Saviola – Microbiology Answers – Flashcards
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| Characteristics of Poxviradae? |
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| Large, Brick-shaped, uses virally encoded enzymes, viral DNA replicates in host cytoplasm |
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| Variola (Small Pox) Characteristics? |
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| inhaled and replicates in URI, after 2 rds. of viremia=dermal and internal tissue seeded, variola major m. rate=15-40% and variola minor = 1% |
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| What is the Vaccinia virus? |
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| similar to smallpox and is basis for modern attenuated vaccine |
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| Characteristics of Herpesviradae? |
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| enveloped icosahedral nucleocapsids, many other animals have herpesviruses and some are oncogenic like Merek's Disease |
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| What is Molluscum contagiosum? |
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| a pox virus that is transmitted through direct contact or formites, infects basal skin layer, tropical climates, kids, HIV+, mucous mem. lesions pearly white papules |
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| Types of herpes viruses? |
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| Alpha, Beta, and Gamma |
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| Types of alpha herpeviradae? |
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| HSV-1=fever blisters, keratoconjunctivitis, encephalitis HSV 2= STD, sacral ganglia in latent phase, transported via dicrectional cytoskeloton of neurons Varicella=chicken pox Herpes Zoster=shingles, cranial posterior root ganglia Varicella-zoster(VZV)=virus used to make chicken pox vaccine |
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| Types of Gamma Herpes Viruses? |
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| EBV and Human Herpes 8 (HHV-8) |
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| EBV causes Heterophile Antibody Positive Infectious Mononucleosis, what is this? |
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| high fev, pharyngitis, malaise, swollen glands, heterophile antibody causes sheep and horse rbc agglut., B cell prolif controlled by CD8 Ts in atypical Downey Form, after infection subsides HA is gone but Igs specific for virus remain |
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| What cancers are associated with EBV? |
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| Burkitt's Lymphoma, Hodgkin's Lymphoma, latently infected cells will express EBNA1 and LMPs, lymphomas can result from organ transplant especially in immunocompromised |
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| What are charc. of Human Herpes Virus 8? |
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| causes Kaposi's Sarcoma (a B-cell lymphoma), especially in immunocompromised |
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| What are the Beta Herpes Viruses? |
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| CMV, Human Herpes Virus 6 (HHV-6) and Human Herpes Virus 7 (HHV-7) |
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| Charc. of CMV? |
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| causes heterophile antibody negative mono, jaundice, neurological damage in fetus, pneumonia and chorioretinitis in immunocompromised, latency in monocytes |
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| Chac. of HHV-6? |
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| causes exanthum subitum=roseola infantum, most common childhood exanthem=3-5 day fever plus a maculopapular rash, latent in peripheral mononuclear cells (PMBC), sometimes chronic infection of salivary gland CD4s and epithelial cells |
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| Char. of HHV-7? |
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| orphan virus with no diease associated with it |
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| Char. of Adenoviradae? |
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| med size (90-100nm), 49 serotypes and 6 subgenera, Acute Respiratory Disease (military) common cold, LRT too, conjunctivitis in kids, cycstitis, gastroenteritis,left ventricular dysfunction, naked icosahedral nucleocapsid, fiber and knobs |
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| Char of Papoviridae? |
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| naked icosahedral nucleocapsids, DNA can be incorportated into host DNA, many have oncogenic potential |
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| Char of HPV (papo. fam)? |
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| condyloma=genital warts, STD, cervical cancer, Epidermodysplasia verruciformis=warts that turn into squamous carcinoma when exposed to sunlight |
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| Char of Polymaviradae=Polyoma virus (papo. fam)? |
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| JC and BK form, both infect through RT, BK forms latent infection in kidney, while BK forms latent infection in kidneys, B cells, and monocytic cells, in immunocompromised JC can lead to CNS infection (PML=progressive multifocal leukoencephalopathy) and subsequent demyelination and BK can lead to severe UTIs |
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| Char Parvoviradae |
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| Char of Parvoviradae? |
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| Tiny, naked, icosahedral, B19 causes erethema infectiosum and possible aplastic crisis in peeps with sickle cell (cuz of drop in heme), and possible hydrops fetalis, adults can get arthritis |
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| Char of Hepadnaviradae (Hep B in partic)? |
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| Icosahedral, enveloped, nicked circ. DNA genome, grown in vitro by transfection, replicates through an RNA intermediate, has RT replicates in hepatocytes without cytopathic effect, symptoms from cytotoxic response, antigens include HBc(core)-HBe(breakdown prod. of core)-HBs(surface), at risk for Primary Hepatocellular Carcinoma, vaccine from gen. en. HBsAg |
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| DNA viruses most likely to cause cancer? |
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| HPV (16, 18 for cerv.), HHV-8(Kaposi's Sarcoma), EBV (Burkitt's lymphoma) and Hep B Burkitt's Lymphoma more common in Africa because malaria has immunosuppressive effect |
