phenelzine/ Nardil

Flashcard maker : Ruth Jones
classification (therapeutic)
antidepressant
classification (pharmacologic)
monamine oxidase (MAO) inhibitors
indications
depression in pt’s who have failed other modes of therapy (tricyclic a., SSRI’s, ECT)
therapeutic effects
improved mood in depressed patients
contraindications/ precautions
liver and renal disease, cardiovascular disease, uncontrolled hypertension, CHF, severe headache, pt undergoing surgery requiring anesthesia (must discontinue day before), concurrent meperidine, SSRI, tricyclic antidepressants, tetracyclic antidepressants, foods containing high concentrations of thyramine, use cautiously in pt: with suicidal thoughts, drug dependency, schizophrenia, bipolar d., diabetes m., hyperthyroidism, seizures
adverse reactions/ side effects
CNS: SEIZURES, dizziness, headache, CV: HYPERTENSIVE CRISIS, arrhythmias, GI: diarrhea, weight gain, constipation, dry mouth, GU: dysuria,
route for adults
PO: 15mg 3 times daily, increase to 60-90 mg/day in devided doses, after max benefit achieved, reduce to smallest effective dose (15mg/day, every other day)
nursing implications
monitor bp and pulse before and freq. during therapy, must report significant changes, head is often 1st symptom of hypertensive crisis, assess metal status and anxiety level, freq., assess for suicidal thoughts during early therapy, monitor I&O, weight, and BMI, ingestion of thyramine foods can cause life-threatening hypertensive crisis, treatment: IV phentolamine, or single dose of oral calcium channel blocker

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