (Osmitrol, Resectisol) Contraindications:
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known allergy, severe pulmonary edema (use loop diuretics instead), anuria, severe dehydration, pulmonary congestion, active intracranial bleeding. Use caution in clients who have HF.
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Mannitol (Osmitrol, Resectisol) Administration Considerations:
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Mannitol may crystallize at low temperatures so it needs to be stored in a warmer. Because of this, it is always administered IV through a filter. Visually inspect mannitol container for precipitants prior to administration.
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Mannitol (Osmitrol, Resectisol) Toxicity/Antidote:
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Immediately terminate treatment if severe cardiac or renal impairment develop after initiation of therapy.
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Mannitol (Osmitrol, Resectisol) Adverse/Side Effects:
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Convulsions, thrombophlebitis, pulmonary congestion or edema, HF,, kidney failure, fluid and lyte imbalances, increased GFR and renal plasma flow, h/a, chest pain, tachycardia, blurred vision, chills, fever
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Mannitol (Osmitrol, Resectisol) Nursing Considerations:
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Administer by continuous IV infusion. Use a filter needle when drawing from the vial and a filter in the IV tubing to prevent administration of microscopic crystals. Monitor daily weight, I&O, serum lytes & for signs of dehydration, acute kidney injury, and edema.

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