Pathophysio Chapter 2 – Flashcards

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Proportion of water to body weight to be expected in a healthy male adult
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60%
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Proportion of blood to body weight in an adult males's body
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10%
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Insensible fluid loss refers to water lost through
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Perspiration only
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When the osmotic pressure of the blood is elevated above normal water would shift from
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The interstitial compartment into the cells
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Result from a deficit of plasma proteins
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Decreased osmotic pressure
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A cause of edema
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increased capillary permeability
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Elevated hematocrit reading could lead to
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fluid deficit
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Typical sign of dehydration
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rough oral mucous
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Decreased circulating blood volume and excess fluid in a body can lead to
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Hypovolemia
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Primary cation in the extracellular fluid
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sodium
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Common cause of hyponatremia
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Excessive sweating
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Common effect of both hypokalemia and hyperkalemia
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Cardiac arrythmias
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Effect of Increased parathyroid hormone
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increased activation of vitamin D
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Results of hypocalcemia
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skeletal muscle twitch and spasms, weak cardiac contractions
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Cause of tetany
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excess calcium ions in skeletal muscle due to excessive parathyroid hormone
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Phosphate in not a major component in
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Blood clotting
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Normal pH
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7.4
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Excess hydrogen ions accumulated in the blood leads serum pH to
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decrease
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Slowest but most effective control for acid-base balance
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kidneys
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Essential to maintain serum pH within normal range
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the ratio of carbonic acid to bicarbonate ion must be 1:20
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Effect on the body of abnormally slow respirations
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increased carbonic acid
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Cause of metabolic acidosis
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prolonged diarrhea
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serum pH of 7.33 in a patient with kidney disease indicates
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metabolic acidosis
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Serum value indicates decompensated metabolic acidosis
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pH is below normal range
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Effect on blood serum when excessive lactic acid accumulates in the body
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Bicarbonate ion levels decrease
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Direct effect of acidosis are manifested primarily in the functioning of the
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Nervous System
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Compensation mechanisms in the body for dehydration include
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increased antidiuretic hormone (ADH)
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Acid-base imbalance results from impaired expiration due to emphysema
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Respiratory acidosis
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impaired expiration associated with emphysema, effective acid-base imbalance compensation would be
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decreased urine pH and increased serum bicarbonate
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Anxiety attack caused by hyperventilation leading to
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decreased PCO2
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factors involved in the increased need for water in infants
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higher metabolic rate
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Compensation for respiratory system depression due to anesthesia and sedation
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increased secretion of hydrogen ions into the filtrate
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a prolonged state of metabolic acidosis often leads to
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hyperkalemia
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Strenuous physical exercise on a hot day is likely to result
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Hypovolemia
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Correct sequence of events when ketoacids increase in the blood of a diabetic patient
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Serum bicarbonate decreases, serum pH decreases, Respiration increases, PCO2 decreases, urine pH increases, serum pH increases
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Manifestation of respiratory alkalosis
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Increased nervous system irritability
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Prolonged diarrhea results in
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loss of fluid and bicarbonate ions, leading to metabolic acidosis
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In the initial stage, vomiting results in
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metabolic alkalosis
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the two ions most important for acid-base balance in the body
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Cl- and HCO3-
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Balance of carbonic acid and bicarbonate ion levels are controlled by
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lungs and kidneys
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Alkalosis increases irritability and spontaneous stimulation of nerves
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increasing the permeability of nerve membranes
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Hypocalcemia causes weak cardiac contractions
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insufficient calcium ions are available for muscle contraction
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Serum potassium levels are affected by
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Aldosterone, serum H+ levels, insulin levels
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Primary control of serum Na+ levels
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Aldosterone
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Control center for thirst is located in
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Hypothalamus
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Atrial natriuretic peptide
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It is secreted by heart muscle cells, it helps to control water and sodium balance
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Three mechanisms that control or compensate for serum pH
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buffer pairs in blood, change in kidney excretion rate, change in respiration rate
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Hypokalemia refers to a condition in which the serum has very low level of this ion
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Potassium
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In the blood and extracellular fluids, hypernatremia refers to
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an excess sodium level
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Increased milk and/or antacid intake can contribute to development of "milk-alkali syndrome" which can cause
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Hypercalcemia
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Hyponatremia
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serum sodium concentration below 3.8 to 5 mmol per liter or 135 miliequivalent (mEq)
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Hypernatremia
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excess sodium results form ingestion of large amounts of sodium without proportionate water intake of loss of water faster than loss of sodium
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Buffer systems
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Sodium-bicarbonate acid, phosphate, hemoglobin, protein
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Hyperkalemia
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abnormally elevated level of potassium in the blood
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Hypokalemia
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deficiency of potassium in the bloodstream
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Hypercalcemia
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Calcium level in your blood is above normal
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Hypocalcemia
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loss of calcium or insufficient entry of calcium into the circulation
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Hypovolemia
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a decreased volume of circulating blood in the body
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Hypervolemia
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fluid overload in the blood
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