question

• +1 Health Up • Fully restores all red heart containers • Has a chance to drop from the Gluttony mini boss fight.

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<3 ItemID: 15 "HP up"

question

• A familiar fly that can be moved around via use of the arrow keys dealing 2.5 contact damage per tick, similar to the Ludovico Technique's mechanic. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies. UNLOCK: Unlock this item by beating Boss Rush with Blue Baby.

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???'S ONLY FRIEND ItemID: 320 "Controlled friend"

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• Gives the player an extra life • When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health. • Resurrection takes place before all other items which give you an extra live, except Guppy's Collar.

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1UP ItemID: 11 "Extra life"

question

• Isaac now shoots from both eyes at the same time. • Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, effectively giving you double damage per second potential.

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20/20 ItemID: 245 "Double shot"

question

• Random tear effect for every room. • Possible tear effects: Fire Mind, Spoon Bender, My Reflection, Ouija Board, 20/20, Inner Eye, Iron Bar, Death's Touch, Scorpio, Tough Love, Proptosis, Number One, Mom's Contacts, Ball of Tar, Dark Matter, Speed Ball or Sagittarius.

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3 DOLLAR BILL ItemID: 191 "Rainbow tears"

question

• Automatically gives you 1 bar of charge after using your spacebar item. • Fully recharges your current space bar item when picked up. • Causes the Sharp Plug item to become useless due to the fact that you can never have 0 charge on your spacebar item. • Any items which are normally a 1 room recharge are now timed instead.

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9 VOLT ItemID: 116 "Quicker charge"

question

• On pickup removes all of your red hearts and gives you 6 black hearts. • +1.5 Damage Up. • +0.2 Speed Up. • Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period. • The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time. • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect. UNLOCK: Unlock this item by beating the Chest with Azazel.

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ABADDON ItemID: 230 "Evil up + DMG up + fear shot"

question

• A familiar that mirrors the player's movements and shoots tears in the opposite direction. • Abel's tears do the same as Isaac's base damage (3.5). • In larger rooms, Abel will mirror to the other side of the screen instead of the entire room. UNLOCK: Unlock this item by beating the Dark Room with Cain.

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ABEL ItemID: 188 "Mirrored buddy"

question

• Spawns troll bombs at random locations around the room. • Bombs are effected by other passive bomb items. • Has a chance to drop from the Pride miniboss fight.

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ANARCHIST'S COOKBOOK ItemID: 65 "Summon bombs"

question

• +5 Range Up. • When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room. • Lazarus' revived form (Lazarus II) respawns with this item.

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ANEMIC ItemID: 214 "Toxic blood"

question

• Upon death, the player respawns as Blue Baby with three Soul hearts. • This is a one time use item and all new heart containers will be soul hearts. • Can be used to unlock some of Blue Baby's secrets before having the character available.

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ANKH ItemID: 161 "Eternal life?"

question

• -2 Tear Delay (Tears Up). • As you hold down the fire button, shots will float in the same place until you release the fire key again. • Allows you to store up a lot of tears in the air and release them all at once. • When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created.

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ANTI-GRAVITY ItemID: 222 "Antigravity tears + tears up"

question

• Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick. • One of the twelve zodiac items available in the game.

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AQUARIUS ItemID: 308 "A trail of tears"

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• +0.25 Speed up. • Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed. • Will not deal contact damage unless you are moving fast enough, but does not prevent you from taking damage yourself. • One of the twelve zodiac items available in the game.

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ARIES ItemID: 300 "Ramming speed"

question

• Gives Isaac an orbital ball of bandages that deals 7 contact damage per tick. Unlike the Cube of Meat, it does not block enemy shots. • Collecting a second Ball of Bandages in the run turns the orbital into a pink head that shoots tears that deal 7 damage each and have a chance to charm enemies. • Getting a third Ball of Bandages will transform the head into bandage girl which will chase enemies dealing 3.5 contact damage per tick while firing charm tears. • A fourth Ball of Bandages will make the Bandage Girl bigger and stronger, making her deal 5.5 damage per tick instead. • Any further Ball of Bandages will repeat the cycle. • Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac. • Has a chance to drop from one of the Horsemen bosses and can be received from using Monster Manual.

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BALL OF BANDAGES ItemID: 207 "Gotta lick em all"

question

• Isaac leaves a trail of tar behind him which will slow down enemies that walk over it. • Tears have a chance to slow enemies and their projectiles for a short period of time. • The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck.

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BALL OF TAR ItemID: 231 "Sticky feet..."

question

• All spacebar items can now be 'overcharged', allowing them to be charged up twice instead of once. • The extra charges appear in yellow on top of the normal green bars. • Has no effect with items which recharge over time instead of on a per-room basis.

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THE BATTERY ItemID: 63 "Stores energy"

question

• A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage. • Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage. • Respawns after 10 seconds or by moving to another room. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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BBF ItemID: 272 "Big beautiful fly"

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• Upon use, this item causes Isaac to fart and poison any enemies in close proximity. • The Bean deals 26 damage total (5 initially then 21 in a Damage over Time effect.

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THE BEAN ItemID: 111 "Toot on command"

question

• +0.3 Speed Up.

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THE BELT ItemID: 28 "Speed up"

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• When Isaac takes damage, a white attack fly will spawn that orbits him at a similar distance to the Distant Admiration fly. • The fly orbits a lot faster than Distant Admiration or Forever Alone and deals 5 damage per tick. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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BEST BUD ItemID: 274 "Sworn protector"

question

• Places a decoy on the floor which attracts enemies and explodes after a period of time. • When it explodes, it deals 110 damage to everything in radius (Same damage as Mr Mega bombs).

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BEST FRIEND ItemID: 136 "Friends 'till the end"

question

• Makes all of Isaac's familiars much bigger, making them deal more damage. • Causes all familiars to deal double damage (x2 / +100%). • Has no effect on Rotten Baby, which instead benefits from Hive Mind.

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BFFS! ItemID: 247 "Your friends rule!"

question

• Gives Isaac angel wings for the current room, allowing him to fly. • If used during the Mom's Foot or Mom's Heart boss fights, The _____ will kill Mom instantly. • If used during the Satan fight, The _____ will instantly kill Isaac.

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THE BIBLE ItemID: 33 "Temporary flight"

question

• A very large orbital that moves around Isaac very slowly, blocking shots and dealing 2 contact damage per tick. • Affects the speed of all other orbitals, slowing them down a lot (NOTE: This effect does not happen until you get a new orbital after _____). • Does not count as one of your three standard orbitals, allowing you to have a total of 4. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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BIG FAN ItemID: 279 "Fat protector"

question

• Upon taking damage, Isaac will fart, causing all enemies in close proximity to become poisoned. • ________ deals 26 damage total (5 initially then 21 in a Damage over Time effect.

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THE BLACK BEAN ItemID: 180 "Toot on touch"

question

• +1 Black Heart. • Immunity to all floor curses (e.g. Curse of the Lost) • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect. • An item that can appear in the shop room or in a Curse Room. • +30% Higher chance of a Devil Deal opening after the boss fight. UNLOCK: Unlock this item by donating 150 pennies to the Shop.

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BLACK CANDLE ItemID: 260 "Curse of immunity + evil up"

question

• +1 Health Up. • +1 Soul Heart. • +1 Black Heart. • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect. • An item only found in the secret room pool.

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BLACK LOTUS ItemID: 226 "HP up x3"

question

• When used, copies the effect of the tarot card you are currently holding without consuming it. • The ______ can also be used to mimic mystic runes as well as tarot cards. • An item that often appears in the shop. UNLOCK: Unlock this item by beating the Isaac boss with Eden.

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BLANK CARD ItemID: 286 "Card Mimic"

question

• +1 Health Up • +0.3 Speed Up (Only applied after the speed stat is next updated) • Heals for 5 full red hearts. • Has a chance to drop while playing any Blood Donation machine. UNLOCK: Unlock this item by playing the Blood Donation machine 30 times.

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BLOOD BAG ItemID: 119 "HP up"

question

• +1.0 Damage Up (Left eye only). • +5 Range Up (Left eye only). • The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only.

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BLOOD CLOT ItemID: 254 "DMG + range up"

question

• +1.0 Damage Up. • +50% / 1.5 times Damage Multiplier if you also have Book of Belial (Does not stack with Magic Mushroom or Cricket's Head multipliers) • This item can only be found in the item room pool, unlike the original game where it was also a god item

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BLOOD OF THE MARTYR ItemID: 7 "DMG up"

question

• Upon use, takes away one full heart and deals 40 damage to the entire room. • With the Isaac's Heart item, you can use Blood Rights without taking damage. UNLOCK: Unlock this item by beating Satan with Samson.

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BLOOD RIGHTS ItemID: 186 "Mass enemy damage at a cost"

question

• Each time you take damage, you gain a damage up which lasts for the rest of the floor and turn a darker red colour each time. • After taking 6 hits you will cap at +6.5 Damage for the rest of the floor. • Damage given for each hit increases as follows: +0.5, +0.5, +0.5, +1.66, +1.66, +1.66. • _____ works differently in Rebirth - Damage is given for taking damage and is persistent for the entire floor. UNLOCK: Unlock this item by beating the Isaac boss with Samson.

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BLOODY LUST ItemID: 157 "RAGE!"

question

• +1 Health Up. • +0.7 Tears Up. • -0.16 Shot Speed Down. • An item only found in the Boss Room pool.

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BLUE CAP ItemID: 342 "HP + tears + shot speed down"

question

• Reveals the locations of the secret and super secret room for the current floor and all future floors. UNLOCK: Unlock this item by donating 10 pennies to the Shop.

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BLUE MAP ItemID: 246 "Secrets"

question

• A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius. • _______can deal anywhere between 67.5 - 69.5 damage (63.5 on hit then 4 or 6 as damage over time poison) and this will scale with further bomb upgrade items. • Regenerates over time. • Will hurt Isaac if he is in the blast radius.

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BOB'S BRAIN ItemID: 273 "Explosive thoughts"

question

• All of Isaac's bombs now leave a poison effect on any enemies within the blast radius. • +5 Bombs. • As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick. • Has a chance to drop from the Super Sloth miniboss fight.

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BOB'S CURSE ItemID: 140 "Poison bombs"

question

• A poison bomb which can be thrown and leaves a poison effect on any enemies within the blast radius. • The bomb deals 50 damage on hit and leaves a damage over time poison effect that does 6 or 8 damage per tick. • Synergizes with tear modifying items such as My Reflection or Tiny Planet. • Has a chance to drop from the Sloth miniboss fight.

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BOB'S ROTTEN HEAD ItemID: 42 "Reusable ranged bomb"

question

• All of Isaac's bombs now having a homing effect when placed on the floor. • +5 Bombs.

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BOBBY - BOMB ItemID: 125 "Friends till the end"

question

• +3 Health Up. • The three heart containers are pre-filled with red hearts. UNLOCK: Unlock this item by beating the Chest with The Lost.

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THE BODY ItemID: 334 "I feel all"

question

• All bomb pickups are now 1+1 bombs. • An item only found in the Shop item pool.

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BOGO BOMBS ItemID: 250 "1+1 bombs"

question

• A __________ that will drop a bomb pickup every 2 rooms. UNLOCK: Unlock this item by beating Satan with Cain.

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BOMB BAG ItemID: 131 "Gives bombs"

question

• Upon use, gives +2 damage up which lasts for the current room. • +50% / 1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers). • Guaranteed Devil or Angel Room if you have it when you kill the boss on all floors where it's possible to get one. • Judas starts with this item. In Afterbirth this is no longer a Guaranteed Devil Deal chance, instead it is +12.5%

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THE BOOK OF BELIAL ItemID: 34 "Temporary DMG up"

question

• Upon use, gives Isaac an extra Soul heart. • Using this item gives you a higher chance of finding a horsemen boss at the end of the floor. • Higher chance of a Devil Deal opening after the boss fight (Exact chance unknown). UNLOCK: Unlock this item by beating one of the horsemen bosses for the first time.

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BOOK OF REVELATIONS ItemID: 78 "Reusable soul protection"

question

• When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations) UNLOCK: Unlock this item by beating Satan with Eden.

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BOOK OF SECRETS ItemID: 287 "??????"

question

• Gives the player an invulnerability effect which lasts for a few seconds.

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BOOK OF SHADOWS ItemID: 58 "Temporary invincibility"

question

• Spawns a random pickup on the floor. • The possible pickups from this item include: Bombs, hearts, keys, coins, pills, batteries or tarot cards. UNLOCK: Unlock this item by beating each of the Seven Sins once.

answer

THE BOOK OF SIN ItemID: 97 "Reusable item generator"

question

• +10 Bombs

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BOOM! ItemID: 19 "10 bombs"

question

• A _____ which can be thrown in a similar fashion to Mom's Knife, to stun any enemies it hits and deal damage. • The damage dealt by the _____ is equal to double your tear damage. • The _____ can also be used to grab pickups and consumables from a distance, similar to the legend of zelda _____. • The range of the _____ is affected by range, with number one the distance is very short and makes the item a lot less effective.

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BOOMERANG ItemID: 338 "It will never leave you"

question

• Spawns one of each type of pickup. • Pickups spawned: 1 heart, 1 key, 1 bomb, 1 coin, 1 card, 1 pill and 1 trinket.

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BOX ItemID: 198 "Stuff"

question

• When used, spawns 2-4 friendly blue spiders on the floor. • Blue Spiders do 2.5x of Isaac's damage.

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BOX OF SPIDERS ItemID: 288 "It's a box of spiders"

question

• +1 Health Up. (1)

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BREAKFAST ItemID: 25 "HP up"

question

• While you hold the spacebar down with this item, it will de-charge gradually and when the charge bar gets to zero it will grant you a brief period of invincibility. • If the spacebar is held for too long (about 1 second) when it has no charge, you will take damage.

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BREATH OF LIFE ItemID: 326 "Invincibility at a cost"

question

• Tears are replaced with the ability to charge and fire a powerful laser that travels in a straight line across the room, dealing a lot of damage (damage * 13) to any enemies it comes into contact with. • Does not directly affect your Damage stat but hits enemies 13 times per charge, spawning Guppy flies with every hit. • Synergizes very well with a lot of items including Tammy's Head, Tiny Planet, Inner Eye (Triple Shot), Mutant Spider (Quad Shot) and many others. • An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool) • Lump of Coal gives no benefit to Brimstone in Rebirth.

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BRIMSTONE Special item ItemID: 118 "Blood laser barrage"

question

• Upon entering a new room, you now have a chance to randomly slow down or speed up all enemies in the room. • An item only found in the Shop item pool.

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BROKEN WATCH ItemID: 337 "I think its broken"

question

• A familiar which follows Isaac and shoots normal tears which do 3.5 damage. • Brother Bobby fires tears at a rate of 1 tear per second.

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BROTHER BOBBY ItemID: 8 "Friends 'till the end"

question

• +2 Health Up. • -0.2 Speed Down. • Of the two heart containers given from this item, only 1/2 a red heart of them is filled. • Has a chance to drop from the Super Gluttony miniboss fight.

answer

BUCKET OF LARD ItemID: 129 "HP up"

question

• A beggar who follows Isaac around and automatically picks up nearby coins. After picking up a coin he has a random chance to drop pickups, including hearts, keys, bombs, coins, pills, cards or trinkets. • (AFTERBIRTH) One of three Bum items required to create SUPER BUM.

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BUM FRIEND ItemID: 144 "He's Greedy"

question

• +5 bombs. • Bombs now become poop bombs, which deal 10 damage to all enemies in the room and daze them for a short period of time.

answer

BUTT BOMBS ItemID: 209 "Toxic blast +5 bombs"

question

• When used, farts on nearby enemies and knocks them backwards away from Isaac. UNLOCK: Unlock this item by destroying 100 poops.

answer

BUTTER BEAN ItemID: 294 "Reusable knockback"

question

• +0.3 Speed Up. • Player Size Down. • Gives you a random pill when picked up. • An item only found in the boss room pool.

answer

CAFFEINE PILL ItemID: 340 "Speed up + size down"

question

• A familiar eye that bounces around the room slowly and fires tears in the same direction as Isaac. • __________ deals 3.5 damage per tear (The same as Isaac's base damage). UNLOCK: Unlock this item by beating Boss Rush with Cain.

answer

CAIN'S OTHER EYE ItemID: 319 "Near sighted friend"

question

• +3 Soul Hearts • After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken). • One of the twelve zodiac items available in the game.

answer

CANCER ItemID: 301 "HP up + you feel protected"

question

• A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick. • Can cause up to a total of 184 potential damage. UNLOCK: Unlock this item by donating 900 coins to the Shop.

answer

THE CANDLE ItemID: 164 "Reusable flame"

question

• +1 Health Up. • +0.5 Damage Up. • -1 Tear Delay (Tears Up). • +0.1 Speed Up. • +1.5 Range Up. • +1 Key, +1 Bomb, +1 Coin. • One of the twelve zodiac items available in the game.

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CAPRICORN ItemID: 307 "All stats up"

question

• +1.0 Damage Up. • +0.23 Shot Speed Up. • An item only found in the Boss room pool.

answer

CAT-O-NINE-TAILS ItemID: 165 "Shot speed up + DMG up"

question

• Upon taking damage, you have a chance to gain an invulnerability shield for a few seconds. • The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time. UNLOCK: Unlock this item by beating the Chest with Maggy.

answer

CELTIC CROSS ItemID: 162 "You feel blessed"

question

• +3 Black Hearts. • +1 Damage Up. • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

answer

CEREMONIAL ROBES ItemID: 216 "Sin up"

question

• +1.0 Damage Up. • Increases the chance of champion enemies appearing. • An item only found in the Shop room pool.

answer

CHAMPION BELT ItemID: 208 "DMG + Challenge up"

question

• Heals half a heart after every 13 enemies killed.

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CHARM OF THE VAMPIRE ItemID: 62 "Kills heal"

question

• +2 Damage Up for tears fired from Isaac's left eye. • If you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage.

answer

CHEMICAL PEEL ItemID: 154 "DMG up"

question

• Isaac can now charge shots for more damage by holding down the fire button. • At full charge, your tears do 4 times more damage. • Tears fired at the minimum possible charge do roughly 1/3 of your normal damage. • Tears up - Spamming the fire button allows for rapid fire shots at normal damage.

answer

CHOCOLATE MILK ItemID: 69 "Charge shots"

question

• Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies. • The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time. • Gives a big increase in damage to Dr. Fetus bombs.

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THE COMMON COLD ItemID: 103 "Poison damage"

question

• Shows all icons on the map (e.g. Shop) • Does not show the layout of the map. • Room icons will not show if a curse of the blind is in effect on the current floor.

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THE COMPASS ItemID: 21 "The end is near"

question

• Doubles your pickup drops including chests, soul hearts and all other consumables which spawn at the end of a room. • Higher chance for 'double trouble' rooms (2 bosses at once).

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CONTRACT FROM BELOW ItemID: 241 "Wealth, but at what cost?"

question

• When used, converts 2 soul or black hearts into 1 red heart container. • This item will take from your soul hearts first.

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CONVERTER ItemID: 296 "Convert your soul"

question

• Creates 5 beams of light at random locations in the room, dealing 20 damage to any enemies which come into contact with them. • The beams tend to favour spawning in the middle of the room but also have a chance to spawn in front of an enemy.

answer

CRACK THE SKY ItemID: 160 "Holy white death"

question

• -1 Tear Delay (Tears Up). • -10.0 Range Down. • Makes tears break into 4 smaller tears on impact with anything which deal half of your damage.

answer

CRICKET'S BODY ItemID: 224 "Splash damage + tears up"

question

• +0.5 Damage Up • +50% / 1.5 times Damage Multiplier (Does not stack with the Magic Mushroom multiplier). • Tears now have a significant knockback effect (Does not increase the shot speed stat). • Can be found in golden chests. • Cricket's Head used to be known as 'Max's Head in the original game and was renamed for Rebirth.

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CRICKET'S HEAD ItemID: 4 "DMG up"

question

• Upon use, reveals the entire map and gives the player a random tarot card, mystic rune or soul heart. • Has a chance to drop from playing a fortune machine.

answer

CRYSTAL BALL ItemID: 158 "I see my future"

question

• An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick. • Exclusively drops from one of the horsemen bosses. • 2 cubes of meat transform the orbital into a meat head which fires blood tears which deal 3.5 damage each. • 3 cubes of meat transform it into a meat boy familiar that walks around and deals 3.5 contact damage per tick to enemies. • 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead. • Any further cubes of meat past 4 will start the cycle again. UNLOCK: Unlock this item by beating Mom for the first time.

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CUBE OF MEAT ItemID: 73 "Gotta meat em all"

question

• Isaac's tears now have a piercing effect which allows them to travel through enemies whilst damaging them.

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CUPID'S ARROW ItemID: 48 "Piercing shots"

question

• Tears are now charged up and fired rapidly in a burst of up to 4 shots at once. • The amount of tears fired in the charge depends on how long you charge for. • The eye has three states, white (not firing), black (first second of charging) and blinking between black and white. If you get hit while __________ is a solid black colour you are guaranteed to be teleported to another random room on the floor. If you get hit in either of the other 2 states you will not be teleported.

answer

CURSED EYE ItemID: 316 "Cursed charged shot"

question

• When used, the D4 re-rolls each item you currently have into another random item from the item room pool. • Each time an item is generated by the D4, it is also removed from the pool. When the pool is empty, it will eventually re-roll all your items into heart containers. • Cannot remove Azazel's Brimstone laser. UNLOCK: Unlock this item by blowing up 30 slot machines.

answer

D4 ItemID: 284 "Reroll into something else"

question

• When used, rerolls all enemies in the room which are currently alive into another random type of enemy from any floor. • Dangerous to use in early floors, it could replace a basement enemy with something usually found in the Womb only. • Cannot reroll mini-bosses or bosses.

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D10 ItemID: 285 "Rerolls enemies"

question

• When used, rerolls each item you currently own into another item room pool item and any pedestal items and pickups in the room. • Has the combined uses of the D4, D6 and D20. UNLOCK: Unlock this item by beating Boss Rush with The Lost.

answer

D100 Special item ItemID: 283 "REEROLLLLL!"

question

• Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup. • This includes hearts, bombs, keys, coins, pills, tarot cards, chests and trinkets. UNLOCK: Unlock this item by beating the Chest with Isaac.

answer

D20 ItemID: 166 "Reroll the basics"

question

• Upon use, any pedestal item (e.g. an item room item) will be re-rolled into another item. UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby.

answer

THE D6 Special item ItemID: 105 "Reroll your destiny"

question

• Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors. • Can be used to open the golden door that appears in the Dark Room or the Chest. UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time.

answer

DAD'S KEY ItemID: 175 "Opens all doors..."

question

• A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp (2 damage ticks at 20 damage each).

answer

DADDY LONGLEGS ItemID: 170 "Daddy's love"

question

• A familiar beggar similar to Bum Friend that follows Isaac and collects red hearts, giving Isaac soul hearts or spiders in return. • Soul hearts are the most common payout with only a small chance to spawn friendly or hostile spiders. • ______ has a small chance to give a black heart instead of a soul heart. • For every 1.5 red hearts he takes, he will give 1 heart/spider in return. • (AFTERBIRTH) One of three Bum items required to create SUPER BUM.

answer

DARK BUM ItemID: 278 "He wants to take your life"

question

• Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac. • +1.0 Damage Up. • Reduced tear size. • The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time. • An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)

answer

DARK MATTER ItemID: 259 "Fear shot"

question

• When Isaac takes damage, the dead bird will spawn and attack nearby enemies in the current room for 2 damage per tick. • Eve starts with this item.

answer

DEAD BIRD ItemID: 117 "Protective buddy"

question

• Isaac's health is set to 1 but he also gets 8 extra lives. • Each time Isaac dies, he will respawn with 1 Health. • Has a chance to drop from the Super Pride mini boss. • The floating ________ head that follows you will disappear when you are on your last life (Very useful for The Lost) • This is one of the items which allows you to transform into Guppy.

answer

DEAD CAT ItemID: 81 "9 lives"

question

• Gives Isaac the ability to fly and spectral tears. • An item only found in the Angel room.

answer

DEAD DOVE ItemID: 185 "Flight + spectral tears"

question

• Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral). • -0.25 Range Down. • -0.4 Shot Speed Down. • -0.5 Tear Height. • Despite the increase in tear size, Dead Onion does NOT increase your damage stat.

answer

DEAD ONION ItemID: 336 "Toxic aura tears"

question

• Upon use, the __________ gives a random spacebar item effect. • An item that can be found in the Angel room.

answer

DEAD SEA SCROLLS ItemID: 124 "It's a mystery"

question

• +1.5 Damage Up. • -0.3 Tears Down. • Isaac's tears turn into large scythes that penetrate through enemies (Similar to how Death's scythes look). UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka).

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DEATH'S TOUCH ItemID: 237 "Penetrative shots + DMG up"

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• Gives Isaac a random tarot card on use.

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DECK OF CARDS ItemID: 85 "Reusable card generator"

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• A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range. UNLOCK: Unlock this item by beating the Dark Room with Azazel.

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DEMON BABY ItemID: 113 "Auto-turret friend"

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• +1 Health Up. (4)

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DESSERT ItemID: 24 "HP up"

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• +1 Health Up. (3)

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DINNER ItemID: 23 "HP up"

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• Gives Isaac an orbiting fly which deals 5 contact damage to enemies per tick. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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DISTANT ADMIRATION ItemID: 57 "Attack fly"

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• A target is placed on the floor which can be controlled. After a few seconds a huge missile hits the target and deals 70 damage to anything nearby. • The damage dealt from this item scales with your damage stat. • Essentially a one-time more powerful use of the Epic Fetus item.

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DOCTOR'S REMOTE ItemID: 47 "Reusable air strike"

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• +99 coins. • Can drop from an exploding slot machine while playing it.

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A DOLLAR ItemID: 18 "$$$"

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• Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby. • Bomb damage = damage * 3. • Tears Down (Tear delay * 2.5). • Poison effects (e.g. Bob's Curse) give Dr. Fetus bombs a flat +50 damage. • Bombs will also synergize with other bomb items and tear modifiers (not including Sad Bombs). UNLOCK: Unlock this item by beating Mom's Heart 9 times.

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DR. FETUS Special item ItemID: 52 "???"

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• A familiar that follows Isaac and blocks any shots that hit it. • If a projectile is blocked by Dry Baby, he has a high chance to activate the Necronomicon effect, dealing 40 damage to the entire room. • The chance to activate the effect is not changed by your Luck stat. • Can drop while destroying skulls in the Depths and Necropolis floors.

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DRY BABY ItemID: 265 "Immortal friend"

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•_____ turns normal enemies into poop if they touch you. • Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage. • Can be combined with Midas Touch to turn enemies into Golden Poop. • This does not work on mini-bosses and bosses.

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E. COLI ItemID: 236 "Turdy Touch"

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• Tears now become missiles which deal huge damage to anything nearby. • Missiles damage = damage * 20. • This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time. UNLOCK: Unlock this item by beating Challenge #19 (The Family Man).

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EPIC FETUS Special item ItemID: 168 "On-demand air strike"

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• x2 Damage Multiplier. • Tears Down by exactly half (Tear delay * 2) • -0.5 Shot Speed Down. • The tears down from this item is a x2.0 multiplier after the formula, meaning it will always halve your tear rate (Unless you have Monstro's Lung or Soy Milk). UNLOCK: Unlock this item by beating Boss Rush with Eve.

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EVE'S MASCARA ItemID: 310 "Shot speed down + DMG up"

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• When picked up, this item will increase or decrease each one of your stats by a random amount. • The flavour text for this item is slightly misleading, it is not an all stats up, however will average out as a slight increase overall. • All 6 stats are affected by this item, including shot speed and luck. • At least one stat is reduced but no more than 3 stats are reduced. • Can kill Blue Baby if it removes health, but not other characters. UNLOCK: Unlock this item by beating Mom's Heart 7 times.

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EXPERIMENTAL TREATMENT ItemID: 240 "All stats up! ... and then shuffled"

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• When Isaac is hit, there is a chance he will drop a pickup (i.e. coin, bomb, key)

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FANNY PACK ItemID: 204 "Filled with goodies"

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• Gives Isaac an eternal heart and the ability to fly. • Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container. UNLOCK: Unlock this item by beating the Chest with Blue Baby.

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FATE ItemID: 179 "Flight eternal"

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• Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick. • There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies. • Exploding tears deal damage * 2 + 22. • The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time.

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FIRE MIND ItemID: 257 "Flaming tears"

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• When used, turns every normal enemy in the room into poop! • Does not work on mini-bosses and bosses. • Kills poop bosses when used.

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FLUSH! ItemID: 291 "..."

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• An orbiting fly which deals 2 contact damage per tick to enemies. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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FOREVER ALONE ItemID: 128 "Attack fly"

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• Upon use, this item refreshes the current floor with brand new rooms, monsters and items. UNLOCK: Unlock this item by beating Satan with Blue Baby.

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FORGET ME NOW ItemID: 127 "I don't remember..."

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• When used Isaac transforms into pacman, which makes him invincible and does 40 contact damage to enemies per chomp. • Every time you 'eat' an enemy, you regain some health. UNLOCK: Unlock this item by visiting 10 arcades.

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THE GAMEKID ItemID: 93 "Temporary Man-Pac"

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• A familiar that is attached to Isaac, which will seek out and damage any enemies close by for 3 contact damage. • One of the twelve zodiac items available in the game.

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GEMINI ItemID: 318 "Conjoined friend"

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• A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage. • Ghost Baby fires tears at a rate of 1 tear per second. • Can drop while destroying skulls in the Depths and Necropolis floors.

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GHOST BABY ItemID: 163 "Spectral buddy"

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• When getting hit, this item has a chance to drop a soul heart or black heart. • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect. • The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time. • Due to a bug, if you have more than 22 luck, Gimpy won't drop any Soul or Black hearts. • Enemies have a chance to drop half a heart when killed.

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GIMPY ItemID: 225 "Sweet suffering"

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• If Isaac stands still for a second, he turns to stone, making him invincible until he moves again. • This item is a reference to the Tanooki suit in Super Mario 3.

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GNAWED LEAF ItemID: 210 "Unbreakable"

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• Gives Isaac a guaranteed devil or angel room on every floor they can appear, even if you have already beaten the boss and it didn't show up originally. • Taking the ______ (or any other item) in a Devil Deal significantly lowers your chance for Angel Rooms in the future.

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GOAT HEAD ItemID: 215 "He accepts your offering"

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• Isaac's tears become homing and have a large aura around them, which will deal a lot of damage to anything inside its radius. • +0.5 Damage Up. • +1.2 Range Up. • -0.3 Tears Down. • -0.3 Shot Speed Down • +0.8 Tear Height. UNLOCK: Unlock this item by beating all bosses and the Boss Rush in Hard Mode with The Lost character.

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GODHEAD Special item ItemID: 331 "God tears"

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• +1.0 Damage Up • +0.4 Speed Up

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GROWTH HORMONES ItemID: 70 "DMG up + speed up"

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• An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals. UNLOCK: Unlock this item by beating Satan with Maggy.

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GUARDIAN ANGEL ItemID: 112 "Extra protection"

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• +1.0 Damage Up. • -1 Tear Delay (Tears Up). • Causes Isaac's head to detach and orbit his body, blocking shots and dealing 7 contact damage per tick. • BFFs will cause the ______ head to do double damage (14 damage per tick) • Tears are still fired from Isaac's head but the hitbox remains around his body. UNLOCK: Unlock this item by beating the Isaac boss with Judas.

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THE GUILLOTINE ItemID: 206 "An out-of-body experience"

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• When Isaac dies, he has a 50% chance to respawn with 1/2 a heart. • This is one of the items which allows you to transform into Guppy.

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GUPPY'S COLLAR ItemID: 212 "Eternal life?"

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• Follows behind Isaac and can be swung back and forth, dealing 3 contact damage per tick to anything it hits. • Every time the ______ kills an enemy, it grows in size allowing it to deal more damage. • This is one of the items which allows you to transform into Guppy. UNLOCK: Unlock this item by collecting 3 Guppy items and transforming into Guppy.

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GUPPY'S HAIRBALL ItemID: 187 "Swing it"

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• When used, spawns between 2-4 blue flies. • This is one of the items which allows you to transform into Guppy. • Blue Flies do 2.0x of Isaac's damage.

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GUPPY'S HEAD ItemID: 145 "Reusable fly hive"

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• When used, removes one heart container and gives you 3 soul hearts. • This is one of the items which allows you to transform into Guppy.

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GUPPY'S PAW ItemID: 133 "Soul converter"

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• When picked up, greatly increases your chance of finding chests at the end of a room, while also reducing your chance to find consumables such as keys and bombs. • This is one of the items which allows you to transform into Guppy.

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GUPPY'S TAIL ItemID: 134 "Cursed?"

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• When you take damage, this item recharges one room's worth of charge to your spacebar item. • For example, with the D6 you would need to take damage 6 times to fully recharge it.

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HABIT ItemID: 156 "Item martyr"

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• +1 Health Up. • +0.3 Damage Up. • +0.2 Tears Up. • +0.25 Range Up. • +0.3 Speed Up. • +0.5 Tear Height. UNLOCK: Unlock this item by killing Mom (Mom's Foot or Mom's Heart) using The Bible.

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THE HALO ItemID: 101 "All stats up"

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• Gives Isaac 2 orbital flies which block enemy shots. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.

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HALO OF FLIES ItemID: 10 "Projectile protection"

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• A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern. • Each of Harlequin Baby's tears deal 4 damage. • Harlequin Baby fires tears at a rate of 1 tear per second.

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HARLEQUIN BABY ItemID: 167 "Double shot buddy"

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• When used, fires a 4 way brimstone laser in all cardinal directions, dealing a lot of damage to any enemies. • Maximum potential damage is 462 (20-21 ticks of 22 damage if the laser makes contact the whole duration) • Laser damage does not scale with your damage stat. • Has a chance to drop after you beat Krampus. • If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal a lot more damage. UNLOCK: Unlock this item by beating Krampus (Krampus is unlocked by taking 20 devil deal items).

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HEAD OF KRAMPUS ItemID: 293 "Krampus rage"

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• A familiar that follows Isaac and leaves blood creep on the floor as it floats, hurting enemies that walk over it.

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HEADLESS BABY ItemID: 269 "Bloody friend"

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• Causes your friendly blue spiders and flies to become bigger and do 2x more damage. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies. • Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5.

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HIVE MIND ItemID: 248 "Giant spiders and flies"

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• +1 Health Up • Gives Isaac the ability to fly.

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HOLY GRAIL ItemID: 184 "Flight + HP up"

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• Each time you enter a new room, damage is negated for the first time you get hit. • Can be used to go in and out of a Curse Room without taking damage.

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HOLY MANTLE ItemID: 313 "Holy shield"

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• When Isaac takes damage, the bottle breaks and leaves a pool on the floor which deals 8 damage per tick to enemies which walk over it.

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HOLY WATER ItemID: 178 "Splash!"

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• +5 Bombs • Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies.

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HOT BOMBS ItemID: 256 "Burning blast +5 bombs"

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• When used, slows down all enemies in the current room and their projectiles for a short period of time.

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THE HOURGLASS ItemID: 66 "Temporary enemy slowdown"

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• When used, makes Isaac leap in the air, similar to the leaper enemies. • Maintains momentum if you are already moving in the same direction. • If you already have an item which gives you flying, this item becomes a dash effect instead. • Can be used in the Isaac boss fight to jump over the beams of light he spawns.

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HOW TO JUMP ItemID: 282 "It's time you learned how"

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• All future pennies, keys, bombs and hearts will drop in pairs. • Does not work for soul hearts, nickels, dimes, cards or pills.

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HUMBLEING BUNDLE ItemID: 203 "1+1 free 4evar!"

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• Puts a shield on Isaac's face making it so he has a high chance to not take damage to projectiles from any direction.

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INFAMY ItemID: 242 "Damage reduction"

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• When Isaac gets hit, a few blue flies will randomly spawn. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies. • Blue Flies do 2.0x of Isaac's damage.

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INFESTATION ItemID: 148 "They grow inside"

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• Creates 1-2 friendly spiders when you kill an enemy. • Spiders are spawned at the location where the enemy died.

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INFESTATION 2 ItemID: 234 "Infestation shot"

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• Tears now shoot three at a time (Triple Shot) • Tears Down significantly (tears = tears * 2.1 + 3).

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THE INNER EYE ItemID: 2 "Triple shot"

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• Isaac's tears are replaced with explosive poison bombs, which will arc upwards and explode on contact with the floor, dealing huge damage and leaving a poison effect on enemies in range. • Ipecac shots are given a flat +40 Damage on top of the normal 3.5 base damage. • Tears Down (Tear delay * 2 + 10). • +13.0 Tear Height. • Shots will damage Isaac if he is in the blast radius when they explode. UNLOCK: Unlock this item by beating Mom's Heart 6 times.

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IPECAC ItemID: 149 "Explosive shots"

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• +0.3 Damage Up. • Tears now have a chance to concuss enemies, causing them to walk around dazed and confused for a short period of time. • The chance to concuss enemies is affected by your luck stat and at +27 Luck it will activate every time.

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IRON BAR ItemID: 201 "Concussive tears"

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• Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. If the heart is hit, Isaac will take damage. • Sharp Plug becomes useless with this item, due to how damage is prevented on Isaac's body. UNLOCK: Unlock this item by beating the Isaac boss with The Lost.

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ISAAC'S HEART ItemID: 276 "Protect it"

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• A spacebar item that fires 8 of Isaac's tears in a circle around him. UNLOCK: Unlock this item by beating the Isaac boss with Isaac.

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ISAAC'S TEARS ItemID: 323 "Collected tears"

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• Upon use, the _____ takes half a red heart and spawns some coins (the same effect as a blood donation machine) • Can drop from a blood donation machine after playing it.

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IV BAG ItemID: 135 "Portable blood bank"

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• Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar. • Up to 4 hearts can be stored in ________. • Soul hearts and black hearts cannot be stored. • If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart.

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THE JAR ItemID: 290 "Save your life"

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• +0.5 Damage Up. • +0.25 Range Up. • +0.5 Tear Height.

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JESUS JUICE ItemID: 197 "Damage + range up"

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• When you die with this item, you respawn in the previous room as Black Judas with 2 black hearts for health. • _____ has a damage multiplier of 2.00 (double Isaac's damage) and an additional +0.1 Speed. • _____ is considered a separate character by the game, however he can be used to unlock Judas' secrets/achievements. UNLOCK: Unlock this item by beating Boss Rush with Judas.

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JUDAS' SHADOW ItemID: 311 "Sweet revenge"

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• A familiar that follows isaac around dropping white creep which slows down enemies that walk over it. • Spawns a familiar blue spider sometimes when you finish a room. • Blue Spiders do 2.5x of Isaac's damage.

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JUICY SACK ItemID: 266 "Sticky babies"

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Causes an explosion near the player which takes away half a heart and does 40 damage all enemies in close proximity.

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KAMIKAZE ItemID: 40 "Become the bomb!"

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• Increases your chances to find an Angel Room instead of a Devil Room. See the dedicated Devil room page for more details. (1) • First half of the key required to enter the door to the Mega Satan boss. • Drops from one of the angels which appear by bombing the statue in an angel room.

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KEY PIECE #1 ItemID: 238 "???"

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• Increases your chances to find an Angel Room instead of a Devil Room. See the dedicated Devil room page for more details. (2) • Second half of the key required to enter the door to the Mega Satan boss. • Drops from one of the angels which appear by bombing the statue in an angel room.

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KEY PIECE #2 ItemID: 239 "???"

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• Allows Isaac to walk over gaps with a width of one tile.

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THE LADDER ItemID: 60 "Building bridges"

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• Gives Isaac an extra life on death, exactly the same as Lazarus' default respawn effect. • When you die with this item, you respawn in the same room with 1 heart and the Anemic item. • The game considers you to be a different character (Lazarus II) when this effect activates. UNLOCK: Unlock this item by beating the Isaac boss with Lazarus.

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LAZARUS' RAGS ItemID: 332 "Eternal life?"

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• Isaac gets a lion's mane and now has the ability to crush rocks by walking over them. • Crushed rocks and poop can fill holes if you walk in their direction. • Allows you to crush Red Poops and sometimes not take damage. However, If you also have flying you will always take damage. • One of the twelve zodiac items available in the game.

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LEO ItemID: 302 "Stompy"

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• +1 Luck Up. • +1 Soul Heart. • Spawns 2 keys on the ground.

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LATCH KEY ItemID: 343 "Luck up"

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• Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one. • The Leech deals 1.5 contact damage per tick.

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LEECH ItemID: 270 "Blood sucker"

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• When used, drops a pool of 'lemonade' on the floor which damages any enemies that come into contact with it for 8 damage per tick.

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LEMON MISHAP ItemID: 56 "Oops..."

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• Gives you 6 keys, 6 bombs and 6 coins. • Balances out your stats to bring the high and low stats closer to an average value. • All future stat upgrading items will now instead spread out across all other stats. For example, an item which usually gives +1 Damage would instead give a small 'all stats up'. • Stats effected by this item are: Damage, Tears, Range, Speed. • When taken with another item which gives an extreme value in a certain stat (e.g. Soy Milk) can lead to interesting synergies. • One of the twelve zodiac items available in the game.

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LIBRA ItemID: 304 "You feel balanced"

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• A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage. • A fully charged laser deals 31.5 damage. • A familiar found in the devil room.

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LIL' BRIMSTONE Special item ItemID: 275 "Evil friend"

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• A familiar ghost that follows Isaac around and chases enemies close-by, damaging them for 2 contact damage and causing a fear effect.

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LIL' HAUNT ItemID: 277 "Fear him"

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• Allows for 2 pills to be held. • Drops a pill on the floor when picked up. • All future tarot card drops will now instead become pill drops. UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball.

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LITTLE BAGGY ItemID: 252 "Extra pill room"

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• A familiar which follows Isaac and drops half a red heart every 3 rooms. UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D.

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LITTLE C.H.A.D. ItemID: 96 "Gives kisses"

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• A familiar that follows Isaac and charges forwards, dealing 3.5 damage per tick to any enemies it comes into contact with. UNLOCK: Unlock this item by beating the Caves II for the first time.

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LITTLE CHUBBY ItemID: 88 "Attack buddy"

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• A familiar that follows Isaac and fires black tar tears, which slow enemy movement and projectile speed for a few seconds. • ________ tears do 3.5 damage. • ________ fires tears at a rate of 1 tear per second. • A Guaranteed drop from the ___ boss fight. UNLOCK: Unlock this item by beating the Depths 20 times and killing the Gish boss.

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LITTLE GISH ItemID: 99 "Sticky friend"

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• A familiar that follows Isaac and fires homing tears that deal 3.5 damage each. • Has a high chance to drop from the _____ boss fight. • __________ fires tears at a rate of 1 tear per second with a slightly longer range than other familiars. UNLOCK: Unlock this item by killing the Steven boss for the first time.

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LITTLE STEVEN ItemID: 100 "Psychic friend"

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• Every Time you fire a tear, there is a chance that you will also fire three more tears in all cardinal directions. • The chance to fire 4-way tears is affected by your luck stat and at +7 Luck it will activate every time. UNLOCK: Unlock this item by beating Lokii for the first time.

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LOKI'S HORNS ItemID: 87 "Cross tears"

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• Gives Isaac demon wings and the ability to fly. • +0.3 Speed Up (Only applied after the speed stat is next updated).

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LORD OF THE PIT ItemID: 82 "Demon wings"

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• All of Isaac's tears now have a shield, allowing them to block an enemy projectile. • If a tear blocks something, both Isaac's and the enemies tears are destroyed. • -0.15 Shot Speed Down.

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LOST CONTACT ItemID: 213 "Shielded tears"

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• +1.0 Luck Up. • Better chance to win while gambling. • Does not make all pills positive or neutral like the original game.

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LUCKY FOOT ItemID: 46 "Luck up"

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• You no longer shoot tears and instead now control a single large tear with the arrow keys. • Items which increase your tears stat will cause the tear to deal damage at a faster rate. • Items which increase your shot speed cause the tear to travel faster across the screen. • _____ and Brimstone create a large controllable red ring of death that does massive damage to anything in its path. • Taking this with Mom's Knife allows you to remote control the knife around the room, dealing huge damage.

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THE LUDOVICO TECHNIQUE Special item ItemID: 329 "Controlled tears"

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• Tears gain a damage up and increase in size based on the distance they travel. • The length of a normal room roughly gives +6 damage, but this can be higher with double rooms or Tiny Planet.

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A LUMP OF COAL ItemID: 132 "My Xmas present"

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• +1 Health Up. (2)

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LUNCH ItemID: 22 "HP up"

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• +1 Health Up. • All future red hearts now heal for double. Half hearts heal a whole heart and full hearts heal 2 red hearts. UNLOCK: Unlock this item by beating Boss Rush with Maggy.

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MAGGY'S BOW ItemID: 312 "HP up + you feel healthy"

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• +0.16 Shot Speed Up. • Gives Isaac a random tarot card when picked up.

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MAGIC 8 BALL ItemID: 194 "Shot speed up"

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• Upon use, consumes a coin and deals damage to everything in the room. • Damage dealt is equal to your tear damage * 2.

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MAGIC FINGERS ItemID: 295 "Pay to play"

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• +1 Health Up. • +0.3 Damage Up. • +50% / 1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr+Book of Belial. • +5.25 Range Up. • +0.3 Speed Up. • +0.5 Tear Height. • Isaac grows in size. • Similar to the original game, the Magic Mushroom does not give a tears up despite saying 'All Stats Up'. • Fully restores all red heart containers. • Can be dropped when exploding mushrooms in the Caves/Catacombs.

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MAGIC MUSHROOM ItemID: 12 "All stats up!"

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• +1 Health Up. • +1.0 Luck Up.

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MAGIC SCAB ItemID: 253 "HP + luck up"

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• Causes pickups on the floor move towards the player.

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MAGNETO ItemID: 53 "Item snatcher"

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• +1.0 Damage Up. • +0.2 Speed Up. • +1 Soul Heart.

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THE MARK ItemID: 79 "DMG up"

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• +1 Black Heart • +3 Bombs • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

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MATCH BOOK ItemID: 344 "Evil up"

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• +1 Health Up. • +0.3 Damage Up.

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MEAT! ItemID: 193 "DMG + HP up"

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• Isaac's touch now petrifies enemies, turning them to gold for a few seconds. • If an enemy is killed while it is golden, it will drop between 1-4 coins. • Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding.

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MIDAS TOUCH ItemID: 202 "Golden touch"

question

• Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms. UNLOCK: Unlock this item by beating Satan with The Lost.

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THE MIND ItemID: 333 "I know all"

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• +0.3 Speed Up • Decreases range stat by -4.25 but increases your tear height by 1.5, increasing your actual tear range. • Causes Isaac to shrink in size. • Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms.

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MINI MUSH ItemID: 71 "Speed + range up"

question

• At the start of each floor this item rerolls all your current items, giving you a new item to over-ride each of the one you had. • A reference to the infamous 'Missingno' glitch from Pokemon. UNLOCK: Unlock this item by beating Boss Rush with Lazarus.

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MISSING NO. ItemID: 258 "Syntax error"

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• +1 Black Heart. • Upon taking damage, if the total sum of Isaac's red hearts + soul hearts is under one and a half hearts, the necronomicon effect will activate, dealing 40 damage to the entire room. • When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.

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MISSING PAGE 2 ItemID: 262 "Evil up + your enemies will pay"

question

• Gives Isaac a much higher chance to find soul hearts

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MITRE ItemID: 173 "You feel blessed"

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• When used, gives Isaac a random pill.

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MOM'S BOTTLE OF PILLS ItemID: 102 "Reusable pill generator"

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• When used, freezes all enemies in the current room temporarily.

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MOM'S BRA ItemID: 39 "Mass fear"

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• Drops 4 random pills on the floor around Isaac.

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MOM'S COIN PURSE ItemID: 195 "What's all this...?"

question

• Tears now have a random chance to freeze enemies in place. • The chance to freeze enemies is affected by your luck stat. • +0.25 Range Up. (Only applied after the range stat is next updated) • +0.5 Tear Height. (Only applied after the height stat is next updated) UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough.

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MOM'S CONTACTS ItemID: 110 "Freeze effect"

question

• Isaac has a random chance to fire another tear out the back of his head. • The chance to fire the second tear can improve based on your luck stat and will always activate at +2 Luck. • Synergizes very well with a lot of items. If used with Brimstone you have a 100% chance to fire a laser out the back of your head.

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MOM'S EYE ItemID: 55 "Eye in the back of your head"

question

• Tears have a random chance to charm enemies. • Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac. • The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time.

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MOM'S EYESHADOW ItemID: 200 "Charm tears"

question

• +5.25 Range Up • +0.5 Tear Height.

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MOM'S HEELS ItemID: 30 "Range up"

question

• +2 Keys • Higher chance to get more consumable drops from chests.

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MOM'S KEY ItemID: 199 "Less is more now +2 keys"

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• Tears are replaced with a knife which can be charged and thrown in a boomerang style action. • The knife can also do damage without being thrown as a close range melee weapon. • When used as a melee weapon, Mom's Knife deals your tear damage * 2 per tick. UNLOCK: Unlock this item by beating Satan with Isaac.

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MOM'S KNIFE Special item ItemID: 114 "Stab stab stab"

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• +5.25 Range Up • +0.5 Tear Height.

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MOM'S LIPSTICK ItemID: 31 "Range up"

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• When used, causes all enemies in the current room to run away from Isaac in fear for a few seconds.

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MOM'S PAD: ItemID: 41 "Gross..."

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• -1 Tear Delay (Tears Up). • Isaac's tears have a 15% chance of causing a fear effect. • Feared enemies will run away from Isaac temporarily. • The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time.

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MOM'S PERFUME: ItemID: 228 "Fear shot"

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• Isaac can now hold two trinkets at the same time • Allows you to pick up more trinkets while also holding The Tick

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MOM'S PURSE ItemID: 139 "More trinket room"

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• Isaac now has a chance to create friendly attack spiders every time he fires a tear. • Can create up to a maximum of 5 spiders in the room at one time. • The Hive Mind item allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5. • The chance to create a spider is affected by your luck stat and at +10 Luck it will activate every time. • Heals you for 1 red heart when picked up.

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MOM'S WIG ItemID: 217 "You feel itchy"

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• +5.25 Range Up • +0.5 Tear Height.

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MOM'S UNDERWEAR ItemID: 29 "Range Up"

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• +0.04 Damage Up for every coin you currently have. • At 99 coins this item gives +3.96 Damage Up.

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MONEY = POWER ItemID: 109 "$$$ = DMG"

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• A familiar that will follow Isaac and copy the effect of one of your other familiars. • If you don't have any other familiars, he will just shoot normal tears.

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MONGO BABY ItemID: 322 "Mongo friend"

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• When used, gives a random familiar for the rest of the room.

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MONSTER MANUAL ItemID: 123 "Temporary buddy generator"

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• Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack.

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MONSTRO'S LUNG ItemID: 229 "Charged attack"

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• When used, spawns a Monstro which will jump on a random enemy in the room, dealing 120 damage. UNLOCK: Unlock this item by beating the Basement II for the first time.

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MONSTRO'S TOOTH ItemID: 86 "Summon monstro"

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• Drops a large bomb below the player which does 110 damage. • Has a chance to drop from the Wrath miniboss fight.

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MR. BOOM ItemID: 37 "Reusable bomb buddy"

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• +5 Bombs • Bombs now do 110 damage (+60, up from 50) and have a larger blast radius. • Can be found in the secret room. • Has a chance to drop from the Super Wrath miniboss fight. UNLOCK: Unlock this item by destroying 10 tinted rocks.

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MR. MEGA ItemID: 106 "Blast damage"

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• Isaac has a 1/6 chance to spawn a blue fly when one of his tears hits an enemy. • Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies. • Blue Flies do 2.0x of Isaac's damage. • The chance to activate this effect is not changed with your Luck stat.

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THE MULLIGAN ItemID: 151 "They grow inside"

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• Tears now shoot 4 at a time (Quad Shot) • Tears Down significantly (Tear delay * 2.1 + 3).

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MUTANT SPIDER Special item ItemID: 153 "Quad Shot"

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• Gives Isaac temporary invincibility and allows him to do 40 contact damage to enemies per hit.

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MY LITTLE UNICORN ItemID: 77 "Temporary badass"

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• Gives tears a boomerang effect. • +1.5 Range Up. • +0.6 Shot Speed Up. • +1 Tear Height.

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MY REFLECTION ItemID: 5 "Boomerang tears"

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• When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies.

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MY REFLECTION ItemID: 5 "Boomerang tears"

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• When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies.

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MYSTERIOUS LIQUID ItemID: 317 "Toxic splash damage"

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A bag that follows Isaac and drops a random pickup every few rooms (Fixed in patch v1.04). • Can drop any kind of heart, coin, bomb or key. UNLOCK: Unlock this item by beating the Dark Room with Eden.

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MYSTERY SACK ItemID: 271 "?"

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• +0.7 Damage Up. • -0.18 Speed Down. • +1 Soul Heart • Gives you the ability to crush rocks by walking over them. • All the above effects are only active when the item is used. UNLOCK: Unlock this item by beating the Boss Rush with Azazel.

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THE NAIL ItemID: 83 "Temporary demon form"

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• Deals 40 damage to everything in the room when used. UNLOCK: Unlock this item by using 4 Death Cards.

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THE NECRONOMICON ItemID: 35 "Mass room damage"

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• Damages all enemies in the room for 40 damage when hit down to 1/2 heart remaining. • Gives you access to the Dark Room floor. • When unlocked, is guaranteed to drop after the Mom's Foot boss fight. UNLOCK: Unlock this item by beating Satan in Sheol 5 times.

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THE NEGATIVE ItemID: 328 "Fate chosen"

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• Each charge of this item allows Isaac to break all rocks, pots and secret room doors in the current room. • Cannot break the stone blocks which appear in the environment. • If Isaac is damaged while the effect is active, it will deactivate.

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NOTCHED AXE ItemID: 147 "Rocks didn't stand a chance"

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• Gives you a very high tear rate in exchange for a big range down. • +1.5 Tears Up. • -15.78 Range Down. • +0.45 Tear Height.

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NUMBER ONE ItemID: 6 "Tears up"

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• +1 Health Up. • +0.3 Damage Up. • +0.25 Range Up. • -0.1 Speed Down. • +0.5 Tear Height.

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ODD MUSHROOM (THICK) ItemID: 121 "DMG up"

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• Gives you a high rate of fire in exchange for a damage down. • +1.7 Tears Up. • +0.3 Speed Up. • Damage Down (damage * 0.9 - 0.4).

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ODD MUSHROOM (THIN) ItemID: 120 "Fire rate up"

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• +1 Health Up. • The given heart container is empty. • When you get hit, you will sometimes cause hearts to drop on the floor.

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OLD BANDAGE ItemID: 219 "HP up"

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• Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).

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OUIJA BOARD ItemID: 115 "Spectral tears"

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• +0.5 Damage Up. • +0.7 Tears Up. • +2 Soul Hearts.

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THE PACT ItemID: 80 "DMG + tears up"

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• Spawns 7 random coins around Isaac on the floor. • Isaac wears a pink crown on his head.

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PAGEANT BOY ItemID: 141 "Ultimate grand supreme"

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• When used, this item will spawn a set of items or consumables based on which floor you are currently on. • Basement 1: 2 Soul hearts. Basement 2: 2 Bombs + 2 Keys. • Caves 1: 1 Boss Item. Caves 2: 1 Boss Item + 2 Soul Hearts. • Depths 1: 4 Soul hearts. Depths 2: 20 coins. • Womb 1: 2 Boss Items. Womb 2: Bible. • Sheol: 1 Devil Room Item + 1 Black Heart. Cathedral: 1 Angel Room Item + 1 Eternal Heart. • Chest: 1 coin. Dark Room: Nothing! • Pandora's Box considers XL floors to always be the first floor of a chapter. • This item disappears when used (One time use). UNLOCK: Unlock this item by beating the Dark Room with Lazarus.

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PANDORA'S BOX ItemID: 297 "? ?"

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• Isaac's tears now split into two upon contact with enemies or the environment. • Tears that split off from the main tear do less damage (tear damage * 0.25). UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head.

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THE PARASITE ItemID: 104 "Split shot"

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• Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies.

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THE PEEPER ItemID: 155 "Plop!"

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• +1.0 Damage Up. • Higher chance of a Devil Deal opening after the boss fight (Approximately +20% through testing).

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PENTAGRAM ItemID: 51 "DMG up"

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• All pills now have a positive or neutral effect. • Pills are identified before using them. • Drops one pill on pickup. • Heals for 2 full red hearts.

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PHD ItemID: 75 "Better pills"

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• +3 Coins when picked up. • When you take damage, 1 or 2 coins will drop on the floor.

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PIGGY BANK ItemID: 227 "My life savings"

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• -1 Tear Delay (Tears Up). • Tears now have a knockback effect, which pushes enemies backwards. • One of the twelve zodiac items available in the game.

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PISCES ItemID: 309 "Tears up + knockback shot"

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• +1 Health Up. • Gives the player health regeneration over time.

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PLACENTA ItemID: 218 "HP up + regen"

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• Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick.

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PINKING SHEARS ItemID: 107 "Cut and run"

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• Gives Isaac an invincibility shield for a few seconds when hit down to 1/2 heart remaining. • Gives you access to the Chest floor. • When unlocked, is guaranteed to drop after the Mom's Foot boss fight. UNLOCK: Unlock this item by beating Isaac in the Cathedral 5 times.

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THE POLAROID ItemID: 327 "Fate chosen"

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• High Damage Up - 2 * (damage + 4). • Tears Down significantly (Tear delay * 2.1 + 3). • If a tear kills an enemy, it continues to travel forward with the leftover damage.

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POLYPHEMUS Special item ItemID: 169 "Mega tears"

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• Allows Isaac to fly while the Pony is held. • Sets your speed stat to 1.5 if it isn't already that high. • When the active attack is used, Isaac will dash across the screen dealing 40 contact damage to anything he hits. • Drops from the Headless Horseman boss fight.

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A PONY ItemID: 130 "Flight + dash attack"

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• Drops a poop on the floor. • Blue Baby starts with this item. • Can be placed next to a pit and exploded to make a bridge. • Can be placed over a broken red poop to overwrite it, causing it to no longer regenerate.

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THE POOP ItemID: 36 "Plop!"

Binding Of Isaac Rebirth Items, Stats, and Effects – Flashcards

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