Home Page Flashcards Bis-choline tetrathiomolybdate C10H28MoN2O2S4 structure - Flashcards

Bis-choline tetrathiomolybdate C10H28MoN2O2S4 structure – Flashcards

Flashcard maker : Daphne Armenta

Contents

Experimental Solubility:
Bio Activity:

Molecular Formula	C₁₀H₂₈MoN₂O₂S₄
Average mass	432.542 Da
Density
Boiling Point
Flash Point
Molar Refractivity
Polarizability
Surface Tension
Molar Volume

Experimental data
Predicted – ACD/Labs
Predicted – ChemAxon

Experimental Physico-chemical Properties
- Experimental Solubility:
  
  DMSO 40 mg/ml MedChem Express HY-16074

Miscellaneous

Bio Activity:

ATN-224(tetrathiomolybdate) is a copper-chelator agent which can inhibit intracellular SOD1 activity with IC50 of 17.5 nM.; IC50 value: 17.5 nM [1]; Target: SOD1; in vitro: ATN-224 inhibits superoxide dismutase 1 (SOD1) in tumor and endothelial cells. MedChem Express HY-16074

ATN-224(tetrathiomolybdate) is a copper-chelator agent which can inhibit intracellular SOD1 activity with IC50 of 17.5 nM.;IC50 value: 17.5 nM [1];Target: SOD1;In vitro: ATN-224 inhibits superoxide dismutase 1 (SOD1) in tumor and endothelial cells. The inhibition of SOD1 leads to inhibition of endothelial cell proliferation in vitro and attenuation of angiogenesis in vivo. The inhibition of SOD1 activity in endothelial cells is dose and time dependent and leads to an increase in the steady-state levels of superoxide anions, resulting in the inhibition of extracellular signal-regulated kinase phosphorylation without apparent induction of apoptosis [1]. ATN-224 (choline tetrathiomolybdate) can induce cell death in oxidative stress-resistant cells and cells overexpressing Bcl-2 by modulating the cellular redox environment and causing mitochondrial dysfunction. ATN-224 treatment decreases superoxide dismutase 1 (SOD1) activity, increases intracellular oxidants, and induces peroxynitrit MedChem Express HY-16074

Others MedChem Express HY-16074

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

No predicted properties have been calculated for this compound.

Density:
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
Molar Refractivity:
#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:

ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
Polarizability:
Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

Bis-choline tetrathiomolybdate C10H28MoN2O2S4 structure – Flashcards

Experimental Solubility:

Bio Activity:

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