Biochemistry Membrane Transport – Flashcards

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An important function of membranes is to serve as barriers to separate and compartmentalize biological molecules and processes. However, at the same time, these barriers are _____
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selectively permeable
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allow transport of specific molecules in and out of the cell through the membrane
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selectively permeable
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membrane transport can be categorized as 2 main types
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passive transport and active transport
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no energy is required for this type of transport
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passive transport
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energy is required for this type of transport. Transport is against a concentration gradient
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active transport
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ions and small molecules are transported through membranes via ____ and ____ during passive transport
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pores and channels
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2 types of passive transport
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passive and facilitated
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transport through the membrane via simple diffusion through a "hole." Type of passive transport
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passive diffusion
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transport facilitated by binding a transporter protein in the membrane. Type of passive transport
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facilitated diffusion
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At high concentrations of solute, the transporter protein becomes saturated w/ solute and cannot transport any faster.
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saturable transport system
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The pathway of transport can be described in 3 ways. All of these describe both active and passive transport.
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uniport, symport, antiport,
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one molecule is transported into or out of the cell
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uniport
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2 molecules moving in the same direction, either in or out of the cell
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symport
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2 molecules moving in different direction
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antiport
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water transporters. It is an example of passive diffusion
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aquaporins
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As a consequence of the solute binding the transporter protein, facilitated transport is much _____
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faster
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The exothermic reactions supply the energy for the endothermic reactions needed for solute transport. There are 3 exothermic reactions.
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ATP sunlight redox reactions
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Two types of active transport
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primary and secondary active transport
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the exothermic reaction generating energy is directly coupled to the endothermic transport reaction
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primary active transport
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The endergonic reaction of one transported solute is coupled to the exothermic reaction of another transported solute
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secondary active transport
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This is an example of primary active transport. It transports Na and K across cell membranes
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Na, K ATPase
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virtually all animal cells internally maintain a lower concentration of Na and a higher concentration of K than is found in the surrounding medium. This process requires energy from ___.
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ATP
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both Na and K ions are transported ___ the concentration gradient in Na, K active transport
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against
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This is an example of secondary active transport. It transports glucose in human erythrocytes. Glucose is transported into the cell to provide energy.
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glucose permease
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glucose permease is coupled to the _______
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Na, K ATPase
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membrane bound protein w/ a specific external binding site for the first messenger
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membrane receptor
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transports the signal to the cytoplasmic side of the membrane bound effector enzyme
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transducer
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regulation of a reaction or biochemical pathway in the cytoplasm, nucleus or organelle
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cytoplasmic response
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Many hormones regulating intracellular metabolism exert their effects through the _____
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G proteins
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Binding of ____ or ____ alters the conformation of the G proteins and either activates or inactivates the protein.
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GDP or GTP
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There are two forms of the G protein
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activating form and inactivating form
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An ____ form coupled to the receptor that binds the stimulatory hormone
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activating
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The _____ form coupled to the receptor that binds the inhibitory hormone
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inactivating
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The receptor, transducer, and effector functions of the tyrosine kinase pathway reside in a ______
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single membrane protein
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The hormone ____ utilizes tyrosine kinase pathway
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insulin
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___ is a peptide hormone consisting of two small peptide chains linked by disulfide bonds and synthesized in the pancrease. It causes cells to take up glucose from the blood
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insulin
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results from the loss of control of insulin levels
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diabetes
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insulin is no longer produced internally and requires administration of external insulin
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type I diabetes
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cells are often insulin resistant and suffer from insulin deficiencies. This can often be controlled by diet although some individuals require external insulin.
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type II diabetes
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single (CH2O)n unit
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monosaccharides
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2-20 (CH2O)n units
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oligosaccharides
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> 20 (CH2O)n units
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polysaccharides
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polysaccharides with identical sugars
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homoglycans
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polysaccharides with different sugars
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heteroglycans
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carbohydrates are classified by (2)
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type of carbonyl group and number of carbon atoms
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type of carbonyl groups (2)
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aldoses and ketoses
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loss of electrons or the loss of hydrogens
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oxidation
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carbon w/ asymmetric substitutions. 4 different bonded atoms/groups
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chiral carbon
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require breaking carbon bonds
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configurations
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require no breaking carbon bonds. Rotation of a functional group around a single bond
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conformations
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chiral carbons rotate _____
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plane polarized light
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a triose sugar
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glyceraldehyde
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the D and L configurations of glyceraldehyde are ______
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stereoisomers
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naturally occurring sugars are _____
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D
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Aldoses and ketoses typically possess between 3 and 9 carbons per monosaccharide unit. Is it possible to have a 2 carbon carbohydrate?
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yes
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linearized presentation of monosaccharide structure
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fischer projection
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circularized presentation of monosaccharide structure. It shows the naturally occurring structure of monosaccharides
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haworth projection
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6 carbon sugar
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pyranose
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5 carbon sugar
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furanose
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The most oxidized carbon of a cyclized monosaccharide.
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anomeric carbon
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primary structural linkage of all monosaccharide polymers. It is a covalent linkage between anomeric carbon of one monosaccharide and one of several possible hydroxyls of a second monosaccharide
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glycosidic bond
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a glycosidic bond is designated by (2)
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alpha or beta configuration at the anomeric carbon and number of carbons of the glycosidic bond
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monosaccharides and most disaccharides which possess a reactive carbonyl group
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reducing sugar
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disaccharides with both anomeric carbons involved in glycosidic bond formation
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non reducing sugar
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polymer chains of oligosaccharides and polysaccharides can define their directionality based upon their
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reducing and non reducing ends
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carbohydrate energy storage for plants
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starch
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A homopolysaccharide. glucose that has an alpha (1->4) linkage and is unbranched.
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amylose
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A homopolysaccharide. Glucose that has a alpha (1->4) and beta (1->6) linkage and is branched.
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amylopectin
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carbohydrate energy storage for animals. It's a homopolysaccharide. Glucose is alpha (1->4) and is branched.
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glycogen
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structural carbohydrate for plants. It a homopolysaccharide. Glucose with a beta (1->4) linkage and is unbranched
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cellulose
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It's the major component of rigid cell walls of many plant cells. It is insoluble in water. Mammals cannot digest this compound because they lack the enzyme to digest the beta linkage.
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cellulose
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structural carbohydrate for animals. It is a homopolysaccharide. Glucose with a beta (1->4) linkage and is unbranched
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chitin
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chitin is present in the cell walls of ____
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fungi
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