Maternity Pharmacology – Flashcards

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Drug classification for Cervidil
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Therapeutic: Cervical ripening agent Pharmacologic: oxytocics, prostaglandins
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Drug action for Cervidil
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Produces contractions similar to those occurring during labor. Initiates softening efface meant, and dilation of the cervix.
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Side effects for Cervidil
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Headache, hypotension, diarrhea, nausea, vomiting, Uterine rupture, anaphylaxis, & chills
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Nursing Implications for Cervidil
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Auscultate breath sounds. Wheezing and sensation of chest tightness may indicate hypersensitivity reaction.
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Routes of administration for Cervidil
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Endocervical gel, vaginal insert, suppository
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Pertinent lab values for Cervidil
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none
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Cervidil (Brand name)
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dinoprostone (generic name)
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Drug classification for Procardia
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Therapeutic: antianginals, antihypertensives Pharmacologic: calcium channel blockers
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Drug action for Procardia
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Inhibits calcium transport into myocardial and vascular smooth muscle cells, resulting in inhibition of excitation-contraction coupling and subsequent contraction.
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Side effects for Procardia
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headache, ARRHYTHMIAS, CHF, peripheral edema, flushing, STEVENS-JOHNSON SYNDROME
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Nursing Implications for Procardia
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Monitor ECG periodically during prolonged therapy. Monitor bp and pulse before therapy, during dose titration, and periodically during therapy.
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Routes of administration for Procardia
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PO
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Pertinent lab values for Procardia
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Monitor serum potassium periodically, monitor renal and hepatic functions periodically during long-term therapy.
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Drug classification for Vitamin K
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Therapeutic: antidotes, vitamins Pharmacologic: fat-soluble vitamins
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Drug action for Vitamin K
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Required for hepatic synthesis of blood coagulation factors II, VII, IX, and X.
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Side effects for Vitamin K
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Gastric upset, hemolytic anemia, pain at injection site, allergic reactions
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Nursing implications for Vitamin K
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Monitor for frank and occult bleeding, monitor pulse and bp frequently. Monitor for side effects and adverse reactions in peds.
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Routes of administrations for Vitamin K
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Subcut, IV, PO
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Pertinent lab values for Vitamin K
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Monitor prothrombin time (PT) prior to and throughout vitamin K therapy to determine response to and need for further therapy.
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Drug classification for RhoGAM
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Therapeutic: vaccines/immunizing agents Pharmacologic: immune globulins
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Drug action for RhoGAM
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Prevent production of anti-Rh (D) antibodies in Rh (D) negative patients who were exposed to Rh (D) positive blood. Increase platelet counts in patients with ITP.
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Side effects of RhoGAM
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Dizziness, headache, anemia, diarrhea, nausea, vomiting.
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Nursing implications of RhoGAM
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Monitor patients for signs and symptoms of (IVH) intravascular hemolysis (back pain, shaking chills, fever, hemoglobinuria), anemia, and renal insufficiency. If transfusions are required, use Rh (D) negative packed red blood cells to prevent exacerbation of IVH
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Routes of administration of RhoGAM
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IM, IV
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Pertinent lab values for RhoGAM
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Monitor platelet counts, RBC counts, hemoglobin, and reticulocyte levels to determine effectiveness of therapy. Coombs test.
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Drug classification of Narcan
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Therapeutic: antidotes (for opioids) Pharmacologic: opioid antagonists
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Drug Actions of Narcan
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Completely blocks the effects of opioids, including CNS and respiratory depression, without producing any agonist effects.
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Side effects of Narcan
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VENTRICULAR ARRHYTHMIAS, hypertension, hypotension, nausea, vomiting
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Nursing implications of Narcan
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Monitor respiratory rate, rhythm, and depth of pulse, ECG, blood pressure and level of consciousness frequently for 3-4 hr after the expected peak of blood concentrations.
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Routes of administration of Narcan
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IV, IM, Subcut
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Pertinent lab values for Narcan
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None noted
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Brand name: Narcan
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Generic name: naloxone
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Drug classification for Stadol
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Therapeutic: opioid analgesics Pharmacologic: opioid agonists/antagonists
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Drug actions for Stadol
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Binds to opiate recpetors in the CNS. Alters the perception of and response to painful stimuli while producing generalized CNS depression. Has partial antagonist properties that may result in opioid withdrawal in physically dependent patients.
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Side effects of Stadol
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Confusion, dysphoria, hallucinations, sedation, nausea, sweating
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Nursing implications of Stadol
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Assess type, location, and intensity of pain before and 30-60 min after IM, 5 min after IV and 60-90 min after intranasal administration.
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Routes of administration of Stadol
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IM, IV, Intranasal
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Pertinent lab values for Stadol
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May cause and increase in serum amylase and lipase levels
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Brand name: Stadol
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Generic name: butorphanol
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Drug classificaion for Methergine
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Therapeutic: oxytocic Pharmacologic: ergot alkaloids
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Drug side effects for Methergine
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HYPERTENSION, nausea, vomiting, cramps
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Drug actions for Methergine
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Directly stimulates uterine and vascular smooth muscle.
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Nursing implications for Methergine
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Monitor bp, heart rate, and uterine response frequently during medication administration. Notify health care professional promptly if uterine relaxation becomes prolonged or if character of vaginal bleeding changes.
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Routes of administration of Methergine
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PO, IM, IV
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Pertinent lab values for Methergine
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If no response to Methergine, calcium levels may need to be assessed. Effectiveness of medication is decreased with hypocalcemia. May cause a decrease in serum prolaction levels.
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Brand name: Methergine
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Generic name: methylergonovine
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Drug classification for Depo Provera
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Therapeutic: antineoplastics, contraceptive hormones Pharmacologic: hormones, progestins
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Drug actions for Depo Provera
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A synthetic form of progesterone--actions include secretory changes in the endometrium, increases in basal body temp, histologic changes in vaginal ephithelium, relaxation of uterine smooth muscle, mammary alveolar tissue growth, pituitary inhibition, and withdrawal bleeding in the presence of estrogen.
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Drug side effects for Depo Provera
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PULMONARY EMBOLISM, ANAPHYLAXIS, and ANGIOEDEMA
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Nursing implications for Depo Provera
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Monitor blood pressure periodically during therapy. Assess patient's usual menstrual history. Monitor intake and output ratios and weekly weight.
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Routes of administrations of Depo Provera
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PO, IM, Subcut
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Pertinent lab values for Depo Provera
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Monitor hepatic function before and periodically during therapy. May cause increase in alkaline phosphatase levels. May decrease pregnanediol excretion concentrations. May cause increase in serum LDL concentrations or decrease in HDL concentrations. May alter thyroid hormone assays.
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Brand name: Depo Provera
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Generic name: medroxyprogesterone
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Drug classification for ferrous sulfate
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Therapeutic: antianemics Pharmacologic: iron supplements
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Drug actions for ferrous sulfate
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An essential mineral found in hemoglobin, myoglobin, and many enzymes. Enters the bloodstream and is transported to the organs of the reticuloendothelial system (liver, spleen, bone marrow) where it is separated out and becomes part of iron stores.
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Side effects of ferrous sulfate
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SEIZURES, ANAPHYLAXIS, hypotensions, nuasea, constipation, diarrhea,
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Nursing implications for ferrous sulfate
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Assess patients for signs and symptoms of anaphylaxis (rash, pruritis, laryngeal edema, wheezing). Notify physician immediately if these occur. Keep epinepherine and resuscitation equipement close by in the event of an anaphylactic reaction.
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Routes of administrations for ferrous sulfate
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PO
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Pertinent lab values for ferrous sulfate
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Monitor hemoglobin, hematocrit, and reticulocyte values prior to and every 3 wks during the first 2 months of therapy and periodically after. Serum feritin and iron levels may also be monitored to assess effectiveness of therapy.
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Generic name: ferrous sulfate
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Brand name: Feosol
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Drug classification for Nubain
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Therapeutic: opioid analgesics Pharmacologic: opioid agonists/analgesics
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Drug actions for Nubain
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Binds to opiate receptors in the CNS. Alters the perception of and response to painful stimuli while producing generalized CNS depression.
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Side effects of Nubain
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Dizziness, headache, sedation, dry mouth, nausea, vomiting, clammy feeling, sweating.
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Nursing implications for Nubain
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Assess type, location, and intensity of pain before and 1 hr after IM or 30 min after IV administration. Assess blood pressure, pulse, and respirations before and periodically during administration. If resp rate is less than 10/min, assess level of sedation.
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Routes of administration of Nubain
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IM, Subcut, IV
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Pertinent lab values related to Nubain
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May cause and increase in serum amylase and lipase concentrations
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Brand name: Nubain
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Generic name: nalbuphine
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Drug classifications for Phenergan
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Therapeutic: antiemetics, anthihistamines, sedative/hypnotics Pharmacologic: phenothiazines
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Drug actions for Phenergan
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Blocks the effects of histamine. Has inhibitory effect on the chemoreceptor trigger zone in the medulla, resulting in antiemetic properties.
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Side effects of Phenergan
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NEUROLEPTIC MALIGNANT SYNDROME, confusion, disorientation, sedation
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Nursing implications for Phenergan
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HIGH ALERT: If administered IV, assess for burning and pain at IV site, may cause severe tissue injury. Avoid IV administration, if possible. If pain occurs, discontinue administration immediately.
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Routes of administration for Phenergan
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PO, IM, IV, Rect
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Pertinent lab values related to Phenergan
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May cause false-positive or false-negative pregnancy test results. Evaluate CBC periodically during chronic therapy; blood dyscrasias may occur. May cause an increase in serum glucose. May cause false-negative results in skin tests using allergen extracts.
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Brand name: Phenergan
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Generic name: promethazine
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Drug classification for magnesium sulfate
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Therapeutic: mineral and electrolyte replacements/supplements Pharmacologic: minerals/electrolytes
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Drug actions for magnesium sulfate
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Essential for the activity of many enzymes. Plays and important role in neurotransmission and muscular excitability.
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Side effects for magnesium sulfate
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diarrhea, decreased respiratory rate, arrhythmias, bradycardai, hypotension
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Nursing implications for magnesium sulfate
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Monitor pulse, bp, respirations, and ECG frequently throughout administration of parenteral magnesium sulfate. Respirations should be at least 16/min before each dose.
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Potential routes of administration for magnesium sulfate
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IM, IV
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Pertinent lab values related to magnesium sulfate
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Monitor serum magnesium levels and renal function periodically throughout administration of parenteral magnesium sulfate.
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Drug classifications for Pitocin
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Therapeutic: hormones Pharmacologic: oxytocics
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Drug action for Pitocin
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Stimulates uterine smooth muscle, producing uterine contractions similar to those in spontaneous labor. Has vasopressor and antidiuretic effects
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Side effects for Pitocin
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COMA, SEIZURES, INTRACRANIAL HEMORRHAGE, ASPHYXIA (fetal), increased uterine motility, painful contractions
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Nursing implications for Pitocin
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Fetal maturity, presentation, and pelvic adequacy should be assessed prior to administration of oxytocin for induction of labor. Assess character, frequency, and duration of uterine contractions.
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Routes of administrations for Pitocin
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IV, IM
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Pertinent lab values related to Pitocin
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Monitor maternal electrolytes. Water retention may result in hypochloremia or hyponatremia.
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Brand name: Pitocin
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Generic name: oxytocin
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Drug classifications for Vicodin
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Therapeutic: allergy, cold, and cough remedies, opioid analgesics Pharmacologic: opioid agonists/nonopioid analgesic combinations
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Drug actions for Vicodin
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Bind to opiate receptors in the CNS. Alter the perception of and response to painful stimuli while producing generalized CNS depression
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Side effects of Vicodin
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Confusion, dizziness, sedation, hypotension, constipation, dyspepsia, nausea
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Nursing Implications for Vicodin
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Assess blood pressure, pulse, and respiration before and periodically during administrations. Accidental overdose of opioid analgesics has resulted in fatalities.
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Routes of administration for Vicodin
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PO
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Pertinent lab values related to Vicodin
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May cause and increase in plasma amylase and lipase concentrations
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Brand name: Vicodin
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Generic name: hydrocodone/acetaminophen
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Drug classification for Ibuprofen
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Therapeutic: antipyretic, antirheumatics, nonopiod analgesics, nonsteroidal anti-inflammatory agent Pharmacologic: nonopiod analgesics
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Drug action for Ibuprofen
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Inhibits prostaglandin synthesis
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Side effects of Ibuprofen
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GI BLEEDING, HEPATITIS, EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOPIC EPIDERMAL NECROLYSIS, ANAPHYLAXIS
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Nursing implications for Ibuprofen
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Patients who have asthma, aspirin induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Assess for rhinitis, asthma, and urticaria. Assess patient for skin rash frequently during therapy.
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Routes of administration for Ibuprofen
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PO, IV
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Pertinent lab values related to Ibuprofen
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BUN, serum creatinine, CBC, and liver function tests should be evaluated frequently.
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Brand name: Motrin
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Generic name: ibuprofen
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Drug classification for Cytotec
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Therapeutic: antiulcer agent, cytoprotective agents Pharmacologic: prostaglandins
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Drug actions for Cytotec
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Acts as a prostaglandin analog, decreasing gastric acid secretion and increasing the production of protective mucus. Caused uterine contractions.
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Side effects of Cytotec
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Abdominal pain, diarrhea, miscarriage
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Nursing implications for Cytotec
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Assess patient frequently for epigastric or abdominal pain or frank or occult blood in stool, emesis, or gastric aspirate. DO NOT CONFUSE CYTOTEC WITH CYTOXAN
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Pertinent lab values for Cytotec
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None noted
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Brand name: Cytotec
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Generic name: misoprostol
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Drug classification for fentanyl
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Therapeutic: opioid analgesic Pharmacologic: opioid agonists
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Drug actions for fentanyl
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Bind to opiate receptors in the CNS, altering the response to and perception of pain. Produces CNS depression.
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Side effects fo fentanyl
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APNEA, LARYNGOSPASM
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Nursing implications of fentanyl
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Monitor respiratory rate and bp freqently throughout therapy. Report significant changes immediately.
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Potential routes of administration of fentanyl
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IM, IV
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Pertinent lab values related to fentanyl
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May cause increase in serum amylase and lipase concentrations
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Brand name: Sublimaze
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Generic name: fentanyl
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Drug classification for terbutaline
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Classification: Therapeutic: bronchodilators ​​ Pharmacologic: adrenergic
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Drug action for terbutaline
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results in the accumulation of cyclic adesine monophosphate at beta-adrenergic receptors. Produces bronchodilation. Inhibits the release of mediator of immediate hypersensitivity reactions from mast cells. Relatively selective for beta2 adrenergic receptor sites with less effect on beta1 adrenergic receptors.
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Side effects for terbutaline
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results in the accumulation of cyclic adesine monophosphate at beta-adrenergic receptors. Produces bronchodilation. Inhibits the release of mediator of immediate hypersensitivity reactions from mast cells. Relatively selective for beta2 adrenergic receptor sites with less effect on beta1 adrenergic receptors.
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Nursing implications for terbutaline
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Preterm labor: Monitor maternal pulse and BP, frequency and duration of contractions, and fetal heart rate. Notify if contractions persist or increase or if fetal or maternal distress occurs. Maternal side effects include tachycardia, palpitations, tremor, anxiety and headache.
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Routes of administration for terbutaline
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PO, Subcut, IV
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Pertinent lab values for terbutaline
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Lab Values: may cause transient decrease in serum potassium concentration with higher than recommended doses. Monitor maternal serum serum glucose and electrolytes. May cause hypokalemia and hypoglycemia. Monitor neonate's serum glucose because hypoglycemia may also occur in neonates.
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Brand name: Brethine
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Generic name: terbutaline
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Drug classification for erythromycin
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Therapeutic: anti-infective Pharmacologic: macrolides
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Drug action for erythromycin
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suppresses protein synthesis at the level of 50S bacterial ribosome
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Side effects for erythromycin
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CV- QTC Prolongation (may results in torsades de pointes) Ventricular arrhythmias
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Nursing implications for erythromycin
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Implications- Assess for infection at beginning and during therapy Obtain specimens for culture and sensitivity before initiating therapy and during
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Routes of administration for erythromycin
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Routes: topical (list specifies ophthalmic ointment) topical for ophthalmic use Other routes include: PO, IV
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Pertinent lab values for erythromycin
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Lab Values: Monitor liver functions on patients receiving long-term therapy May cause increased serum bilirubin, AST, ALT, and alkaline phosphates concentrations May cause false increase of urinary catecholamine
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Brand name: E-Mycin
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Generic name: erythromycin
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Drug classification for gentamicin
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​Therapeutic: anti-infectives ​Pharmacologic: aminoglycosides
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Drug action for gentamicin
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Inhibits protein synthesis in bacteria at level of 30S ribosome
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Side effects of gentamicin
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Ataxia
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Nursing implications for gentamicin
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- Assess for infection at the beginning of and throughout therapy o Vital signs, wound appearance, sputum, urine, stool, WBC
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Potential routes of administration for gentamicin
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- Parenteral (IV, IM) - IT - Topical
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Pertinent lab values for gentamicin
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None noted
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Brand name: Gentamicin
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Generic name: Aminoglycosides
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