Pathology: Paraneoplastic syndromes – Flashcards
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Neoplasms that cause Cushing-Like syndrome
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small cell lung carcinoma = ACTH or ACTH-like peptide
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Clinical effect of ACTH or ACTH-like secretion
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Cushing-like syndrome
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All paraneoplastic syndromes caused by small cell lung cancer
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"Napoleon ACTS SAD when adam LAMBERT dumps him" ACTH (Cushing-like syndrome) = ACTS ADH (SIADH) = SAD Antibodies against presynaptic Ca2+ channels at NMJ (Lambert Eaton Syndrome) = LAMB
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"Napoleon ACTS SAD when Adam LAMBERT dumps him"
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Mnemonic to remember all the paraneoplastic syndromes small cell lung cancer creates ACTH (cushing-like syndrome) ADH (SIADH) Antibodies to presynaptic Ca2+ channels at NMJ (Lambert Eaton)
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SIADH causes
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Small cell lung carcinoma Intracranial neoplasms (stroke, bleed etc.)
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Intracranial neoplasms (i.e. strokes, bleeds too)
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SIADH
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Name the cancers: PTHrP
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PTHrP = hypercalcemia 1. RCC 2. Squamous cell carcinoma of the lung 3. Breast carcinoma "RCC reabsorbs calcium, squamous cell has "pearls" (white like calcium) and breast produce milk (calcium)"
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Paraneoplastic syndrome caused by squamous cell carcinoma of the lung
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PTHrP secretion = hypercalcemia
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1,25-OH2-D3 (calcitriol) secretion
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Hodgkin lymphoma Non-Hodgkin lymphomas Caltriol secretion = hypercalcemia
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Paraneoplastic metabolites that can cause hypercalcemia
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PTHrP = RCC, squamous cell lung, breast Calcitriol = Hodgkin, non-hogdkin lymphoma
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Cancers that can cause polycythemia vera
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Increased EPO secretion = polycythemia vera "HEP HEM RENT PHEEs" Hepatocellular carcinoma Hemangioblastoma RCC Pheochromocytoma
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Syndrome caused by pheochromocytoma
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polycythemia vera (via EPO secretion) "HEP HEM Bloody RENT PHEEs"
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"HEP HEM Bloody RENT PHEEs"
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Mnemonic to remember cancers that cause elevated EPO secretion and polycythemia vera: HCC = HEP Hemangioblastoma = HEM RCC = rent Pheochromocytoma = PHEE Bloody = EPO
