Urinary Tract Infection (UTI) – Flashcards
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most common bacterial infection in women, at least 20 % of women will develop a UTI during their lifetime
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Urinary Tract Infection
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Most common pathogen responsible for UTI is
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E. Coli
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counts of 10 to 5th power 10 5 CFU /ML or more indicate
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significant UTI
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counts as low as 10 to 2nd power 10 2- 10 3 CFU/ML in a person with signs/symptoms are
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indicative of UTI
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common causes for UTI
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bad hygiene, immunosupressed, multiple antibiotics, diabetic, Elderly ( UTI and Lungs is the most common site for elderly to develop infections)
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fungal and parasitic infection are uncommon, however can cause UTI's- patients at risk are
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immunosupressed, Diabetic, having undergone multiple antibiotic courses , have traveled to developing countries
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Renal parenchyma, pelvis, and ureters ( typically causes fever, chills, flank pain) ex. Pyelonephritis: inflammation of renal parenchyma and collecting system
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Upper UTI
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usually no systemic manifestations ( ex. cystitis: inflammation of bladder, and Urethritis: inflammation of Urethra)
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Lower UTI
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more simple bladder infect, burning on urination , full bladder, feeling that you can't pee are signs/symptoms of :
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Lower UTI
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a UTI that as spread systemically and is life-threatening condition necessitating emergency treatment
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Urosepsis
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Occurs in otherwise normal urinary tract and usually involves only the bladder ( usually coexist with other things)
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Uncomplicated UTI
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Coexists with presence of - obstruction - stones - catheters - diabetes/ neurologic disease - pregnancy- induced changes - recurrent infection
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Complicated UTI
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individual with complicated infect: is at risk for:
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Pyelonephritis, urosepsis, and renal damage
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factors increasing urinary stasis Ex: BPH, tumor, neruogenic bladder
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predisposing factors of UTI
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Foreign bodies EX. catheters, calculi, and instrumentation
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predisposing factors of UTI
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urinary stasis can be caused by:
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BPH, Tumor, long and short term catheters
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a common factor contributing to ascending infection is urologic instrumentation ( e.g. catheterization, cystoscopic examinations)
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( e.g. catheterization, cystoscopic examinations)
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Etiology and Pathophysiology Predisposing factors:
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Functional disorders such as constipation
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Other Factors : predisposing to UTI
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pregnancy , multiple sex partners (woman)
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Etiology & Pathophysiology continued:
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Hospital- acquired UTI accounts for 30 % of all nosocomial infections - causes often E. Coli - Seldom : Pseudomonas species catheter -acquired UTIs - bacteria biofilms develop on inner surface of catheter Be cautious of this because the Hospital will not be paid!
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clinical manifestations: Bladder Storage
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urinary frequency - abnormally frequent if more often than every 2 hours)
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clinical manifestations: Urgency
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sudden strong desire to void immediately
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clinical manifestations: Incontinence
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loss or leakage of urine
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Urinary frequency, urgency, and incontinence are all related to a ______ type of infection
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Bladder
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Lower Urinary tract symptoms ( LUTS) are experienced in patients who have
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UTIs of the upper urinary tracts, as well as those confined to the lower tract. The urine may contain grossly visible blood ( hematuria) or sediment, which gives it a cloudy appearance. Symptoms are related to either bladder storage or bladder emptying
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Clinical Manifestations: Bladder storage: Nocturia: sign of bladder infect.
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waking up two or more times at night to void
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clinical manifestations: Nocturnal enuresis: sign of bladder infect.
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Loss of urine during sleep
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clinical manifestations: Bladder emptying : sign of bladder infect.
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-weak stream -Hesitancy ( difficulty starting the urine stream)
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clinical manifestations : Bladder emptying : sign of bladder infect.: Intermittency: is
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Interruption of urinary stream during voiding
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Clinical manifestations: Bladder emptying:sign of bladder infect: Postvoid dribbling is
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Urine loss after completion of voiding
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Clinical manifestations: Bladder emptying : is sign of infection: Urinary retention:
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inability to empty urine from bladder
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clinical manifestations: Bladder emptying: is sign of infection: Dysuria:
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difficulty voiding
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clinical manifestations of : flank pain, chills, and fever indicate infection of :
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upper tract ( pyelonephritis) (systemic symptoms associated with upper UTI note : people with significant bacteriuria may have no symptoms of may have nonspecific symptoms such as fatigue or anorexia
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Clinical manifestations: in older adults know that
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- symptoms are often absent - nonlocalized abdominal discomfort rather than dysuria - cognitive impairment possible - fever less likely Presentation is usually totally different than other types of infections: with elderly most common symptom is change of mental status as with other types of infections, b/c as we age immune systems are less responsive. May not see elevated Temp, but a lot of times will see change in mental
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because older adults are less likely to experience a fever with a UTI, the value of body temp. as an indicator of a UTI is unreliable
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clinical manifestations
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Diagnostic Studies:
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History and physical examination Dipstick Urinalysis ( identify presence of nitrites, WBCs, and leukocyte esterase)
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In a patient suspected of having a UTI, initially conduct a dipstick urinalysis to identify
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the presence of nitrites ( indicating bacteriuria), white blood cells (WBCs), and leukocyte esterase ( an enzyme present in WBCs that indicates pyruia) These findings can be confirmed by microscopic urinalysis.
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How to read a Urininalysis
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Dark color, positive nitrate, large amy of WBC, Trace of occult blood, urine culture and sensitivity know how to properly collect for the different procedures. Know how to collect a 24 hour cultures 3 different collections it takes 48 hours for any urine culture to get results on fecal, sputum or any of those will not wait to start antibiotics anyways
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Diagnostic Studies: Urine for culture and sensitivity ( if indicated) - clean -catch sample preferred - specimen by catheterization or suprapubic needle aspiration more accurate - determine bacteria susceptibilityys to antibiotics
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takes 48 hours to get a final report
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Diagnostic Studies : Imaging studies
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CT urography or ultrasonography when obstruction is suspected
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Collaborative Care: Drug Therapy - Antibiotics selected on empiric therapy or results of sensitivity testing
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Treated Easily PO or more complicated cases IV -selected on empiric therapy or results of sensitivity testing -uncomplicated cystitis ( short-term course ( 1 to 3 days) - complicated UTIs ( long-term treatment ( 7 to 14 days) The collaborative care and drug therapy for cystitis are summarized in table 46-4.. many residents of long-term care facilities, especially women, have chronic asymptomatic bacteriuria. However, usually only symptomatic UTIs are treated. 1st- choice drugs to empirically treat uncomplicated or initial UTIs are trimethoprim/sulfamethoxazole (TMP/ SMX) (Bactrim, Septra) nitrofurantoin ( Macrodantin), and fosfomycin (Monurol)
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Collaborative Care Drug Therapy: Antibiotics
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Trimethoprim/sulfamethoxazole (TMP/SMX) - used to treat uncomplicated or initial UTI - inexpensive - Taken twice a day - E. Coli resistance to TMP-SMX increase
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Collaborative Care Drug Therapy: Antibiotics
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Nitrofurantoin ( macrodantin) - given 3 to 4 times a day - long-acting preparation (macro bid) is taken twice daily - Ampicillin, amoxicillin, cephalosporins / to treated uncomplicated UTI
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Collaborative Care: Drug Therapy: antibiotics
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Fluroquinolones - treat complicated UTIs - Example: ciprofloxacin (cipro) Antifungals - Amphotericin or fluconazole - for UTIs secondary to fungi
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Drug Alert: NItrofurantoin ( Furadantin, Macrodantin)
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- avoid sunlight. use sunscreen; wear protective clothing. - notify health care provider immediately if fever, chills, cough, chest pain, dyspnea , rash , or numbness or tingling of fingers or toes develops
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Collaborative Care Drug Therapy: Urinary analgesic Phenazopyridine ( Pyridium)
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used in combination with antibiotics provides soothing effect on urinary tract mucosa stains urine reddish orange ( can be mistaken for blood and may stain underclothing)
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can get pyridium over the counter
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note that it doesn't treat bacteria , but can treat the discomfort
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Although this drug is typically effective in relieving the transient acute discomfort associated with a UTI, the nurse should advise patients to avoid long-term use of phenazopyridine because it can produce hemolytic anemia.
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Pyridium
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Collaborative Care Drug Therapy: urinary analgesic
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Methenamine/phenyl salicylate (urised) - use in combination with antibiotics - used to treat UTI symptoms - preparations with methylene blue tint will turn urine blue or green
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Nursing management: Nursing Assessment: Health History
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Nausea, vomiting, anorexia, chills, nocturia, frequency, urgency= Suprapubic/lower back pain, bladder spasms, dysuria, burning sensation on urination
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if pt is experiencing nausea , vomiting, or anorexia this is more indicative of an
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upper UTI
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Nursing Management : Nursing Assessment: objective data
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fever, Hematuria, foul-smelling urine, tender, enlarged kidney Leukocytosis, positive findings for bacteria, WBCs, RBCs, pyuria, ultrasound, CT scan , IVP
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nursing diagnosis
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impaired urinary elimination readiness for enhanced self-health management
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planning
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patient will have relief from lower urinary tract symptoms prevention of upper urinary tract involvement prevention of recurrence
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Nursing implementation: educational intervention
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Health promotion - recognize individuals at risk - debilitated persons - older adults - underlying diseases ( HIV, diabetes) - taking immunosuppressive drug or corticosteroids
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Health promotion
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Emptying bladder regularly and completely , evacuating bowel regularly and completely, wiping perineal area front to back, drinking adequate fluids ( person's wt. in pounds / 2 (twenty percent of fluid comes from food) Teach pt. to drink adequate fluids every 24 hours
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Health promotion
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Cranberry juice or cranberry tablets may reduce the number of UTIs ( its thought that enzymes in cranberries inhibit attachment of urinary pathogens ( especially E. Coli) to the bladder epithelium avoid unnecessary catheterization and early removal of indwelling catheters aseptic technique must be followed during instrumentation procedures cranberry is good especially for chronic UTIs
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Health promotion
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wash hands before and after contact wear gloves for care of urinary system routine and thorough perineal care for all hospitalized patients avoid incontinent episodes by answering call light and offering bedpan at frequent intervals
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acute intervention
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adequate fluid intake - pt may think condition will worsen because of discomfort - dilutes urine, making bladder less irritable - flushes out bacteria before they can colonize
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acute intervention
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avoid caffeine, alcohol, citrus juices, chocolate, and highly spiced foods because these are potential bladder irritants
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acute interventions
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Very important to take full course of antibiotics -application of local heat to ---suprapubic or lower back may relieve discomfort instruct pt. about drug therapy and side effects The nurse may advise the patient to apply a heating pad (turned to its lowest setting) against the back or suprapubic area. A warm shower or sitting in a tub of warm water filled above the waist can also be effective in providing temporary relief.
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serious upper UTI type
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acute Pyleonephritis
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Etiology of pyleonephritis
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actual cells in the kidneys are infected and this is very serious
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Inflammation of renal parenchyma and collecting system most commonly caused by bacteria,fungi, protozoa, or viruses can also infect kindness
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Etiology of pyleonephritis
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systemic infection from urologic source prompt diagnosis/treatment critical - can lead to septic shock and death - septic shock: outcome of unresolved bacteremia involving gram- negative organism
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Urosepsis
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Infect has gone from kidneys to sepsis- risk for septic shock- life threatening situation
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Urosepsis
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usually begins with colonization and infection of lower tract via ascending urethral route frequent causes E. coli proteus klebsiella enterobacter
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Urosepsis
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preexisting factor usually present , such as backward movement of urine from lower to upper urinary tract
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vesicourecteral reflux
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obstruction from BPH Stricture Urinary Stone
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Dysfunction of lower urinary tract
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nursing intervention
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keep bag low bc we don't want back flow of urine, keep bag off of floor also
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for residents of long-term care facilities, urinary tract catheterization is
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a common cause of pyelonephritis and urosepsis
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commonly starts in renal medulla and spreads to adjacent cortex recurring episodes lead to scarred, poorly functioning kidney and chronic pyelonephritis
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pyleonephritis One of the most important risk factors for acute pyelonephritis is pregnancy-induced physiologic changes in the urinary system.
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mild fatigue chills fever vomiting malaise flank pain are all clinical manifestations of:p
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pyleonephritis; symptoms of polyphrinitis is a more serious systemic type upper UTI
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lower Urinary tract characteristics of cystitis
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costovertebral tenderness is usually presented on the affected side
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manifestations usually subside in a few days, even without therapy
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Bacteriuria and pyuria still persist
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costovetebral tenderness is a sign of a
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UTI
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Diagnostic studies for UTIs
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History , physical examination ( palpation for CVA pain), Lab tests: Urinalysis Urine for culture and sensitivity CBC with differential Blood culture ( if bacteremia is suspected)
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urinalysis results indicate:
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Pyuria, bacteriuria, and varying degrees of hematuria
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WBC casts
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may be found in the urine, indicating involvement of the renal parenchyma
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a CBC
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will show leukocytosis ; a shift to the left with an increase in immature neutrophils (bands)
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Ultrasonography and CT urography
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Diagnostic studies that are noninvasive pre or post care
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Ultrasonography of the urinary system
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may be performed to identify anatomic abnormalities, hydronephrosis, renal abscesses, or the presence of an obstructing stone.
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CT urography is also used to assess for signs of
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infection in the kidney and complications of pyelonephritis, such as impaired renal function, scarring, chronic pyelonephritis, or abscesses.
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If bacteremia is a possibility , close observation and vital sign monitoring are essential prompt recognition and treatment of septic shock may prevent irreversible damage or death
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BLOOD CULTURE- USE CHLORICEP SWABS TO KILL BACTERIA ON SKIN. COLLECT FROM TWO DIFFERENT SITES 15 MIN APART TO SEE THAT BOTH SETS COME BACK POSitive IF ONE NEG AND ONE POSTIVE NOT SYSTEMIC KNOW RULES AND REGS FOR COLLECTING BLOOD CULTURES
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Hospitalization for patients with severe infections and complications such as: nausea and vomiting with dehydration signs/symptoms typically improve within 48-72 hours after therapy starts
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The diagnostic tests and collaborative therapy of acute pyelonephritis are summarized in Table 46-7. The patient with mild symptoms may be treated as an outpatient with antibiotics for 14 to 21 days. When initial treatment alleviates acute symptoms and the patient is able to tolerate oral fluids and drugs, the patient may be discharged on a regimen of oral antibiotics for an additional 14 to 21 days.
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Drug therapy ( antibiotics)
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parenteral administration in hospital to rapidly establish high drug levels. NSAIDS or antipyretic drugs for fever and discomfort Urinary analgesics
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Relapses may be treated with
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6 week course of antibiotics and follow-up urine culture and imaging studies PT MAY NEED TREATMENT FOR 6 WEEKS WITH CHRONIC ISSUES
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Reinfections treated as individual episodes or managed with long-term therapy
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Prophylaxis may be used for recurrent infection
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Nursing Assessment: Health History
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Previous UTIs, calculi, stasis, retention, pregnancy, STDs, bladder cancer Antibiotics, anticholinergics, antispasmodics Urologic instrumentation Urinary hygiene Subjective and objective data that should be obtained from a patient with pyelonephritis are similar to those for the patient with UTI
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Nausea, vomiting, anorexia, chills, nocturia, frequency, urgency Suprapubic or lower back pain, bladder spasms, dysuria, burning sensation on urination
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Nursing Management Nursing Assessment
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Fever Hematuria, foul-smelling urine, tender, enlarged kidney Leukocytosis; positive findings for bacteria, WBCs, RBCs; pyuria; ultrasound, CT scan, and IVP abnormalities LOOK AT LABS TO VALIDATE DIAGNOSIS
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Objective data
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Acute pain Impaired urinary elimination
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Nursing Management Nursing Diagnoses
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Patient will have Relief of pain Normal body temperature No complications Normal renal function No recurrence of symptoms OUTCOMES WE WANT TO ACHEIVE
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Nursing Management Planning
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Early treatment for cystitis to prevent ascending infections Patients with structural abnormalities are at high risk Stress the need for regular medical care WARN OF SYMPTOMS OF RELAPSE, FINISH ANTIBIOTICS,
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Nursing Management Nursing Implementation
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Continue drugs as prescribed Follow-up urine culture Recognize manifestations of recurrence or relapse Encourage adequate fluids Nursing interventions vary depending on the severity of symptoms.
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Nursing ManagementNursing Implementation Ambulatory and home care
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Rest to increase comfort Long-term, low-dose antibiotics to prevent relapses or reinfections Explain rationale to increase compliance The patient should drink at least eight glasses of fluid every day, even after the infection has been treated.
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Ambulatory and home care
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Use of nonanalgesic relief measures Appropriate use of analgesics Pass urine without urgency Urine free of blood Adequate intake of fluids
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Nursing Management Evaluation
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Crystals in a supersaturated concentration can unit to form stones - Keeping urine dilute and free flowing can prevent SEVERE PAIN GIVE LARGE DOSE OF FLUID, START IV, 150 CC FLUID AN HOUR TO PASS GIVE MORPHINE FOR COMFORT AMBULATE THEM THEY CAN INTEREFERE WITH NORMAL FLOW OF URINE
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URINARY TRACT CALCULI - NEPHROLITHIASIS
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abnormalities that result in increased urine level of calcium, oxaluric acid, uric acid and citric acid
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Metabolic
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Warm climates cause increased fluid loss, low urine volume and increased concentration of urine
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Climate
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Large intake of proteins that increase uric acid, excessive tea or fruit juices that elevate urinary oxalate, Low fluid intake
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Diet
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family history, sedentary, immobility
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Genetic Factors
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sardines, herring, mussels, liver, goose, venison, meats, sweet breads
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Purine:
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All dairy products made from milk, sardines, herring, salmon, dried fruits, chocolate and cocoa
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Calcium:
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dark roughage, spinach, rhubarb, asparagus, cabbage, tomatoes, beets, nuts celery, beans chocolate, worcestershire sauce
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Oxalate:
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Abdominal or flank pain, hematuria, renal colic, nausea vomiting Pain associated with the passage of calculus is intense and colicky Possible urinary trat infection accompanied by fever and chills
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Urinary Stones Symptoms CRAMPING PAIN FROM FLANK TO ABDOMEN NAUSEA, VOMITING ASSOCIATED WITH SEVERE PAIN DUE TO MOVEMENT OF STONE PT. CAN GET INFECT FROM URNIARY STASIS OR BACK UP
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Urinalysis, urine culture, IVP, retrograde pyelogram (localizes degree and site of obstruction, ultrasounds and cystoscopy
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Urinary Tract Stones - Diagnostic Studies WILL PROBABLY TO A CT TO SEE THE STONE
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Treat the symptoms of pain, infection and obstruction Many stones will pass spontaneously while larger stones will may require stent placement to prevent obstruction The second priority is to evaluate cause of stone formation to prevent future problems
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Urinary Tract Stones - Collaborative Care BIG THINGS: MANGAGE PAIN, PREVENT INFECT, AND PREVENT OBSTRUCTION IF LARGE MAY HAVE TO GO IN AND REMOVE IT OR LITOTHOPY TO BREAK IT DOWN SO PT. CAN PASS IT
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Encourage fluid intake to produce urine output of 2 L/day Assess and manage pain Strain all urine Encourage ambulation to increase peristalsis and promote stone movement.
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Nursing Interventions KEY FACTORS TO MANAGING PT. WITH KIDNEY STONE
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Immunologic processes affecting predominately renal glomerulus in both kidneys - third leading cause of ESRD , end stage renal disease
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Glomerulonephritis WILL USUALLY EFFECT BOTH KIDNEYS 3RD LEADING CASUE OF END STAGE RENAL DISEASE ON DIALYSIS
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Post-streptococcal infection complication Infective endocarditis Viral Infections (HIV, Hepatitis) Systemic lupus erythematosus Scleroderma Diabetic neuropathy Hypertension
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Common Causes or Risk Factors for Glomerulonephritis VERY COMMON WITH DIABETIC NERUOPATHY CANT FILTER PROPERLY
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glomerular filtration Hypertension Oliguria Hematuria with rusty appearance of urine due to bleeding in upper urinary tract Proteinuria, elevated BUN and Creatinine
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General Signs and Symptoms of Glomerulonephritis NOTICABLE AROUND FACE , EYES , ORBITAL EDEMA, ELEVATED BUN AND CREATININE
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Focuses on symptom relief Rest until signs of glomerular inflammation (proteinuria, hematuria, hypertension) subside Restrict sodium and fluid intake Dietary restriction of protein When caused by autoimmune diseases, corticosteroids may be used
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Nursing Management NO CURE SO FOCUS AND COMFORT/ KEEP IN CONTROL
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Results from glomerulus become excessively permeable to plasma proteins that leads to low plasma albumin and tissue edema
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Nephrotic Syndrome WITH NEPHROTIC SYNDROME PT PUTS OUT TOO MUCH PROTEIN IN URINE. PURPOSE OF PROTEIN ( CREATES OSMOTIC PRESSURE) TO KEEP IN VASCULARATURE WILL CAUSE FLUID TO SEEPS OUT OF THE CELLS WILL SEE EDEMA
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Primary Glomerular disease Systemic Lupus Diabetes Infections Neoplasms
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Common Causes of Nephrotic Syndrome
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Peripheral Edema Proteinuria Hypertension Decreased serum albumin
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Manifestations of Nephrotic Syndrome
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Corticosteroids Cyclophosphamide (Cytoxic drug used with limited success in steroid resistant cases) Management of edema ( Diuretic Therapy,sodium restriction, daily weights, I/O, measuring abdominal girth and extremity size Keep edematous areas clean and dry Nutritional status compromised because of excessive loss of protein in urine - small frequent meals
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Nursing and Collaborative Management TREAT WITH STEROIDS WILL SEE SEVERE EDEMA DAILY WT. MOST ACCURATE MEARUEMENT WET LOSS OR GAIN OF 2.2 LBS = 1,000 L OF FLUID LOSS
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What is the landmark to locate the kidneys
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the Costovertebral angle (CVA) and it's formed by the ribcage & vertebral column
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( T 11- T12) and sacral (s2-s4)
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is responsible for urination control
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a pt. complaining of : Burning, frequency, and difficulty when urinating is indicative of a
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UTI
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if a renal artery bruit is heard , this may indicate:
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impaired blood flow to the kidneys : is due to renal artery stenosis ( narrowing of the renal artery)
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if costovertebral angle (CVA) tenderness are present
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may indicate a kidney infection or polycystic kidney disease
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Normal WBC levels in urine
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5/hpf greater levels would indicate inflammation or UTI
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Ranges for specific gravity are:
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1.003-1.030
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normal creatine clearance values range from
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70-135 ml/min
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what is the most accurate indicator of kidney/renal function
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creatinine clearance
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Bun is also used, but not as reliable as
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creatinine clearance
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When a patent is having a urine cytology study , the 1st urine void of the day
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should not be used
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Large Amt of urine passed at any given time is called
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polyuria
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blood urea nitrogen (BUN) is order in pt with
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Dehydration
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getting up frequently to urinate at night greater than 6 times and with large amounts of urine would have a _____ level checked in urine
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Glucose level test - do detect diabetes mellitus
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insertion of a catheter into the femoral artery up to the aorta and to the level of the renal arteries is called a
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renal arteriogram
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nursing interventions for Renal Arteriogram procedures
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Assess for iodine sensitivity Administer Enema the night before Explain the procedure to the patient
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Normal levels of Phosphorus are
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between 2.4 and 4.0 mg/dl
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normal levels of Potassium are
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between 3.5 and 5.0 mEq/L
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phosphourous of 6.0 and potassium of 6.2 would indicate
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renal failure; kidneys are not functioning properly and therefore can not excrete potassium and phosphorous which would make the levels higher
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When the bladder reaches 400-600 ml of urine
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the pt feels uncomfortable and needs to pee
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When the bladder reaches 200-250 ml of urine in the bladder this can cause
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moderate distention and the urge to urinate
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bladder capacity varies but generally ranges from
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600-1000 ml
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serium albumin levels are assessed with
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chronic kidney disease
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serium creatinine levels are assessed with
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renal disorders
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renal biopsy is contraindicated in those with
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high BP
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bowel prep is appropriate for kidney failure and
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castor oil, bisacodyl is ok for use
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fleet enema, milk of magnesia, and magnesium is
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not suitable for kidney/renal failure bed it can't be eliminated
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Normal Blood Urea Nitrogen Levels
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7-18 or 8-20 for client ; 60
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Normal creatine levels
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0.6 to 1.2 mg/dl
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Glomerular filtration (GFR) Norm is
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120 ml/ min
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Normal creatine clearance is
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85-125 ml/min for males and 75-115 ml/min for females
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group B beta-hemolytic strep infection indicates
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acute glomerulonephritis
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acute viral pneumonia infection
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acute glomerulonephritis
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Fatigue , headache, polyruia as well as loss of weight, anorexia, and excessive thirst are signs of
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chronic pyelonephritis
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fever, chills, flank pain ; dysuria
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acute pyelonephritis / UTI
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nausea, vomiting, pallor, and cool, clammy skin
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uretral stone
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dull, aching flank pain and microscopic hematuria
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renal stone in kidney
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gross hematuria and dull suprapubic pain with voiding
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stone in bladder
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may produce no symptoms, but a ureteral stone "always" causes pain on the affected side because a
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ureteral spasm occurs when the stone obstructs the ureter
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used to evaluate kidney function not stones
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creatine/Bun levels
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5,000-10,000
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is a normal WBC count
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a WBC of 14,000
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is elevated an indicates an infection
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the urine collection bag of a catheter
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has to be kept below the level of the bladder to prevent reflux of urine into the renal system and off the floor (microbes)
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what does serum creatinine of 1.4 mg/dl indicate:
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dehydration