Neurology – Headaches: Tension and Migraine – PPT/Book – Flashcards
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It is unusual to have your first tension headache above the age of what?
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50.
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Tension headaches associated with stressful events, moderate intensity, and self-limited with response to non-pharmacological treatment is most likely a [episodic/chronic] tension headache.
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Episodic.
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Daily tension headaches that bilateral in the occipital-frontal regions and associated with contracted neck/scalp muscles are more likely [episodic/chronic] tension headaches.
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Chronic.
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What is the International Headache Society's diagnostic criteria for tension headaches?
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2 or more of the following: 1. Non-pulsatile pressure or tightening. 2. Frontal-occipital. 3. Bilateral. 4. Mild to moderate. 5. Not aggravated by physical activity.
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True or False: The pain of a tension headache is usually throbbing.
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False. It is usually steady and often described as a pressure feeling or viselike sensation.
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Describe the location of tension headaches.
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*May be frontal, occipital, or generalized. *Often pain in neck area [differentiates from migraine]. *Usually bilateral.
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What is the usual onset of a tension headache?
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*Often present upon waking up or shortly after. *Gradual onset.
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Describe the duration of tension headaches.
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*Lasts for 30 minutes to days. *Does not rapidly appear and disappear.
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Do tension headaches have an aura.
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No.
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Do tension headaches have associated photophobia and/or phonophobia.
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Yes, they can, but these are not prominent symptoms.
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Which of the following are tension headaches not associated with: a. Nausea and vomiting. b. Insomnia. c. Difficulty concentrating. d. Emotional distress or intense worry.
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a. Nausea and vomiting.
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Which type of headache is commonly associated with muscular tightness in the head or neck?
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Tension headaches.
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Physical exam findings of someone with a tension headache.
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1. Normal vital signs. 2. Normal neuro exam. 3. +/- Neck/scalp tenderness. 4. No pain over temporal arteries. 5. +/- Very tender cervical muscles. 6. Pain with neck flexion [distinguish from nuchal rigidity]. 7. Stress/anxiety/depression.
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Should lab or imaging studies for tension headaches be ordered? If so, what?
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Order: 1. Specific labs only if indicated --> should be normal in tension headaches. 2. Head CT/MRI only if headaches have changed or neruo exam is abnormal.
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What are non-pharmaceutical treatment options for tension headaches.
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1. Eliminate potential triggers [medications, drug dependency]. 2. Biofeedback Relaxation therapy. 3. Physiotherapy. 4. Acupuncture. 5. Electrical stimulation. 6. Life style modifications [exercise, diet, sleep]. 7. Massage, PT, posture training. 8. Cervical traction.
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Per the book, what has been shown to be the most useful for prevention of tension-type headaches.
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Tricyclic antidepressants drugs in low doses. *Especially since many patients have concurrent anxiety/depression. *Amitriptyline is the most researched.
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What drugs might be considered for symptomatic relief of a tension headache?
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1. NSAIDS. 2. Acetylsalicyclic acid [ASA]. 3. Barbituates [with ASA and caffeine]. 4. Acetominophen. 5. Analgesics/antiemetic or sedatives [phenergan, compazine]. 6. Ergot alkaloids [e.g. cafetrate].
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Besides non-pharmaceutical options and oral medication treatments for tension headaches, what are 2 other injectable options to treat tension headaches?
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1. Injection of trigger points. 2. Botox.
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You walk into the ER room of a 22 year old female who has turned off all of the lights and is wearing dark sunglasses. She is curled up in a ball, holding her stomach. She grabs the left side of her head and tells you that she has a throbbing headache and nausea that has been steadily building over the past several hours. What type of headache is this most likely?
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Migraine.
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Migraine headaches are the [first/second/third] most common type of headache.
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Second.
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What percent of the U.S. population has migraines?
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10-20%.
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What is the female/male ratio for migraine prevalence?
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3 females: 1 male.
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Migraines may begin at any age, but what are the peak ages of onset? By what age will 80% of people have their first migraine if they are going to have them?
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Peak = Adolescence and early adulthood. Most by age 30.
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New onset of migraines past age _____ is rare.
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Past age 50.
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A positive family history of migraine headaches is reported in what percent of cases?
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65-91%.
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A migraine attack is the end result of the interaction of a number of factors of varying importance in different individuals. What are 4 factors discussed in the book?
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1. Genetic predisposition. 2. Susceptibility of CNS to certain stimuli. 3. Hormonal factors. 4. Sequence of neurovascular event.
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The pathophysiology of migraines involves many factors is not well understood. However, what is one of the key structures in the mechanism of pain in a migraine? Describe this pathophysiology?
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Trigeminal Vascular System: 1. Stimulation of trigeminal nucleus caudalis activates serotonin receptors and nerve endings on nearby dural arteries. 2. Vasodilation and neurogenic inflammation results. 3. Consequently, perivascular nerve endings are stimulated, leading to referred pain along the trigeminal nerve.
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Which 2 neurogenic peptides have been linking to the pathophysiology of migraines?
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1. Serotonin. 2. Dopamine.
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Which neuropeptide receptor is the most important in the migraine headache pathway?
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Serotonin receptor 5-HT. *note, Triptans target this.
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True or False: Neuropeptides are vasoactive.
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True.
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What is the migrainous aura likely caused by and what does it correspond to?
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"Cortical spreading depression," corresponds to: *Wave of neuronal depolarization. *Spreads over cortex posterior to anterior.
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What are some triggers for migraines that were discussed in class?
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1. Emotional or physical stress. 2. Lack or excess of sleep. 3. Missed meals. 4. Specific foods [chocolate, alcohol]. 5. Menstruation. 6. Oral contraceptives.
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Where is the usual location of a migraine headache?
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1. Frontotemporal distribution. 2. Usually unilateral, but can be bilateral.
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Describe the character/quality of migraine pain.
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1. Pulsating. 2. Dull, throbbing. 3. Severe, disabling pain.
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Describe the onset and duration of a migraine.
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1. Builds gradually. 2. May last hours or more.
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What is the usual severity level of a migraine?
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Severe, disabling.
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Is a migraine headache worse with activity?
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Yes.
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Besides an aura, what are some symptoms that are often present during a migraine?
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1. Photo-/phono-phobia. 2. Anorexia. 3. Nausea. 4. Occasionally vomiting.
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Especially in the absence of GI symptoms, the diagnosis of migraine requires the presence of at least one of which features/symptoms?
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1. Photophobia. 2. Phonophobia. 3. Osmophobia.
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In children, migraine is often associated with what types of symptoms?
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Episodic: 1. Abdominal pain. 2. Motion sickness. 3. Vertigo. 4. Sleep disturbances.
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Which type of migraine is more common, one with or without an aura?
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Migraine without aura is more common = 70% - 80%
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What is a migraine aura?
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Focal neurological symptoms that precede accompany, or rarely, follow an attack.
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Describe the onset/timing/duration of a migraine aura.
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Usually: 1. Develops over 5-20 minutes. 2. Lasts less than 60 minutes.
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What types of symptoms can an aura involve?
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1. Visual. 2. Sensorimotor. 3. Language. 4. Brainstem disturbances.
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What is the most common type of migraine aura?
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Positive visual disturbances.
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What are some visual disturbances that often precede a headache?
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1. Scotoma. 2. Scintilla.
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A migraine aura can include symptoms like unilateral paresthesia/weakness, diplopia, visual field abnormalities, dysarthria, etc. What are 2 things from the history that indicate that a migraine is more likely than a TIA?
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1. Symptoms of a migraine evolve, where as they do not in a TIA. 2. Symptoms are typically "negative" in TIA, vs "positive in migraine. *i.e. positive = presence of abnormal sensation, vs. negative = absence of normal sensory.
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Migraines with auras were formerly called what? Without auras?
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With auras = classic. Without auras = common.
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In primary care especially, migraines are commonly mis-diagnosed as what?
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Sinus headaches.
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What are rare, variants of migraines?
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1. Hemiplegic migraine. 2. Basilar migraine. 3. Ophthalmoplegic migraine. 4. Vestibular migraine.
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What types of symptoms are associated with a basilar migraine?
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Bilateral occipital lobe, brainstem, or cerebellar dysfuction, including: 1. Diplopia. 2. Ataxia. 3. Aphasia. 4. Syncope. 7. Other balance problems.
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Basilar migraines primarily occur in which age group?
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Children.
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What are vestibular migraines?
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Symptoms of vertigo with or without the other typical migraine symptoms.
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True or False: Tension headaches are associated with the presence of a patent foramen ovale.
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False. Migraine headaches are associated with a patent foramen ovale. Some hypothesize that this might contribute to the increased stroke risk in those with migraines.
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One prospective study of women younger than 45 found that active migraine with aura was associated with significantly increased risk of what serious conditions?
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1. CVD. 2. MI. 3. Ischemic stroke. 4. Death due to ischemic CVD.
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3 treatment goals of migraine treatment.
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1. Making an accurate and confident diagnosis, and reassuring the patient that there is not a more sinister cause. 2. Relieving acute attacks. 3. Preventing pain and associated symptoms of recurrent headaches.
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Women who have migraine with aura already have an increased risk of stroke, but this risk is about doubled if they also take what medication?
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Oral contraceptives. ***Copper IUD is an option, but avoid hormonals.
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The patient should be involved in their treatment plan for migraines. What is the most important way they can do this and what 3 purposes of this?
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Keep a headache diary: 1. Identify triggers. 2. Monitor headache frequency. 3. Monitor treatment response.
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When are migraines treated prophylactically?
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Frequency of migraines >2-3/month.
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For a preventative drug to be considered effective, it should decrease headache frequency rate by how much?
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50% decrease.
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In general, what are 5 drug classes that can be used to prevent migraines?
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1. Beta-adrenoceptor blockers. 2. Antiepileptic drugs. 3. Antidepressants. 4. Calcium channel blockers. 5. Other.
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What are the top 3 migraine prophylaxis drugs?
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1. Topiramate. 2. Amitriptyline. 3. Propranolol.
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4 important things to know about topiramate.
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1. Contraindicated if kidney stone history. 2. Can cause forgetfulness and cloudy thinking. 3. Significant weight loss. 4. Teratrogenic, so contraceptives a must [causes cleft palate].
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3 things to know about amitriptyline.
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1. Black box for suicide risk. 2. Urinary retention [in elderly]. 3. Good for chronic pain.
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What drug class is propranolol in? Who is it contraindicated in?
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Class = Beta Blocker. Contraindicated in = Asthma patients.
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What are 6 general treatments/things you can do to treat a symptomatic migraine?
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1. Dark, quiet room. 2. Simple analgesic immediately will often help. 3. Extracranial vasoconstrictors [e.g. cafergot]. 4. Triptans. 5. Treat nausea/vomiting. 6. Hydration.
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What is the MOA of triptans in migraine therapy?
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5-HT1 serotonin receptor agnoists that: 1. Stimulate 5-HT1 receptors to produce a direct vasoconstrictive effect. 2. Suppress inflammation.
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When are triptans contraindicated?
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1. Vasospastic vascular disorders. 2. Ischemic vascular disorders. 3. Uncontrolled HTN. *e.g. Vasocontrictive angina.
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Women who take oral contraceptives are at increased risk of what if they take triptans?
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Strokes. *2-4 fold rate increase.
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What is the MOA of ergotamines in migraine therapy?
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1. Direct vasoconstrictors of smooth muscle in cranial blood vessels. 2. Alpha-adrenergic antagonist and serotonin antagonists effects.
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What is the main ergotamine used to treat migraines?
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Ertotamine tartrate. *[Brands = Cafergot, Cafatine, Cafertrate, which also contain caffeine].
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True or False: By definition, migraines are not responsive to simple analgesics, such as acetaminophen, aspirin or NSAIDS.
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False. Many attacks will respond to this, especially if only a mild to moderate attack.
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Opiods and barbituates should not be used in routine migraine management. However, if used, what things do barbituates help with?
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1. Induces sleep. 2. Provides analgesia.
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What other medications are barbituates usually given with for migraine?
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1. ASA or acetaminophen. 2. Caffeine.
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Why is caffeine given with barbituates is there is a migraine?
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Increases GI absorption.
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Which combination barbituate is most commonly used to treat acute migraines? What is in it?
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Fioricet: 1. Acetaminophen. 2. Butalbital. 3. Caffeine.
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What are 4 antiemetics commonly prescribed for nausea and vomiting with migraines?
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1 Odansetron [Zofran]. 2. Promethazine [Phenergan]. 3. Prochlorperazine [Compazine]. 4. Droperidol [Inapsine]. *Note, they will also help the headache. *Connelly prefers Odansetron.
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What is it called when a severe migraine lasts longer than 72 hours?
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Status migrainosus.
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How is status migrainosus treated?
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Consider admission and give: 1. IV diphenhydramine [antihistamine]. 2. Ketorolac [no longer than 5 days]. 3. IV dihydroergotamine. 4. IV dexamethasone.
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