Rate determining enzymes of metabolic processes first aid USMLE step 1 (2017)

question

Rate determining enzyme of glycolysis
answer

Phosphofructokinase-1 (PFK-1)
question

Rate determining enzyme of gluconeogenesis
answer

Fructose-1,6-bisphosphatase
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Rate determining enzyme of TCA cycle
answer

Isocitrate dehydrogenase
question

Rate determining enzyme of glycogenolysis
answer

Glycogen phosphorylase
question

Rate determining enzyme of HMP shunt
answer

Glucose-6-phosphate dehydrogenase (G6PD)
question

Rate determining enzyme of de novo purine synthesis
answer

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
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Rate determining enzyme of urea cycle
answer

Carbamoyl phosphate synthetase I
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Rate determining enzyme of fatty acid synthesis
answer

Acetyl-CoA carboxylase (ACC)
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Rate determining enzyme of fatty acid oxidation
answer

Carnitine acyltransferase I
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Rate determining enzyme of ketogenesis
answer

HMG-CoA synthase
question

Rate determining enzyme of cholesterol synthesis
answer

HMG-CoA reductase
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Positive regulators of glycolysis
answer

AMP fructose-2,6-bisphosphate
question

Positive regulator of gluconeogenesis
answer

citrate
question

Positive regulators of TCA cycle
answer

ADP
question

Positive regulators of glycogenesis
answer

Glucose-6-phosphate Insulin Cortisol
question

Positive regulators of glycogenolysis
answer

Epinephrine Glucagon AMP
question

Positive regulators of HMP shunt
answer

NADP+
question

Positive regulators of urea cycle
answer

N-acetylglutamate
question

Positive regulators of fatty acid synthesis
answer

Insulin Citrate
question

Positive regulators of cholesterol synthesis
answer

Insulin Thyroxine
question

Negative regulators of glycolysis
answer

ATP citrate
question

Negative regulators of gluconeogenesis
answer

AMP Fructose-2,6-bisphosphate
question

Negative regulators of TCA cycle
answer

ATP NADH
question

Negative regulators of glycogenesis
answer

epinephrine Glucagon
question

Negative regulators of glycogenolysis
answer

Glucose-6-phosphate Insulin ATP
question

HMP shunt
answer

NADPH
question

Negative regulators of de novo purine synthesis
answer

AMP inosine monophosphate (IMP) GMP
question

Negative regulators of fatty acid synthesis
answer

Glucagon Palmitoyl-CoA
question

Negative regulators of fatty acid oxidation
answer

Malonyl-CoA
question

Negative regulators of cholesterol synthesis
answer

Glucagon Cholesterol
question

Rate determining enzyme of glycogenesis
answer

Glycogen synthase
question

Rate determining enzyme of de novo pyrimidine aynrhesis
answer

Carbamoyl phosphate synthetase II

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