PhysioEx 4 (Endocrine System Physiology) Activity Questions – Flashcards
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Using a water filled manometer, you observed the amount of oxygen consumed by rats in a sealed chamber. What happened to the carbon dioxide the rat produced while in the sealed chamber?
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the sodalite absorbed the CO2 so you were able to measure just the O2 amount
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What would happen to the fluid levels of the manometer (and thus, the results of the metabolism experiment) if the rats in the sealed chamber were engaged in physical activity (such as running in a wheel)?
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they would decrease due to the rat using up more oxygen to compensate for the extra physical activity
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Describe the role of the hypothalamus in the production of thyroxine.
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the hypothalamus sends endocrine signals to the pituitary gland
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What does it mean if a hormone is a tropic hormone?
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they have other endocrine glands as their target
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How could you treat a thyroidectomized rat so that it functions like a " normal" rat? How would you verify that your treatments were safe and effective?
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give the rat T4 supplements
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What is the role of the hypothalamus in the production of thyroid stimulating hormone (TSH)?
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it secreted TRH which stimulates TSH production
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How does thyrotropin releasing hormone (TRH) travel from the hypothalamus to the pituitary gland?
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it travels via the bloodstream
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Why didn't the administration of TSH have any effect on the metabolic rate of the thyroidectomized rat?
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because it doesn't have a thyroid effect
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Why didn't the administration of propylthiouracil have any effect on the metabolic rate of either the thyroidectomized rat or the hypophysectomized rat?
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because both rats had the thyroid gland removed
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Propylthiouracil inhibits the production of thyroxine by blocking the attachment of iodine tot he amino acid tyrosine. What naturally occurring problem in some parts of the world does this drug mimic?
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iodine deficiency
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How would you know if your glucose standard curve was aberrant and thus inappropriate for patient diagnostics?
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it is a point of reference for converting optical density into glucose readings
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What are potential sources of variability when generating a glucose standard curve?
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experimental error and inherent variability
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What recommendations would you make to a patient with fasting plasma glucose levels in the impaired/borderline impaired range who was in the impaired/borderline impaired range for the oral glucose tolerance test?
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should be counseled to alter their diet and exercise
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The amount of corn syrup in the American diet has been described as alarmingly high (especially in the foods that children eat). In the context of this activity, predict the likely trends in the fasting plasma glucose levels of our children as they mature.
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more likely to experience insulin resistance, leading to type 2 diabetes
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In hormone replacement therapy, how is the hormone dose determined by the prescribing physician?
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osteoporosis risk, menopausal symptom relief, suspected cardiovascular benefit
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Discuss the benefits and drawbacks of giving glucocorticoids to young children that have significant allergy induced asthma.
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it improves the health status and reduces symptoms but there is a chance of developing pneumonia
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Explain the difference between Cushing's syndrome and Cushing's disease.
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syndrome refers to the signs and symptoms associated with excess cortisol. disease is caused by a pituitary gland tumor
