Mastering A&P – Flashcards
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What is the function associated with the indicated neural activity?
(Synaptic Activity)
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the production of graded potentials in the plasma membrane of the postsynaptic cell
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Ions are unequally distributed across the plasma membrane of all cells. This ion distribution creates an electrical potential difference across the membrane. What is the name given to this potential difference?
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Resting membrane potential (RMP)
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Sodium and potassium ions can diffuse across the plasma membranes of all cells because of the presence of what type of channel?
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Leak channels (Passive)
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On average, the resting membrane potential is -70 mV. What does the sign and magnitude of this value tell you?
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The inside surface of the plasma membrane is much more negatively charged than the outside surface.
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The plasma membrane is much more permeable to K+ than to Na+. Why?
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There are many more K+ leak channels than Na+ leak channels in the plasma membrane.
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The resting membrane potential depends on two factors that influence the magnitude and direction of Na+ and K+ diffusion across the plasma membrane. Identify these two factors.
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The presence of concentration gradients and leak channels
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What prevents the Na+ and K+ gradients from dissipating?
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Na+ - K+ ATPase
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The membranes of neurons at rest are very permeable to _____ but only slightly permeable to _____.
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K+; Na+
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During depolarization, which gradient(s) move(s) Na+ into the cell?
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both the electrical and chemical gradients
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What is the value for the resting membrane potential for most neurons?
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-70 mV
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The Na+-K+ pump actively transports both sodium and potassium ions across the membrane to compensate for their constant leakage. In which direction is each ion pumped?
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Na+ is pumped out of the cell and K+ is pumped into the cell.
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The concentrations of which two ions are highest outside the cell.
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Na+ and Cl-
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In a neuron, sodium and potassium concentrations are maintained by the sodium-potassium exchange pump such that __________.
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the sodium concentration is higher outside the cell than inside the cell and the potassium concentration is higher inside the cell than outside the cell.
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The sodium-potassium exchange pump transports potassium and sodium ions in which direction(s)?
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Sodium ions are transported out of the cell. Potassium ions are transported into the cell.
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Leak channels allow the movement of potassium and sodium ions by what type of membrane transport?
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channel-mediated diffusion
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The electrochemical gradient for potassium ions when the transmembrane potential is at the resting potential (-70 mV) is caused by what?
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a chemical gradient going out of the cell and an electrical gradient going into the cell
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What is the electrochemical gradient of an ion?
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the sum of the electrical and chemical gradients for that ion
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What is the function associated with the indicated neural activity?
(Action Potential)
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the electrical impulse that propagates along the surface of the axon
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The events that occur at a functioning cholinergic synapse cause _____________ .
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synaptic delay
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Which type of ion channel is always open?
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Passive (leak)
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The sodium-potassium exchange pump stabilizes resting potential at about __________.
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-70 mV
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Where do most action potentials originate?
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Initial segment
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What opens first in response to a threshold stimulus?
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Voltage-gated Na+ channels
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What characterizes depolarization, the first phase of the action potential?
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The membrane potential changes from a negative value to a positive value.
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What characterizes repolarization, the second phase of the action potential?
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Once the membrane depolarizes to a peak value of +30 mV, it repolarizes to its negative resting value of -70 mV.
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What event triggers the generation of an action potential?
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The membrane potential must depolarize from the resting voltage of -70 mV to a threshold value of -55 mV.
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What is the first change to occur in response to a threshold stimulus?
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Voltage-gated Na+ channels change shape, and their activation gates open.
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What type of conduction takes place in unmyelinated axons?
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Continuous conduction
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An action potential is self-regenerating because __________.
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the influx of Na+ flow down the axon and trigger an action potential at the next segment
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Why does regeneration of the action potential occur in one direction, rather than in two directions?
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The inactivation gates of voltage-gated Na+ channels close in the node, or segment, that has just fired an action potential.
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What is the function of the myelin sheath?
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The myelin sheath increases the speed of action potential conduction from the initial segment to the axon terminals.
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What changes occur to voltage-gated Na+ and K+ channels at the peak of depolarization?
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Inactivation gates of voltage-gated Na+ channels close, while activation gates of voltage-gated K+ channels open.
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In which type of axon will velocity of action potential conduction be the fastest?
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Myelinated axons with the largest diameter
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Where in the neuron is an action potential initially generated?
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axon hillock
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The depolarization phase of an action potential results from the opening of which channels?
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voltage-gated Na+ channels
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The repolarization phase of an action potential results from __________.
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the opening of voltage-gated K+ channels
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Hyperpolarization results from __________.
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slow closing of voltage-gated K+ channels
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What is the magnitude (amplitude) of an action potential?
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100 mV
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Action potential propagation begins (is first generated at) what region of a neuron?
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initial segment
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Where are action potentials regenerated as they propagate along an unmyelinated axon?
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at every segment of the axon
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The movement of what ion is responsible for the local currents that depolarize other regions of the axon to threshold?sodium (Na+)
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sodium (Na+)
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In an unmyelinated axon, why doesn't the action potential suddenly "double back" and start propagating in the opposite direction?
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The previous axonal segment is refractory.
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Approximately how fast do action potentials propagate in unmyelinated axons in humans?
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1 meter per second
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In contrast to the internodes of a myelinated axon, the nodes __________.
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have lower membrane resistance to ion movement
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Where are action potentials regenerated as they propagate along a myelinated axon?
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at the nodes
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The node-to-node "jumping" regeneration of an action potential along a myelinated axon is called __________.
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saltatory propagation
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How do action potential propagation speeds in myelinated and unmyelinated axons compare?
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Propagation is faster in myelinated axons.
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Multiple sclerosis (MS) is a disease that stops action potential propagation by destroying the myelin around (normally) myelinated axons. Which of the following best describes how MS stops action potential propagation?
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Without myelin, the internode membrane resistance decreases, preventing local currents from reaching adjacent nodes.
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During propagation of the action potential, __________.
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All of these events occur during propagation of the action potential (the axon hillock depolarizes the initial segment, local currents depolarize a spot adjacent to the active zone, after threshold is reached, sodium channels open rapidly)
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Compared to type A axons, type C axons are __________.
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Type C axons have all of these characteristics (unmyelinated, slower propagating, smaller diameter)
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Which of these axons will conduct an action potential most quickly?
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Type A fiber
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The small space between the sending neuron and the receiving neuron is the
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synaptic cleft.
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A molecule that carries information across a synaptic cleft is a
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neurotransmitter.
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When calcium ions enter the synaptic terminal,
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they cause vesicles containing neurotransmitter molecules to fuse to the plasma membrane of the sending neuron.
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When neurotransmitter molecules bind to receptors in the plasma membrane of the receiving neuron,
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ion channels in the plasma membrane of the receiving neuron open.
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If a signal from a sending neuron makes the receiving neuron more negative inside,
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the receiving neuron is less likely to generate an action potential.
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In a synapse, neurotransmitters are stored in vesicles located in the __________.
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presynaptic neuron
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An action potential releases neurotransmitter from a neuron by opening which of the following channels?
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voltage-gated Ca2+ channels
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Binding of a neurotransmitter to its receptors opens __________ channels on the __________ membrane.
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chemically gated; postsynaptic
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Binding of the neurotransmitter to its receptor causes the membrane to __________.
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either depolarize or hyperpolarize
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The mechanism by which the neurotransmitter is returned to a presynaptic neuron's axon terminal is specific for each neurotransmitter. Which of the following neurotransmitters is broken down by an enzyme before being returned?
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acetylcholine
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Which of the following is an example of a presynaptic cell?
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a neuron
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What separates the presynaptic and postsynaptic cells at a chemical synapse?
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synaptic cleft
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Which of the following best describes the role of calcium in synaptic activity?
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Calcium influx into the synaptic terminal causes vesicle fusion with the plasma membrane and the release of neurotransmitter.
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What is the role of neurotransmitter at a chemical synapse?
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Neurotransmitter binds to receptors on the postsynaptic cell membrane.
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What mechanism releases neurotransmitter from presynaptic neurons?
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exocytosis
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What type of channel in the postsynaptic membrane binds neurotransmitter?
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a chemically gated channel
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What is the primary role of the enzyme acetylcholinesterase (AChE) at a cholinergic synapse?
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AChE degrades acetylcholine in the synaptic cleft.
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Events that occur at a cholinergic synapse are listed here, but they are arranged in an incorrect order. Choose the correct order of these events below.
(a) Calcium influx triggers exocytosis of ACh.
(b) An action potential depolarizes the synaptic terminal.
(c) ACh is removed by AChE.
(d) ACh binds to receptors on the postsynaptic membrane.
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b→ a→ d→ c
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The effect of a nerve impulse on a postsynaptic neuron depends on the __________.
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All of these factors affect what happens at the postsynaptic neuron (characteristics of the receptor on the postsynaptic neuron, kind of neurotransmitter released by the, presynaptic neuron quantity of neurotransmitter released)
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EPSPs and IPSPs summate at the __________.
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axon hillock
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Which of these neurotransmitters does not bind to a plasma membrane receptor?
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nitric oxide
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Which of these neurotransmitters is released at CNS adrenergic synapses?
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norepinephrine
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The neurotransmitter glutamate opens channels that are permeable to sodium ions. What effect does glutamate produce on a postsynaptic neuron?
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EPSPs
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The simplest level of information processing takes place at the __________.
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axon hillock
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If EPSPs summate to a sustained value above threshold, then the initial segment will __________.
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generate a string of action potentials
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EPSPs are ___________.
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EPSPs have all of these characteristics (postsynaptic, graded, excitatory)
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If a nerve cell receives many IPSPs at the same time, __________.
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it will show temporal summation
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What is the function of the brain structure indicated by the arrow? (cerebrum)
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conscious thought
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What is the function of the brain structure indicated by the arrow? (Pons)
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relaying sensory information to the thalamus
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What is the function of the brain structure indicated by the arrow? (Cerebellum)
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coordination of complex motor patterns
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The cerebrum develops from the embryonic __________.
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telencephalon
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In the adult brain, which is the largest region?
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cerebrum
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What is indicated by the arrow? (Arachnoid mater)
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the space surrounding the brain, spinal cord, and cauda equina through which CSF flows
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What is indicated by the arrow? (Arachnoid granulation)
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absorption of cerebrospinal fluid into the venous circulation
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What is indicated by the arrow?
(Choroid plexus)
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a network of specialized ependymal cells that are involved in the production of CSF
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The CSF leaves the CNS and enters the circulation at the __________.
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arachnoid granulations
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The CSF circulates within the __________.
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subarachnoid space
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Which of these is not a property of cerebrospinal fluid (CSF)?
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It is produced at the arachnoid granulations
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Which of these statements about the medulla oblongata is true?
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All of these statements are true of the medulla oblongata (It connects the brain and spinal cord, It is part of the brain stem, It contains centers for respiration).
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Which of these is found in the pons?
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All of these are found in the pons (tracts to the cerebellum, nuclei for four cranial nerves, respiratory control nuclei).
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Making rapid postural adjustments is a major function of the __________.
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cerebellum
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The huge, highly branched neurons known as Purkinje cells are found in the __________.
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cerebellar cortex
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The cerebellum __________.
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All of these are true for the cerebellum (has peduncles connecting to the cerebrum, adjusts posture, coordinates learned movements).
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Which structure connects the left and right cerebral hemispheres?
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corpus callosum
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What structure secretes the hormone melatonin?
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pineal gland
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Which of these is not a property of the epithalamus?
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It is the roof of the fourth ventricle.
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The largest component of the diencephalon is the __________.
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thalamus
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Which of these is not a property of the limbic system?
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It regulates body temperature.
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Which of the following cranial nerves is classified as mixed nerve?
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vagus nerve (X)
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Which of the following cranial nerves relays information regarding hearing, motion and balance?
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vestibulocochlear nerve (VIII)
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Which of the following cranial nerves innervates the tongue musculature?
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hypoglossal nerve (XII)
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The region of cerebrum anterior to the central sulcus is the __________ lobe.
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frontal
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The region of cerebral cortex inferior to the lateral sulcus is the __________ lobe.
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temporal
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The primary somatosensory cortex is found on the __________.
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postcentral gyrus
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The cerebrum is divided into two hemispheres by the __________.
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longitudinal fissure
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Which of these cranial nerves does not carry motor impulses to the eyes?
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cranial nerve II