MCMP 407 Final – Flashcards
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| Muscarine |
answer
| Muscarine receptor no medical use, SLUD |
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| ACh |
answer
| M+N, intraocular use for miosis, SLUD |
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| Carbachol |
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| M+N, intraocular use for miosis, glaucoma, SLUD |
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| Pilocarpine |
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| M, Glaucoma, SLUD |
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| Bethanechol |
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| M, urinary retention, post operative ileus, SLUD |
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| Chantix |
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| Partial N agonsist, smoking cessation, SLUD |
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| Edrophonium |
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| Rev. AChE inh., Myassthenia Gravis, SLUD |
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| Neostigmine |
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| Reversible AChE, myasthenia gravis, glaucoma, post operative ileus, SLUD |
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| Pyridostigmine |
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| Rev. AChE inh., Myasthenia gravis, post op ileus, glaucoma, SLUD |
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| Physostigmine |
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| Reversible AChE, glaucoma, AD, antidote to anticholinergic OD, SLUD |
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| Rivastigmine |
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| Rev. AChE inh., glaucoma, AD, N&V, anorexia, weight loss |
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| Isofluorophate |
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| Irr. AChE inh. Glaucoma |
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| Echothiophate |
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| Irr. AChE inh., glaucoma |
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| Tacrine |
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| Rev. AChE inh. AD |
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| Donepezil |
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| Rev. AChE inh, AD |
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| 2-PAM |
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| AChE poisoning antidoe |
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| Memantine |
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| NDMA rec. antagonist, AD |
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| Reminyl |
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| Rev. AChE inh., AD |
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| Atropine |
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| non-selective M antagonist, mydriatic, sedation, tachycardia, dry mouth |
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| Scopolamine |
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| M ant. sea sickness, ANTI SLUD |
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| Homatropine |
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| Non-selective M ant. topically to produce cycloplegia, anti-SLUD |
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| Anistotropine |
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| non-selective M ant. GI spasms and peptic ulcers, anti-slud |
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| Glycopyrrolate |
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| non-selective M ant. GI spasms and peptic ulcers, anti-SLUD |
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| Topicamide |
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| M in the eyes, mydriasis, anti SLUD |
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| Ipratropium bromide |
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| M3 rec ant., asthma of COPD, anti slud |
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| Benztropine |
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| anti-AChE and antihistamine effects, PD, anti-slud |
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| Procyclidine |
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| PD, Anti-slud |
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| Tolterodine (detrol) |
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| M ant. urinary incontinence, anti slud |
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| Diphemanil |
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| M ant., antispamodic, anti-slud |
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| Benadryl |
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| M ant., antihistamine, anti-slud |
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| Imipramine |
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| M. ant, TCA antidepressant, anti-slud |
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| Vesamicol |
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| Depletes ACh vesicles |
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| Botox |
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| Inhibits ACh release, old skin |
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| Hemicholinium |
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| Inhibits uptake of choline |
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| Trimethaphan camphorsulfonate |
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| Ganglionic (nicotinic) blocker, hypertensive crisis |
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| Mescamylamine |
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| Ganglionic (nicotinic) blocker, hypertensive crisis |
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| d-tubocurarine |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Pancuronium bromide |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Vecuronium |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Rocuronium |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Atracurium |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Mivacurium |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| Succinyl Choline |
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| Nic. rec block at motor end plate, muscle relaxation during surgery |
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| l-NE |
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| alpha, b1, b2 agonist, pressor - dec HR |
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| Epinephrine |
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| alpha, B1, B2, anaphylaxis, glaucoma, local anestetics (adjunct), inc HR |
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| Phenylephrine |
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| alpha 1, mydriasis, glaucoma, pressor, nasal decongestant |
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| Naphazoline |
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| A1 partial agonist, decongestant |
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| Visine |
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| A1 partial agonist, decongestant |
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| Afrin |
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| A1 partial agonist, decongestant |
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| Clonidine |
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| A2 agonist, HTN, sedation, H20 retention, dry mouth |
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| Guanabenz |
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| A2 agonist, HTN, sedation, H20 retention, dry mouth |
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| Guanfacine |
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| A2 agonist, HTN, sedation, H20 retention, dry mouth |
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| Methyldopa |
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| A2 agonist, HTN, sedation, H20 retention, dry mouth |
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| Apraclonidine |
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| A2 agonist, glaucoma, sedation, H20 retention, dry mouth |
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| Tizanidine |
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| A2 agonist, muscle spasticity, sedation, H20 retention, dry mouth |
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| Isoproterenol |
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| non-selective beta agonist, asthma, COPD, cardiostimulant - inc HR |
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| Dopamine |
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| B1 receptor, critical life threatening situations |
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| Terbutaline |
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| B2 agonist, asthma, COPD, tocolytic |
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| Metaproterenol |
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| B2 agonist, asthma, COPD, tachycardia |
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| Albuterol |
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| B2 agonist, asthma, COPD, tachycardia |
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| Salmeterol |
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| B2 agonist, asthma, COPD, tachycardia |
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| Formoterol |
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| B2 agonist, asthma, COPD, tachycardia |
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| Ritodrine |
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| B2 agonist, tocolytic |
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| Dobutamine |
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| B1 agonist, acute heart failure, shock; + inotropic effect |
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| Amphetamine |
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| NET reverser, ADHD, narcolepsy |
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| Ephedrine |
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| Direct acting agonist, nasal decongestant, CTN: HTN |
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| Pseudoephedrine |
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| NET reverser, nasal decongestant, CTN: HTN |
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| Cocaine |
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| DAT blocker, tachycardia |
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| Desipramine |
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| Transport blocker, depression, ADD |
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| Phenelzine |
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| MAO inh., depression |
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| Selegiline |
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| MAO inh. early PD, depression |
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| Phenoxybenzamine |
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| A1, A2 ant. pheochromocytoma, HTN crisis, orthostatic hypotension, tachycardia |
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| Phentolamine |
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| A1, A2 ant. phenochromocytoma, HTN crisis, impotence, orthostatic hypotension, tachycardia |
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| Prazosin |
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| A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension |
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| Terazosin |
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| A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension |
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| Doxazonsin |
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| A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension |
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| Ergot alkaloids |
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| A1, A2 ant, migraines, LSD effect |
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| Yohimbine |
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| A2 ant. impotence |
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| Propranolol |
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| B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD |
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| Nadolol |
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| B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD |
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| Timolol |
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| B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD |
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| Pindolol |
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| B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD |
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| Carteolol |
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| B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD |
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| Toprol |
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| B1 ant., HTN, angina, CHF, bradycardia, AV block, sedation CTN: asthma, COPD |
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| Bisoprolol |
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| B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD |
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| Atenolol |
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| B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD |
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| Esmolol |
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| B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD |
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| Labetalol |
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| B1 B2 A1 ant. HTN and HTN crisis, B-blocking prevents reflex tachycardia from A1 block |
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| Carvediolol |
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| B1, B2, A1 ant. HTN and CHF, B-blocking blocks reflex tach. from A block |
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| alpha-methytrosine |
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| Inh. NE synthesis, pheochromocytoma, EPS, orthostatic hypotension |
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| Reserpine |
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| deplete vesicular stores of NE, HTN, may be linked to depression |
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| Bretylium Tosylate |
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| NE release inhibitor, antiarrhythmic, CTN: pts with AV block |
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| D-ephedrine |
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| DA, NE, 5-HT releasing agent, decongestant |
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| Methamphetamine |
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| DA, NE, 5-HT releaser |
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| Amphetamine |
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| DA, NE, 5-HT releaser, ADHD |
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| Ritalin |
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| DA/NE reuptake inh., ADHD |
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| Focalin |
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| DA/NE reuptake inh. ADHD |
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| Strattera |
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| NET inh. ADHD |
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| Provigil |
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| Narcolepsy |
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| Phentermine |
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| NET blocker - appetite suppression |
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| Benzpheramine |
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| DAT/NET blocker, appetite suppression |
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| Phenmetrazine |
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| DAT/NET blocker, appetite suppression |
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| Diethylpropion |
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| DAT/NET blocker, appetite suppression |
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| Meridia |
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| SERT/NET inh. appetite suppressant |
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| L-DOPA |
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| PD |
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| Sinemet (levadopa/carbidopa) |
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| PD, inhibits decarboxylase in periphery |
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| Apomorphine |
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| D1/D2 ag. PD |
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| Pramipexole |
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| D2/D3 ag. PD |
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| Requip |
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| D2/D2 ag. PD |
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| Pergolide |
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| D2/D3 ag. PD |
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| Bromocriptine |
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| D2/D3 ag. PD |
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| Rotigotine |
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| D2/D3 ag. PD |
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| Selegiline |
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| Irr. MAO inh. PD |
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| Rasagiline |
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| Irr. MAO inh. PD |
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| Entacapone |
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| COMT inh. PD |
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| Psilocybin |
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| 5-HT ag. Shrooms |
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| DMT |
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| 5HT-2A |
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| LSD |
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| 5HT2A most potent |
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| Mescaline |
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| 5HT2A |
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| Ectasy |
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| 5HT and DA release |
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| THC |
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| CB1 ag |
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| PCP |
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| NMDA blocker |
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| Ketamine |
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| NMDA blocker |
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| Chloropromazine (Thorazine) |
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| A1 and 5HT ag. 1st gen antipsychotic, EPS |
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| Promethazine (Phenergan) |
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| H1 ant. 1st gen antipsychotic |
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| Thioridazine (Mellaril) |
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| D2 ant. 1st gen antipsychotic |
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| Fluphenazine |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Prochlorperazine |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Perphenazine |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Thiothixene |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Halperiodl |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Molindone |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Pimozide |
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| D2 ant. 1st gen antipsychotic, EPS |
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| Clozapine |
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| 5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms |
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| Olanzapine |
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| 5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms |
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| Loxapine |
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| 5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms |
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| Seroquel |
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| 5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms |
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| Risperione |
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| 5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms |
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| Ziprasidone (Geodon) |
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| 5HT, D2, A1 ant. atypical antipsychotic, less EPS, treats secondary symptoms |
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| Abilify |
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| 5HT2 and D2 partial agonist, antipyschotic |
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| Phenelzine |
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| non-selective MAOI, antidepressant |
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| Tranylcypromine |
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| non-selective MAOI, antidepressant |
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| Selegiline |
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| MAOBI, antidepressant |
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| Moclobemide |
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| MAOAI, antidepressant |
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| Imipramine |
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| TCA - NET and SERT inh. antidepressant, can OD - tertiary amine |
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| Amitriptyline |
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| TCA - NET and SERT inh. antidepressant, can OD - tertiary amine |
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| Doxepin |
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| TCA - NET and SERT inh. antidepressant, can OD - tertiary amine |
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| Trimipramine |
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| TCA - NET and SERT inh. antidepressant, can OD - tertiary amine |
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| Clomipramine |
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| TCA - NET and SERT inh. antidepressant, can OD - tertiary amine |
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| Desipramine |
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| TCA - NET and SERT inh. antidepressant, can OD - secondary amine |
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| Nortriptyline |
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| secondary TCA - NET/SERT inh. can OD |
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| Protriptyline |
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| secondary TCA - NET/SERT inh. can OD |
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| Maprotiline |
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| secondary TCA - NET/SERT inh. can OD |
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| Fluoxetine (Prozac) |
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| SSRI - depression, OCD, PTSD |
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| Fluvoxamine (Luvox) |
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| SSRI - depression, OCD, PTSD |
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| Paroxetine (Paxil) |
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| SSRI - depression, OCD, PTSD |
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| Sertaline (Zoloft) |
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| SSRI - depression, OCD, PTSD |
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| Citalopram (Celexa) |
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| SSRI - depression, OCD, PTSD |
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| Escitalopram (Lexapro) |
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| SSRI - depression, OCD, PTSD |
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| Amoxapine |
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| D2 ant, NET inh. anitdepressant |
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| Trazodone |
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| 5HT2 ant. antidepressant |
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| Nefazodone |
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| 5HT2A ant. antidepressant |
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| Bupropion (Wellbutrin) |
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| DAT>NET=SERT inh. antidepressant |
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| Mirtazapine |
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| A2 ant, 5HT2, 5HT3, H1, ant. antidepressant |
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| Venlafaxine (Effexor) |
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| NET and SERT inh. SNRI, GAD, panic, depression |
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| Duloxetine (Cymbalta) |
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| NET/SERT inh. SNIR; GAD, depression |
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| Reboxetine (Vestra) |
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| NET inh. Depression, ADHD |
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| Atomoxetine (Straterra) |
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| NET inh. antidepressant, ADHD |
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| Diazepam (Valium) |
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| BZD; muscle spasms, sedation |
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| Baclofen (Lioresal) |
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| GABA-B ag. activates K+ channels, muscle relaxant |
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| Tizanidine |
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| A2 ag. works in reflex arc, muscle relaxant |
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| Cyclobenzaprine |
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| Acute muscle spasm, anitmuscarinic properties |
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| Dantrolene |
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| Reduces release of Ca++ from SR, cerebral palsy, MS, malignant hyperthermia |
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| Succinylchonline |
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| AChE, Neuromuscular blocks |
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| Mivacurium |
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| AChE, Neuromuscular blocks |
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| Atracurium |
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| AChE, Neuromuscular blocks |
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| Vecuronium |
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| AChE, Neuromuscular blocks |
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| Rocuronium |
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| AChE, Neuromuscular blocks |
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| Pancuronium |
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| AChE, Neuromuscular blocks |
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| Ether |
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| Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia |
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| Nitrous oxide |
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| Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia, FAST |
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| Halothane |
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| Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia |
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| Enflurane |
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| Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia |
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| Isoflurane |
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| Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia |
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| Ketamine |
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| Block NDMA rec. dissociative anesthesia |
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| Etomidate |
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| IV anesthetic |
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| Propofol |
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| GABA channels, rapid onset/recovery |
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| Procain |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Tetracaine |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Benzocaine |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Lidocaine |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Mepivacaine |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Bupivacaine |
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| Local anesthetic (blocks activated and inactivated Na+ channels) |
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| Chlordiazepoxide |
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| BZD, metabolites, anxiolytic |
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| Diazepam (Valium) |
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| BZD, metabolites, anxiolytic |
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| Flurzaepam |
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| BZD, hypnotic, metabolites |
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| Clorazepate |
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| BZD, metabolites, anxiolytic |
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| Quazepam |
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| BZD, hypnotic, metabolites |
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| Alprazolam (Xanax) |
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| BZD, anxiolytic and anesthetic |
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| Lorazepam |
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| BZD, metabolites, hypnotic |
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| Clonazepam |
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| BZD, anticonvulsant |
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| Oxazepam |
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| BZD, anxiolytic, EtOH withdrawal |
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| Temazepam |
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| BZD, anxiolytic, EtOH withdrawal |
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| Estrazolam |
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| BZD, short term hypnotic |
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| Midazolam |
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| BZD, rapid anesthesia |
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| Triazolam |
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| BZD, short term hypnotic |
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| Flumazenil |
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| BZD ant. BZD overdose |
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| Zolpidem (Ambien) |
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| Z-drug, insomnia, bind A1 subunit of BZ1 site |
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| Zaleplon (Sonata) |
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| Z-drug, insomnia, bind A1 subunit of BZ1 site |
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| Eszopiclone (Lunesta) |
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| Z-drug, insomnia, bind A1 subunit of BZ1 site |
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| Phenobarbital |
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| Barbiturate, anticonvulsant |
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| Mephobarbital |
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| Barbiturate, anticonvulsant |
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| Amobarbital |
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| Barbiturate, sedative-hypnotic |
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| Butabarbital |
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| Barbiturate, sedative-hypnotic |
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| Pentobarbital |
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| Barbiturate, sedative-hypnotic |
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| Secobarbital |
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| Barbiturate, sedative-hypnotic |
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| Aprobarbital |
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| Barbiturate, sedative-hypnotic |
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| Thiopental |
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| Barbiturate, IV anesthetic |
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| Methohexital |
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| Barbiturate, IV anesthetic |
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| Thiamylal |
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| Barbiturate, IV anesthetic |
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| Ramelteon |
answer
| MT1 and MT2 ag. works on circardian cycles, sleep |
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| GHB |
answer
| GABA-A,B,? narcolepsy |
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| Buspirone |
answer
| Partial 5HT1A ag. GAD, socail anxiety |
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| Clomipramine |
answer
| Partial SERT inh. TCA |
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| Hydroxyzine |
answer
| H1 ant, anxiolytic |
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| Phenytoin |
answer
| Na+ blocker, partial/tonic clonic |
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| Fosphenytoin |
answer
| Na+ blocker, partial/tonic-clonic |
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| Carbmazepine |
answer
| All Sz's except absense, Na+ blocker |
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| Oxcarbamazepine |
answer
| Partial, Na+ blocker |
question
| Phenobarbital |
answer
| Partial/tonic-clonic |
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| Primidone |
answer
| All but absence |
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| Gabapentin |
answer
| Partial, inc. GABA and Ca++ blocker |
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| Pregablin (Lyrica) |
answer
| Neuropathic pain, increase GABA |
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| Vigbatrin (Sabile) |
answer
| Adjunct for refractory Sz's, Irr inh. of GABA transaminase |
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| Tiagabine |
answer
| Partial/tonic-clonic, Inh. GAT-1 |
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| Lacosmaine |
answer
| Partial, Na+ blocker |
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| Rufinamine |
answer
| Partial and Lennox-Gastaut syndrome |
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| Lamotrigine (Lamictal) |
answer
| Partial, Na+ channel blocker |
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| Zonisamide (Zonegram) |
answer
| Partial in children |
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| Levetiraceptam (Keppra) |
answer
| Partial, GABA and Ca++ |
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| Felbamate |
answer
| Partial, NDMA ant |
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| Topiramate (Topamax) |
answer
| Partial/tonic-clonic, AMAP ant. |
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| Ethosuximide |
answer
| Absence, T-type Ca++ blocker |
question
| Valproic acid (Depakote) |
answer
| Absense, partial, generalized, bipolar; Na+, Ca++, GABA |
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| Valproate |
answer
| Tonic/clonic, absence, Na+ |
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| Codeine |
answer
| Weak analgesic, good antitussive |
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| Morphine |
answer
| Sever, acute, chronic pain |
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| Hydromorphone |
answer
| Severe pain |
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| Oxymorphone |
answer
| Severe pain |
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| Levophanol |
answer
| Severe pain |
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| Apomorphine |
answer
| Severe pain |
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| Hydrocodone |
answer
| Moderate pain |
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| Oxycodone |
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| Moderate/severe pain |
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| Dextromethorphan |
answer
| good antitussive no analgesic |
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| Heroin |
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| Illegal |
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| Meperidine (Demerol) |
answer
| Analgesia Mu agonist |
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| Propoxyphene (Davon) |
answer
| Mild/moderate pain, weak Mu agonist |
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| Methadone |
answer
| Pain and addiction, Mu ag |
question
| Tramadol |
answer
| Analgesia, weak Mu ag |
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| Ketorolac (Toradol) |
answer
| NSAID, severe pain |
question
| Tapentadol (Nucynta) |
answer
| Pain, weak Mu ag |
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| Methotrimeprazine |
answer
| Pain, increases theshold and creates amnesia |
question
| Fentanyl |
answer
| Severe pain, Mu agonist |
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| Sufentanil |
answer
| Severe pain, Mu agonist |
question
| Alfentanil |
answer
| Severe pain, Mu agonist |
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| Remifentanil (Ultiva) |
answer
| Severe pain, selective Mu agonist |
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| Diphenoxylate with atropine (Lomotil) |
answer
| Diarrhea, Mu and Delta ant |
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| Difenoxin with atropine (Motofen) |
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| Diarrhea, Mu and delta ant |
question
| Loperamine (Imodium AD) |
answer
| diarrhea, Mu and delta ant |
question
| Buprenophine (Buprenex, Subutex) |
answer
| Opioid withdrawal, partial Mu agonist, weak kappa ag and delta ant |
question
| Butorphanol (Staldol) |
answer
| Moderate to severe pain, strong kappa agonist, partial mu agonist |
question
| Nalbuphine (Nubain) |
answer
| Mod/severe pain K ag mu ant |
question
| Pentazocine (Talwin) |
answer
| mild/mod pain; kappa ag partial mu ag |
question
| Dezocine (Dulgan) |
answer
| severe pain, parial mu agonist |
question
| Pentazocine with naloxone |
answer
| Severe pain |
question
| Naloxone |
answer
| Opioid OD, mu ant |
question
| Naltrexone |
answer
| Heroin addiction and EtOH dependence, opioid receptor ant |
question
| Nalmefene |
answer
| Alcohol dependence, opioid receptor ant |
question
| Fomepizole |
answer
| Methanol/ethylene glycol poisoning |
question
| Disulfiram |
answer
| Aldehyde dehydrogenase inh. alcoholism |
question
| Acamprosate |
answer
| NMDA ant. reduced withdrawal from EtOH |
