NYCPM-Indi-final – Flashcards

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LIPID ENVELOPE

INACTIVATED BY ETHER OR LOW CONCETRATIO OF DETERGENT

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ARBOVIRUSES
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ARTHROPOD-BORNE VIRUSES
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ARBOVIRUSES
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DOES NOT INACTIVATED BY LOW CONCENTRATIONS OF DETERGENT
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IS REOVIRUS
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ICOSAHEDRAL, ENVELOPED, SINGLE STRANDED WITH + STRANDED RNA GENOME
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TOGAVIRUSES
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ICOSAHEDRAL,

ENVELOPED,

SINGLE-STRANDED WITH (+) STRANDED RNA GENOME

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FLAVIVIRUSES
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ORBIVIRUSES AND COLTIVIRUSES FAMILY
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REOVIRUS
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NON-ENVELOPED,

ICOSAHEDRAL (DOUBLE LAYER OF CAPSID),

DOUBLE STRANDED RNA VIRUSES,

10 SEGMENT IN GENOME

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REOVIRUS
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HELICAL SYMMETRY

ENVELOPED (VIRAL PARTICLE IS SPHERICAL)

SINGLE STRANDED WITH PRIMARILY NEGATIVE STRANDED RNA GENOME

3 SEGMENT IN GENOME

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BUNYAVIRUSES
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GENOME REASSORTMENT-AMBISENSE
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BUNYAVIRUSES
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UNUSUAL CYCLE
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FOR HUMAN ARTHROPOD CYCLE
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UNUSUAL CYCLE
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HUMAN IS TYPICALLY "DEAD-END" HOST
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IN SUMMER MONTHS WHEN ARTHROPODS BREED I.E MOSQUITOES, TICKS.

ARTHROPOD VECTOR PICKS UP VIRUS FROM HOST WITH VIREMIA -->IN VECTOR USUALLY PERSISTENT BUT IN ANIMAL HOST THE VIRUS INFECTION MIGHT BE PERSISTENT OR LYTIC; THEREFORE SOMETIMES THE HOST IS DEAD-END HOST SUCH AS THE HUMAN HOST.

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ARTHOPOD
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 AMONG THE RARE VIRUSES DOCUMENTED TO DO THIS IS DENGUE AND YELLOW FEVER VIRUSES ( AND POTENTIALLY CHIKUNGUNYA & ST. LOUIS ENCEPHAL

 

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WESTERN EQUINE ENCEPHALITIS (WEE)-WEST MISSISIPPI RIVER

 

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ALPHAVIRUSES
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EASTERN EQUINE ENCEPHALITIS (EEE): EASTERN U.S CARIBBEAN
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ALPHAVIRUSES
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CHIKUNGUNYA: S. AMERICA AND W. AFRICA CAUSES A CRIPPLING ARTHRITIS" THAT WHICH BENDS UP IN" SWAHILI
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ALPHAVIRUSES
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ROSS RIVER VIRUS: IN AUSTRALIA AND S. PACIFIC
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ALPHAVIRUSES
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YELLOW FEVER-HEMORRHAGIC FEVER SPREAD BY AEDES AEGYPTI MOSQUITO

 

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FLAVIVIRUSES
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YELLOW FEVER-JAUNDICE

GI HEMORRHAGE-BLACK VOMIT (COFFEE-GROUND EMESIS).

 

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FLAVIVIRUSES
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YELLOW FEVER: COUNCILMAN BODY (HYALINE BODY)
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FLAVIVIRUSES
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PREVENTABLE BY VACCINE
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FLAVIVIRUSES
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DENGUE FEVER (BREAKBONE FEVER)-FEVER, MYALGIA, RASH LEAD TO DENGUE HEMORRHARIC.

MIGHT SEE ECCHYMOSES

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FLAVIVIRUSES
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ST. LOUIS ENCEPHALITIS (ANTIGENICALLY RELATED TO WEST NILE) ENDEMIC TO REGIONS ALONG MISSISSIPPI RIVER.

JAPANESE ENCEPHALITIS GROUP

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FLAVIVIRUSES
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WEST NILE ENCEPHALITIS (WNV)-ARE IN THE JAPANESE ENCEPHALITIS GROUP.
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FLAVIVIRUSES
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TICK BORNE ENCEPHALITIS, OMSK HF VIRUS AND KYASANUR HF VIRUS
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FLAVIVIRUSES
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HUMAN TO VECTOR TO HUMAN SPEAD
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YELLOW FEVER VIRUS AND DENGUE FEVER VIRUS AND BOTH SPEAD BY THE AEDES AEGYPTI MOSQUITO.
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HUMAN TO VECTOR (CULEX MOSQUITO) TO HUMAN
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S. LOUIS ENCEPHALITIS
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FOUND IN BIRDS SPREAD BY MOSQUITOES.

VECTOR IS CULEX MOSQUITO

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FLAVIVIRUSES
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HUMANS ARE DEAD-END HOST (ACCIDENTAL/INCIDENTAL HOSTS).

ELDERLY AND IMMUNOCOMPROMISED MORE AT RISK FOR CNS COMPLICATIONS OR ENCEPHALITIS.

YOUNG CHILDREN ALSO AT RISK

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WEST NILE VIRUS (VNV)
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MILD FEBRILE DISEASE ("NON-SPECIFIC" FLU-LIKE SYMPTOMS) CAN LEAD TO FETAL ENCEPHALITIS
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WEST NILE VIRUS (VNV)

 

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MOSTLY ARBOVIRUSES

CALI ENCEPHALITIS

LA CROSSES VIRUS

RIFT VALLEY FEVER VIRUS

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BUNYAVIRUS
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HANTAVIRUS IS A ROBOVIRUS (RODENT BORNE VIRUS)
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BUNYAVIRUS
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CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS SPREAD BY CULICOID FLY
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BUNYAVIRUS
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SANDFLY FEVER VIRUS
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BUNYAVIRUS
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COLORADO TICK FEVER VIRUS (COLTIVIRUS)-WESTERN, NORTHWESTERN U.S AND CANADA
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REOVIRUS
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ORBIVIRUSES: AFRICAN HORSE SICKNESS AND BLUE TONGUE VIRUSES; ORUNGO NIGERIA AND KEMEROVO VIRUSES FROM RUSSIA AND EGYPT
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REOVIRUS
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RHABDOVIRUSES
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REOVIRUS
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HELICAL SYMMETRY, ENVELOPED SPHERICAL, SINGLE-STRANDED WITH PRIMARILY NEGATIVE STRANDED RNA GENOME; GENOME IN 3 SEGMENTS
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BUNYAVIRUSES
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GENOME REASSORTMENT-AMBIENSE
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BUNYAVIRUSES
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BUNYAVIRUSES HAVE THE SAME STRUCTURE TO
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ARENAVIRUSES
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2 SEGMENT GENOME-BIPARTITE; PART OF GENOME IS AMBISENSE
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ARENAVIRUSES
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SANDY (ARENOSE) APPEARANCE B/C THE VIRUS PARTICLE CONTAINS RIBOSOMES PICKED UP FROM HOST CELL
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ARENAVIRUSES

 

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LONG FILAMENTS (CYCLINDER SHAPE), GENOME IS SINGLE-STRANDED, NEGATIVE-STRAND RNA, ENVELOPED
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FILOVIRUSES
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EBOLA VIRUS, MARBURG VIRUS, RESTON VIRUS
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FILOVIRUSES
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ENDEMIC TO AFRICA ASSOCIATED WITH MONKEYS ALTHOUGH IT IS BELIEVED THAT THERE IS RODENT RESERVOIR
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FILOVIRUSES
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HANTAAN VIRUS CAUSE HEMORRHAGIC NECROSIS KIDNEY AND LETHAL PULMONARY DISEASE HANTA VIRAL INFECTION
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BUNYAVIRUSES
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SIN NOMBRE VIRUS IN NEW MEXICO AREA CAUSE HANTAVIRUS PULMONARY SYNDROME--->PULMONARY EDEMA
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BUNYAVIRUSES
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BLACK CREEK CANAL OF FLORIDA AND BAYOU VIRUS OF TEXAS AND LOUISIANA
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BUNYAVIRUSES
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LASSA FEVER, BEST KNOWN HEMORRHAGIC VIRUS
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ARENAVIRUS
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LYMPHOCYTIC CHORIONMENINGITIS (LCM)-FLU LIKE-25% CNS SYMPTOMS
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ARENAVIRUS

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HIGH FEVER, NECK RIGIDITY-EVIDENCE OF MENINGEAL IRRITATION
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ARENAVIRUS
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OUTBREAKS HAVE OCCURRED IN URBAN AREAS SUCH AS WASHINGTON. D.C
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ARENAVIRUS
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BELIEVED THAT THERE IS A RODENT RESERVOIR

STARTS WITH MILD FLU-LIKE SYMPTOMS

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FILOVIRUSES

 

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SEVERE BLEEDING, WITH KIDNEY AND RESPIRATORY COMPLICATIONS, MUSCLE ACHES
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FILOVIRUSES
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SEVERE OR FATAL HEMORRAGIC FEVER LEAD TO DEATH OCCURING IN 50-90% OF CASE DEPENDING ON STRAIN!

APPROX. 90% OF INFECTION CAN BE FATAL

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PROTEIN INFECTIOUS PARTICLE AKA PRIONS, IN WHICH THE INCUBATION PERIODS ARE VERY LONG AND THE CLINICAL EXPRESSIONS OF THE DISEASE ARE RELATIVELY SLOW IN PROGRESSION.
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SLOW "VIRUS" INFECTION
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ASSOCIATED WITH TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSE); THE DISEASE APPEARS MANY YEARS LATER
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PRIONS
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EQUINE INFECTIONS ANEMIA
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VISNA (LENTIVIRUS)
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SCARPIE, TRANSMISSIBLE MINK ENCEPHALOPATHY

BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) (MADCOW) DISEASE), CHRONIC WASTING DISEASE OF DEER AND ELK

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PRION
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SUBACUTE SCLEROSING PANENCEPHALITIS

PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (JC VIRUS)

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SLOW VIRUS INFECTION CAUSE BY VIRUS
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KURU, CREUTZFELDT-JAKOB DISEASE, VARIAN CREUTZFELDT-JAKOB DISEASE (ASSOCIATE WITH MADCOW DISEASE AND CHRONIC WASTING DISEASE OF ELK)
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SLOW VIRUS INFECTION IN MAN CAUSE BY PRION
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SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE): INVOLVES A DEFECTIVE MEASLES VIRUS
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CONVENTIONAL SLOW VIRUS
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SLOW PROGRESSIVE DEMYELINATION OF THE CNS
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CONVENTIONAL SLOW VIRUS
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M PROTEIN
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CONVENTIONAL SLOW VIRUS

 

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PROGRESSIVE MULIFOCAL LEUKOENCEPHALOPATHY (PML): JC VIRUS LEAD TO CNS DEMYELINATION
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PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)
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