Sliding Filament Theory Steps – Flashcards
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Sliding filament theory for the contraction of skeletal and cardiac muscle
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(tropomyosin, troponin, myosin binding site, Ca++ channel, Ca++ active transport pumps, ATP, acetylcholine, acetylcholinesterase,
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Sliding Filament theory Step 1
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Action potential (electrical stimulation) from Somatic (motor) nerve, stimulates skeletal muscle fibers (cells) at neuromuscular junction (latent period)
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Sliding Filament theory Step 2
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Action potential causes the opening of potassium (Na+) channels on the sarcolemma thus causing a wave of depolarization to travel from the neuromuscular junction (latent period)
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Sliding Filament theory Step 2
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Action potential causes the opening of potassium (Na+) channels on the sarcolemma thus causing a wave of depolarization to travel from the neuromuscular junction (latent period)
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Sliding Filament theory Step 3
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depolarization event is communicated deep into the sarcoplasm via t-tubules (latent period)
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Sliding Filament theory Step 4
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depolarization of sarcoplasmic reticulum causes the opening of calcium channels and the subsequent release of calcium from sarcoplasmic reticulum (contraction period)
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Sliding Filament theory Step 5
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Calcium binds to troponin, troponin molecules change shape causing tropomyosin, to move off of crossbridge binding sites on actin. (contraction period)
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Sliding Filament theory Step 6
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Myosin crossbridges bind to crossbridge binding sites on actin (contraction period)
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Sliding Filament theory Step 7
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ATPase acts on ATP in the binding site on the myosin to convert it into ADP+ Pi+ Energy (contraction period)
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Sliding Filament theory Step 8
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Released kinetic energy causes a "power-stroke which causes actin to slide over myosin (contraction occurs) (contraction period)
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Sliding Filament theory Step 9
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Sarcolemma repolarizes due to the opening of potassium channels (relaxation period)
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Sliding Filament theory Step 10
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Calcium channels close and an active transport pump carries calcium back to sarcoplamic retculum, troponin returns to pre-calcium shape, and ATP reforms to release the actin-myosin bond. (relaxation period)
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Sliding Filament theory Step 10
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Calcium channels close and an active transport pump carries calcium back to sarcoplamic retculum, troponin returns to pre-calcium shape, and ATP reforms to release the actin-myosin bond. (relaxation period)
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Sliding Filament theory Step 10
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Calcium channels close and an active transport pump carries calcium back to sarcoplamic retculum, troponin returns to pre-calcium shape, and ATP reforms to release the actin-myosin bond. (relaxation period)
