CCOM Micro Exam 3 helps – Flashcards
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23 serotypes account for _______% of __________ infection |
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90% of Pneumococcal |
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Gr+ lancet-shaped diplococci |
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Strep pneumo |
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Single bout of rigors |
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Strep Pneumo |
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Strep Pneumo virulence factors |
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Capsule - Pneumolysin |
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Strep Pneumo CXR |
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Atypical: generally patchy |
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Optochin Sensitive? |
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Strep Pneumo |
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Positive Quelling |
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Strep Pneumo |
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Bile (or deoxycholate) soluble |
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Strep Pneumo |
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When does Strep pneumo become invasive? |
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A: In children <5 with severe illness such as -Cancer -Renal Disease -Splenectomy -Transplant |
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Catalase Positive |
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Staph (NOT Strep) |
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Coagulase + |
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Staph aureus |
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What is Staph aureus' aerotolerence? |
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Facultative Anaerobe |
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Q: Agent of most soft tissue infections? |
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A: Staph aureus |
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Infection of Staph aureus is due to ________ |
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contact |
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If 2 BCX are + for _________, PT has a ___% risk of _______ (with ___% mortality if present). |
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If 2 BCX are + for Staph aureus, PT has a 50% risk of ACUTE INFECTIOUS ENDOCARDITIS (with 100% mortality if present). |
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Best prevention for SA transmission? |
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Chlorhexadine soap |
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Pneumonia presentation with Staph aureus? |
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Necrotizing |
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blue-green pigment |
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Pseudomonas aeruginosa (Ps. aeruginosa) |
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Fruity odor |
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Pseudomonas aeruginosa (Ps. aeruginosa) |
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How typical is pneumonia from fruity organism? |
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Unlikely. |
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Normal reservoir for Pseudomonas aeruginosa (Ps. aeruginosa)? |
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Ubiquitous |
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**Mortality of Pseudomonas aeruginosa (Ps. aeruginosa) pneumonia? |
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Highest mortality (just of necrotizing pneumonias?) |
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Pseudomonas aeruginosa (Ps. aeruginosa) morphology |
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GNR, motile, capsule possible, |
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Pseudomonas aeruginosa (Ps. aeruginosa) respiration |
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fermentor, facultative anaerobe |
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What is Pyoverdin? |
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Green pigment from Pseudomonas aeruginosa (Ps. aeruginosa) |
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What is Pyocyanin? |
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Blue pigment from Pseudomonas aeruginosa (Ps. aeruginosa) |
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Function of Pyoverdin and Pyocyanin? (incl. sp.) |
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Iron sequestration for Pseudomonas aeruginosa (Ps. aeruginosa) |
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Produced by Pseudomonas aeruginosa (Ps. aeruginosa): |
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1) Pyoverdin - Iron (fluorescent) 2) Pyocyanin - Iron 3) Exotoxin A (AKA Exoenzyme A) - ADP-Ribosyltransferase action 4) Proteases/Elastases 5) Slime Layer |
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ADP-Ribosyltransferase is present in which 2 compounds? |
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Diphtheria Toxin, & Exotoxin A (Pseudomonas aeruginosa) |
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Biofilm formers include: |
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1) Pseudomonas aeruginosa (Ps. aeruginosa) 2) ? |
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Presentation of P. aeruginosa pneumonia? |
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Rapidly fulminant consolidation - high mortality |
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Describe Pseudomonas aeruginosa resistance patterns |
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Ceftazidine-resistance common (MDR) Resistance includes: -Ceftazidime & Cefepime -cipro -imipenem -piperacillin Susceptibility: TOBRA (Aminoglycosides) |
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K. pneumoniae lab diagnosis |
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GNR, Fac. Anaerobe with capsule, Oxidase negative, Mucoid colony morpholgy |
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K. pneumoniae risk factors? |
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Usually HAP - 50% immunocompromised PTs Comorbidities include: -Diabetics with UTI -Bacteremia/Meningitis in neonates -Liver abscesses + meningitis or ophthalmitis |
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Does Kleb pneumoniae have a capsule? |
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Yes - Polysaccharide (causes mucoid appearance of colonies) |
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Opportunistic pathogens |
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1) K. pneumoniae 2) MTB 3) Nocardia |
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Most virulent K. pneumoniae capsules? |
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K1 & K2 |
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# of different K. pneumoniae capsules? |
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72 |
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Current jelly appearance? |
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K. pneumoniae |
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Abscess formers: |
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1) K. pneumoniae |
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Agents of Chronic Pneumonia |
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1) K. pneumoniae |
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Respiratory Isolation recommended |
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1) P. aeruginosa 2) K. pneumoniae |
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** Describe K. pneumoniae resistance patterns |
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Panresistant (CRKP) -Cefepime & Imipenem? |
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K. pneumoniae mortality |
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Pneumonia: 50% Bacteremia: 100% |
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Acinetobacter (A. baumanii) Lab diagnosis |
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GNCB (appear diplococci), non-motile, aerobic, Oxidase negative, Fermentation negative |
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Pneumonia presentation of Acinetobacter (A. baumanii) |
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CAP & HAP (VAP!) Infections also include Endocarditis, Meningitis, Peridontitis, Osteomyelitis, Endophthalmitis, UTIs, Skin infections, wound infections. |
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Describe resistance patterns of Acinetobacter (A. baumanii) |
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Easily acquire resistance genes. --------- >1/3 are resistant Carbapenems are the effective Tx |
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H. influenzae (Type B) lab diagnosis |
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Small GNR, fastidious (CO2 on chocolate), oxidase positive(+), |
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Typical presentation with Hib? |
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Tracheitis, AECB, AECOPD Pneumonia after viral infection |
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H. influenzae (Type B) is where? |
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Initially on mucosal surfaces, but may become invasive. |
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Treatment of HiB |
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Cephalosporins or Bactrim |
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Vaccine-preventable Bugs |
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HiB Strep Pneumo |
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L. pneumophilia laboratory diagnosis |
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AEROBIC, GNR |
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Facultative intracellular organisms: |
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1) L. pneumophilia |
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Predisposing factors for L. pneumophilia |
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1) Age 2) alcohol abuse 3) Heart disease 4) smoker 5) chronic disease 6) Age 7) Immunosuppression |
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Reservoir for L. pneumophilia |
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Water systems |
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Walking pneumonia can be caused by |
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M. pneumoniae, U. urealyticum, |
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Smallest cellular organism? |
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M. pneumoniae |
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M. pneumoniae lab diagnosis |
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fastidious, requiring long incubation |
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Transmission of M. pneumoniae |
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Direct contact and inhalation of aerosols |
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How infectious is M. pneumoniae? |
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Not very. Usually only infecting closed populations under stress. |
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Predominance of Mono/Macroph indicates what? |
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M. pneumoniae |
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Lab incubation of M. pneumoniae takes ____. |
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2 weeks |
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Dx of M. pneumoniae based on _____? |
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1) CXR 2) Cx (special medium) 3) Serology (DFA/IFA/"Cold aggultinins") |
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What should M. pneumoniae be treated with? |
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1) Macrolides ("-mycin") 2) Tetracycline 3) Quinolones |
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__-__% of sexually mature women are colonized with ____________. |
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40-80%, with U. urealyticum&parvum |
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Children typically infected with U. urealyticum&parvum by which means? |
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Vertical transmission |
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What disease process results in children infected with U. urealyticum&parvum |
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Bronchiolitis ARDS |
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How does U. urealyticum&parvum typically present? |
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Coughing and wheezing child of infected mother |
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Cx site for U. urealyticum&parvum? |
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Mom: Vaginal (or from urine) Child: Throat |
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Tx for U. urealyticum&parvum? |
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Clarithromycin |
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Lab diagnosis of Chlamydia pneumoniae? |
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(small GNR) - slow growing in cell Cx. |
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How does Chlamydia normally present? |
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Cervicitis |
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What is an Elementary body? |
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The infectious particle of a Chlamydia infection |
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What is a reticulate body? |
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The Replicative particle of a Chlamydia infection. Obligate intracellular particle. |
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How long is the incubation period for Chlamydia? |
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4 weeks |
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Chlamydia trachomatis by vertical infection causes: |
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Pneumonia and Conjunctivitis (or just one) |
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TWAR |
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Taiwan associated Respiratory Disease (Chlamydia pneumoniae) |
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What is MIF? |
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Micro-Immuno-Fluorescence |
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Systems that can be complicated by Chlamydia |
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CNS Joints Asthma Heart |
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Tx of Chlamydia? |
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Macrolides (-mycin) |
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Chronic necrotizing pneumonia is most often from which type of respiratory organism? |
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facultative anaerobes |
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Most common neoplastic pneumonia? |
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Primary squamous carcinoma |
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Signs of Chronic necrotizing pneumonia? |
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Prolonged onset, fever, chills, night sweats, Anorexia, weight loss, pleuritic chest pain Solitary cavitating lesion on CXR |
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MTB organism |
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Fac intracellular pathogen Obligate AEROBE |
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MTB Transmission |
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Human to human (only host/reservoir) |
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Virulence factors of MTB |
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1) Mycolic acids 2) Cord factor (Trehalose dimycolate) |
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What causes TB from MTB? |
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Immunosuppression is commonly the trigger to activate latent infections. |
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Where will MTB replicate after inhalation (as dusts/aerosols)? |
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Often lungs, but anywhere where oxygen is present (usually within the macrophages) |
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What causes the lesion in pulmonary TB? |
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CMI response |
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How is latent TB diagnosed? |
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Dx by ppd or quantiferon test. |
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What response is a positive PPD? |
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DTH w/ induration |
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Will quantiferon be positive with BCG vaccine? Why or why not? |
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No. Quantiferon tests for proteins only made by MTB, not by BCG. |
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Fastest way to conclusively detect MTB in lab? |
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PCR |
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Tx for TB? |
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Isoniazid Rifampin Pyrazinamide Ethambutol |
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reservoir of Actinomyces israelii? |
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Human mouth & GI Female repro |
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Lab diagnosis of Actinomyces israelii |
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Branching, filamentous Gram Positive or variable, Facultative Anaerobe (ANACx) |
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Risk for Actinomyces israelii pneumonia? |
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Male, Tobacco and alcohol use, Poor oral hygiene, oral trauma |
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How does Actinomyces israelii get to pathogenic sites? |
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hematogenous spread |
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How does Actinomyces israelii pneumonia present? |
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Abscesses with sinus tracts and sulfur crystals. (Can also infect skin, bones, lower GI, brain, other organs) |
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Tx of Actinomyces israelii? |
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Penicillin |
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How does Nocardia asteroides stain? |
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Filamentous appearance, variable AFB/Gram positive |
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Life cycle of Nocardia asteroides |
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Opportunistic, facultative intracellular bacteria. |
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How is Nocardia asteroides transmitted? |
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NOT person to person Environmental source + CMI supression |
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Which factors increase risk of Nocardia asteroides infections? |
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CMI Suppression Lymphoma Other pulmonary problems Males affected most |
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How is Nocardia asteroides spread? |
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First by environment Second by hematogenous spread |
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How does Nocardia asteroides present? |
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Purulent lesions WITHOUT GRANULOMA formation Nodular masses Can be acute to chronic Can infect other tissues (ie skin) |
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Tx of Nocardia asteroides? |
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Bactrim or Cephalosporins |
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Reservoir of Non-TB Mycobacteria? |
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Environment & Animals (NF to some degree) |
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Common strains of Non-TB Mycobacteria? |
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M. kansasii M. fortuitum MAC |
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Length of latency of Non-TB Mycobacteria |
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No latency or reactivation |
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diagnosing PT's Non-TB Mycobacteria |
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weak PPD test positive. |
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Tx of Non-TB Mycobacteria? |
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Depends on senstivities |