Home Page Flashcards Lapatinib C29H26ClFN4O4S structure - Flashcards

Lapatinib C29H26ClFN4O4S structure – Flashcards

Flashcard maker : Chloe Barnes

Contents

Experimental Boiling Point:
Experimental Flash Point:
Experimental Gravity:
Experimental Solubility:
Safety:
Target Organs:
Bio Activity:

Molecular Formula	C₂₉H₂₆ClFN₄O₄S
Average mass	581.057 Da
Density	1.4±0.1 g/cm³
Boiling Point	750.7±60.0 °C at 760 mmHg
Flash Point	407.8±32.9 °C
Molar Refractivity	152.5±0.4 cm³
Polarizability	60.4±0.5 10^-24cm³
Surface Tension	57.7±3.0 dyne/cm
Molar Volume	420.7±3.0 cm³

Experimental data
Predicted – ACD/Labs
Predicted – ChemAxon

Experimental Physico-chemical Properties
- Experimental Boiling Point:
  
  750.7 °C Biosynth Q-101353
- Experimental Flash Point:
  
  407.8 °C Biosynth Q-101353
- Experimental Gravity:
  
  407.8 g/mL Biosynth Q-101353
- Experimental Solubility:
  
  10 mM in DMSO MedChem Express HY-50898

Miscellaneous

Safety:

IRRITANT Matrix Scientific 094127

P261; P262 Biosynth Q-101353
Target Organs:

EGFR inhibitor; HER2 inhibitor TargetMol T0078

Bio Activity:

EGFR MedChem Express HY-50898

EGFR, ErbB2 TargetMol T0078

JAK/STAT Signaling MedChem Express HY-50898

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-50898

Lapatinib(GW-572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. MedChem Express

Lapatinib(GW-572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.; IC50 Value: 10.8 nM (EGFR); 9.2 nM (ErbB2); Target: EGFR/ErbB2; Lapatinib ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. MedChem Express HY-50898

Lapatinib(GW-572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.;IC50 Value: 10.8 nM (EGFR); 9.2 nM (ErbB2);Target: EGFR/ErbB2Lapatinib ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. ErbB-2 and EGFR dual tyrosine kinases are growth promoting factors that are over expressed in some breast cancer cell lines. Research studies have reported that Lapatinib Ditosylate can inhibit breast cancer cell proliferation. MedChem Express HY-50898

Tyrosine Kinase/Adaptors; JAK/STAT Signaling TargetMol T0078

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density:	1.4±0.1 g/cm³
Boiling Point:	750.7±60.0 °C at 760 mmHg
Vapour Pressure:	0.0±2.5 mmHg at 25°C
Enthalpy of Vaporization:	109.4±3.0 kJ/mol
Flash Point:	407.8±32.9 °C
Index of Refraction:	1.645
Molar Refractivity:	152.5±0.4 cm³
#H bond acceptors:	8
#H bond donors:	2
#Freely Rotating Bonds:	11
#Rule of 5 Violations:	2

ACD/LogP:	5.14
ACD/LogD (pH 5.5):	4.07
ACD/BCF (pH 5.5):	385.29
ACD/KOC (pH 5.5):	1159.41
ACD/LogD (pH 7.4):	5.18
ACD/BCF (pH 7.4):	5026.48
ACD/KOC (pH 7.4):	15125.46
Polar Surface Area:	115 Å²
Polarizability:	60.4±0.5 10^-24cm³
Surface Tension:	57.7±3.0 dyne/cm
Molar Volume:	420.7±3.0 cm³

Click to predict properties on the Chemicalize site

Lapatinib C29H26ClFN4O4S structure – Flashcards

Experimental Boiling Point:

Experimental Flash Point:

Experimental Gravity:

Experimental Solubility:

Safety:

Target Organs:

Bio Activity:

Haven't found what you were looking for?

Search for samples, answers to your questions and flashcards