USMLE – Paraneoplastic Syndromes – Flashcards
Unlock all answers in this set
Unlock answersquestion
*Acanthosis nigricans* Hyperpigmented velvety plaques in axilla and neck
answer
Gastric adenocarcinoma and other visceral malignancies (but more commonly associated with obesity and insulin resistance)
question
*Sign of Leser-Trélat* Sudden onset of multiple seborrheic keratoses
answer
GI adenocarcinomas and other visceral malignancies
question
*Hypercalcemia* PTHrP ^ 1,25-(OH)2 vitamin D3 (calcitriol)
answer
Squamous cell carcinomas of lung, head, and neck; renal, bladder, breast, and ovarian carcinomas Lymphoma
question
*Cushing syndrome* ^ ACTH
answer
Small cell lung cancer
question
*Hyponatremia* (SIADH) ^ADH
answer
Small cell lung cancer
question
*Polycythemia* ^Erythropoietin
answer
Renal cell carcinoma, hepatocellular carcinoma, hemangioblastoma, pheochromocytoma, leiomyoma
question
*Pure red cell aplasia* Anemia with low reticulocytes
answer
Thymoma
question
*Good syndrome* Hypogammaglobulinemia
answer
Thymoma
question
*Trousseau syndrome* Migratory superficial thrombophlebitis
answer
Adenocarcinomas, especially pancreatic
question
*Nonbacterial thrombotic (marantic) endocarditis* Deposition of sterile platelet thrombi on heart valves
answer
Adenocarcinomas, especially pancreatic
question
*Anti-NMDA receptor encephalitis* Psychiatric disturbance, memory deficits, seizures, dyskinesias, autonomic instability, language dysfunction
answer
Ovarian teratoma
question
*Opsoclonusmyoclonus ataxia syndrome* "Dancing eyes, dancing feet"
answer
Neuroblastoma (children), small cell lungcancer (adults)
question
*Paraneoplastic cerebellar degeneration* Antibodies against Hu, Yo, and Tr antigens in Purkinje cells
answer
Small cell lung cancer, gynecologic and breast cancers, and Hodgkin lymphoma
question
*Paraneoplastic encephalomyelitis* Antibodies against Hu antigens in neurons
answer
Small cell lung cancer
question
*Lambert-Eaton myasthenic syndrome* Antibodies against presynaptic (P/Q-type) Ca2+ channels at NMJ
answer
Small cell lung cancer
question
*Myasthenia gravis* Antibodies against postsynaptic AChR at NMJ Thymoma
answer
Thymoma
