A&P Chapter 3 – Flashcards
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are the building blocks for all living things
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cells
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are the smallest units that perform all vital physiological functions
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cells
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at higher levels (e.g tissues, organs, and body) reflects combined, coordinated action of many cells
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homeostasis
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each cell acts __________________ in response to its environment to maintain homeostasis
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individually
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Cells come in a variety of sizes and shapes. Some cells in the human body are over (__) feet long
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3
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An average cell is only about (___) µm (0.1 mm) in diameter.
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100
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(___)% of cells are not human cells in the body, they are mainly bacteria
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90
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have half of the DNA that somatic cells have
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sex cells
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largest cell in the body (can be seen with the naked eye)
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oocyte
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tend to be rounded and spherical
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blood cells
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tend to have a jagged shape
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bone cells
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- Basic unit of life - Protection and support through production and secretion of various kinds of molecules - Movement. Various kinds occur because of specialized proteins produced in the cell - Communication. Cells produce and receive electrical and chemical signals - Cell metabolism and energy release - Inheritance. Each cell contains DNA. Some cells are specialized to gametes for exchange during sexual intercourse
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functions of the cell
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the study of the structure and function of cells
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Cytology
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is a phospholipid bilayer that also contains cholesterol, proteins, lipids and carbohydrates that is selectively permeable and determines what is inside/outside of the cell fatty acids point towards each other phosphoralated ends away from each other (cell membrane between the fatty acids)
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cell membrane
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1. A cell is the basic structural and functional unit of living organisms. 2. The activity of an organism depends on both the individual and combined activities of itself. 3. The biochemical activities of cells are dictated by their shapes or forms, and by the relative number of the subcellular structures they contain. 4. Cells can only arise from other cells.
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cell theory
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a cells __________ reflects its function
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shape
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the outer boundary of the cell which acts as a selectively permeable barrier
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plasma membrane
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the cellular material between the plasma membrane and the nucleus, is the cite of most cellular activities
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cytoplasm
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the metabolic machinery of the cell
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organelles
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an organelle that controls cellular activities (near the center of the cell)
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nucleus
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substances contributing to body mass that are found outside the cells
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extracellular materials
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include interstitial fluid, blood plasma, and cerebrospinal fluid; are important transport and dissolving media
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body fluids (extracellular fluids)
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include substances that aid in digestion and some act as lubricants
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cellular secretions
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the most abundant extracellular material; mesh in the extracellular space called the "cell glue"
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extracellular matrix
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separates 2 of the body's major fluid compartments - the intracellular fluid within cells and the extracellular fluid
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plasma membrane
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This is constructed largely of phospholipids, with smaller amounts of glycolipids and cholesterol that forms the basic "fabric" of the plasma membrane
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lipid bilayer
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having a tendency to mix with, dissolve in, or be wetted by water
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hydrophilic
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tending to repel or fail to mix with water
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hydrophobic
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lipids with attached sugar groups
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glycolipid
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make up about half of the plasma membrane by mass and are responsible for most of the specialized membrane functions
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proteins
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tightly attached to membrane (may span the whole cell membrane)
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integral proteins
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transmembrane proteins are receptors for hormones or other chemical messengers and relay messages to the cell interior, a process called ____________ ___________
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signal transduction
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some transmembrane proteins are involved in transport, and cluster together to form _________, or pores
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channels
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speed up chemical reaction
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enzymes
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rarer, easily dissociate from membrane
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peripheral proteins
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consists of glycoproteins and glycolipids that form a fuzzy, sticky, carbohydrate-rich area at the cell surface
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glycocalax
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because every cell type has different sugar patterns in the glycocalx, it provides highly __________ biological markers by which approaching cells recognize each other
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specific
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in the glycocalyx act as an adhesive for cell binding
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glycoproteins
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_______ _________ of the cell membranes of adjacent cells fit together in a tongue-and-groove fashion to create cell binding
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wavy contours
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a series of integral protein molecules in the plasma membranes of adjacent cells fuse together, forming an impermeable junction that encircles the cell
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tight junction
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help prevent molecules from passing through the extracellular space between adjacent cells (seals around the cells)
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tight junctions
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serve as anchoring junctions - mechanical couplings scattered like rivets along the sides of adjacent cells to prevent their separation (like velcro)
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desmosomes
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communicating junctions that allow ions and small molecules to pass are particularly important for communication in heart cells and embryonic cells (cells connected by hollow cylinders called connexons)
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gap junctions
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substances cross the membrane without any energy input from the cell
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passive process
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the cell provides the metabolic energy (usually ATP) needed to move substances across the membrane
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active process
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is the tendency of molecules or ions to move from an area of higher concentration to an area where they are lower in concentration
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diffusion
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the __________ the difference in concentration of diffusing molecules and ions in the process of diffusion, the faster these particles difuse
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greater
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the driving force for diffusion
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kinetic energy
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the _________ of diffusion is influenced by molecular size and by temperature (smaller-faster, warmer-faster)
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speed
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the plasma membrane is ____________ __________, it allows some substances to pass while excluding others
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selectively permeable
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the unassisted diffusion of lipid-soluble or very small particles
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simle diffusion
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the transported substance either binds to protein carriers in the membrane and is ferried across or moves through water-filled protein channels
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facilitated diffusion
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are transmembrane proteins that transport substances, usually ions or water, through aqueous channels from one side of the membrane to the other
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channels
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are always open and simply allow ions or water to move according the concentration gradients
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leakage channels
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are controlled usually by chemical or electrical signals
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gated channels
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the diffusion of a solvent, such as water, through a selectively permeable membrane
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osmosis
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water-specific channels constructed by transmembrane proteins, which allow single file diffusion of water molecules
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aquaporins
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occurs whenever the water concentration differs on the two sides of a membrane
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osmosis
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the total concentration of all solute particles in a solution
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osmolarity
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is reached when the water concentration on both sides of the membrane are the same
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equilibrium
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refers to the ability of a solution to change the shape or tone of cells by altering the cells' internal water volume
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tonicity
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no net gain or loss of water (cell volume doesn't change)
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isotonic
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net water flow out of cell (cell shrinks) crenation
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hypertonic
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net gain of water into cell (cell swells) Hemolysis
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hypotonic
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move solutes against a concentration gradient
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active transporters (solute pumps)
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in primary transport, the energy to do work comes directly from hydrolysis of ________
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ATP
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use potential energy to move something in/out of a cell (coupled systems; they move more than one substance at a time) ex. sling shot
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secondary active transport
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the two transported substancess move in the same direction
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symport system
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the transported substances cross the membrane in opposite directions
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antiport system
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fluids containing large particles and macromolecules are transported across cellular membranes inside bubble-like, membranous sacs called vessicles
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vesicular transport
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moves substances into the cell
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endocytosis
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moves substances out of the cell
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exocytosis
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moving substances into, across, and then out of the cell
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transcytosis
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moving substances from one area in the cell to another
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vesicular trafficking
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the cell engulfs some relatively large or solid material, such as a clump of bacteria, cell debris, or inanimate particles and digests whatever it is
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phagocytosis
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these cells help protect the body by ingesting and disposing of bacteria, other foreign substances, and dead tissue cells
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phagocytes
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a bit of infolding plasma membrane surrounds a very small volume of extracellular fluid containing dissolved molecules
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pinocytosis
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allows cells to concentrate material that is present only in small amounts in the extracellular fluid
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receptor-mediated endocytosis
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the resting membrane potential is determined mainly by the concentration gradient of ______________ and by the differential permeability of the plasma membrane to K+ and other ions
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potassium
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are found on almost every cell in the body and play key roles in embryonic development and wound repair and in immunity (bind with other cells)
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cell adhesion molecules
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huge and diverse group of integral proteins and glycoproteins that serve as binding sites
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membrane receptors
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cells come together and touch, is the means by which cells recognize one another
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contact signaling
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chemicals that bind specifically to plasma membrane receptors
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ligands
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is the viscous, semitransparent fluid in which the other cytoplasmic elements are suspended (just the fluid)
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cytosol
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site of ATP synthesis, powerhouse of the cell (converts energy from food to ATP) REQUIRES OXYGEN
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mitochondria
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the sites of protein synthesis
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ribosomes
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ribosomes that make soluble proteins that function in the cytosol, as well as those imported into the mitochondria and other organelles (float freely in the cytosol)
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free ribosomes
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are ribosomes that are attached to membranes, forming a complex called the rough endoplasmic reticulum they synthesize proteins destined either for incorporation into cell membranes or lysosomes, or for export from the cell
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membrane-bound ribosomes
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Is externally studded with ribosomes. Sugar groups are attached to proteins within the cisterns. Proteins are bound in vesicles for transport to the golgi apparatus and other sites. The external face synthesizes phospholipids.
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rough endoplasmic reticulum
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site or lipid and steroid synthesis, lipid metabolism, and drug detoxification
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smooth endoplasmic reticulum
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packages, modifies, and segregates proteins for secretion from the cell, inclusion in lysosomes, and incorporation into the plasma membrane
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golgi apparatus
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are spherical membranous organelles containing activated digestive enzymes (acidic)
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lysosomes
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are projections formed by centrioles, but are substantially longer than cilia that propel the cell itself (only form is sperm in the human body)
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flagella
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increase surface area of the cell for absorption
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microvilli
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a double membrane barrier separated by a fluid filled space that separates the nucleoplasm from the cytoplasm and regulates passage of substances to and from the nucleus
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nuclear envelope
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where the ribosomal subunits are assembled
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nucleoli
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are composed of the protein actin, the smallest cytoskeleton element, form the terminal web, anchor integral proteins to the cytoskeleton, and interact with myosin to cause cell movement
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microfilaments
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the period from cell formation to cell division
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interphase
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act as a lubricant for cells
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carbohydrates
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telling the world what the cell is
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recognition proteins
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bind and transport ions and molecules across the membrane, including ATPases
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Carrier proteins
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may be involved in cell recognition (immunity, cancer protection, and transplant compatibility), lubrication, protection, adhesion, and locomotion
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glycocalyx
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Differences of concentrations of a substance is known as the ________ ________
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concentration gradient
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continues until concentration gradient is eliminated
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net diffusion
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force of water movement into a solution
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Osmotic pressure
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is similar to osmotic pressure but is caused by large molecules such as proteins
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Oncotic pressure
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pressure of water pushing on the membrane itself
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Hydrostatic pressure
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Which of the following is the main component of the cell membrane? phospholipids water carbohydrates cholesterol
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phospholipids
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Which of the following is a characteristic of the cell membrane? not permeable impermeable fully permeable semipermeable
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semipermeable
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Which of the following is not a major function of proteins in the cell membrane? forming the entire glycocalyx forming channels acting as receptors anchoring cells to other structures
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forming the entire glycocalyx
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What part of a cell membrane is usually in contact with the interstitial fluid?
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phosphate heads of phospholipids
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Which of the following best explains diffusion? movement of molecules farther away from equilibrium movement of molecules from an area of high concentration to an area of low concentration exchange of nonpolar molecules for polar molecules movement of molecules from where there are fewer of them to where there are more
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movement of molecules from an area of high concentration to an area of low concentration
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Which of the following is most likely to move through the cell membrane by facilitated diffusion? CO2 Na+ small lipids O2
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Na+
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What is the basic difference between simple diffusion and facilitated diffusion across a cell membrane? In simple diffusion, molecules move down the concentration gradient but in facilitated diffusion molecules move up the concentration gradient. Simple diffusion requires molecules to move through special doorways in the cell membrane. Simple diffusion is passive but facilitated diffusion is an active process that uses energy. In facilitated diffusion, molecules only move with the aid of a protein in the membrane.
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In facilitated diffusion, molecules only move with the aid of a protein in the membrane.
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Which of the following is least likely to increase the rate of diffusion? small molecule size small concentration gradient higher concentration of molecules high temperature
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small concentration gradient
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Which of the following is not required for osmosis to occur? selectively permeable membrane cellular energy water concentration gradient
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cellular energy
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Which of the following solutions contains the most solute? hypertonic hypotonic equilibrium isotonic
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hypertonic
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In general, to maintain homeostasis the relationship between our intracellular and extracellular fluids should be which of the following? intracellular should be hypertonic to extracellular isotonic to each other intracellular and extracellular should both be hypertonic intracellular should be hypotonic to extracellular
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isotonic to each other
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If a person is severely dehydrated, their extracellular fluids will become hypertonic to the intracellular fluid. What do you predict will happen to the person's cells? The cells will swell. Extracellular fluids do not impact cell size, because cells contain intracellular fluid. The cells will rupture. The cells will lose water and shrink.
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The cells will lose water and shrink.
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Active processes:
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Primary and Secondary active transport Endocytosis Exocytosis
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Passive Processes:
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Simple Diffusion, osmosis, facilitated diffusion
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Which of the following is characteristic of cilia? They are whiplike, motile cellular extensions that occur in large numbers on the exposed surfaces of certain cells. They move substances in many directions across a cell's surfaces. They are substantially longer than flagella, and are less common than flagella in humans. They are used for cellular adhesion.
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They are whiplike, motile cellular extensions that occur in large numbers on the exposed surfaces of certain cells.
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What is a membrane potential? cooperation between cells the possibility of cell activity a voltage or electrical charge across the plasma membrane the ability of the cells to perform their specialized functions
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a voltage or electrical charge across the plasma membrane
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Drinking alcohol makes the blood hypertonic. Which option best describes the consequences of this hypertonic blood? Hypertonic blood draws water out of the interstitial fluid, which makes the interstitial fluid hypotonic. This, in turn, makes the interstitial fluid lose water to the cells. Hypertonic blood draws water out of the interstitial fluid, which makes the interstitial fluid hypertonic. This, in turn, draws water out of the cells. Hypertonic blood forces water into the interstitial fluid, which makes the interstitial fluid hypotonic. This, in turn, makes the interstitial fluid lose water to the cells. Hypertonic blood will lose water to the interstitial fluid, which makes the interstitial fluid hypertonic. This, in turn, causes water to move into the cell.
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Hypertonic blood draws water out of the interstitial fluid, which makes the interstitial fluid hypertonic. This, in turn, draws water out of the cells.
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Assume that Na+ is being transported across a membrane via facilitated diffusion. Which of the following conditions would allow for the most transport of Na+ across that membrane? a gradient of more than 50% difference between sides for the Na+ and Na+ diffusing toward K+ a gradient of less than 5% difference between sides for the Na+ and Na+ diffusing toward Cl− a gradient of less than 5% difference between sides for the Na+ and Na+ diffusing toward K+ a gradient of more than 50% difference between sides for the Na+ and Na+ diffusing toward Cl−
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a gradient of more than 50% difference between sides for the Na+ and Na+ diffusing toward Cl−
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How do unsaturated phospholipid fatty acid tails affect plasma membrane fluidity? Less unsaturated fatty acids means less tightly packed phospholipids, resulting in less membrane fluidity. Less unsaturated fatty acids means more tightly packed phospholipids, resulting in greater membrane fluidity. More unsaturated fatty acids means less tightly packed phospholipids, resulting in greater membrane fluidity. More unsaturated fatty acids means more tightly packed phospholipids, resulting in less membrane fluidity.
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More unsaturated fatty acids means less tightly packed phospholipids, resulting in greater membrane fluidity.
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Which of the following molecules might change over time in a cancer cell? membrane glycolipids membrane glycoproteins glycocalyx sugars all of the above
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all of the above
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What is the difference between active and passive transport across the plasma membrane? Active transport is used to move substances down their concentration gradient, whereas passive transport is used to move substances against their concentration gradient. Active transport implies that the cell is working with other cells, whereas passive transport implies that the cell does not cooperate with other cells. Active transport means that the cell is actively going after substances that it wants to bring into the cell, whereas passive transport means that the cell just waits for the substance to cross the membrane. Active transport is ATP dependent, whereas passive transport uses only the kinetic energy of the particles for movement across the plasma membrane.
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Active transport is ATP dependent, whereas passive transport uses only the kinetic energy of the particles for movement across the plasma membrane.
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binding and transporting specific ions by integral proteins
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carrier mediated transport
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Compounds to be transported bind to a receptor site on a carrier protein
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facilitated diffusion
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rate of transport limited to number of available carrier proteins
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saturation
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if a cell is moving against a concentration gradient _____ is required (active transport)
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energy
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moves sodium out of the cell and potassium into the cell
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Ion pumps
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high concentration of _____ outside of the cell
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sodium
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much more concentrated inside the cell than outside of the cell and create potential difference (more negative on the inside of the cell than the outside)
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proteins
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cells have a _______ potential inside compared to outside of the cell
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negative
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loose 3 sodium ions and pick up 2 potassium ions
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sodium ion pump
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solutes travel in the same direction
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symport
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solutes travel in opposite directions
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antiport
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receptor binds to a substance that triggers endocytosis
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receptor mediated endocytosis
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provides strength and flexibility to the cell
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cytoskeleton
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are tough, insoluble protein fibers that resemble woven ropes (strong)
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intermediate filaments
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Are only present in muscle cells. They are large bundles of myosin and are involved with contraction.
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thick filaments
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Are largest cytoskeletal elements in most cells and are made of tubulin and are the major component of centrioles and cilia Involved in transporting proteins and other molecules away from the center of the cell body. During cell division they make up the spindle apparatus
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microtubules
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contains DNA, RNA, proteins (enzymes and structural proteins) contains everything within the nucleus (similar to cytoplasm)
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Nucleoplasm
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the nucleus communicates with cytoplasm through ____ _____
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nuclear pores
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a supportive nuclear matrix of the nucleus
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lamins
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attachment site for the chromatids
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centromere
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loose strands of DNA plus the proteins they interact with
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Chromatin
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____ pairs of chromosomes
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23
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what DNA is wrapped around
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histone
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forms cisternae
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endoplasmic reticulum
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Proteins formed in the RER are packed and sent to ______ ______ for further processing
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golgi apparatus
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3 Types of Vesicles - Secretory vesicles for discharge by exocytosis - Membrane renewal vesicles - contain new membrane components - Packages lysosomes
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Golgi apparatus
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receiving side of the golgi apparatus
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cis face
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shipping side of the golgi apparatus
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transface
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Responsible for autolysis of injured cells
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lysosomes
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Carry enzymes that neutralize toxins, break down lipids
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Peroxisomes
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Consists of several large proteins Remove and break down damaged or abnormal proteins
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Proteasomes
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fluid contents of mitochondria
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matrix
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folds in inner membrane of the mitochondria
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cristae
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mitochondria has _____ used to make certain proteins
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DNA
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only present in cells that are capable of dividing and they direct the movement of chromosomes during cell division
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centrioles
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help organize they cytoskeleton
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centrioles
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centrioles are made up of an array of ____ triplets of tubulin fibers
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9
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Cytoplasm surrounding the centrioles is the _______. This is the area that makes microtubules.
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centrosome
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Beats rhythmically to move fluids across cell surface. (respiratory tract, reproductive tract, embryo)
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cilia
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move in the direction they want the fluid to move first (power stroke) leaving the cilia close to the plasma membrane to perform the recovery stroke - sneaks back up
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cilia
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the cell's information storage system
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genetic code
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contains all the triplets needed to code for a specific polypeptide
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gene
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is a variation of a gene
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allele
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is a change in the normal genetic code
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mutation
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the language or words used in the DNA that the cell can use to build proteins (A,C,T,G - four letters possible, 64 possible combinations)
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triplet code
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builds up big molecules from small molecules
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polymerase
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is the formation of mRNA from DNA
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transcription
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tell where to start RNA
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promotor regions
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tell RNA when to stop
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stop code
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each set of triplet codes
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codon
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material inside the DNA and eventually gets cut out
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introns
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where codons are found
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exons
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1. have exons and introns 2. before they leave the nucleus, is going to have all of its introns removed 3. sometimes cells will also splice out one or more exons
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mRNA
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sometimes cells will splice out one or more exons in addition to introns
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alternative splicing
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mRNA is ________ to protein after binding to ribosomes
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translated
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once a ribosome finds this start codon, it will carry on
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AUG
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Sequence of _____ in the mRNA determines the sequence of amino acids
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codons
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(anticodon) transfers amino acid to the ribosome and decodes mRNA
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tRNA
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ribosomes are made up of
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RNA
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DNA (gene) is transcribed to _____
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RNA
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RNA is translated to _______
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protein
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Protein can be further modified after translation in _______ _______ (posttranslational modification)
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golgi apparatus
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______ is the nuclear and cytoplasmic division of somatic cells
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mitosis
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_______ produces sex cells (reduction division)
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Meiosis
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_______ is regulated cell suicide
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Apoptosis
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most somatic cells spend the majority of their lives in this phase
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interphase
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Stages of interphase
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G1 S G2
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(Interphase) Phase where the cell is hanging out, taking up nutrients and making proteins. The cell is getting bigger. (Growth and normal metabolic rates)
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G1
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(Interphase) cells sit here in this phase if they are never going to divide
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G0
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(Interphase) Phase where DNA synthesis occurs. Each of the 46 chromosomes gets replicated here.
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S
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(Interphase) Phase in growth and preparation for mitosis.
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G2
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After a certain amount of time or certain number of cell divisions, cells die
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cellular clock
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end of the chromosome strand
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telomere
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atoms or molecules with an unpaired electron (look to steal electrons from DNA causing mutation and damage OR mitochondrial damage)
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Free radicals
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Generally, the longer the life expectancy of the cell, the ______ the mitotic rate
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slower
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process of specialization (what cells perform what tasks)
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differentiation
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unregulated mitosis (stem cells replenish themselves)
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cancer
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cells divide but don't move anywhere (tumor)
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benign
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tumors that grow rapidly and move (metastasis)
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malignant
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A protein contains 100 amino acids. The mRNA that encodes this protein must contain at least how many nucleotides (bases)?
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303