Test 3B – Chemistry Flashcard

What is an Alditol?
Carbonyl group is reduced to a hydroxyl group by a reducing agent
How does an Alpha amino acid exist in solution?
Zwitterion
List BASIC amino acids.
Arginine
Histidine
Lysine
List Acidic Amino Acids.
Aspartic Acid
Glutamic Acid
What is distinctive about a peptide bond?
Carbon double bond to oxygen
conntcted to Nitrogen bonded to hydrogen
When can Chymotrypsin cleave a protein chain?
After PHEnylanaline
After TRYptophan
After TYRosine
Where does Trypsin cleave protein chains?
After ARGinine
After LYSine
EXCEPT wehre followed by PROlein
List 4 means of stabiliztion for a TERTIARY protein.
Covalent bonds: S-S disulfide bonds
Hydrogen bonding
Salt bridge NH3+ C-O-
Hydorphobic between non-polar side chains
Describe a Fibrous protein.
Linear
Insoluble in water
Folds so hydrophobic side chains are on the exterior
Example is Keratin
Describe a Globular Protein.
Spherical
soluble in water-colloid
Hydrophilic side chains ar directed to exterior
Example: Albumin
Describe secondary structure protein
Hydrogen bonding between amide linkages of main chain
alpha helix-spiral clockwise coil held by H bonding between carbonyl of amide and N-H of other
Side chain point outward
Beta pleated sheets
Random coil
Can a secondary protein structure have Beta pleated sheets, alpha helix, and random coils?
YES
Name 2 teritary structure proteins
Keratin-fibrous
Albumin-Globular
Describe Quaternary Structure
2 or more polypeptide chains
Chains are SUBUNITS-identical or different
Conjugated proteins-material other than amino chaines
What structure are Glycoproteins?
Quaternary sugars
What structure are lipoproteins and hemoglobin?
Quaternary
What is a conjugated protein?
Protein with a small organic molecule-Quatenary
What is the small organic molecule of a conjugated protein called?
Prosthetic group
Vasopressin and Oxytocin are examples of which structure of proteins?
Primary
How many combinations are possible in a chain of “n” amino acids?
20 raised to the power of “n”
Name amino acids with a phenyl ring.
Phenylalanine
Tyrosine
Which amino acid contains a thiol?
Cystein can form disulfide bonds
List some ways to denature a protein
Heat
6M aqueous Urea
Detergent
Reducing agent-mercaptoethanol
Heavy metal ions Pb, Hg, Cd
alcohols 70% ethanol

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