The Memmler’s 13th Edition – Chapter 3: Cells – Flashcards

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Cytology
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Study of cells
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Compound Light Microscope
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1000x Magnification; Usually has 2 lenses & uses visible light (Most commonly used in labs)
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Transmission Electron Microscope
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1,000,000x Magnification; Uses electron beam in place of visible light
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Scanning Electron Microscope
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100,000x Magnification; 3D
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Micrometer
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1/1,000 of a millimeter; Abbrev: mcm
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Stain
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Dye used to aide in viewing cells and tissues taken under a microscope
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Plasma Membrane
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Outer layer of the cell; Composed mainly of lipids and proteins; Freely permeable to lipid-soluble substances because they can dissolve in & pass through the lipid bilayer (Steroid hormones & gases); (FROM H/W: CONTAINS CHOLESTEROL & PHOSPHOLIPIDS)
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Microvilli
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Found on cells specializing in absorption of materials from EC fluid; Plasma membrane is folded into multiple small projections that increase the membrane's surface area allowing for greater absorption (like a sponge)
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Channels
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Pores in the membrane that allow specific substances to enter or leave
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Transporters
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Proteins that change shape as they shuttle substances across the membrane
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Receptors
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Allow for attachment of substances to the membrane
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Enzymes
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Participate in reactions at the membrane surface
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Linkers
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Help stabilize the plasma membrane and attach cells together
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Organelles
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Specialized structures inside the cell that perform different tasks
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Nucleus
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Largest of the organelles; "Control center" of the cell; Surrounded by the nuclear membrane; Contains chromosomes (DNA)
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Chromosomes
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Threadlike structures of heredity; Info from chromosomes govern all cellular activities; Most of the time, the chromosomes are loosely distributed throughout the nucleus, except for when the cell is dividing, at which time the chromosomes tighten into their threadlike forms
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Nucleolus
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"Little Nucleus"; Assembles ribosomes
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Ribosomes
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Assemble amino acids into proteins
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Cytoplasm
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Material that fills the cell between the nuclear & plasma membranes
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Cytosol
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Liquid part of the Cytoplasm; A suspension of nutrients, electrolytes, enzymes, and other specialized materials in water
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Endoplasmic Reticulum
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(ER) Membranous network located between the nuclear membrane and the plasma membrane
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Rough Endoplasmic Reticulum
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(Rough ER) Roughness due to ribosomes attached to it; modifies, folds, and sorts PROTEINS; Cells that secrete proteins have lots of this; (FROM H/W: MODIFIES PREVIOUSLY SYNTHESIZED PROTEINS)
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Smooth Endoplasmic Reticulum
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Participates in lipid synthesis; Cells producing lipids have lots of this
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Golgi Apparatus
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Stack of membranous sacs; PACKAGES PROTEINS; Cells that secrete proteins have a prominent Golgi Apparatus
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Mitochondria
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Large & bean shaped w/ internal folded membranes; PRODUCE ATP
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Lysosomes
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Small sacs of digestive enzymes; REMOVES or DEGRADES WASTE & FOREIGN MATERIALS FROM CELL
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Peroxisomes
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Destroy harmful substances produced in metabolism
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Proteasomes
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BARREL SHAPED; Destroy improperly synthesized proteins; "Quality control" of proteins
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Vesicles
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Small, membrane-bound sacs in the cytoplasm; Store materials & move materials into or out of the cell in bulk
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Centrioles
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Rod-shaped, near nucleus; Help separate chromosomes during cell division
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Cilia
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Short, hairlike projections from the cell; Move fluids around the cell
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Flagellum
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Long, whiplike extension from the cell; Moves the cell (Only found on sperm cells)
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Semipermeable
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The plasma membrane is permeable, or passable, to some molecules but impermeable, or impassable, to others
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Passive Movement
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Movement through the plasma membrane that does not directly require energy output by the cell; Depend on gradients
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Gradients
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Differences in a particular quality between two regions (EX: a sled moves freely down an altitude gradient from a higher altitude to a lower altitude); In the body, many substances move because of concentration gradients but some also use pressure gradients
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Diffusion
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The net movement of particles from a region of relatively higher concentration to one of lower concentration (Diffusing substances spread throughout a space until concentration is even); DOES NOT REQUIRE ATP; Particles follow or MOVE DOWN their CONCENTRATION GRADIENT from higher concentration to lower concentration; Lipid-soluble substances diffuse freely across the plasma membrane when a concentration gradient exists while Water-soluble substances require an ion channel or transporter protein for diffusion (EX: Glucose)
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Osmosis
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Diffusion of water through a semipermeable membrane; water moves rapidly through the plasma membrane of most cells with the help of AQUAPORINS
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Isotonic Solution
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Contains the same concentration of dissolved substances (solutes) as the cytoplasm of the cell (EX: IV Fluids: 0.9% Salt or normal saline, 5% dextrose aka glucose)
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Hypotonic Solution
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Less concentrated (Contains less dissolved substances & more water) than the cytoplasm; Cells placed in this solution will draw in water, swell, and often burst; (Less than 0.9% salt or 5% dextrose)
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Hypertonic Solution
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More concentrated (Contains more dissolved substances & less water) than the cytoplasm; Cells placed in this solution will lose water to the surrounding fluids & shrink (Higher than 0.9% salt or 5% dextrose)
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Hemolysis
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When a red blood cell draws in water, swells, and bursts; Occurs in hypotonic solutions (hem/o means "blood")
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Crenation
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When a cell loses water & shrinks; Occurs in hypertonic solutions
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"Water follows salt"
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You can figure out which direction water will move through the plasma membrane if you remember this saying. In this saying, "Salt" refers to any dissolved material or 'solute.'
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Filtration
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The passage of water and dissolved materials through a membrane down a PRESSURE gradient from an area of higher pressure to an area of lower pressure (EX: coffee filter)
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Active Transport
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The movement of solutes AGAINST the CONCENTRATION GRADIENT using membrane transporters. (Requires ATP)
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Bulk Transport
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Uses vesicles & ATP to move large amounts of substances (Endocytosis & exocytosis)
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Endocytosis
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Bulk movement of materials INTO the CELL (Phagocytosis & Pinocytosis)
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Phagocytosis
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Large particles are engulfed by the plasma membrane and moved into the cell; PHAG/O MEANS "TO EAT"
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Pinocytosis
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DROPLETS of FLUID are engulfed by the plasma membrane; PINOCYTOSIS MEANS "CELL DRINKING"
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Exocytosis
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Cell moves materials OUT in vesicles
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Genes
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Carry messages for development of particular inherited characteristics
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DNA
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Deoxyribonucleic Acid; Composed of sub-units called Nucleotides; Double-stranded helix (A,T,G,C)
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RNA
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Ribonucleic Acid; Participates in protein synthesis but is NOT part of the DNA (A,C,G,U)
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Transcription
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Info from DNA is copied to RNA inside nucleus; (FROM H/W: RNA SYNTHESIS; also stated it as ASSEMBLY OF RNA STRAND)
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Messenger RNA (mRNA)
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Carries DNA info from nucleus to a ribosome in the cytoplasm
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Ribosomal RNA (rRNA)
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Compose ribosomes along w/ proteins
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Translation
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Info retrieved from the mRNA is decoded to assemble amino acids into the long chains that form proteins (FROM H/W: AMINO ACIDS ASSEMBLED INTO PROTEINS)
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Transfer RNA (tRNA)
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Carries amino acids to ribosome
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Meiosis
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Sex cells divide by this method; Cuts the chromosome number in half to prepare for union of the egg & sperm in fertilization
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Mitosis
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Each original parent cell divides into two IDENTICAL daughter cells
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Stem Cells
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Actively dividing cells
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Interphase
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Period of cell life before & after mitosis; DNA is replicated during this phase & held at the centromere awaiting mitosis
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Mature Cells
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Spend their entire lives in interphase and never enter mitosis
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Prophase
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Each replicated chromosome winds up tightly & separates from other chromosomes; Nucleolus & Nuclear Membrane begin to disappear; Centrioles move toward opposite ends of the cell; Spindle-shaped structure made of thin fibers begins to form between centrioles (FROM H/W: SPINDLE FIBERS FORM & CHROMATINS CONDENSE INTO CHROMOSOMES, also stated in h/w as CHROMOSOMES CONDENSE)
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Metaphase
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Chromosomes line up across the center (equator) of the cell attached to the spindle fibers (FROM H/W: CHROMOSOMES IN MIDDLE OF CELL)
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Anaphase
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Centromere splits & the spindle fibers begin to pull the chromosomes to opposite ends of the cell (FROM H/W: CHROMOSOMES SEPARATE)
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Telophase
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A membrane appears around each group of separated chromosomes, formed two new nuclei (FROM H/W: NUCLEAR MEMBRANE REFORMS)
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Mutation
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Alteration of the genes; natural occurrence in the process of cell division & is increased by exposure to harmful substances & radiation; sometimes harm cells & lead to cancer
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Apoptosis
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Programmed or natural cell death
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Cancer
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Results from mutations causing cells to reproduce without control; most common in epithelial stem cells which naturally multiply at a fast rate (less likely in slow growing cells); If the immune system does not kill these cells they become cancerous
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Risk Factors for Cancer
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Heredity, chemicals, radiation, obesity, physical inactivity, poor nutrition, infectious agents
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Risk Factor
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Aspects of an Individual's heredity, lifestyle, or environment that increase his or her chances of developing a disease
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cyt/o-
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cell
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micr/o-
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small
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chrom/o-
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color
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end/o-
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in
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lys/o-
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loosening, dissolving, separating
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-some
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body
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ex/o-
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outside, out of, away
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hem/o
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blood
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hyper-
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above, over, excessive
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hypo-
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deficient, below, beneath
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iso-
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same, equal
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phag/o-
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to eat, ingest
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pin/o-
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to drink
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semi-
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partial, half
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ana-
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upward, back, again
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inter-
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between
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meta-
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change
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pro-
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before, in front of
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tel/o-
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end
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carcin/o-
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cancer, carcinoma
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-gen
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agent that produces or originates
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Carcinogen
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Any chemical that causes cancer
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Nucleotide
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FROM H/W: Building block of RNA & DNA
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Cancer results from genetic mutations
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FROM H/W: TRUE
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The immune system often kills cancerous cells
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FROM H/W: TRUE
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Tumors that do not spread to other tissues are called cancers
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FROM H/W: FALSE
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Proteins
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FROM H/W: Makes up transporters, carriers, & DNA enzymes in the plasma membrane
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