Differentiate sporadic, familial and inherited cancer. – Flashcards
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What is Sporadic Cancer?
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Cancer that occurs usually as a result of environmental exposure or unknown factors and does not have any observable pattern of inheritance within the family.
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What is familial cancer?
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Cancer that occurs more frequently than expected within a family but does not demonstrate any observable pattern of inheritance.
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What is inherited cancer?
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Cancer that occurs with an observable autosomal dominant pattern within a family.
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Sporadic Cancer cannot be passed on, there is no predisposition to a type of cancer because:
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Mutations are acquired only in the tissues that develop the cancer.
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Sporadic Cancer is not present in higher than expected levels in:
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Three family generations.
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Sporadic cancer mutations through carcinogenesis disrupt:
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Regulation of cell division (usually somatic cells).
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Familial cancer does not demonstrate any:
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Observable pattern of inheritance
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Familial cancer usually affect people over age:
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Sixty
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Familial cancer is cancer that occurs:
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At higher-than-expected frequency within a family.
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Inherited Cancer occurs with:
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An observable autosomal dominant pattern w/in a family.
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Inherited Cancer is caused:
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By germline mutations (any detectable and heritable variation in the lineage of germ cells) in suppressor genes
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Inherited Cancer is usually diagnosed:
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At much younger-than-expected age.
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Inherited Cancer risks are:
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Inherited, not the actual cancer Is greatly increased but not absolute.
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Inherited cancer is caused by:
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A germline mutation.
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What causes a gene to be inactivated and contributes to tumor suppressor gene silencing?
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DNA methylation.
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What are used to identify specific cancers, monitor the progress of treatment or screen individuals for risk?
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Tumor markers
