RES111 – Flashcard
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The largest single group of drugs among aerosolized agents used for inhalation
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Adrenergic bronchodilators
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A drug that stimulates a receptor responding to norepinephrine
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Adrenergic
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Duration for ipratropium bromide plus albuterol sulfate (DuoNeb)
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4 to 6 hours
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Strong a1-vasoconstricting effects to reduce swelling in the nose and larynx and to control bleeding during bronchoscopic biopsy
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Racemic epinephrine
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Ipratropium bromide should be used with precaution in all of the following diseases
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prostatic hypertrophy, urinary retention, and glaucoma.
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Time course and disposition of a drug in the body based on its absorption, distribution, metabolism, and elimination
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Pharmacokinetic
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Ipratropium bromide (Atrovent) is used for treating
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chronic bronchitis, emphysema, and COPD
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used with metered dose inhaler therapy to reduce the need for hand-breathing coordination and oropharyngeal impaction of aerosolized drugs
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Nonvalved spacer devices, One-way spacer, and Holding chambers
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neurotransmitter in the sympathetic system
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Norepinephrine
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short-acting noncatecholamine bronchodilator
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Pirbuterol, Terbutaline, and Albuterol
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Proventil and Ventolin
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Albuterol brand names
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Amount of ipratropium bromide (Atrovent) delivered by MDI
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18 µg/puff
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limits the systemic distribution of an inhaled aerosolized drug
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A fully ionized drug
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short-acting noncathecholamine agent
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Bitolterol is a prodrug
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According to the National Asthma Education and Prevention Program a "Rescue" is what type of agent
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Short-acting adrenergic bronchodilators
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ultra-short-acting catecholamine bronchodilator
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Isoetharine
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dosage for ipratropium bromide (Atrovent)
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2 puffs four times daily
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duration of action for ipratropium bromide
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4 to 6 hours
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Pharmacologic control of the airway is mediated by
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smooth muscle, secretory cells, and blood vessels
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When M3 receptor is stimulated
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bronchoconstriction
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ß-adrenergic bronchodilator "Formoterol" brand name
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Foradil
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Advantage for treating respiratory tract with inhaled aerosols
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Doses are usually smaller, Onset of drug action is rapid, and Systemic side effects are often fewer and less severe.
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short-acting noncatecholamine agents duration
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4 to 6 hours average
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potential adverse effects with use of adrenergic bronchodilators
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Hypokalemia, Dizziness, and Worsening ventilation/perfusion ratio (V/Q)
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assessment features for evaluating patient response to bronchodilator therapy
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Reversibility of airflow obstruction, Changes in flow rates using a peak flowmeter or portable spirometry, Changes in vital signs, Changes in ventilation and oxygenation, & The patient's subjective reaction to treatment.
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constitute the course of drug action from dose to effect
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Drug administration, Pharmacokinetic and Pharmacodynamic
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The long-acting adrenergic bronchodilator salmeterol (Serevent) peak effect occurs
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3 to 5 hours long
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effects within the body through drug-receptor interactions
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Pharmacodynamic phase
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Adrenergic bronchodilators improve flow rates for
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asthma, acute bronchitis and chronic bronchitis
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Demonstrates the most efficient aerosol delivery in lung availability/total systemic availability (L/T)
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a ratio of 0.6
