Chapter 21 Immune system – Flashcards

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Area where B cells become immunocompetent
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C) Bone marrow
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Area where T cells become immunocompetent
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B) Thymus
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Area where activated immunocompetent B & T cells recirculate
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E) Blood capillaries
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Area seeded by immunocompetent B & T cells
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D) Lymph nodes
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Area where antigen challenge and clonal selection are most likely to occur
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D) Lymph nodes
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First line of defense
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A) Intact skin and mucous membranes
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Second line of defense
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B) Inflammatory response
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Third line of defense
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D) Immune response
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Innate defense system
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C) Inflammatory response & skin & mucous membranes
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Adaptive defense system
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D) Immune response
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Enables quick and efficient response to secondary exposure to antigen
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E) Memory cell
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Absence results in no immune response
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D) Helper T cell
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Forms antibody producing cells
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B) B cell
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Kills cancer cells and virus infected body cells
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C) Cytotoxic T cell
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Slow or stops the immune response
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A) Regulatory T cell
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Main antibody of both primary and secondary immune respones
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E) IgG (Guard the fetus)
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Protects mucosal barries
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B) IgA (apple juice --> intestinal juice)
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Involved in allergies
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C) IgE (Ellergies-Allergies--histamine)
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Along with IgM, this is a B cell receptor
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D) IgD (D to the B--B cell)
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First to peak during a primary immune response
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A) IgM (Must go 1st)
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Virus infected cells secrete complement to "warn" other cells of the presence of virus
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FALSE
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The mechanism of the "lethal hit" of cytotoxic T cells and NK cells involves a protein called perforin
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TRUE
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The directional movement of cells in response to chemicals is called chemotaxis
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TRUE
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Substances capable of triggering the adaptive immune system and provoking an immune response are called antigens
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TRUE
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A given pathogen will provoke either a cell-mediated respone or an antigent-antibody mediated response but not both
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FALSE
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Fever is seldom beneficial because it speeds up the cellular metabolic rate and will not allow antigen-antibody reactions to occur
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FALSE
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Some immunocompetent cells will never be called to service in our lifetime
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TRUE
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Adaptive immunity is provided only by lymphocytes that secrete antibodies
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FALSE
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Somatic recombination by B cells allows each B cell to form its own unique antibody genes.
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TRUE
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It is our genes, not antigens, that determine what specific foreign substances our immune system will be able to recognize and resist.
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TRUE
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Which of the following is associated with passive immunity? A) exposure to an antigen B) infusion of weakened viruses C) passage of IgG antibodies from a pregnant mother to her fetus D) booster shot of vaccine
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C) passage of IgG antibodies from a pregnant mother to her fetus
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The redness and heat of an inflamed area are due to a local hyperemia caused by A) Vasodilation B) Vasoconstriction C) Phagocyte mobilization D) complement production
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A) Vasodilation
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Small molecules that bind with self-proteins to produce antigenic substance are called A) Haptens B) Antibodies C) Ions D) regains
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A) Haptens
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Regulatory T cells ________. A) release cytokines that increase the activity of cytotoxic T cells and activated B cells B) decrease their activity as antigenic stimulus decreases C) may function in preventing autoimmune reactions D) aid B cells in antibody production
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C) may function in preventing autoimmune reactions
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Select the correct definition about skin grafts A) Isografts are between identical twins B) Allografts are between different species C) Xenografts are between individuals of the same species D) Autografts are between two genetically identical individuals
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A) Isografts are between identical twins
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Which of the statements below does not describe antigens? A) Antigens exhibit immunogenicity and reactivity B) Antigens only come from microbes C) the parts of the antigen moleucles that initiate immune responses are called epitopes or antigenic determinants D) Antigens can include proteins, nucleic acids, lipoproteins, glycoproteins, and certain large polysaccharides
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B) Antigens only come from microbes
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Activated T cells and macrophages release ________ to mobilze immune cells and attract other leukocytes into the area A) Cytokines B) Perforines C) Interlukin-1 proteins D) Interlukin-2 protines
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A) Cytokines
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Which of the following is part of the second line of defense against microorganisms? A) Kertain B) cilia C) gastric juice D) phagocytes
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D) phagocytes
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T cell activation requires ________. A) antigen binding and co-stimulation B) antigen binding and antibody production C) antibody production and co-stimulation D) antigen binding, antibody production, and co-stimulation
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A) antigen binding and co-stimulation
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Select the correct statement about immundeficieny A) Severe combined immunodeficient (SCID) disease is an acquired condition. B) The causative agent in acquired immune deficiency syndrome (AIDS) is a virus that recognizes CD4 proteins C) Hodgkin's disease is a hereditary immunodeficiency found in children D) The most common form of immunodeficiency is a graft-versus-host (GVH) disease
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B) The causative agent in acquired immune deficiency syndrome (AIDS) is a virus that recognizes CD4 proteins
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Cytotoxic T cells ______. A) are the only t cells that can directly attack and kill other cells B) require the double recognition signal of I MHC plus II MHC on the target cell in order to function C) function mainly to stimulate the proliferation of other T cell populations D) self-destruct once the antigen has been neutralized
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A) are the only t cells that can directly attack and kill other cells
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Select the correct statement about antigens A) "Self-antigens" is another name for incomplete antigens B) The largest type of antigen is called a hapten C) Only small antigens exhibit reactivity D) One antigen may have different antigenic determinants and may therefore cause the formation of more than one antibody
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D) One antigen may have different antigenic determinants and may therefore cause the formation of more than one antibody
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Clonal selection of B cells A) Occurs during fetal development B) results in the formation of plasma cells C) cannot occur in the presence of antigens D) only occurs in the secondary immune response
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B) results in the formation of plasma cells
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The primary immune response _________. A) occurs more rapidly and is stronger than the secondary response B) occurs when memory cells are stimulation C) is another name for immunological memory D) has a lag period while B cells proliferate and differentiate into plasma cells
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D) has a lag period while B cells proliferate and differentiate into plasma cells
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Select the correct statement about the function of antibodies A) Antibodies may directly destroy "invaders" B) Neutralization is the process by which antibodies cause invading cells to clump together C) Complement fixation is the main mechanism by which antibodies provide protection D) The most potent agglutination agent is IgG
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C) Complement fixation is the main mechanism by which antibodies provide protection
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Which of the following cells is the most critical cell in immunity? A) B cell B) helper T cell C) cytotoxic T cell D) APC
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B) helper T cell
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