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pexidartinib C20H15ClF3N5 structure – Flashcards

Flashcard maker : Shelby Arnold

Contents

Experimental Solubility:
Safety:
Target Organs:
Bio Activity:

Molecular Formula	C₂₀H₁₅ClF₃N₅
Average mass	417.815 Da
Density	1.5±0.1 g/cm³
Boiling Point	580.0±50.0 °C at 760 mmHg
Flash Point	304.6±30.1 °C
Molar Refractivity	106.1±0.3 cm³
Polarizability	42.1±0.5 10^-24cm³
Surface Tension	57.3±3.0 dyne/cm
Molar Volume	286.6±3.0 cm³

Experimental data
Predicted – ACD/Labs
Predicted – ChemAxon

Experimental Physico-chemical Properties
- Experimental Solubility:
  
  DMSO:40mg/mL MedChem Express HY-16749

Miscellaneous

Safety:

5 Axon Medchem 2501

H303;H313;H317;H333;H334;H335;H383 Axon Medchem 2501

no pictogram Axon Medchem 2501

P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P350 Axon Medchem 2501

Warning Axon Medchem 2501

Target Organs:

c-Kit inhibitor; FLT3 inhibitor TargetMol T2115

Bio Activity:

c-Fms MedChem Express HY-16749

c-Fms c-Kit MedChem Express HY-16749

Kit;CSF-1R;FLT3 TargetMol T2115

Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. MedChem Express

Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.; IC50 value: 28/16 nM(Fms/Kit); Target: multikinase inhibitor; Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. MedChem Express HY-16749

Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.;IC50 value: 28/16 nM(Fms/Kit);Target: multikinase inhibitorMultitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. MedChem Express HY-16749

Protein Tyrosine Kinase/RTK MedChem Express HY-16749

Protein Tyrosine Kinase/RTK; MedChem Express HY-16749

Tyrosine Kinase/Adaptors TargetMol T2115

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density:	1.5±0.1 g/cm³
Boiling Point:	580.0±50.0 °C at 760 mmHg
Vapour Pressure:	0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization:	86.8±3.0 kJ/mol
Flash Point:	304.6±30.1 °C
Index of Refraction:	1.662
Molar Refractivity:	106.1±0.3 cm³
#H bond acceptors:	5
#H bond donors:	2
#Freely Rotating Bonds:	6
#Rule of 5 Violations:	0

ACD/LogP:	4.77
ACD/LogD (pH 5.5):	4.05
ACD/BCF (pH 5.5):	573.67
ACD/KOC (pH 5.5):	2594.75
ACD/LogD (pH 7.4):	4.40
ACD/BCF (pH 7.4):	1291.47
ACD/KOC (pH 7.4):	5841.48
Polar Surface Area:	66 Å²
Polarizability:	42.1±0.5 10^-24cm³
Surface Tension:	57.3±3.0 dyne/cm
Molar Volume:	286.6±3.0 cm³

Click to predict properties on the Chemicalize site

pexidartinib C20H15ClF3N5 structure – Flashcards

Experimental Solubility:

Safety:

Target Organs:

Bio Activity:

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