Chapter 3: The Cellular Level of Organization (Biology) – Flashcards
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Interstitial Fluid
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*AKA Extracellular fluid *AKA the outside environment *Fluid that is outside of the cell (watery medium) **Separated by a plasma membrane boundry
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Plasma Membrane
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*AKA Boundary *Boundary that seperates the cells contents from the interstitial fluid (the environment) *A way that cells talk to one another.
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Types of Cells in Body
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1. Somatic Cell - Normal body Cells prefix Soma = "body" 2. Germ cell (sex cell) - Egg/sperm cells
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Cytology
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Study of cells "Ctyo" = Cell "Ology" = Study of
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Robert Hooke
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First discovered the existence of cells through dead cork slides.
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Who named "Nucleus?"
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Robert Brown
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Cell Theory: What is is and who established it?
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Established by Schleiden and Schwann States that: *All organisms are made up of cells *Cell is a functional unit of life *Smallest living unit *Cells arise from preexisting cells - There's no longer a spontaneous generation
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Cell Technology
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Opened up a NEW WORLD for people to see that there's a smaller world, unavailable to the naked eye.
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Bacteria are what kinds of cells?
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Prokaryotic Cells
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Eukaryotic Cells Characteristics
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They are with nucleus. *Eu - True (nucleus) Contain MEMBRANE BOUND ORGANELLES (such as nucleus, lysosomes, Golgi Apparatus, Peroxisomes *larger than Prokaryotic cells *have nucleus *DNA in linear chromosomes
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Membrane Bound Organelle
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Definition: Seperates their interiors by a bilipid layer from cytosol) *Nucleus *Endoplasmic Reticulum --Smooth ER (no ribosomes) --Rough ER (ribosomes) --Golgi Body (synchronized with rough ER) *Mitochondria
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Non-Membrane Bound Organelle
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*Ribosomes *Various vesicles -lysosomes -perioxisome *Cytoskeleton Centrosome and Centrioles Microvili Flagella Cilia Proteasomes
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Prokaryotic Cells Characteristics
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*Do not have organelles -Meaning, Prokaryotic cells aren't as efficient at cell mechanisms. *Smaller than Eukaryotic *No organelles *No Nucleus *Have DNA in a circular loop; or in plasmids
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How Are Eukaryotic Cells More Advanced?
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Eukaryotic cells are allowed to work faster and more efficiently , considering their organelles are in their own membranes. By sectioning off certain innerworkings of the cell, it leads to specialization. So the cell can work on its specific areas with no disruption. Similar to having one big house. You have to have walls to separate the rest of the rooms, otherwise you can never get anything done in that one room. EUKARYOTIC CELLS ARE ALLOWED TO BE INDIVIDUALIZED THIS WAY.
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Plasma Membrane Composition
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*Lipid bilayer is made up of PHOSPHOLIPS (phosphorus head which is hydrophillic) (Lipid head that is hydrophobic) *Different kinds of proteins interspersed; -Channels -Transports -Pumps - Require ATP because it's active transport - Receptors - Inside cell and outside
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DNA containing region?
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Nucleus
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What is Microscopy?
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Using microscopes to see small items
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What does a Condenser on a Microscope do?
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Focuses light through specimen
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What does a Diaphragm of a Microscope do?
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Focuses amount of light through specimen
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Photoautorophs
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Light energy turns into glucose *ex. Plants
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Gamma Rays on Electromagnetic Spectrum
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Highest energy; Shortest waves. Blue/Violet
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Visible light
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*The light that photoautotrophs use for energy *Visible light is 380-750
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TEM Microsope
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*Transmission Electron Microscope *Using Electrons ----> Cells must be dehydrated *Embeded in wax *Cuts cell in half to see the cross section of cell
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Magnification increases.....
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With shorter reflective waves of light. KTP THOUGHT (The longer waves cannot penetrate as deeply, so they cannot see as closely. You can use the shorter waves (on the Gamma side of the spectrum, the left, and you can penetrate like the harmful waves do. So using electrons is the ultimate way to view something small because you're using the most dangerous way to do so)
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SEM Microscope
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*Scanning Electron Microscope *Not in color. *Electrons bounce off of the item and are collected to see the picture *Views surface detail
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Phase-Contrast
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You can see things in 3D and you can see through the cytoplasm
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98.6 in Metric
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37 Centigrade
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"Fluid Mosaic Model"
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*Consists of double layer of phospholipids *Adjusts to changing in the environment *The membrane is the first line of defense. *Cholesterol is what keeps this "fluid" composition, which is 25% of make up. ---More cholesterol, more fluidity *Just like how phospholipids in plasma membrane have hydrophillic and hydrophobic sections, the protein does too. The same areas that the phospholipids do.
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What Cell Responds to
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Hormones and Enzymes
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Hydrophobic Tails
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Fatty Acid
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Hydrophillic Head
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Glycerol + Polar Group
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Membrane of cell consists of:
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*Phospholipid (not changing) *Protein molecules (changing)
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Glycoproteins (MARKERS)
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Gly - Sugar - Carbohydrate + Protein Protein with a Carbohydrate component Due to the carbohydrates naturally occurring in the cell's membrane
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Glycolipids (MARKERS)
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Gly - Sugar - Carbohydrate + Lipid Lipid with a carbohydrate component Due to the carbohydrates naturally occurring in the cell's membrane
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Glycocalyx
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Made up of Glycolipids and GlycoProteins (remember that lipids and proteins already exist in a majority of the cell. The carbohydrate 3% is also there, and they bond to make Glycolipids and GlycoProteins) Functions: Lubrication: On outside of the cell Anchoring: Is a sticky residue on outside of membrane Receptors: binding specific extracellular compounds Recognition: Can recognize the glycoproteins and glycolipids as "it's own" so cell of the immune system know it's "self" and not "foreign" ^^^ This helps your body not attack its own cells and attack pathogens with no the same glycocalyx composition instead. *Ex. Human egg cells have a lot of Glycocalyx to stick, and to identify that it's a good cell and not an invader.
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Integral Protein Within Plasma Membrane
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*AKA transmembrane Protein *Extends into or all the way through bilipid layer, (trans = through) ---- (ex glycoproteins)
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Channel Protein Within Plasma Membrane
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*Have a pore or hole allowing single types of ions and water to pass (because ions cannot dissolve in lipids, hence cannot cross phosopholipid bilayer) *selective channels *Controlled by proteins *Allows one ion at a time
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Receptor Protein Within Plasma Membrane
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*Serves as a cellular recognition site binding to specific molecule (hormones) *Sensitive to ligands (small ion like calcium, or hormones) that come upon a cell's membrane and will bind to the approperate receptor and will trigger change in the cell. ----Ex. Insulin, to change glucose intake levels.
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Transporter Protein In Plasma Membrane
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*change shape to accommodate molecule (amino acids)
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Colloid
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A solution containing dispersed proteins or other large molecules. *thick and Jell-O consistency.
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Cytosol
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LIQUID part of inside the cell *contains disolved nutrients, ions, soluble and insoluble proteins, and waste products.
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Cytoplasm
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Material located from the Plasma Membrane, all the way to the nucleus. *Contains mostly proteins and organelles (Cytoplasms CONTAIN Cytosol)
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Salt Ions within Cellular Interaction
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Na+ (Sodium) is always HIGHER outside of the cell; Higher in the extracellular fluid outside the cell. KTP IDEA (Sodium=bad. So keep it outside. Grosso.
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Potassium within Cellular Interaction
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K+ (Potassum) is higher in the cytosol inside the cell; Lower in the extracellular fluid outside the cell. KTP IDEA (Potassium = Good. Keep it inside (BANANAS. YIPPIE!))
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Viscosity of Cytosol
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Determined by amounts of enzymes and the cytoskeleton
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Mitochondria
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*Makes ATP through Krebs Cycle ---heart makes a lot of mitochondria because of the amount of energy(ATP) it needs to always be beating/pumping blood. ---Liver cells need the same thing, for they are always filtrating blood.
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Nucleolus
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Where Ribosomes are made and held *Stores ribosomal RNA (rRNA) and proteins that will be assembled into ribosomal subunits
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Loosely assembled DNA
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*Found in the perimeter of the nucleus (not nucleolous) *Loosely assembled for easy access to replicate
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Chromatin
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Loosely assembled DNA *grannular looking DNA
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Chromosome
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Tightly wound DNA, like a spring so you don't lose pieces of DNA. *The only time you see chromosomes is during mitosis Some- Body. A fully composed body ready to run the race of mitosis.
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Function of Organelles
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*To COMPARTMENTALIZE cellular activities: separate incompatible reaction w/o interference of other reactions from other organelles = greater efficiency ^^ -------->>> this is what makes eukaryotic cells more complex and advanced. *STORAGE *PROTECTION OF VITAL STRUCTURE
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Nucleus Functions
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*Nucleus is the command and control center, control of metabolism and development of the cell *
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Nucleotides
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Building blocks of Amino Acids ---Phosphate grou, five carbon sugar, nitrogenous base.
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Gene Expression
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All of the chromosomes are inherited, but only if the gene is "turned on" it will be expressed through GENE EXPRESSION. *It changes the way DNA expresses itself, as to make a specific tissue or express a certain characteristic
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Histones
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Histones = Protein. Histone are the smaller pebbles that the DNA wraps around to coil tightly. The GROUPS of HISTONES that the DNA bundle around maker bigger balls, called Nucleosome Like thread winds around a spool, DNA winds around histones (proteins) to make a nucleosome (which are bigger balls than the histones Nuclosomes form chromatin to tightly compact a lot of information into a small space. *found within nucleolus *Helps with gene expression
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Ribosome
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*Help protein synthesis Consists of two subunits. Large and small subunit. ---these come into play during TRANSLATION of mRNA strand making a tRNA to make the final polypeptide (Polypeptide = a chain composed of a lot of amino acids). *Organelles responsible for protein synthesis. *higher the demand for more proteins in a particular cell, thehighest the ribosome number will be ---ex. Liver cells produce more blood proteins. More ribosomes needed than liver.
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Nucleus Pores allow exchange between....
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Cytoplasm and extracellular fluid *Allows mRNA to leave the nucleus
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The only cell without nucleus
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RED BLOOD CELL It's mature and realizes that the only way to support his family that depends on him (the body) is to drop the habit of having a nucleus and be a man; he must obtain a hemoglobin and provide oxygen. He must bring home that bacon.
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Endoplasmic Reticulum (ER) includes
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1) Golgi Bodies 2) Lysosomes 3) Peroxisomes
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Smooth ER
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*No ribosomes 1) *Involved with synthesis of phospholipids and cholesterol for membranes (lipids to reconstruct the bilipid membrane layer) *Storage of triglycerides *Synthesis of steroid hormones Synthesis of GLYCOGEN in BOTH SKELETAL MUSCLE AND LIVER 2) Detoxification of metabolic wastes and drugs *ex. Liver has a lot of Smooth ER to get rid of toxins
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Rough ER
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Fixed Ribosomes on surface 1) Protein synthesis - Polypeptides (many Amino Acids in a sequence) are exported from ER to go into Golgi, where they are modified (folded to whatever protein) 2) Proteins are modified and joined with a carbohydrate (undergoing Glycosylation) to be shipped to Golgi via transport vesicles
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Glycosylation
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The processes needed to form a carbohydrate and a protein together to make a glycoprotein. *GLYCOSYLATION HAPPENS WITHIN THE ROUGH ER
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Glycoproteins
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Important for hormone and enzyme creation and for markers for the cell.
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Golgi Bodies/Apparatus
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*Appears to be like stacked pancakes 1) Renews or modifies plasma membrane 2) Prepares secretions for export ---Can fold proteins into their tertiary structure or whatever needed in the cell/body 3) Labels molecules ****Any of the proteins it exports are done through Exocytosis through vesicles that BUD OFF and head into cytoplasm to where it might be needed ---The cell membrane ---Outside of the cell into the interstitial fluid
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Lysosomes
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**Produced at the Golgi Apparatus. *Filled with digestive enzymes (Hydrolytic) Helps take unfamiliar particles within the cell or surface of cell and eliminate them 1)Digestion of bacteria through intracellular digestion through Macrophages 2)Isolate toxic chemicals 3) Break down old organelles = Atrophy ---To break down old organelle (for example, RER) into little pieces (like you would do a car for scrap metal) and reuse the parts elsewhere. ---To cause Autolysis by releasing digestive enzymes to kill cell when time is needed.
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"Lysis" prefix
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=Splitting "Lysosomes"
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"Some" Suffuix
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=Body "Somatic Cell"
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"Atrophy" Definition
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To break something down when old or unused
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Autolysis
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Programmed Cellular Death through release of destructive enzymes released by LYSOSOMES. (NOT ORGANISMAL DEATH) Doesn't always have to be the whole organism that dies, it could just be part of the organism, but it's just those specific cells that die. Ex. The tail of a tadpole dies off, so those specific cells undergo apoptosis as an understood that a tadpole looses its tail to become a frog. Called AutoLYSIS because they are directly involved with Lysosomes.
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Apoptosis
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(Programmed Cellular Death) by some gene or biological reasoning.
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Perioxisome
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*Similar to Lysosomes, but they're smaller *Way to remember called PERIOXI(Sounds like peroxide) *Perioxisomes are produced at Golgi Appartatus *After breaking down fatty acids, they produce H2O2 in cell (PEROXIDE). This creates free radical. ---This H2O2 is used by macrophages to kill substances like alcohol and toxins ----Perioxisomes are usually found in the LIVER or kidneys. For detoxification *H2O2 is then broken down into water and oxygen and leaves the cell.
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rRNA structure
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Made of large and small Ribosomes that help mRNA transfer over to tRNA to help make POLYPEPTIDE to be used as a protein later.
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Free Ribosomes
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Make proteins that function IN THE cytosol (WITHIN THE CELL) **Can be chillin and moving around anywhere because they're still gonna be used in the cell. They don't have to be bound anywhere to prepare its off products to be shipped off.
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Attached Ribosomes
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Make Proteins to export. Must be stationary so they know exactly where to go to leave the cell
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Direction (And explained) Protein synthesis
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*First happening within the nucleus, a DNA gene is reproduced in the way of transcription into a mRNA. *mRNA is moved out of the nucleus through the nucleus pore (the mRNA can leave the nucleus because it doesn't contain the nitrogenous base Thymine, instead it contains uracil) *mRNA attaches to a ribosome (either attached on ER or free ribosome in cytoplasm) and there translation happens by having tRNA make a polypeptide chain with all the Amino Acids. *The polypeptide chain then moves into the ER where it begins to be folded into it's 3D shape, where it becomes a real protein. ---protein might undergo Glycosylation, where it is turned into a glycoprotein. (added carbohydrate to the protein). *Protein needs to be modified even more, so it is buddeed off by a transport vesicle, and is sent through the Cyst of the Golgi Apparatus where further modifications happen. *Vesicles bud off with modified proteins from the Golgi Apparatus, where it preforms Exocytosis to be released outside of the cell.
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Vacuoles (Vesicles)
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*Double membrane Storage Areas for; *Food *Water *Waste Central Vacuole is important for plant cells, it holds the nutrients for them "because they can't go to the water fountain" Adipocyte - Fat cell. Holds fat within that vacuoles
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Proteosomes
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BREAKING DOWN OF PROTEINS. FOR REUSE. *Contains protein digesting enzymes, or PROTEASES. *Removes only proteins that are denatured or damaged. ---the broken down amino acids are released back into cytoplasm for reuptake and reuse for transcription.
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Proteases
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Protein digesting enzymes. Found within Proteosomes
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Mitochondria
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*"Powerhouse of the cell" *Only in Eukaryotes.
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Cellular Respiration
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Is also the Krebs Cycle that makes ATP.
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Two Main kids of respiration
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Anarobic - Occurs in cytosol only. Makes 4 ATP. Occurs through glycolysis. Aerobic - Occurs in mitochondria
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Anarobic
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Without Oxygen- *This makes ATP without oxygen. Occurs in cytosol through glycolysis (breaking up of glucose molecules (6 carbon ) ----> 2 pyruvic acids.
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Anerobic
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With Oxygen. Produces 95% of ATP in the cell. Occurs within Mitochondria.
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Hydrolysis
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Adding water, you're breaking the two chemically bounded substances apart. Ex. The piece of hard candy. With the introduction of saliva, the candy breaks down and becomes simplized for you to digest. Also called digestion Reverse of Dehydration synthesis.
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Dehydration Synthesis
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By taking away water, you're adding two chemical substances together. ex. The piece of hard candy is assembled and made by taking out the water and making a complete substance of solid molecules . Reverse of Hydrolysis.
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Glycolysis
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Breaking down of glucose into two three carbon molecules = pyruvates
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Phosphorlyation
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Connects phophrus bonds together to make ADP to ATP.
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Glycolysis
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6 carbon sugar (glucose) ----breaks down---> two 3 carbon
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Cytoskeleton
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*Protein fillaments that are like saffolding that holds up the organelles. ---they move organelles to other side of the cell for their benefit. *EXTREMELY DYNAMIC. Like a lasso to move organelles to where it needs to be. Functions; * Support of organelles *movement and transports cell parts *Reinforce and organize (like scaffold) *Strength and Shape
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Three types of motor proteins
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1) Microfilaments (smallest) 2) Intermediate Filaments 3)Microtubles (largest) ***ALL ASSEMBLED FROM PROTEIN SUBUNITS****
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Microfilaments
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*Smallest of cytoskeletal elements *Composed of Actin *found in periphery of the cell, never in the middle. *they connect the cytoskeleton to the plasma membrane. *Depending on their thickness in the cell, they determine the consistency of the cytoplasm ***Like minnoes. They're small and little, so they're gonna be on the periphery of the body of water and never in the middle. They're micro. Small. Weeee.
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Intermediate Filaments
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Part of the Cytoskeleton *only in animal cells *Second largest motor protein *most durable of cytoskeletal elements 1) Strengthen cell and gives shape 2) Stabilize organelle 3) Stabilize position of cell in respect to other cells Example is Keratin. It allows stretching of skin and gives durability and toughness to skin and hair.
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Microtubules
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*Largest and thickest part of cytoskeleton fibers. *built from globular protein tublin (TUBLES=TUBLIN) *Assist in moving cell organelles from one side of cell to another. CALLED MOLECULAR MOTOR FOR THIS REASON. ---Ex. in mitosis, when spindle fibers pull chromosomes to either side of the cell.
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Thick Filaments
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Massive bundles appearing only in muscle cells
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4 Cell Extension Structures
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1) Pseudopods 2) Cilia 3) Flagella 4) Microvilli
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Psedudopod
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Cell Extension; Called a "falsefoot" Produced by microfilaments. Seen in macrophages during phagocytosis; ---grabs the bacteria or substance to bring it inside to be exposed to lysosomes to kill the substance.
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Cilia
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Way to clean air that is taken in *found only in respiratory and reproductive system.
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Flagella
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Found only on one human cell; Sperm Used for locomotion
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Microvili
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Used to increase surface area for nutrient absorption. ----found in digestive system to uptake nutrients for digestion.
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Cilia Structure
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Nine PAIRS of microtubules surround a central pair in the middle of the circular formation. *****9+2 array These microtubials are anchored to a basal body just under cell curface as an anchor. KTP THOUGHT (The middle pair is needed to anchor the cilia into the cell body, so it can be connected deep within the plasma membrane)
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Centrioles Structure
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IN ANIMAL CELLS ONLY (not in plants) Microtubials form 9 groups, three in each group. Each of these nine "triplets" is connected to its nearest neighbor with no central microtuble ***Forms 9+0 array 9 groups of three, grouped together with no center. KTP THOUGHT (No central triplet needed because it is free chilin' in the cytosol, and needs not to be anchored)
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Junctions (three types)
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Communcation between cells, as in how they articulate 1) Tight Junctions - cytoskeletal strands FUSE with other cells. ---Epithelial cells 2) Adhering Junctions - cells only weld in one section, because they're stretching and moving a lot ---Heart and skin cells 3) Gap Junctions - Joined at a specific place, but there's a lot of pores and channels open between both sides of the cell.
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PROKARYOTIC CELL
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Bacteria Cells *NO Nucleus *DNA are not double helix, they have a circular chromosome, and bound in a nucleoid. *Smallest cell *Contains a capsule that's composed of polysaccharides. *Surface projections called pili to attach it to surfaces *contain plasmids, which are DNA particles
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Nucleoid
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Non membrane surrounded area where a prokaryotic cell's DNA is found.
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Plasmid
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DNA particles. Antibiotic resistant gene
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Pili
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Found in bacteria Helps attach bacteria to surfaces
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Glycoproteins
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Proteins within the membrane layer, but with carbohydrate groups or OLIGOSACCHARIDES
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Electrochemical gradient
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Concentration of both the concentration gradient and the electrical gradient
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Passive Transport
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*requires no energy 1) Diffusion - Moving high concentration ----> Low concentration through phospholipid layer 2) Facillitated Difussion -
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Concentration Gradient
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The "downhill" slow process. It's the natural way that things should flow. From high concentration to the low. To diffuse outwards
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Intracellular
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Within the cell higher concentration of CO2 and K+ (giving off that CO2 through cellular respiration)
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Extracellular
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Outside of the cell membrane Higher levels of O2 and Na+ (Think that there's more oxygenoutside of the cell because it's coming straight from your blood to the cell.
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Active Transport
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Moves AGAINST concentration gradient, so it used ATP to make exchange. Moves from low concentration to high concentration.
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Diffusion
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Rnadom movement towards a state of equilibrium Moves with concentration gradient.
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Factors affecting diffusion
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Molecular size --smaller molecules move faster because smaller mass Temperature --Higher diffusion rate at higher temperatures because more energy for the particles to move faster Electric or pressure gradient --electrical charge difference across membrane makes it move faster
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Facillitated Diffusion
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Follows Concentration gradient Requires NO ATP Requires gateway - Channel/Carrier transport
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Channel Proteins
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*INTEGRAL PROTEINS Glu T is the glucose transporter protein (water soluble)
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Ligand
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Could be insulin
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Glu T
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The message that the cell needs more insulin to get glucose across the membrane
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Membrane Potential
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The membrane bilayer causes an attraction of charges to one another, creating potential energy, and giving the membrane potential to have energy.
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Volts
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The "force" or potentential difference between the membrane
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Trans-Membrane potential
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.07V or 70mV
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Osmosis
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Follows concentration gradient.
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Electrical Impulses
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Are responsible for transmission of information within the nervous system
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Cytolysis
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The cell will swell with osmosis diffision
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Plasmolysis
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The cell will shrink
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Cell Water/Salt Composure
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Cell is 95% water 5% solute. Always.
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Sodium/Potassium Pump
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This is active transport and requires ATP One ATP ticket is required for a "fare" and gives you 3 sodium ions out of the cell, and 2 potassium reclaimed to equal homeostasis. After the leaking has happened of Potassium and Sodium ions, there needs to be an exchange to get them backwhere the belong. So the sodium potassium pump comes along and requires ATP to work against concentration gradient. One ATP will get 3 Sodium out of the cell cytoplasm, and will bring 2 Potassium molecules back within the cell's cytoplasm
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Semi Permable
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This is concerning the size of the carrier. Only a certain size of something can come within the cell/without
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Selectively Permable
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That depends on the charge of the substance trying to come in or out Anions have a hard time coming into the cell because of the cell's negative charge
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Nucleotide
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One structure that makes up a whole DNA strand *Phosptate backbone *5 Carbon sugar *Nitrognous base
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Purine
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Has "larger garage" Either Adenine, Guanine, or uracil as a purine. (Smaller word has larger garage) THIS CONCERNS THE CHEMICAL MAKE UP
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Pyrimidine
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Has "smaller garage" Thymine and Cytosine "Larger word has smaller garage" THIS CONCERNS THE CHEMICAL MAKE UP AND BAKCBONE OF THE NUCLEOTIDE
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How are nucleotides joined together?
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DEHYDRATION SYNTHESIS (TAKING THE WATER MOLECULE OUT TO BUILD UP THIS DNA MOLECULE)
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Genome definition
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Complete set of information of an organism
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Mutation
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Permanent change in gene's base pair sequence If mutation caused in normal somatic body cell, sometimes it is expressed and harful If it is in reproductive/germ cell it may be passed to offspring and result in a boat load of damage
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Mutations Caused By:
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1) Ultraviolet Radiation 2) Ionizing radiation (gamma and X rays) 3) Chemicals such as alkylating agents, which act as carcinogens
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Morula
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Within 4 days of fertilization, a Morula is 64 cells big. Hormones within cells allows these cells to latch onto uterus to undergo further growth
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Within 14 weeks of fertilization
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There is already specalization and differentation of body parts and cells.
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Transcription
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Scribe From DNA to mRNA
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Translation
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Translates base pair sequence in mRNA into amino acid sequence to assemble protein.
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Promotor
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Start codon sequence of a DNA strand
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Intron
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Unnecessary information that the DNA strand doesn't need to complete its job, so it is snipped out
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Exon
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What is left behind after introns are cut out. This is considered a mature protein strand to be used now
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Reduction Division
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Synonymous for Meiosis
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Differentiation
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Specialization of cells *happens 5th week of embroyotic growth.
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Total Chromosomal number in somatic cells
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Humans =46 Gorillas=64 Number of chromosomes isn't realative to complexity in the organism.
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How many chromosomes in human cells?
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We have 23 PAIRS. There are 23 PAIRS, meaning there's 46 individualized chromosomes.
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Diploid number of chromosomes in humans
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23 diploids. Meaning two of 23. Meaning 46 2n = Diploid number
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Monoploid / Haploid
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1n = Sex cell number. Meaning the 1n comes from one parent. There's only 1 SET, where n still is 23, meaning there's 23 coming from mom, while dad contributes 23 also.
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Diploid
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Doesn't just refer to humans. It's the "2" that's before the "n" which just stands for how many chromosomes come from each parent. Potatoes, which have 84 chromosomes total, will have a diploid number of 2n, where "n" is 48.
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Human's "n" number in meiosis
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23 = n
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Matched pairs
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The chromosomes you get from your parents are matched up where both your eye characteristic and hair characteristic match up together and both sets of chromosomes contribute to the actual expression that you represent.
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Autosomes
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The 23rd pair of chromosomes in karyotype that determine the sex of the individual
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Karyotype
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the number and appearance of chromosomes in the nucleus of a eukaryotic cell. The chart. Where the 23rd pair is the sex chromosome.
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Matched X Chromosomes
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Female
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Non Matched Sex chromosomes
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X and Y = Male Y is very small. The male's gene relies on that X chromosome to get that protein information. Hopefully that X cell is good
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Syndrome
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Extra chromosome Downs Syndrom is extra 21 chromosome.
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Loci
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Location Specific place where the gene is on the chromosome.
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Transposion
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Jumping gene. When genes don't stay on their specific chromosome. Barbra McClintock discovered this
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Barbra McClintock
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Discovered jumping genes and Transposon witin corn
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Roslin Franklin
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Helped watson and crick put the connection of DNA and its structure together
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Semiconservative
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Each new cell have one old and one new halves of the DNA it was replicated from.
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Repair Enzymes
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P53 - Checks to make sure that the DNA replication isn't messed up. Colon cancer and breast cancer is caused this way when P53 are broken.
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Chromatid
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Chromosome already replicated, where the chromatid is held together by centromere, and it will be broken so the doubled DNA information can be split and evenly go into either one of the eukaryotic cells.
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The volume of the cell. Surface area is too large
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Leads a cell to divide and replicate. Cell membrane doesn'thave enough space to do the things it needs to do to bring in all the nutrients that it needs and wastes it needs to expell. So it divides.
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Interphase
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DNA replication - Most important thing to happen
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Diffusion happens best when....
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Cell is smaller so it can move
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Slowest growing cell in human body
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Neuron
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Fastest growing cell
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Epithelial cell - Skin cell
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Growth Factors
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Regulate cell cycle **Peptides **Hormones Cell cycle protein weather to go or not is CYCLIN
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Repressor Gene
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P53 Cancers are caused by defect in gene P53
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Telomere
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Sections on every chromosome Repeating set of nucleotides that forms a cap. Cap protecting end of chromosome. Every mitotic division, you loose some of the nucleotides in the "end cap" of telomere break off. ----> And then cell division will stop, and is linked to aging.
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S Phase of interphase
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Chromosomes replicate
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Early Prohase
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Centrioles double, so there's one on each end of the dividing cell so they can use the spindle fibers to pull the chromatids to either side of the cell.
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Kinetichores
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Protein in the region that connects to centromere (connects the chromatids) to microtubial
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Cytoplasm plits into two
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In plant cells, it happens from the center out (because of cell wall, the cell wall stays there forever as its dividing In animal cells, the CINCH cord is going to pull from the outside in.
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Stem Cell
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Relatively undifferentiated cell. *right before differentiation *we can make it become any other cell we want it to.
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Starvation through nutrition
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*Slows cell division *slows wound healing *lowers resistance to disease; immune system is slow *Thin the skin *changes lining of cells in digestive tract.
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Regulatory proteins
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Internally controlled Externally controlled
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Cancer
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Uncontrolled cell division -Skin warts -Benign or malignant tumors -Metastasis
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Oncogenenes
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Prepgene that has a mutation that is involved in cell cycle and it's involved in cell growth/cell division/cell division. A normal cell that has the chance to become cancerous.
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Characteristics of Cancer Cells
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Change to plasma membrane -they put out proteins on their membrane that are different
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Abnormal Growth
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Tumor. (neoplasm) Excess tissue.
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Neoplasm
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Tumor. If it's cancerous = maligancy
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Weakened capacity for adhesion
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Metastasis - It will spread throughout the body because it doesn't want to stay in one place. NOT incapsulated.
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Oncology
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Study of tumors
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Side effects to Chemotherapy
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Nauseous, hair falling out Epithelial cells (inside lining of digestive tract) are damaged by Chemo, and it makes you nauseated. Your epithelial cells are also damaged around your hair follicles, so your hair falls out.
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Carcinoma
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Cancerous cells coming up from epithelial tissue *internal and enternal MOST COMMON TYPE OF CANCERS
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Melanoma
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Within the melanin of skin that's much deeper. Within connective tissue.
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UV tanning beds
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Cause frameshift mutations.