Stereochemistry Answers Flashcard

If molecules have different stereochemistry, this means…
that they have the same connections of atoms, but differ from one another by the orientation of those atoms in three-dimensional space.
Left
S, sinister
Right
R, rectus
Molecules with different stereochemistry are ___________ of each other.
stereoisomers
What is a chiral center?
A carbon atom with four different (unique) attached atoms or groups.
Cahn-Ingold-Prelog rules for assigning priority
Use to assign R or S configuration. Prioritize using numbers 1-4. Highest priority goes to the group whose first atom has the highest atomic number. Double and triple bonds expanded into equivalent number of single bonds (C tripled bonded to N counts as C connected to three N).
Assigning R and S configurations to chiral centers
1) Rotate the molecule so the fourth-priority substituent is in the back (on a dashed bond sticking back into the paper). 2) Draw a curve from the first- to second – to third-priority substituent: is clockwise, R, if counterclockwise, S.

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